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公开(公告)号：US20070225632A1
公开(公告)日：2007-09-27
申请号：US11688630
申请日：2007-03-20
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0444 , A61N1/0448
摘要： A transdermal electrotransport drug delivery system to an individual. The system has a liquid imbibing polymer with carboxyl groups available for noncovalently associating with a cationic drug. The liquid imbibing polymer is applicable for imbibing liquid before the device is deployed on a patient for electrotransport drug delivery.
摘要翻译： 一种透皮电转运药物递送系统给个体。 该系统具有可用于非阳离子药物非共价结合的具有羧基的液体吸收性聚合物。 液体吸收性聚合物适用于在将装置部署在病人身上进行电输送药物递送之前吸入液体。
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2.发明申请Methods for preparing polymeric buffer formulations for electrotransport applications 审中-公开制备用于电转运应用的聚合物缓冲剂配方的方法公开(公告)号：US20050129655A1
公开(公告)日：2005-06-16
申请号：US10994004
申请日：2004-11-19
CPC分类号： A61N1/0448 , A61K9/0095 , A61N1/0412
摘要： The present invention provides methods for preparing compositions for use in electrotransport delivery systems that comprise providing a drug solution comprising drug ions and associated counterions; adjusting the pH of the drug solution by contacting the drug solution with a first ion exchange material; separating the first ion exchange material from the pH-adjusted drug solution; adding the pH-adjusted drug solution to a reservoir of an electrotransport delivery system; and contacting the pH-adjusted drug solution with a second ion exchange material.
摘要翻译： 本发明提供了用于制备用于电转运递送系统的组合物的方法，其包括提供包含药物离子和相关抗衡离子的药物溶液; 通过使药液与第一离子交换材料接触来调节药液的pH; 将第一离子交换材料与pH调节药液分离; 将pH调节的药物溶液加入到电转运递送系统的储存器中; 并将pH调节的药物溶液与第二离子交换材料接触。
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公开(公告)号：US20070060861A1
公开(公告)日：2007-03-15
申请号：US11513761
申请日：2006-08-30
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/0448
摘要： A cathode for an electrotransport drug delivery system for the delivery of anionic drugs. The cathode has a composite structure that contains an electroactive species that upon reduction does not generate any gas or an anion that competes with the anionic drug during electrotransport.
摘要翻译： 用于递送阴离子药物的电转运药物递送系统的阴极。 阴极具有包含电活性物质的复合结构，其在还原时不产生在电输运期间与阴离子药物竞争的任何气体或阴离子。
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公开(公告)号：US20070149916A1
公开(公告)日：2007-06-28
申请号：US11613327
申请日：2006-12-20
IPC分类号： A61N1/30 , A61K38/16 , A61K31/573 , A61K31/473 , A61K31/445 , A61K31/24
CPC分类号： A61N1/30 , A61N1/0448
摘要： The present invention provides methods and devices for the electrotransport delivery of beneficial agents that utilize polymer electrolyte matrices as drug reservoirs. In certain aspects of the invention, the beneficial agents are hydrolytically unstable, and methods are provided for enhancing the stability of the hydrolytically unstable beneficial agents during long-term storage of devices for the electrotransport delivery of the hydrolytically unstable beneficial agents and during electrotransport delivery of the hydrolytically unstable beneficial agents.
摘要翻译： 本发明提供了利用聚合物电解质基质作为药物储库的有益药物的电转运递送方法和装置。 在本发明的某些方面，有益试剂是水解不稳定的，并且提供了用于增强水解不稳定有益试剂在长期储存用于电转移递送水解不稳定有益剂的装置和在电输送期间的稳定性的方法 水解不稳定的有益剂。
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公开(公告)号：US20050273047A1
公开(公告)日：2005-12-08
申请号：US11144005
申请日：2005-06-01
IPC分类号： A61K9/00 , A61K9/70 , A61K31/155 , A61K31/455 , A61N1/30 , A61N1/32 , A61P7/02
CPC分类号： A61N1/325 , A61K9/0009 , A61K9/7023 , A61K31/155 , A61K31/455 , A61N1/044 , A61N1/0448 , A61N1/30
摘要： A device for transdermally delivering an anticoagulant agent by electrotransport. Preferably, the anticoagulant comprises a benzamidine or a naphthamidine derivative. A particularly preferred benzamidine derivative is a 2-[3-[4-(4-piperidinyloxy)anilino]-1-propenyl]benzamidine derivative. The devices are configured to maintain a plasma concentration of 20-80 ng/mL or providing a flux in the range of approximately 20-40 mg/day. Suitable current densities include 0.050 and 0.10 mA/cm2. Methods of the invention include delivering the anticoagulants to precisely maintain the desired plasma concentrations. The invention also comprises treating thromboembolic disease and inhibiting Factor Xa.
摘要翻译： 用于通过电转运透皮递送抗凝血剂的装置。 优选地，抗凝血剂包含苯甲脒或萘啶脒衍生物。 特别优选的苯甲脒衍生物是2- [3- [4-（4-哌啶基氧基）苯胺基] -1-丙烯基]苯甲脒衍生物。 这些装置被配置为维持20-80ng / mL的血浆浓度或提供约20-40mg /天范围内的通量。 合适的电流密度包括0.050和0.10mA / cm 2。 本发明的方法包括递送抗凝剂以精确地保持所需血浆浓度。 本发明还包括治疗血栓栓塞性疾病和抑制因子Xa。
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公开(公告)号：US20050123565A1
公开(公告)日：2005-06-09
申请号：US10971877
申请日：2004-10-21
CPC分类号： A61B17/205 , A61B2017/00765 , A61K9/0021 , A61M37/0015 , A61M2037/0023 , A61N1/30
摘要： A system and method for transdermally delivering a vaccine to a patient including an iontophoresis delivery device having a donor electrode, a counter electrode, and electric circuitry for supplying iontophoresis energy to the electrodes, and a non-electroactive microprojection member having a plurality of stratum corneum-piercing microprojections extending therefrom. The vaccine can be contained in a hydrogel formulation in an agent reservoir disposed proximate the donor electrode, in a biocompatible coating that is disposed on the microprojections or in both.
摘要翻译： 一种用于向患者透皮递送疫苗的系统和方法，包括具有供体电极的离子电渗递送装置，对电极和用于向电极提供离子电渗能量的电路，以及具有多个角质层的非电活性微突出物构件 从其延伸的微喷射。 疫苗可以包含在设置在供体电极附近的药剂容器中的水凝胶制剂中，该生物相容性涂层设置在微喷射体上或两者中。
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公开(公告)号：US20060036209A1
公开(公告)日：2006-02-16
申请号：US10978806
申请日：2004-11-01
IPC分类号： A61N1/30
CPC分类号： A61N1/303 , A61M37/0015 , A61M2037/0023 , A61N1/0424 , A61N1/044 , A61N1/0476 , A61N1/306 , A61N1/327
摘要： A system and method for transdermally delivering a biologically active agent comprising one or more electrodes having stratum corneum-piercing projections and a circuit that delivers an electrical signal to the electrodes to electroporate a cell membrane. Preferably, the system is configured to generate homogeneous electrical fields and, more preferably, to generate spherically or semispherically symmetrical electric fields. Methods of the invention include applying a first electric signal to facilitate transdermal transport of the agent and applying a second electric signal to facilitate intracellular transport of the agent.
摘要翻译： 一种用于透皮递送生物活性剂的系统和方法，所述生物活性剂包括一个或多个具有角质层刺穿突起的电极和将电信号传递到电极以电穿孔细胞膜的电路。 优选地，该系统被配置为产生均匀的电场，并且更优选地，以产生球形或半对称电场。 本发明的方法包括施加第一电信号以促进试剂的透皮转运并施加第二电信号以促进试剂的细胞内运输。
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