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    Stable, highly concentrated fluoro carbon emulsions
    1.
    发明授权
    Stable, highly concentrated fluoro carbon emulsions 失效
    稳定，高度浓缩的氟碳乳液

    公开(公告)号：US5393513A

    公开(公告)日：1995-02-28

    申请号：US100664

    申请日：1993-07-30

    Applicant: David M. Long, Jr.

    Inventor： David M. Long, Jr.

    IPC: A61K9/00 ,  A61K31/02 ,  A61K49/04 ,  A61B5/055 ,  A61K31/35 ,  A61K31/56

    CPC classification number: A61K9/0026 ,  A61K31/02 ,  Y10S514/832 ,  Y10S514/937 ,  Y10S514/941 ,  Y10S514/943 ,  Y10S977/904 ,  Y10S977/915 ,  Y10S977/927 ,  Y10T436/24

    Abstract: A non-toxic, brominated perfluorocarbon emulsion for internal and intravenous use in animals (including humans) is disclosed, for use as an oxygen transport medium and as a contrast enhancement medium capable of facilitating the detection of tumors and other elements within the body. This emulsion is stable and maintains its very small particle size characteristics for extended periods of time, often exceeding eighteen months after sterilization, and further may include a stabilizing component selected from the group consisting of steroids, tocopherols, cholesterols, and combinations thereof. An anti-oxidizing component enhances delivery in oxygen transport.

    Abstract translation: 公开了用于动物（包括人）内部和静脉内使用的无毒溴化全氟化碳乳液，用作氧传输介质和能够促进体内肿瘤和其它元件的检测的对比增强介质。 该乳液是稳定的，并且在灭菌后通常超过十八个月，并且可以包括选自类固醇，生育酚，胆固醇及其组合的稳定组分，延长的时间段保持其非常小的粒度特征。 抗氧化组分增强了氧运输中的输送。

    Magnetic resonance imaging with perfluorocarbon hydrides
    4.
    发明授权
    Magnetic resonance imaging with perfluorocarbon hydrides 失效
    全氟化碳氢化物的磁共振成像

    公开(公告)号：US4993415A

    公开(公告)日：1991-02-19

    申请号：US551884

    申请日：1990-07-12

    Applicant: David M. Long

    Inventor： David M. Long

    IPC: A61B5/055 ,  A61K49/04 ,  A61K49/06

    CPC classification number: A61B5/055 ,  A61K49/0433 ,  A61K49/06 ,  A61B5/418

    Abstract: Perfluorocarbon hydrides, either alone or in combination with other perfluorocarbon compounds, may be introduced into a non-vascular animal space as a contrast agent in magnetic resonance imaging (MRI), computed tomography (CT) or conventional x-ray procedures. In the image generated by these systems, the fluorocarbon introduced into the space is contrasted with the remaining body tissues or spaces to distinguish the fluorocarbon-occupied space from other tissues and spaces.Perfluoroctyl hydride vaporizes at body temperature, and its gas phase, which also provides in effective contrast to tissues, is disclosed in imaging areas of comparatively large void volume while using a lower fluorocarbon dose then than required for fluid fluorocarbon.Perfluorocarbon hydrides offer less radiodensity to x-ray imaging and less hydrogen density to MRI imaging, and are disclosed as diluents for perfluorocarbon bromides in applications where concentrated brominated compounds are found to cause imaging artifacts.Perfluorocarbon emulsions comprising a mixture of perfluorocarbon bromide and at least 0.1% perfluorocarbon hydride are disclosed for intravascular use as a contrast agent or for oxygen transport.

    Abstract translation: 单独或与其他全氟化碳化合物组合的全氟化碳氢化物可以作为磁共振成像（MRI），计算机断层扫描（CT）或常规x射线程序中的对比剂引入非血管动物空间。 在由这些系统产生的图像中，引入空间的碳氟化合物与剩余的身体组织或空间形成对比，以区分氟碳化合物占据的空间与其他组织和空间。 全氟辛基化合物在体温下蒸发，并且其与组织有效对比的气相也被用于比较大的空隙体积的成像区域，同时使用低于氟碳化合物所需的低碳氟化合物剂量。 全氟化碳氢化物对于x射线成像的放射线密度较低，而且对MRI成像具有较低的氢密度，并且在发现浓缩的溴化化合物引起成像伪影的应用中，作为全氟化碳溴化物的稀释剂公开。 公开了包含全氟化碳溴化物和至少0.1％全氟化碳氢化物的混合物的全氟化碳乳剂用于血管内用作造影剂或用于氧气输送。

    Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use
    5.
    发明授权
    Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use 失效
    生物相容，稳定和浓缩的氟碳乳液，用于内部动物使用中的对比增强和氧气输送

    公开(公告)号：US4987154A

    公开(公告)日：1991-01-22

    申请号：US82846

    申请日：1987-08-05

    Applicant: David M. Long, Jr.

    Inventor： David M. Long, Jr.

    IPC: A61K9/00 ,  A61K31/02

    CPC classification number: A61K9/0026 ,  A61K31/02 ,  Y10S514/832 ,  Y10S977/738 ,  Y10S977/773 ,  Y10S977/895 ,  Y10S977/902 ,  Y10S977/906 ,  Y10S977/915

    Abstract: An up to 125% fluorocarbon emulsion for use in or with animal bodies and organs thereof, maintains emulsion stability through normal sterilization procedures with selective osmotic and buffering agents, maintains the emulsion at within predetermined osmolarity levels and, when desired, free of excessive calcium precipitation, reduces in vivo and in vitro red blood cell injury, reduces adverse anemia effects, reduces viscosity and reduces the rate of oxidation, and tends to equilibrate its distribution in major body organs thereby reducing toxicity. The osmotic agents may buffer and may provide nutrient in the form of sugars. The osmotic and buffering agents can comprise, selectively, hexahydric alcohols, namely mannitol and sorbitol; certain sugars, namely glucose, mannose and fructose; along with buffering agents that will affect osmolarity including imidazole, tris(hydroxymethyl)aminomethane, sodium chloride, sodium bicarbonate, monobasic potassium phosphate, dibasic potassium phosphate, calcium chloride, magnesium sulfate, monobasic sodium phosphate, dibasic sodium phosphate or combinations of them. The emulsion may include tocopherol. A method of emulsifying the fluorocarbon includes forced flow impingement under pressure after mixing the fluorocarbon into the discontinuous phase. The fluorocarbon emulsion can be used to deliver drugs and medicines soluble in, or transportable by the emulsion.

    Abstract translation: 用于动物体及其器官中的高达125％的氟碳乳液，通过选择渗透和缓冲剂的正常灭菌程序保持乳液稳定性，将乳液保持在预定的渗透压浓度范围内，并且当需要时，不含过量的钙沉淀 减少体内和体外红细胞损伤，减少不良的贫血作用，降低粘度和降低氧化速率，并趋于平衡其在主体器官中的分布，从而降低毒性。 渗透剂可以缓冲并且可以以糖的形式提供营养物质。 渗透和缓冲剂可以选择性地包含六元醇，即甘露糖醇和山梨糖醇; 某些糖，即葡萄糖，甘露糖和果糖; 以及将影响渗透压的缓冲剂，包括咪唑，三（羟甲基）氨基甲烷，氯化钠，碳酸氢钠，一磷酸钾，磷酸氢二钾，氯化钙，硫酸镁，磷酸二氢钠，磷酸氢二钠或它们的组合。 乳液可以包括生育酚。 将碳氟化合物乳化的方法包括在将碳氟化合物混入不连续相之后的压力下的强制流动冲击。 氟碳乳液可用于输送可溶于乳剂或可由乳剂运输的药物和药物。

    Telomerase reverse transcriptase (TERT) genes from Candida albicans
    6.
    发明授权
    Telomerase reverse transcriptase (TERT) genes from Candida albicans 失效
    来自白色念珠菌的端粒酶逆转录酶（TERT）基因

    公开(公告)号：US06541202B1

    公开(公告)日：2003-04-01

    申请号：US09417485

    申请日：1999-10-13

    Applicant: David M. Long ,  Anneke M. Metz ,  Ruschelle A. Love

    Inventor： David M. Long ,  Anneke M. Metz ,  Ruschelle A. Love

    IPC: C12Q168

    CPC classification number: C12N9/1276 ,  C12N15/79

    Abstract: The present invention pertains, in general, to the identification, isolation and use of Telomerase Reverse Transcriptase (TERT) genes and the proteins encoded by such genes. In particular, the present invention pertains to the identification, isolation and use of TERT genes and TERT proteins from several genetically diverse and economically important organisms, including two human pathogens, Candida albicans and Plasmodium falciparum and an agronomic crop species, Oryza sativa.

    Abstract translation: 本发明一般涉及端粒酶逆转录酶（TERT）基因和由这些基因编码的蛋白质的鉴定，分离和使用。 特别地，本发明涉及鉴定，分离和使用来自几种遗传多样性和经济上重要的生物体的TERT基因和TERT蛋白质，包括两种人类病原体，白色念珠菌和恶性疟原虫以及农艺作物种类。

    Process of recycling paint waste
    8.
    发明授权
    Process of recycling paint waste 失效
    回收涂料废物的过程

    公开(公告)号：US5496404A

    公开(公告)日：1996-03-05

    申请号：US523192

    申请日：1995-09-05

    Applicant: James W. Price ,  David M. Long

    Inventor： James W. Price ,  David M. Long

    IPC: C04B18/18 ,  C04B7/36

    CPC classification number: C04B18/18 ,  C04B2103/30 ,  Y02W30/96

    Abstract: A process for utilizing waste by combining of the waste with a mineral based solid material forming an additive. This additive is included as an ingredient in the manufacture of Portland cement with the additive being added to the cement clinker after heat treating of the raw material constituents producing the cement clinker.

    Abstract translation: 通过将废物与形成添加剂的矿物基固体材料结合来利用废物的方法。 该添加剂作为波特兰水泥生产中的一种成分，添加剂经过对生产水泥熟料的原料成分进行热处理后添加到水泥熟料中。

    Brominated perfluorocarbon radiopaque agents
    9.
    发明授权
    Brominated perfluorocarbon radiopaque agents 失效
    溴化全氟化碳不透射线剂

    公开(公告)号：US4073879A

    公开(公告)日：1978-02-14

    申请号：US714392

    申请日：1976-08-16

    Applicant: David M. Long, Jr.

    Inventor： David M. Long, Jr.

    IPC: A61K49/04 ,  A61K29/02

    CPC classification number: A61K49/0461

    Abstract: Brominated cyclic and dibrominated aliphatic perfluorocarbons are useful as radiopaque agents for examination of the body of an animal.

    Abstract translation: 溴化环状和二溴化脂肪族全氟化碳可用作检查动物身体的不透射线剂。

    PROCESS OF RECYCLING PAINT WASTE
    10.
    发明申请
    PROCESS OF RECYCLING PAINT WASTE 审中-公开
    回收废纸的过程

    公开(公告)号：US20170066687A1

    公开(公告)日：2017-03-09

    申请号：US15256085

    申请日：2016-09-02

    Applicant: James W. Price ,  David M. Long

    Inventor： James W. Price ,  David M. Long

    IPC: C04B18/30 ,  C04B7/02

    CPC classification number: C04B18/0481 ,  C04B28/04 ,  Y02W30/91 ,  C04B14/28 ,  C04B40/0028 ,  C04B14/18

    Abstract: A cement composition and a process are provided for recycling a waste material by using the waste in the manufacture of Portland cement. The process generally comprises mixing a first quantity of the waste material thoroughly with a second quantity of a solid material so as to produce a non-compacted additive. The non-compacted additive is applied to cement clinker, wherein the additive is utilized as a substitute for virgin ingredients normally used in the manufacture of the Portland cement. In an embodiment, the non-compacted additive comprises a consistency of wet earth which is readily pliable with the second quantity by weight not exceeding three times the first quantity by weight. The cement clinker is then pulverized so as to distribute the additive within the resulting Portland cement.

    Abstract translation: 提供了一种水泥组合物和方法，用于通过在制造波特兰水泥中使用废物来再循环废料。 该方法通常包括将第一量的废料与第二量的固体材料充分混合以产生未压实的添加剂。 将未压实的添加剂应用于水泥熟料，其中添加剂用作通常用于制造波特兰水泥的原始成分的替代物。 在一个实施方案中，非压实添加剂包括湿土的稠度，其容易柔软，第二重量计不超过第一重量的三倍。 然后将水泥熟料粉碎，以便在所得波特兰水泥中分配添加剂。

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