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公开(公告)号：US20090111866A1
公开(公告)日：2009-04-30
申请号：US12226372
申请日：2007-04-18
申请人： Keith Biggadike , Anthony William James Cooper , David House , Iain McFarlane McLay , Grahame Robert Woollam
发明人： Keith Biggadike , Anthony William James Cooper , David House , Iain McFarlane McLay , Grahame Robert Woollam
IPC分类号： A61K31/416 , C07D231/56 , A61P37/08
CPC分类号： C07D403/10 , C07D231/56
摘要： The present invention provides compounds of formula (I): pharmaceutical compositions comprising the compounds and the use of the compounds for the manufacture of a medicament, particularly for the treatment of inflammation and/or allergic conditions.
摘要翻译： 本发明提供式（I）化合物：包含该化合物的药物组合物和该化合物在制备药物中的用途，特别是用于治疗炎症和/或过敏性疾病。
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公开(公告)号：US08178573B2
公开(公告)日：2012-05-15
申请号：US12226372
申请日：2007-04-18
申请人： Keith Biggadike , Anthony William James Cooper , David House , Iain McFarlane McLay , Grahame Robert Woollam
发明人： Keith Biggadike , Anthony William James Cooper , David House , Iain McFarlane McLay , Grahame Robert Woollam
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： C07D403/10 , C07D231/56
摘要： The present invention provides compounds of formula (I): pharmaceutical compositions comprising the compounds and the use of the compounds for the manufacture of a medicament, particularly for the treatment of inflammation and/or allergic conditions.
摘要翻译： 本发明提供式（I）化合物：包含该化合物的药物组合物和该化合物在制备药物中的用途，特别是用于治疗炎症和/或过敏性疾病。
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公开(公告)号：US07943651B2
公开(公告)日：2011-05-17
申请号：US11736606
申请日：2007-04-18
IPC分类号： C07D231/56 , A01N43/56
CPC分类号： C07D403/10 , C07D231/56
摘要： The present invention provides compounds of formula (I): pharmaceutical compositions comprising the compounds and the use of the compounds for the manufacture of a medicament, particularly for the treatment of inflammation and/or allergic conditions.
摘要翻译： 本发明提供式（I）化合物：包含该化合物的药物组合物和该化合物在制备药物中的用途，特别是用于治疗炎症和/或过敏性疾病。
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公开(公告)号：US20100016331A1
公开(公告)日：2010-01-21
申请号：US12444719
申请日：2007-10-10
IPC分类号： A61K31/497 , C07D231/56 , A61K31/415 , C07D403/08 , C07D401/08 , A61K31/445
CPC分类号： C07D231/56 , A61K45/06 , C07D401/10 , C07D403/10 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention provides compounds of formula (I): a process for their preparation, pharmaceutical compositions comprising the compounds and the preparation of said compositions, intermediates and use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or skin disease.
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公开(公告)号：US20080292561A1
公开(公告)日：2008-11-27
申请号：US12092974
申请日：2006-11-07
申请人： Keith Biggadike , David House , Graham George Adam Inglis , Simon John Fawcett MacDonald , Iain McFarlane McLay , Philip Alan Skone
发明人： Keith Biggadike , David House , Graham George Adam Inglis , Simon John Fawcett MacDonald , Iain McFarlane McLay , Philip Alan Skone
IPC分类号： A61K9/12 , C07D487/04 , A61P17/00 , A61K31/519
CPC分类号： C07D487/04
摘要： A compound of formula (I): is claimed wherein A represents 2,3-dihydro-1-benzofuran-7-yl, 5-fluoro-2-methoxy-phenyl or 5-fluoro-2-hydroxy-phenyl; R1 represents phenyl, pyridyl or thienyl wherein the phenyl group may be optionally substituted by one or two groups independently selected from fluorine, cyano, —C(O)OCH3 and —C(O)OCH2CH3, and the pyridyl group may be optionally substituted by one fluorine group; and R2 represents methyl or ethyl; along with physiologically functional derivatives thereof, pharmaceutical compositions and formulations thereof, combinations thereof, methods of treatment employing such compounds and processes for preparing the compounds.
摘要翻译： 要求的式（I）化合物：其中A代表2,3-二氢-1-苯并呋喃-7-基，5-氟-2-甲氧基 - 苯基或5-氟-2-羟基 - 苯基; R 1表示苯基，吡啶基或噻吩基，其中苯基可以任选地被一个或两个独立地选自氟，氰基，-C（O）OCH 3和-C（O）OCH 2 CH 3的基团取代，并且吡啶基可以任选地被 一氟类; R2代表甲基或乙基; 以及其生理功能衍生物，药物组合物及其制剂，其组合，使用这些化合物的治疗方法和制备该化合物的方法。
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公开(公告)号：US07947727B2
公开(公告)日：2011-05-24
申请号：US12444713
申请日：2007-10-10
申请人： Keith Biggadike , Anthony William James Cooper , David House , Simon John Fawcett MacDonald , Philip Alan Skone , Gordon Gad Weingarten
发明人： Keith Biggadike , Anthony William James Cooper , David House , Simon John Fawcett MacDonald , Philip Alan Skone , Gordon Gad Weingarten
IPC分类号： A01N43/56 , A61K31/415 , C07D231/56
CPC分类号： C07D231/56 , C07C251/86 , C07D405/12 , C07D409/12 , Y10S514/885
摘要： The present invention provides compounds of formula (I): a process for their preparation, pharmaceutical compositions comprising the compounds and the preparation of said compositions, intermediates and use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or skin disease.
摘要翻译： 本发明提供式（I）化合物：其制备方法，包含所述化合物的药物组合物和所述组合物的制备，所述化合物的中间体和用途，用于制备用于治疗性治疗的药物，特别是用于治疗 炎症，过敏和/或皮肤疾病。
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公开(公告)号：US20100120883A1
公开(公告)日：2010-05-13
申请号：US12444713
申请日：2007-10-10
申请人： Keith Biggadike , Anthony William James Cooper , David House , Simon John Fawcett MacDonald , Philip Alan Skone , Gordon Gad Weingarten
发明人： Keith Biggadike , Anthony William James Cooper , David House , Simon John Fawcett MacDonald , Philip Alan Skone , Gordon Gad Weingarten
IPC分类号： A61K31/416 , C07D231/56 , C07D409/12 , A61P11/02 , A61P11/00 , A61P27/14 , A61P11/06 , A61P29/00 , A61P5/44 , A61P17/00 , A61P17/06
CPC分类号： C07D231/56 , C07C251/86 , C07D405/12 , C07D409/12 , Y10S514/885
摘要： The present invention provides compounds of formula (I): a process for their preparation, pharmaceutical compositions comprising the compounds and the preparation of said compositions, intermediates and use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or skin disease.
摘要翻译： 本发明提供式（I）化合物：其制备方法，包含所述化合物的药物组合物和所述组合物的制备，所述化合物的中间体和用途，用于制备用于治疗性治疗的药物，特别是用于治疗 炎症，过敏和/或皮肤疾病。
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8.发明授权Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases 有权嘌呤衍生物用于治疗过敏性，炎性和感染性疾病公开(公告)号：US08765772B2
公开(公告)日：2014-07-01
申请号：US13058470
申请日：2009-08-07
申请人： Keith Biggadike , Diane Mary Coe , Xiao Qing Lewell , Charlotte Jane Mitchell , Stephen Allan Smith , Naimisha Trivedi
发明人： Keith Biggadike , Diane Mary Coe , Xiao Qing Lewell , Charlotte Jane Mitchell , Stephen Allan Smith , Naimisha Trivedi
IPC分类号： A61K31/522 , C07D473/34
CPC分类号： A61K31/522 , A61K9/0043 , A61K31/55 , A61K45/06 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , C07D473/16 , C07D473/18
摘要： The present invention relates to compounds of formula (I): wherein R1 is C1-6alkylamino, C1-6alkoxy, or C3-7cycloalkyloxy; m is an integer having a value of 3 to 6; n is an integer having a value of 0 to 4; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.
摘要翻译： 本发明涉及式（I）的化合物：其中R 1是C 1-6烷基氨基，C 1-6烷氧基或C 3-7环烷氧基; m为3〜6的整数， n为0〜4的整数， 其盐是人类干扰素的诱导剂。 诱导人类干扰素的化合物可用于治疗各种疾病，例如治疗过敏性疾病和其它炎性病症，例如过敏性鼻炎和哮喘，治疗感染性疾病和癌症，并且也可用作疫苗佐剂。
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9.发明申请公开(公告)号：US20140051720A1
公开(公告)日：2014-02-20
申请号：US14110437
申请日：2012-04-05
申请人： Keith Biggadike , Gianpaolo Bravi , Aurelie Cecile Champigny , Diane Mary Coe , Deborah Needham , Dainiel Terence Tape
发明人： Keith Biggadike , Gianpaolo Bravi , Aurelie Cecile Champigny , Diane Mary Coe , Deborah Needham , Dainiel Terence Tape
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： A compound of formula (I) wherein X represents a H atom, or a CH2OH group, Y represents a H atom, or a CH2OH group, but X and Y are not both CH2OH groups and Ar is selected from or a pharmaceutically acceptable salt thereof.
摘要翻译： 式（I）的化合物，其中X表示H原子，或CH 2 OH基，Y表示H原子或CH 2 OH基，但X和Y不同时为CH 2 OH基，Ar选自其药学上可接受的盐 。
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公开(公告)号：US20120142651A1
公开(公告)日：2012-06-07
申请号：US13370493
申请日：2012-02-10
申请人： Keith Biggadike , Ian Buxton , Steven John Coote , Rosalyn Kay Nice , Kenton Lewis Reed , Amyn Sayani , Avinash Chander Sharma
发明人： Keith Biggadike , Ian Buxton , Steven John Coote , Rosalyn Kay Nice , Kenton Lewis Reed , Amyn Sayani , Avinash Chander Sharma
CPC分类号： A61K9/0078 , A61K9/0043 , A61K31/56 , A61K31/58 , A61K47/38
摘要： There is provided a method of treatment of allergic rhinitis which comprises administering to a patient a pharmaceutically acceptable amount of a pharmaceutical formulation comprising an aqueous suspension of particulate compound of formula (I) or a solvate thereof, wherein the administration is once-per-day and intranasal, and the total daily dose of the compound (I) is 50 to 100 μg.
摘要翻译： 提供了一种治疗过敏性鼻炎的方法，其包括给予患者药学上可接受量的药物制剂，其包含式（I）的颗粒化合物或其溶剂化物的水性悬浮液，其中所述给药是每天一次 和鼻内，化合物（I）的总日剂量为50〜100μg。
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