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公开(公告)号：US20110071095A1
公开(公告)日：2011-03-24
申请号：US12718812
申请日：2010-03-05
申请人： Calvin Bruce Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Yung-hou Wong , David M. Miller-Martini
发明人： Calvin Bruce Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Yung-hou Wong , David M. Miller-Martini
IPC分类号： A61K31/7048 , C07D307/12 , A61K31/58 , C07H17/04 , A61P17/02 , A61P29/00 , A61P1/04 , C12N5/071 , C12N5/077 , C12Q1/02 , A61P31/18 , A61P25/28 , A61P9/10 , A61P7/06 , A61P27/02 , A61P19/02 , A61P19/08
CPC分类号： A61K31/7048 , A61K31/56 , A61K31/58 , A61K36/481 , C07J1/00
摘要： The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin ailments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.
摘要翻译： 本发明涉及增加细胞中端粒酶活性的方法和组合物。 这样的组合物包括药物，包括局部和营养制剂。 所述方法和组合物可用于治疗患者的细胞或组织中例如HIV感染，各种退行性疾病以及急性或慢性皮肤疾病中端粒酶活性增加而治疗的疾病。 它们也可用于增强培养细胞的复制能力，如离体细胞治疗和干细胞增殖。
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公开(公告)号：US20080113925A1
公开(公告)日：2008-05-15
申请号：US10562374
申请日：2004-06-23
申请人： Calvin Bruce Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Wong Yung-hou , David M. Miller-Martini
发明人： Calvin Bruce Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Wong Yung-hou , David M. Miller-Martini
IPC分类号： A61K31/704 , A61K31/58
CPC分类号： A61K31/7048 , A61K31/56 , A61K31/58 , A61K36/481 , C07J1/00
摘要： The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin aliments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.
摘要翻译： 本发明涉及增加细胞中端粒酶活性的方法和组合物。 这样的组合物包括药物，包括局部和营养制剂。 所述方法和组合物可用于治疗患者的细胞或组织中例如HIV感染，各种退行性疾病和急性或慢性皮肤营养物质中端粒酶活性增加而治疗的疾病。 它们也可用于增强培养细胞的复制能力，如离体细胞治疗和干细胞增殖。
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公开(公告)号：US5837453A
公开(公告)日：1998-11-17
申请号：US482132
申请日：1995-06-07
IPC分类号： A61K38/00 , C12N5/00 , C12N9/12 , C12N15/10 , C12N15/113 , C12Q1/48 , C12Q1/68 , C12Q1/70 , G01N33/574 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： A61K31/70 , C12N15/10 , C12N15/113 , C12N15/1137 , C12N5/0018 , C12N9/1241 , C12Q1/48 , C12Q1/6816 , C12Y207/07049 , G01N33/57496 , A61K38/00 , C12N2501/70 , C12N2510/04 , G01N2333/91245
摘要： Telomerase activity in a sample can be measured using a two reaction protocol involving telomerase substrate and primer extension steps. The presence of telomerase activity in a human somatic tissue or cell sample is positively correlated with the presence of cancer and can be used to diagnose the course of disease progression in a patient.
摘要翻译： 样品中的端粒酶活性可以使用涉及端粒酶底物和引物延伸步骤的两个反应方案来测量。 人体细胞组织或细胞样品中端粒酶活性的存在与癌症的存在呈正相关，可用于诊断患者疾病进展的过程。
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公开(公告)号：US5804380A
公开(公告)日：1998-09-08
申请号：US632662
申请日：1996-04-15
IPC分类号： A61K38/00 , C12N5/00 , C12N9/12 , C12N15/10 , C12Q1/48 , C12Q1/68 , G01N33/574 , C07H21/04 , C12P19/34
CPC分类号： C12N5/0018 , A61K31/70 , C12N15/10 , C12N15/113 , C12N15/1137 , C12N9/1241 , C12Q1/48 , C12Q1/6816 , C12Q1/6844 , C12Q1/6876 , C12Q1/6886 , C12Y207/07049 , G01N33/57496 , A61K38/00 , C12N2501/70 , C12N2510/04 , C12Q2600/136 , G01N2333/91245 , Y10S435/81
摘要： Telomerase activity in a sample can be measured using a two reaction protocol. The first reaction involves the formation of telomerase substrate extension products from a telomerase substrate. The second reaction involves replication of the telomerase substrate extension products and/or amplification of signal generated by a bound probe. The presence of telomerase activity in a human somatic tissue or cell sample is positively correlated with the presence of cancer and can be used to diagnose a disease or other conditions of medical interest, as well as the course of disease progression or remission in a patient.
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公开(公告)号：US08759304B2
公开(公告)日：2014-06-24
申请号：US12718812
申请日：2010-03-05
申请人： Calvin Bruce Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Yung-hou Wong , David M. Miller-Martini
发明人： Calvin Bruce Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Yung-hou Wong , David M. Miller-Martini
CPC分类号： A61K31/7048 , A61K31/56 , A61K31/58 , A61K36/481 , C07J1/00
摘要： The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin ailments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.
摘要翻译： 本发明涉及增加细胞中端粒酶活性的方法和组合物。 这样的组合物包括药物，包括局部和营养制剂。 所述方法和组合物可用于治疗患者的细胞或组织中例如HIV感染，各种退行性疾病以及急性或慢性皮肤疾病中端粒酶活性增加而治疗的疾病。 它们也可用于增强培养细胞的复制能力，如离体细胞治疗和干细胞增殖。
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公开(公告)号：US5863726A
公开(公告)日：1999-01-26
申请号：US631554
申请日：1996-04-12
IPC分类号： A61K38/00 , C12N5/00 , C12N9/12 , C12N15/10 , C12P19/34 , C12Q1/48 , C12Q1/68 , G01N33/574 , C07H21/04
CPC分类号： C12Q1/6886 , A61K31/70 , C12N15/10 , C12N15/113 , C12N15/1137 , C12N5/0018 , C12N9/1241 , C12Q1/48 , C12Q1/6816 , C12Q1/6844 , C12Q1/6876 , C12Y207/07049 , G01N33/57496 , A61K38/00 , C12N2501/70 , C12N2510/04 , C12Q2600/136 , G01N2333/91245 , Y10S435/81
摘要： Telomerase activity in a sample can be measured using a two reaction protocol. The first reaction involves the formation of telomerase substrate extension products from a telomerase substrate. The second reaction involves replication of the telomerase substrate extension products and/or amplification of signal generated by a bound probe. The presence of telomerase activity in a human somatic tissue or cell sample is positively correlated with the presence of cancer and can be used to diagnose a disease or other conditions of medical interest, as well as the course of disease progression or remission in a patient.
摘要翻译： 样品中的端粒酶活性可以使用两种反应方案测定。 第一反应涉及从端粒酶底物形成端粒酶底物延伸产物。 第二个反应涉及端粒酶底物延伸产物的复制和/或由结合的探针产生的信号的放大。 人体细胞组织或细胞样品中端粒酶活性的存在与癌症的存在呈正相关，可用于诊断疾病或其他医疗感兴趣的病症，以及患者疾病进展或缓解过程。
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7.发明授权Telomerase activity associated with hematological and colorectal malignancies 失效与血液和结肠直肠恶性肿瘤相关的端粒酶活性
公开(公告)号：US5840490A
公开(公告)日：1998-11-24
申请号：US485454
申请日：1995-06-07
CPC分类号： C12Q1/6886 , C12Q2600/112
摘要： Methods for detecting hematologic and colorectal malignancies are provided comprising: (a) collecting a sample suspected of containing cancer cells; (b) analyzing the sample for telomerase activity; (c) correlating the presence of telomerase activity with the presence of cancer cells. A method for staging leukemia is also provided comprising analyzing a blood or bone marrow sample for telomerase activity, correlating the activity with a standard level of telomerase activity, and correlating a low telomerase activity with early stage leukemia.
摘要翻译： 提供了用于检测血液和结肠直肠恶性肿瘤的方法，包括：（a）收集怀疑含有癌细胞的样品; （b）分析样品的端粒酶活性; （c）将端粒酶活性的存在与癌细胞的存在相关联。 还提供了一种分期白血病的方法，包括分析血液或骨髓样品的端粒酶活性，将活性与标准水平的端粒酶活性相关联，并使低端粒酶活性与早期白血病相关。
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公开(公告)号：US20140088055A1
公开(公告)日：2014-03-27
申请号：US13936823
申请日：2013-07-08
申请人： Calvin Bruce HARLEY , Soo-Peang KHOR , Mahesh RAMASESHAN , Premchandran H. RAMIYA , Zhu Z. PIROT , Steven FAUCE , Tong LIN
发明人： Calvin Bruce HARLEY , Soo-Peang KHOR , Mahesh RAMASESHAN , Premchandran H. RAMIYA , Zhu Z. PIROT , Steven FAUCE , Tong LIN
IPC分类号： C07J17/00
CPC分类号： A61K31/58 , A61K31/56 , C07J17/00 , C07J53/004
摘要： The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.
摘要翻译： 本发明涉及增加细胞中端粒酶活性的方法和组合物。 这样的组合物包括药物制剂。 所述方法和组合物可用于通过在患者的细胞或组织中端粒酶活性的增加来治疗受治疗的疾病。 它们也可用于增强培养细胞的复制能力，如离体细胞治疗和增强干细胞和祖细胞的增殖。
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公开(公告)号：US07846904B2
公开(公告)日：2010-12-07
申请号：US10562374
申请日：2004-06-23
申请人： Calvin Bruce Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Yung-hou Wong , David M. Miller-Martini
发明人： Calvin Bruce Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Yung-hou Wong , David M. Miller-Martini
CPC分类号： A61K31/7048 , A61K31/56 , A61K31/58 , A61K36/481 , C07J1/00
摘要： The present invention relates to methods for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The method and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin aliments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.
摘要翻译： 本发明涉及增加细胞中端粒酶活性的方法。 这样的组合物包括药物，包括局部和营养制剂。 该方法和组合物可用于治疗患者的细胞或组织中例如HIV感染，各种退行性疾病以及急性或慢性皮肤营养物质中端粒酶活性增加而治疗的疾病。 它们也可用于增强培养细胞的复制能力，如离体细胞治疗和干细胞增殖。
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公开(公告)号：US5891639A
公开(公告)日：1999-04-06
申请号：US100153
申请日：1998-06-18
CPC分类号： C12Q1/6886 , A61K31/70 , C12N15/10 , C12N15/113 , C12N15/1137 , C12N5/0018 , C12N9/1241 , C12Q1/48 , C12Q1/6816 , C12Q1/6844 , C12Q1/6876 , C12Y207/07049 , G01N33/57496 , A61K38/00 , C12N2501/70 , C12N2510/04 , C12Q2600/136 , G01N2333/91245 , Y10S435/81
摘要： Telomerase activity in a sample can be measured using a two reaction protocol. The first reaction involves the formation of telomerase substrate extension products from a telomerase substrate. The second reaction involves replication of the telomerase substrate extension products and/or amplification of signal generated by a bound probe. The presence of telomerase activity in a human somatic tissue or cell sample is positively correlated with the presence of cancer and can be used to diagnose a disease or other conditions of medical interest, as well as the course of disease progression or remission in a patient.
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