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    Urogenital sinus derived growth inhibitory factor
    2.
    发明授权
    Urogenital sinus derived growth inhibitory factor 失效
    致癌细胞生长抑制因子

    公开(公告)号：US5196334A

    公开(公告)日：1993-03-23

    申请号：US240171

    申请日：1988-09-02

    申请人： David R. Rowley ,  Donald J. Tindall, Sr.

    发明人： David R. Rowley ,  Donald J. Tindall, Sr.

    IPC分类号： A61K38/00 ,  C07K14/47

    CPC分类号： C07K14/4703 ,  A61K38/00 ,  Y10S530/828

    摘要： A process is provided for purifying Urogenital Sinus Derived Growth Inhibitory Factor (UGIF) from embryonic tissue which comprises chromatographing medium from cultures of embryonic tissue derived from the urogenital sinus by gel filtration chromotography. Further purification by reverse phase high pressure liquid chromotography is also demonstrated. The UGIF is obtained in 70-fold to 8000-fold purification over the conditioned medium. A UGIF composition of matter is also provided.

    摘要翻译： 提供了一种从胚胎组织中纯化泌尿生殖窦衍生生长抑制因子（UGIF）的方法，其中包括通过凝胶过滤色谱从源自泌尿生殖窦的胚胎组织的培养物中分离培养基。 还证明了通过反相高压液相色谱进一步纯化。 在经过条件培养基的70倍至8000倍纯化中获得UGIF。 还提供了一种UGIF物质组成。

    Growth inhibitory factor from urogenital sinus
    3.
    发明授权
    Growth inhibitory factor from urogenital sinus 失效
    泌尿生殖窦生长抑制因子

    公开(公告)号：US5496800A

    公开(公告)日：1996-03-05

    申请号：US928867

    申请日：1992-08-11

    申请人： David R. Rowley

    发明人： David R. Rowley

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K2/00 ,  C12P21/00 ,  G01N33/53

    CPC分类号： C07K14/4703 ,  A61K38/00 ,  Y10S530/828

    摘要： A process is provided for purifying Urogenital Sinus Derived Growth Inhibitory Factor (UGIF) from embryonic tissue which comprises chromatographing medium from cultures or culture-derived spheroids of embryonic tissue derived from the urogenital sinus by gel filtration chromatography. Further purification by reverse phase high pressure liquid chromatography is also demonstrated. The UGIF is obtained in 70-fold to 8000-fold purification over the conditioned medium. A UGIF composition of matter is also provided, as is a method for treating neoplasia with UGIF.

    摘要翻译： 提供了一种从胚胎组织中纯化泌尿生殖窦衍生生长抑制因子（UGIF）的方法，其中包括通过凝胶过滤色谱从源自泌尿生殖窦的胚胎组织的培养物或来源于培养物的球体中分离培养基。 还证明了通过反相高压液相色谱进一步纯化。 在经过条件培养基的70倍至8000倍纯化中获得UGIF。 还提供了UGIF物质组合物，以及用UGIF治疗瘤形成的方法。

    Viral Therapeutic
    4.
    发明申请
    Viral Therapeutic 审中-公开
    病毒治疗

    公开(公告)号：US20110212076A1

    公开(公告)日：2011-09-01

    申请号：US12682978

    申请日：2008-10-15

    申请人： Annapurna Vyakarnam ,  David R. Rowley

    发明人： Annapurna Vyakarnam ,  David R. Rowley

    IPC分类号： A61K39/395 ,  C12N5/071 ,  A61K31/7088 ,  G01N33/53 ,  A61P31/12 ,  A61P31/16 ,  A61P37/04

    CPC分类号： C07K16/38 ,  A61K31/7088 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/705 ,  C07K2317/76 ,  G01N33/56988

    摘要： The invention provides a method of inhibiting viral infection of a mammalian cell, said method comprising reducing or inhibiting ps20 polypeptide expressed by said cell. Suitably ps20 is inhibited by contacting said cell with an antibody capable of binding to ps20 polypeptide. Suitably said antibody is ps20 neutralising antibody. The invention also provides antibody capable of binding ps20 polypeptide, siRNA targeted to a transcript encoding ps20 polypeptide, or antisense ps20 polynucleotide for use as a medicament for viral infection. The invention also provides a method of identifying an agent for inhibiting a viral infection, comprising determining level of ps20 expression in first and second samples, the first contacted with test agent; and comparing the level of ps20 expression in said first and second samples; wherein lower level of ps20 expression in said first sample relative to said second sample identifies test agent as an agent for inhibiting a viral infection.

    摘要翻译： 本发明提供抑制哺乳动物细胞病毒感染的方法，所述方法包括减少或抑制由所述细胞表达的ps20多肽。 通过使所述细胞与能够结合ps20多肽的抗体接触来适当地抑制ps20。 适当地说抗体是ps20中和抗体。 本发明还提供能够结合ps20多肽的抗体，靶向编码ps20多肽的转录物的siRNA或反义ps20多核苷酸用作病毒感染的药物。 本发明还提供鉴定用于抑制病毒感染的试剂的方法，包括测定第一和第二样品中ps20表达的水平，首先与测试试剂接触; 以及比较所述第一和第二样品中ps20表达水平; 其中所述第一样品中相对于所述第二样品的较低水平的ps20表达鉴定了作为抑制病毒感染的试剂的试验剂。

    Diagnostic Methods for HIV Infection
    5.
    发明申请
    Diagnostic Methods for HIV Infection 审中-公开
    艾滋病毒感染诊断方法

    公开(公告)号：US20100216119A1

    公开(公告)日：2010-08-26

    申请号：US12682992

    申请日：2008-10-15

    申请人： Annapurna Vyakarnam ,  David R. Rowley

    发明人： Annapurna Vyakarnam ,  David R. Rowley

    IPC分类号： C12Q1/70

    CPC分类号： C07K16/38 ,  A61K31/7088 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/705 ,  C07K2317/76 ,  G01N33/56988

    摘要： The invention relates to a method of aiding the diagnosis of a human immunodeficiency virus infection in a subject, said method comprising (i) providing a sample from the subject (ii) determining the level of ps20 in said sample (iii) comparing the level of ps20 of (ii) with the level of ps20 in an uninfected reference sample, wherein a higher level of ps20 in the sample from the subject compared to the uninfected reference sample indicates an increased likelihood of human immunodeficiency virus infection in said subject. The invention also relates to methods for assessing susceptibility of a subject to human immunodeficiency virus infection. Most suitably the ps20 level is determined via binding by an anti-ps20 antibody such as the 107 antibody. The invention also relates to kits for use in said methods.

    摘要翻译： 本发明涉及帮助受试者中人类免疫缺陷病毒感染的诊断的方法，所述方法包括（i）提供来自受试者的样品（ii）确定所述样品中的ps20的水平（iii） （ii）中的ps20与未感染参考样品中ps20的水平相比，其中与未感染的参考样品相比，来自受试者的样品中较高水平的ps20表明在所述受试者中人类免疫缺陷病毒感染的可能性增加。 本发明还涉及用于评估受试者对人类免疫缺陷病毒感染的易感性的方法。 最合适的是通过抗-PS20抗体如107抗体的结合来确定ps20水平。 本发明还涉及用于所述方法的试剂盒。

    Two-wire interface to automobile horn relay circuit
    7.
    发明授权
    Two-wire interface to automobile horn relay circuit 失效
    汽车喇叭继电器二线接口

    公开(公告)号：US5789827A

    公开(公告)日：1998-08-04

    申请号：US728807

    申请日：1996-10-09

    申请人： David R. Rowley ,  Cesar A. Montano ,  Gordon B. Langford

    发明人： David R. Rowley ,  Cesar A. Montano ,  Gordon B. Langford

    IPC分类号： B60Q5/00 ,  H01C10/10 ,  B60R21/20

    CPC分类号： H01C10/106 ,  B60Q5/00 ,  Y10T307/766

    摘要： A system selectively completes a horn circuit through which electrical power is provided to a horn in an automobile. A relay is connected to a power supply and completes the horn circuit when a current signal passing through the relay has at least a threshold magnitude. A relay driver is selectively activated by processing circuitry. When it is activated, the relay driver is in a conductive state, and when it is not activated, the relay driver is in a high impendance state. When the relay driver is in the conductive state, it places the relay in series with a low potential conductor thereby establishing the current signal at at least the threshold magnitude. The processing circuitry is electrically connected to a manually actuated sensor, which may be a flexible potentiometer. The processing circuitry activates the relay driver when the manually actuated sensor is actuated. The processing circuitry receives electrical power from the relay when the relay driver is in the high impendance state, but receives essentially no electrical power from the relay when the relay driver is in the conductive state. While the processing circuitry receives essentially no electrical power from the relay, the processing circuitry momentarily places the relay driver in the high impendance state so that the processing circuitry may receive electrical power from the relay and determine whether the manually actuated sensor is still actuated. An auxiliary power supply provides electrical power to the processing circuitry while electrical power is not received from the relay.

    摘要翻译： 一种系统选择性地完成一个喇叭电路，通过该喇叭电路向汽车中的喇叭提供电力。 当通过继电器的电流信号至少具有阈值幅度时，继电器连接到电源并完成喇叭电路。 继电器驱动器由处理电路选择性地激活。 继电器驱动器激活时，处于导通状态，当未激活时，继电器驱动器处于高阻塞状态。 当继电器驱动器处于导通状态时，它将继电器与低电位导体串联，从而以至少阈值大小建立电流信号。 处理电路电连接到手动致动的传感器，传感器可以是柔性电位计。 当手动致动的传感器被致动时，处理电路激活继电器驱动器。 当继电器驱动器处于高阻塞状态时，处理电路从继电器接收电力，但当继电器驱动器处于导通状态时，基本上不从继电器接收电力。 虽然处理电路基本上不从继电器接收电力，但是处理电路将瞬时地将继电器驱动器置于高阻止状态，使得处理电路可以从继电器接收电力并且确定手动致动的传感器是否仍然被致动。 辅助电源向处理电路提供电力，而不从继电器接收电力。