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公开(公告)号:US08759304B2
公开(公告)日:2014-06-24
申请号:US12718812
申请日:2010-03-05
申请人: Calvin Bruce Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Yung-hou Wong , David M. Miller-Martini
发明人: Calvin Bruce Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Yung-hou Wong , David M. Miller-Martini
CPC分类号: A61K31/7048 , A61K31/56 , A61K31/58 , A61K36/481 , C07J1/00
摘要: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin ailments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.
摘要翻译: 本发明涉及增加细胞中端粒酶活性的方法和组合物。 这样的组合物包括药物,包括局部和营养制剂。 所述方法和组合物可用于治疗患者的细胞或组织中例如HIV感染,各种退行性疾病以及急性或慢性皮肤疾病中端粒酶活性增加而治疗的疾病。 它们也可用于增强培养细胞的复制能力,如离体细胞治疗和干细胞增殖。
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公开(公告)号:US08033037B2
公开(公告)日:2011-10-11
申请号:US12497919
申请日:2009-07-06
申请人: Lorraine L. Achterberg , James William Kendall , David M. Miller , Ronald M. Nowell, Jr. , William J. Schill, Jr. , Richard A. Sunshine , Ameresh Babu Viswanathan , Vicki Lyn Wyatt
发明人: Lorraine L. Achterberg , James William Kendall , David M. Miller , Ronald M. Nowell, Jr. , William J. Schill, Jr. , Richard A. Sunshine , Ameresh Babu Viswanathan , Vicki Lyn Wyatt
CPC分类号: A47B46/00 , A47B77/10 , D06F81/00 , D06F81/003
摘要: An ironing station has a cabinet defining an interior space, an accessible storage area defined within the interior space of the cabinet, an ironing board stowably mounted in the cabinet for movement between a stowed position and a use position. The ironing board can be coupled to the cabinet via a non-vertical guide rail. A handle can be coupled to the ironing board to aid a user in moving the ironing board between the stowed and use positions. A multi-position docking station can be provided on the top wall of the cabinet for receiving an iron. A cover can be provided for selectively covering the docking station.
摘要翻译: 熨烫站具有限定内部空间的机柜,限定在机柜内部空间内的可访问存储区域,可收容地安装在机柜中的熨衣板,用于在收起位置和使用位置之间移动。 熨衣板可以通过非垂直导轨连接到机柜。 手柄可以连接到熨衣板,以帮助使用者在收起和使用位置之间移动熨衣板。 可以在机柜的顶壁上设置多位置对接站,用于接收熨斗。 可以提供用于选择性地覆盖坞站的盖。
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公开(公告)号:US07647430B2
公开(公告)日:2010-01-12
申请号:US11038632
申请日:2005-01-19
申请人: Norman N. Ng , Michael P. Hart , David M. Miller , Jonathan Wilkins , Kenneth Fern , Markham F. MacLin , Peter S. Ford , Scott D. Sanders , Walter VonKoch
发明人: Norman N. Ng , Michael P. Hart , David M. Miller , Jonathan Wilkins , Kenneth Fern , Markham F. MacLin , Peter S. Ford , Scott D. Sanders , Walter VonKoch
CPC分类号: H04L12/2823 , H04L2012/2849
摘要: A robust device messaging framework is disclosed that enables a user to send commands to a device. A provisioning service is used to provision unique device identities and maps user web identities to device identities. The provisioning service also limits device per day provisioning attempts to limit denial of service attacks. A command service allows remote users to issue commands to a device, synchronize outgoing commands with incoming results, receive accurate feedback about whether a command was received, and maintain state information about the device. A device layer encrypts and stores device identities, authenticates itself with the command service, establishes a high-availability Internet connection to receive alerts that a command has issued, and reports results to the server-based command service.
摘要翻译: 公开了一种强大的设备消息传递框架,使得用户能够向设备发送命令。 配置服务用于提供唯一的设备身份,并将用户网络身份映射到设备身份。 配置服务还限制每天的设备配置尝试限制拒绝服务攻击。 命令服务允许远程用户向设备发出命令,将传出命令与传入结果进行同步,接收关于命令是否收到的准确反馈,以及维护有关设备的状态信息。 设备层加密并存储设备标识,使用命令服务对其进行身份验证,建立高可用性Internet连接以接收命令发出的警报,并将结果报告给基于服务器的命令服务。
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公开(公告)号:US07254545B2
公开(公告)日:2007-08-07
申请号:US11265636
申请日:2005-11-02
IPC分类号: G10L21/00
CPC分类号: G10L15/193
摘要: Systems and methods are described for a speech system that includes one or more speech controls incorporated into one or more speech-enabled applications that run on the speech system. The controls allow applications to be developed with minimal programming effort to incorporate common speech-enabled application functions. A question control provides a customizable template for requesting information from a user. An announcer control allows a speech-enabled application to provide a user with information without having to re-create an entire announcer process each time it is used. A command control provides a simple way to attach command and control functions to speech-enabled applications. A word trainer control provides a way to associate user-selected voice tags with certain information. Providing the controls for use with speech-enabled applications ensures standardized user interfaces across multiple speech-enabled applications.
摘要翻译: 描述了用于语音系统的系统和方法,该语音系统包括结合到在语音系统上运行的一个或多个支持语音的应用中的一个或多个语音控制。 该控件允许以最少的编程工作来开发应用程序,以结合通用的支持语音的应用程序功能。 问题控件提供用于从用户请求信息的可定制模板。 播音员控制允许支持语音的应用程序向用户提供信息,而无需在每次使用时重新创建整个播音员进程。 命令控制提供了一种将命令和控制功能附加到支持语音的应用程序的简单方法。 字培训者控制提供了一种将用户选择的语音标签与某些信息相关联的方式。 提供与语音使能应用程序一起使用的控件可确保跨多个支持语音的应用程序的标准化用户界面。
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公开(公告)号:US3953220A
公开(公告)日:1976-04-27
申请号:US492053
申请日:1974-07-26
申请人: David M. Miller
发明人: David M. Miller
CPC分类号: C03C10/0036
摘要: The present invention is concerned with the production of glass-ceramic articles wherein the crystal phase consists essentially of celsian (BaO.Al.sub.2 O.sub.3.2SiO.sub.2) with a minor amount of rutile (TiO.sub.2). Such articles consist essentially, by weight, of about 20-40% SiO.sub.2, 20-35% Al.sub.2 O.sub.3, 20-35% BaO, 5-15% PbO and/or 2-15% P.sub.2 O.sub.5, and 7-12% TiO.sub.2. Such articles can have a use temperature up to about 1250.degree.C, exhibit a coefficient of thermal expansion (room temperature to 900.degree.C) between about 35-50 .times. 10.sup.-.sup.7 /.degree.C, may demonstrate modulus of rupture values in excess of 20,000 psi, and will have a high density (about 3.1-3.5 g/cc), thereby recommending their utility as heat transfer media in a process such as that devised for extracting oil from oil-containing shale.
摘要翻译: 本发明涉及玻璃陶瓷制品的生产,其中晶相基本上由具有少量金红石(TiO 2)的凝胶(BaO.Al2O3.2SiO2)组成。 这些制品基本上由约20-40%SiO 2,20-35%Al 2 O 3,20-35%BaO,5-15%PbO和/或2-15%P 2 O 5和7-12%TiO 2组成。 这种制品的使用温度可达1250℃左右,在35-50×10-7 /℃之间呈现出热膨胀系数(室温至900℃),可显示出断裂模数 超过20,000psi,并且将具有高密度(约3.1-3.5g / cc),从而推荐其在诸如用于从含油页岩中提取油的过程中作为传热介质的实用性。
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公开(公告)号:US09107755B2
公开(公告)日:2015-08-18
申请号:US12889910
申请日:2010-09-24
CPC分类号: A61F2/38 , A61F2/3094 , A61F2/3859 , A61F2/389 , A61F2002/30014 , A61F2002/30934 , A61F2002/30937 , A61F2250/0018 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00131 , A61F2310/00203 , A61F2310/00239 , A61F2310/00281 , A61F2310/00317 , A61F2310/0058 , A61F2310/0088 , A61F2310/00886
摘要: A femoral prosthesis may be formed as a femoral component incorporating a base material and an articulating material. In one exemplary embodiment, the base material is a metal and the articulating material is a polymer. Specifically, the base material provides strength and rigidity to the femoral component, while the articulating material contacts a tibial prosthesis or natural tibia during joint articulation. In one exemplary embodiment, the articulating material forms the articulating surface of one or more condyle portions of the femoral component.
摘要翻译: 股骨假体可以形成为并入基材和关节材料的股骨部件。 在一个示例性实施例中,基底材料是金属,并且铰接材料是聚合物。 具体地说,基体材料为股骨部件提供强度和刚性,而在关节铰接过程中,铰接材料接触胫骨假体或天然胫骨。 在一个示例性实施例中,关节运动材料形成股骨部件的一个或多个髁部分的关节表面。
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公开(公告)号:US20140020889A1
公开(公告)日:2014-01-23
申请号:US13987729
申请日:2013-08-26
申请人: David M. Miller
发明人: David M. Miller
摘要: Apparatus facilitating successive installation of casing sections endwise in a well, that includes hanger structure sized for installation at a well head, the hanger structure having a vertical through opening via which successive casing sections are installable vertically in the well, the hanger structure having vertically spaced shoulders for landing casing sections, there being adjustable structure for enabling controllable adjustment of hanger length, whereby uncemented casing weight is applied on the hanger structure.
摘要翻译: 一种便于连续地将套管部分连续地安装在井中的装置,其包括尺寸适于安装在井口处的吊架结构,所述衣架结构具有垂直通孔,连续的套管部分可以通过该垂直通孔垂直地安装在井中,衣架结构具有垂直间隔开 用于着陆套管部分的肩部,具有可调节的结构,用于使衣架长度可以可控地调节,由此在衣架结构上施加未套管的套管重量。
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公开(公告)号:US08522884B2
公开(公告)日:2013-09-03
申请号:US12927572
申请日:2010-11-17
申请人: David M. Miller
发明人: David M. Miller
IPC分类号: E21B23/02
CPC分类号: E21B33/04
摘要: The method of installing a plurality of casing sections in a well, that includes providing a hanger supporting the casing sections to extend longitudinally in the well, landing the hanger on structure in the well, whereby weight of the casing sections longitudinally compresses the hanger, cementing the casing sections in position in the well, below the hanger, adjusting the hanger to provide for controllable longitudinal shortening of hanger length, thereby removing exertion of casing weight on the hanger, and removing at least part of the hanger away from the well head.
摘要翻译: 在井中安装多个套管部分的方法,包括提供支撑壳体部分以在井中纵向延伸的衣架,将衣架着陆在井中的结构上,由此套管部分的重量纵向压缩衣架,固井 套管部分位于井中的位置,在衣架下方,调整衣架以提供衣架长度的可控纵向缩短,从而消除衣架上的衣物重量的影响,并将至少一部分衣架移离井口。
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公开(公告)号:USD651778S1
公开(公告)日:2012-01-03
申请号:US29365946
申请日:2010-07-16
申请人: David M. Miller , Seth E. Bixby
设计人: David M. Miller , Seth E. Bixby
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公开(公告)号:US07846904B2
公开(公告)日:2010-12-07
申请号:US10562374
申请日:2004-06-23
申请人: Calvin Bruce Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Yung-hou Wong , David M. Miller-Martini
发明人: Calvin Bruce Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Yung-hou Wong , David M. Miller-Martini
CPC分类号: A61K31/7048 , A61K31/56 , A61K31/58 , A61K36/481 , C07J1/00
摘要: The present invention relates to methods for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The method and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin aliments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.
摘要翻译: 本发明涉及增加细胞中端粒酶活性的方法。 这样的组合物包括药物,包括局部和营养制剂。 该方法和组合物可用于治疗患者的细胞或组织中例如HIV感染,各种退行性疾病以及急性或慢性皮肤营养物质中端粒酶活性增加而治疗的疾病。 它们也可用于增强培养细胞的复制能力,如离体细胞治疗和干细胞增殖。
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