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1.发明申请Peptidically buffered formulations for electrotransport applications and methods of making 审中-公开用于电转运应用的肽缓冲制剂和制备方法公开(公告)号：US20050142531A1
公开(公告)日：2005-06-30
申请号：US10993649
申请日：2004-11-19
申请人： David Rauser , Rama Padmanabhan , Joseph Phipps , Michel Cormier
发明人： David Rauser , Rama Padmanabhan , Joseph Phipps , Michel Cormier
CPC分类号： A61N1/0448 , A61K9/0095 , A61N1/0412
摘要： Methods for preparing compositions for use in electrotransport delivery systems. The method includes providing a drug solution comprising drug ions and associated counterions; adjusting the pH of the drug solution by contacting the drug solution with a ion exchange material first; separating the ion exchange material from the pH-adjusted drug solution; and buffering the pH-adjusted drug solution with a buffer. A peptidic buffer is preferably used. The methods result in compositions suitable for use in electrotransport delivery systems.
摘要翻译： 制备用于电转运系统的组合物的方法。 该方法包括提供包含药物离子和相关联的抗衡离子的药物溶液; 首先通过使药液与离子交换材料接触来调节药液的pH值; 将离子交换材料与pH调节药液分离; 并用缓冲液缓冲pH调节的药物溶液。 优选使用肽缓冲剂。 该方法导致组合物适用于电转运递送系统。
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公开(公告)号：US20070225632A1
公开(公告)日：2007-09-27
申请号：US11688630
申请日：2007-03-20
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0444 , A61N1/0448
摘要： A transdermal electrotransport drug delivery system to an individual. The system has a liquid imbibing polymer with carboxyl groups available for noncovalently associating with a cationic drug. The liquid imbibing polymer is applicable for imbibing liquid before the device is deployed on a patient for electrotransport drug delivery.
摘要翻译： 一种透皮电转运药物递送系统给个体。 该系统具有可用于非阳离子药物非共价结合的具有羧基的液体吸收性聚合物。 液体吸收性聚合物适用于在将装置部署在病人身上进行电输送药物递送之前吸入液体。
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3.发明申请Methods for preparing polymeric buffer formulations for electrotransport applications 审中-公开制备用于电转运应用的聚合物缓冲剂配方的方法公开(公告)号：US20050129655A1
公开(公告)日：2005-06-16
申请号：US10994004
申请日：2004-11-19
CPC分类号： A61N1/0448 , A61K9/0095 , A61N1/0412
摘要： The present invention provides methods for preparing compositions for use in electrotransport delivery systems that comprise providing a drug solution comprising drug ions and associated counterions; adjusting the pH of the drug solution by contacting the drug solution with a first ion exchange material; separating the first ion exchange material from the pH-adjusted drug solution; adding the pH-adjusted drug solution to a reservoir of an electrotransport delivery system; and contacting the pH-adjusted drug solution with a second ion exchange material.
摘要翻译： 本发明提供了用于制备用于电转运递送系统的组合物的方法，其包括提供包含药物离子和相关抗衡离子的药物溶液; 通过使药液与第一离子交换材料接触来调节药液的pH; 将第一离子交换材料与pH调节药液分离; 将pH调节的药物溶液加入到电转运递送系统的储存器中; 并将pH调节的药物溶液与第二离子交换材料接触。
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