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1.发明授权Thiophenyl and pyrrolyl azepines as serotonin 5-HT2C receptor ligands and uses thereof 失效噻吩基和吡咯基吖庚因作为5-羟色胺5-HT 2C受体配体及其用途公开(公告)号：US08716276B2
公开(公告)日：2014-05-06
申请号：US13005395
申请日：2011-01-12
IPC分类号： A61P25/00 , A61K31/55 , C07D487/02 , C07D223/16
CPC分类号： C07D495/04 , C07D495/06
摘要： The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are thiophenyl and pyrrolyl azepine compounds. These compounds are serotonin receptor (5-HT2c) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT2c) is desired (e.g. addiction, anxiety, depression, obesity, and others).
摘要翻译： 本发明一般涉及一系列化合物，含有该化合物的药物组合物，以及该化合物和组合物作为治疗剂的用途。 更具体地，本发明的化合物是噻吩基和吡咯基吖庚因化合物。 这些化合物是5-羟色胺受体（5-HT2c）配体，可用于治疗需要调节血清素受体（5-HT2c）的活性的疾病，病症和状况（例如成瘾，焦虑，抑郁，肥胖等） 。
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2.发明授权Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators 有权三环杂芳基哌嗪，吡咯烷和氮杂环丁烷作为血清素受体调节剂公开(公告)号：US07981919B2
公开(公告)日：2011-07-19
申请号：US12221668
申请日：2008-08-05
IPC分类号： A61K31/40 , C07D209/56
CPC分类号： C07D491/04 , C07D495/04
摘要： The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are hexahydroazepinoindole and octahydroazepinoindole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity).
摘要翻译： 本发明一般涉及一系列化合物，含有该化合物的药物组合物，以及该化合物和组合物作为治疗剂的用途。 更具体地说，本发明的化合物是六氢吖庚因吲哚和八氢吖辛因吲哚化合物。 这些化合物是5-羟色胺受体（5-HT）配体，并且可用于治疗需要调节5-羟色胺受体（5-HT）的活性的疾病，病症和状况（例如焦虑，抑郁和肥胖）。
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3.发明申请THIOPHENYL AND PYRROLYL AZEPINES AS SEROTONIN 5-HT2C RECEPTOR LIGANDS AND USES THEREOF 失效作为丝氨酸5-HT2C受体配体的噻吩和吡咯烷酮及其用途公开(公告)号：US20110112072A1
公开(公告)日：2011-05-12
申请号：US13005395
申请日：2011-01-12
IPC分类号： C07D495/04 , C07D495/06 , A61K31/55 , A61P25/00 , A61P25/30 , A61P25/24 , A61P25/22 , A61P3/06
CPC分类号： C07D495/04 , C07D495/06
摘要： The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are thiophenyl and pyrrolyl azepine compounds. These compounds are serotonin receptor (5-HT2c) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT2c) is desired (e.g. addiction, anxiety, depression, obesity, and others).
摘要翻译： 本发明一般涉及一系列化合物，含有该化合物的药物组合物，以及该化合物和组合物作为治疗剂的用途。 更具体地，本发明的化合物是噻吩基和吡咯基吖庚因化合物。 这些化合物是5-羟色胺受体（5-HT2c）配体，可用于治疗需要调节血清素受体（5-HT2c）的活性的疾病，病症和状况（例如成瘾，焦虑，抑郁，肥胖等） 。
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4.发明申请公开(公告)号：US20100190772A1
公开(公告)日：2010-07-29
申请号：US12752601
申请日：2010-04-01
IPC分类号： A61K31/55 , C07D495/04 , C07D495/10 , C07D495/06 , A61P3/04 , A61P25/22 , A61P25/24 , A61P25/30
CPC分类号： C07D495/04
摘要： The present invention generally relates to compounds and pharmaceutical compositions containing the compounds. More specifically, compounds of the present invention are hexahydroazepinoindole and octahydroazepinoindole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity).
摘要翻译： 本发明一般涉及含有这些化合物的化合物和药物组合物。 更具体地说，本发明的化合物是六氢吖庚因吲哚和八氢吖辛因吲哚化合物。 这些化合物是5-羟色胺受体（5-HT）配体，并且可用于治疗需要调节5-羟色胺受体（5-HT）的活性的疾病，病症和状况（例如焦虑，抑郁和肥胖）。
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公开(公告)号：US20090163572A1
公开(公告)日：2009-06-25
申请号：US12339184
申请日：2008-12-19
申请人： David C. Bom
发明人： David C. Bom
IPC分类号： A61K31/39 , C07D327/06 , A61K31/385 , C07D339/08
CPC分类号： A61K8/49 , A23G3/36 , A23G4/06 , A23L27/30 , A61K8/4986 , A61K2800/244 , A61Q19/00
摘要： A method of providing a cooling sensation to the skin or the mucous membranes of the body, comprising the application thereto of at least one compound of the Formula I in which X is selected from S and O, R1 is selected from H and OMe, R2 is selected from OH, OMe and OEt, and R3 is selected from H and OH. Some of the compounds provide simultaneously cooling and sweetening effects.
摘要翻译： 向身体的皮肤或粘膜提供冷却感的方法，其中包括至少一种其中X选自S和O的式I化合物，R1选自H和OMe，R2 选自OH，OMe和OEt，R 3选自H和OH。 一些化合物同时提供冷却和甜味效果。
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6.发明授权Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators 有权三环杂芳基哌嗪，吡咯烷和氮杂环丁烷作为血清素受体调节剂公开(公告)号：US07423056B2
公开(公告)日：2008-09-09
申请号：US11217991
申请日：2005-09-01
IPC分类号： A61K31/40 , C07D209/56 , C07D495/02
CPC分类号： C07D491/04 , C07D495/04
摘要： The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are hexahydroazepinoindole and octahydroazepinoindole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity).
摘要翻译： 本发明一般涉及一系列化合物，含有该化合物的药物组合物，以及该化合物和组合物作为治疗剂的用途。 更具体地说，本发明的化合物是六氢吖庚因吲哚和八氢吖辛因吲哚化合物。 这些化合物是5-羟色胺受体（5-HT）配体，并且可用于治疗需要调节5-羟色胺受体（5-HT）的活性的疾病，病症和状况（例如焦虑，抑郁和肥胖）。
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公开(公告)号：US08309598B2
公开(公告)日：2012-11-13
申请号：US12339184
申请日：2008-12-19
申请人： David C. Bom
发明人： David C. Bom
IPC分类号： A61K31/39 , A61K31/385 , C07D327/06 , C07D339/08
CPC分类号： A61K8/49 , A23G3/36 , A23G4/06 , A23L27/30 , A61K8/4986 , A61K2800/244 , A61Q19/00
摘要： A method of providing a cooling sensation to the skin or the mucous membranes of the body, comprising the application thereto of at least one compound of the Formula I in which X is selected from S and O, R1 is selected from H and OMe, R2 is selected from OH, OMe and OEt, and R3 is selected from H and OH. Some of the compounds provide simultaneously cooling and sweetening effects.
摘要翻译： 向身体的皮肤或粘膜提供冷却感的方法，其中包括至少一种其中X选自S和O的式I化合物，R1选自H和OMe，R2 选自OH，OMe和OEt，R 3选自H和OH。 一些化合物同时提供冷却和甜味效果。
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公开(公告)号：US20120230924A1
公开(公告)日：2012-09-13
申请号：US13503127
申请日：2010-10-28
申请人： David C. Bom
发明人： David C. Bom
CPC分类号： C07D209/08 , C07D209/32
摘要： Organic compounds of formula (I) wherein: X is N, or C, R1-R6 may be independently selected from the group consisting of, H, substituted, unsubstituted, branched or unbranched C1-C4 alkyl, methoxy, ethoxy, Br, F, Cl, provided that when X is nitrogen there is no substituent at R6 Y is an alkylene group of the formula (CR7R8)m wherein R7 and R8 may be independently selected from the group consisting of hydrogen, substituted, unsubstituted, branched or unbranched C1-C4 alkylene, and m is an integer selected from 1 to 6. The compounds create or modify flavour, in particular sweet flavour and may be used in compositions and consumable products.
摘要翻译： 式（I）的有机化合物其中：X为N或C 1，R 1 -R 6可以独立地选自H，取代的，未取代的，支链或非支链的C 1 -C 4烷基，甲氧基，乙氧基，Br，F ，Cl，条件是当X是氮时，在R6没有取代基，Y是式（CR 7 R 8）m的亚烷基，其中R 7和R 8可以独立地选自氢，取代的，未取代的，支链的或未支链的C1 -C4亚烷基，m是选自1至6的整数。化合物产生或改变风味剂，特别是甜味，并可用于组合物和消费品中。
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9.发明授权Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof 有权噻吩基和吡咯基吖庚因作为5-羟色胺5-HT 2C受体配体及其用途公开(公告)号：US07893051B2
公开(公告)日：2011-02-22
申请号：US11654979
申请日：2007-01-17
IPC分类号： A61P25/00 , A61K31/55 , C07D487/02 , C07D223/16
CPC分类号： C07D495/04 , C07D495/06
摘要： The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are thiophenyl and pyrrolyl azepine compounds. These compounds are serotonin receptor (5-HT2c) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT2c) is desired (e.g. addiction, anxiety, depression, obesity, and others).
摘要翻译： 本发明一般涉及一系列化合物，含有该化合物的药物组合物，以及该化合物和组合物作为治疗剂的用途。 更具体地，本发明的化合物是噻吩基和吡咯基吖庚因化合物。 这些化合物是5-羟色胺受体（5-HT2c）配体，可用于治疗需要调节血清素受体（5-HT2c）的活性的疾病，病症和状况（例如成瘾，焦虑，抑郁，肥胖等） 。
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10.发明申请Cyclic N-Hydroxy Imides as Inhibitors of Flap Endonuclease and Uses Thereof 有权环状N-羟基酰亚胺作为瓣内切核酸酶的抑制剂及其用途公开(公告)号：US20080287465A1
公开(公告)日：2008-11-20
申请号：US11632920
申请日：2005-07-20
申请人： Lawrence N. Tumey , Youssef Bennani , Bayard Huck , David C. Bom
发明人： Lawrence N. Tumey , Youssef Bennani , Bayard Huck , David C. Bom
IPC分类号： A61K31/519 , C07D495/04 , C07D491/048
CPC分类号： C07D495/04 , C07D491/048
摘要： Acrylic n-hydroxy imides and their use in pharmaceutical compositions and in the inhibition of flap endonuclease are disclosed.
摘要翻译： 公开了丙烯酸正羟基酰亚胺及其在药物组合物中的用途和抑制皮瓣内切核酸酶的用途。
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