公开(公告)号：USD910936S1

公开(公告)日：2021-02-16

申请号：US29663722

申请日：2018-09-18

申请人： David Frank

设计人： David Frank

公开(公告)号：US20200157545A1

公开(公告)日：2020-05-21

申请号：US16618010

申请日：2018-06-01

申请人： Chandra VARGEESE ,  Naoki IWAMOTO ,  David Charles Donnell BUTLER ,  Subramanian MARAPPAN ,  Genliang LU ,  Jason Jingxin ZHANG ,  Vinod VATHIPADIEKAL ,  Maria David FRANK-KAMENETSKY ,  Luciano Henrique APPONI ,  WAVE LIFE SCIENCES LTD.

发明人： Chandra Vargeese ,  Naoki Iwamoto ,  David Charles Donnell Butler ,  Subramanian Marappan ,  Genliang Lu ,  Jason Jingxin Zhang ,  Vinod Vathipadiekal ,  Maria David Frank-Kamenetsky ,  Luciano Henrique Apponi ,  Young Jin Cho

IPC分类号： C12N15/113 ,  A61K31/712

摘要： Among other things, the present disclosure provides designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide improved single-stranded RNA interference and/or RNase H-mediated knockdown. Among other things, the present disclosure encompasses the recognition that structural elements of oligonucleotides, such as base sequence, chemical modifications (e.g., modifications of sugar, base, and/or internucleotidic linkages) or patterns thereof, conjugation with additional chemical moieties, and/or stereochemistry [e.g., stereochemistry of backbone chiral centers (chiral internucleotidic linkages)], and/or patterns thereof, can have significant impact on oligonucleotide properties and activities, e.g., RNA interference (RNAi) activity, stability, delivery, etc. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions, for example, in RNA interference and/or RNase H-mediated knockdown.

公开(公告)号：US08892350B2

公开(公告)日：2014-11-18

申请号：US13328771

申请日：2011-12-16

申请人： David Frank Russell Weir ,  Roger Melen ,  Kentaro Oguchi

发明人： David Frank Russell Weir ,  Roger Melen ,  Kentaro Oguchi

IPC分类号： G01C21/00 ,  G06F15/18

CPC分类号： G01C21/3617 ,  G06K9/00664 ,  G06K9/6218 ,  G08G1/0112 ,  G08G1/0129 ,  G08G1/0962 ,  G09B29/00 ,  G09B29/10 ,  G09B29/106 ,  H04W4/029

摘要： A system and method for estimating journey destinations is disclosed. The system comprises a conversion module, a frequency module, a metric module, a quality module and a summary module. The conversion module converts a set of driver history data to a set of learning parameters. The frequency module analyzes the set of learning parameters and current journey data to generate estimated journey data describing one or more potential journeys. The metric module analyzes the estimated journey data and the set of current status data to determine one or more metrics associated with the estimated journey data. The quality module determines one or more quality scores associated with the estimated journey data. The summary module determines one or more status summaries and one or more estimate summaries. The summary module associates the one or more status summaries and the one or more estimate summaries with the estimated journey data.

摘要翻译： 公开了一种用于估计旅程目的地的系统和方法。 该系统包括转换模块，频率模块，度量模块，质量模块和汇总模块。 转换模块将一组驱动程序历史数据转换为一组学习参数。 频率模块分析一组学习参数和当前旅程数据，以生成描述一个或多个潜在旅程的估计旅程数据。 度量模块分析估计旅程数据和当前状态数据集，以确定与估计旅程数据相关联的一个或多个度量。 质量模块确定与估计旅程数据相关联的一个或多个质量得分。 摘要模块确定一个或多个状态摘要和一个或多个估计摘要。 摘要模块将一个或多个状态摘要和一个或多个估计摘要与估计的旅程数据相关联。

公开(公告)号：US08584989B2

公开(公告)日：2013-11-19

申请号：US13237402

申请日：2011-09-20

申请人： David Lemay ,  David Frank ,  Michel Basset ,  Yann Chamaillard

发明人： David Lemay ,  David Frank ,  Michel Basset ,  Yann Chamaillard

IPC分类号： G05D3/00

CPC分类号： G05D1/0083

摘要： The invention relates to a method of managing movement of an aircraft on the ground, the aircraft including at least one left main undercarriage and at least one right main undercarriage, each comprising wheels associated with torque application members for applying torque to the wheels in response to a general setpoint, the general setpoint comprising a longitudinal acceleration setpoint and an angular speed setpoint, the method including the successive steps of braking down the general setpoint into general torque setpoints for generating by the torque application members associated with each of the wheels.

摘要翻译： 本发明涉及一种管理飞机在地面上的运动的方法，飞行器包括至少一个左主起落架和至少一个右主起落架，每个副底盘包括与扭矩施加构件相关联的轮，用于响应于 通用设定点，所述总设定点包括纵向加速度设定点和角速度设定点，该方法包括将通用设定值制动到通用转矩设定点的连续步骤，用于由与每个车轮相关联的转矩施加构件产生。

公开(公告)号：US08555155B2

公开(公告)日：2013-10-08

申请号：US12794674

申请日：2010-06-04

申请人： David Frank Harrison ,  Jing Jin ,  Kevin Decker ,  Michael Paul Thole ,  Dan Bernstein

发明人： David Frank Harrison ,  Jing Jin ,  Kevin Decker ,  Michael Paul Thole ,  Dan Bernstein

IPC分类号： G06F3/048

CPC分类号： G06F3/0481 ,  G06F17/2235 ,  G06F17/2247 ,  G06F17/30899

摘要： Methods and apparatuses that automatically detect availability of a reader mode for article content in a web page addressed by a URL are described. Availability detection may be progressively performed such that cheap operations are performed first to reduce the need to perform more expensive ones. A retrieval status of the web page may be detected to determine when enough content has been retrieved to initiate a detection of the reader mode for the web page. A reader indicator may be presented in a user interface of a browser if the availability of the reader mode is detected. A user of the browser may be noted with an alternative presentation of the article content from the web page in addition to a presentation of the whole web page by the browser. If the reader mode of the web page is not available, no reader indicator may be present in the browser.

摘要翻译： 描述了自动检测由URL寻址的网页中的文章内容的读取器模式的可用性的方法和装置。 可以逐渐执行可用性检测，使得首先执行廉价操作以减少执行更昂贵的操作的需要。 可以检测网页的检索状态以确定何时已经检索到足够的内容来启动对网页的读取器模式的检测。 如果检测到读取器模式的可用性，则可以在浏览器的用户界面中呈现读取器指示符。 除了浏览器对整个网页的呈现之外，还可以从网页上替代地呈现文章内容来注意浏览器的用户。 如果网页的阅读器模式不可用，则浏览器中可能不存在读取器指示符。

公开(公告)号：US20130158866A1

公开(公告)日：2013-06-20

申请号：US13328786

申请日：2011-12-16

申请人： David Frank Russell Weir ,  Roger Melen

发明人： David Frank Russell Weir ,  Roger Melen

IPC分类号： G01C21/00

CPC分类号： G01C21/3617

摘要： A system and method for establishing a journey destination endpoint is disclosed. The system comprises a communication module, a stop classification module and an endpoint establishment module. The communication module receives a stream of data including a first data element and a second data element from a global positioning system. The communication module receives a set of sensor data from one or more sensors. The stop classification module detects a stop for a traveling vehicle based at least in part on the stream of data and the set of sensor data. The stop classification module applies one or more metric criteria to the first data element and the second data element to determine a type of the stop. The endpoint establishment module establishes a journey destination endpoint based on the type of the stop. The endpoint establishment module associates the journey destination endpoint with retrieval identification data.

摘要翻译： 公开了一种用于建立旅程目的地终点的系统和方法。 该系统包括通信模块，停止分类模块和端点建立模块。 通信模块从全球定位系统接收包括第一数据元素和第二数据元素的数据流。 通信模块从一个或多个传感器接收一组传感器数据。 停止分类模块至少部分地基于数据流和传感器数据集来检测行驶车辆的停止。 停止分类模块将一个或多个度量标准应用于第一数据元素和第二数据元素以确定停止的类型。 端点建立模块基于停止的类型建立旅程目的地端点。 端点建立模块将旅程目的地端点与检索标识数据相关联。

公开(公告)号：US08351591B2

公开(公告)日：2013-01-08

申请号：US12902088

申请日：2010-10-11

申请人： Leland W. Kirchhoff ,  David S. Trandal ,  Colin Kelley ,  David J. Brahm ,  Robert F. Smith ,  David Frank Hofstatter ,  Robert A. Dolan

发明人： Leland W. Kirchhoff ,  David S. Trandal ,  Colin Kelley ,  David J. Brahm ,  Robert F. Smith ,  David Frank Hofstatter ,  Robert A. Dolan

IPC分类号： H04M3/42

CPC分类号： H04L51/36 ,  H04L51/043 ,  H04L65/1069 ,  H04L65/1079 ,  H04L65/1096 ,  H04M1/274516 ,  H04M3/42042 ,  H04M3/42263 ,  H04M3/436 ,  H04M3/5158 ,  H04M3/5183 ,  H04M3/5232 ,  H04M3/543 ,  H04M3/56 ,  H04M2203/2005 ,  H04M2203/2011 ,  H04M2203/651

摘要： The present invention provides flexible call processing. For example, a call processor system can receive an inbound call intended for a called party and place an outbound call to the called party. The call processing system can provide the called party with a call transfer option.

公开(公告)号：US08318525B2

公开(公告)日：2012-11-27

申请号：US10535567

申请日：2003-11-25

申请人： David Frank Davies ,  Ian Paul Andrews ,  Anthony Richard Cowburn ,  Stuart Christopher Cutler

发明人： David Frank Davies ,  Ian Paul Andrews ,  Anthony Richard Cowburn ,  Stuart Christopher Cutler

IPC分类号： G01N27/16

CPC分类号： G01N27/16 ,  Y10T29/49002

摘要： A device for sensing a gas comprises a plastics housing (106, 107) moulded in situ around at least one portion of a conducting lead frame (100), the housing defining an enclosure (113) and being provided with means for enabling gas flow into the enclosure. A gas sensitive element (114) within the enclosure (113) is mounted to the conducting lead frame (100). The conducting lead frame (100) comprises connection leads which are accessible through, and at least partially encapsulated by, the wall of the housing.

摘要翻译： 用于感测气体的装置包括塑料壳体（106,107），其围绕导电引线框架（100）的至少一部分原位模制，所述壳体限定外壳（113），并且设置有用于使气体流入 外壳。 外壳（113）内的气体敏感元件（114）安装到导电引线框架（100）。 导电引线框架（100）包括能够通过壳体壁接近并且至少部分地被壳体壁封闭的连接引线。

公开(公告)号：US20120223572A1

公开(公告)日：2012-09-06

申请号：US13411810

申请日：2012-03-05

申请人： David FRANK

发明人： David FRANK

IPC分类号： B64C25/44 ,  B60T13/58

CPC分类号： B60T8/00 ,  B60T13/662 ,  B60T13/686 ,  B64C25/44

摘要： Aircraft hydraulic parking architecture, including a brake with a wheel braking hydraulic actuator, a pressure source (Alim) of high-pressure fluid, a normal braking hydraulic circuit (C1) including at least pressure control servo valve with a supply port (P) connected to the pressure source (Alim), a return port (R), a utilization port (U) connected to the actuator, the brake architecture further including a parking hydraulic circuit (C2) including a parking brake valve (PkBV) having an outlet port (Ps1) selectively connected either to the pressure source (Alim) or a low-pressure return circuit (CR).The outlet port (Ps1) of the parking brake valve (PkBV) is connected to the return port (R) of the pressure control servo valve.

摘要翻译： 飞机液压停车架构，包括具有车轮制动液压致动器的制动器，高压流体的压力源（Alim），至少包括压力控制伺服阀的正常制动液压回路（C1），其中连接有供给口（P） 压力源（Alim），返回端口（R），与致动器连接的利用口（U），制动结构还包括驻车液压回路（C2），其包括驻车制动阀（PkBV），其具有出口 （Ps1）选择性地连接到压力源（Alim）或低压回路（CR）。 驻车制动阀（PkBV）的出口（Ps1）连接到压力控制伺服阀的返回口（R）。

公开(公告)号：US20120046834A1

公开(公告)日：2012-02-23

申请号：US13211659

申请日：2011-08-17

申请人： David LEMAY ,  David Frank ,  Michel Basset ,  Yann Chamaillard

发明人： David LEMAY ,  David Frank ,  Michel Basset ,  Yann Chamaillard

IPC分类号： G05D1/02 ,  B64C25/50

CPC分类号： G05D1/0083 ,  B64C25/50 ,  Y10T70/5664

摘要： The invention relates to a method of controlling a yawing movement of an aircraft running along the ground, the aircraft comprising at least one first landing gear with a steerable bottom part bearing wheels. According to the invention, the method comprises the steps of: on the basis of a yaw rate setpoint {dot over (φ)}c, determining a wheel-steering prepositioning angle θp; using closed-loop control which as its input has the yaw rate setpoint and which generates a command to steer the bottom part in order to steer it through a steering angle θc equal to the sum of this prepositioning angle θp and of an angle θz which is determined taking account of an error between the yaw rate setpoint {dot over (φ)}c and the measured yaw rate {dot over (φ)}m when the steerable bottom part is steered by the steering angle θc.

摘要翻译： 本发明涉及一种控制沿着地面运行的飞行器的偏航运动的方法，该飞行器包括至少一个具有可转向的底部轴承轮的第一起落架。 根据本发明，该方法包括以下步骤：基于偏航率设定点{dot over（＆phgr;）} c，确定车轮导向预定位角; 使用闭环控制，其作为其输入具有横摆率设定点，并且产生用于引导底部的指令，以便引导其转向角度; c等于该预定位角与该点的和 考虑到横向速度设定点{dot over（＆phgr）} c与所测量的横摆率{dot over（＆phgr）} m之间的误差确定的角度和角度;当可转向的底部由转向 角度和角度; c。