利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

31 条记录 (耗时 0.022 秒)

    Novel drug compositions and dosage forms
    3.
    发明申请
    Novel drug compositions and dosage forms 审中-公开
    新型药物组合物和剂型

    公开(公告)号：US20050175690A1

    公开(公告)日：2005-08-11

    申请号：US11024330

    申请日：2004-12-28

    申请人： David Edgren ,  Frank Jao ,  Rhea Kimbel ,  Shaoling Li ,  Noymi Yam ,  Sylvia Seroff ,  Padmaja Shivanand

    发明人： David Edgren ,  Frank Jao ,  Rhea Kimbel ,  Shaoling Li ,  Noymi Yam ,  Sylvia Seroff ,  Padmaja Shivanand

    IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K9/24 ,  A61K31/35

    CPC分类号： A61K9/209 ,  A61K9/0004

    摘要： The present invention is directed to novel drug compositions and dosage forms comprising said drug compositions. The drug compositions of the present invention comprise a pharmaceutical agent and a solubilizing agent. The drug compositions of the present invention are particularly advantageous for use with low solubility and/or low dissolution rate pharmaceutical agents. The present invention is further directed to methods for manufacturing of said drug compositions and dosage forms. The present invention is further directed to methods of treatment comprising administration of said drug compositions and dosage forms.

    摘要翻译： 本发明涉及包含所述药物组合物的新型药物组合物和剂型。 本发明的药物组合物包含药剂和增溶剂。 本发明的药物组合物特别适用于低溶解度和/或低溶解速率的药剂。 本发明还涉及制备所述药物组合物和剂型的方法。 本发明进一步涉及包括施用所述药物组合物和剂型的治疗方法。

    Dosage Form for Time-Varying Patterns of Drug Delivery
    8.
    发明申请
    Dosage Form for Time-Varying Patterns of Drug Delivery 审中-公开
    药物递送时间变化模式的剂型

    公开(公告)号：US20070207204A1

    公开(公告)日：2007-09-06

    申请号：US11744999

    申请日：2007-05-07

    申请人： David Edgren ,  Patrick Wong ,  Shu Li

    发明人： David Edgren ,  Patrick Wong ,  Shu Li

    IPC分类号： A61K9/66

    CPC分类号： A61K9/0004 ,  A61K31/277

    摘要： The present invention provides a multi-release oral drug delivery system that initiates drug release following an initial drug-free release interval, after administration to a subject, and a second drug-free release period before release of another dose of drug. The system has (1) inner compartments enclosed within a semipermeable membrane, and (2) a drug coating on the exterior of the semipermeable membrane surrounded by a microporous membrane, which microporous membrane is permeable to fluid and drug. The drug coating is released after the initial drug-free release interval. An inner compartment drug is released after a second drug-free release interval provided by a drug-free inner compartment.

    摘要翻译： 本发明提供一种多次释放的口服药物递送系统，其在给予受试者之后，在初始无药物释放间隔之后启动药物释放，以及释放另一剂量药物之前的第二无药物释放期。 该系统具有（1）封闭在半透膜内的内隔室，（2）由微孔膜包围的半透膜外部的药物涂层，该微孔膜可渗透流体和药物。 药物涂层在初始无药物释放间隔后释放。 在由无药物的内隔室提供的第二无药物释放间隔后释放内室药物。

    Volume Efficient Controlled Release Dosage Form
    9.
    发明申请
    Volume Efficient Controlled Release Dosage Form 审中-公开
    体积有效的控制释放剂型

    公开(公告)号：US20070184112A1

    公开(公告)日：2007-08-09

    申请号：US11684821

    申请日：2007-03-12

    申请人： Patrick Wong ,  Francisco Jao ,  David Edgren ,  Robert Skluzacek ,  Shu Li

    发明人： Patrick Wong ,  Francisco Jao ,  David Edgren ,  Robert Skluzacek ,  Shu Li

    IPC分类号： A61K9/24

    CPC分类号： A61K9/0004

    摘要： A dosage form that facilitates the controlled release of an active agent at a desired release rate or release rate profile includes a bi-layer membrane system and an osmotic core. The bi-layer membrane system includes a semipermeable membrane and an osmosensitive membrane and forms an internal compartment occupied by the osmotic core. The osmotic core includes an active agent composition and a light push layer. A passageway is formed through the bi-layer membrane system and permits expulsion of the active agent composition from the dosage form during operation. The bi-layer membrane system and the osmotic core are formulated and formed to provide controlled release of the active agent included in the active agent composition, while simultaneously facilitating increased loading of active agent within a dosage form of given dimension and increasing the delivery efficiency of such active agent relative to prior osmotic dosage forms including a push layer.

    摘要翻译： 有利于以期望的释放速率或释放速率曲线控制释放活性剂的剂型包括双层膜系统和渗透核。 双层膜系统包括半透膜和渗透膜，并形成由渗透芯占据的内部隔室。 渗透芯包括活性剂组合物和轻推层。 通过双层膜系统形成通道，并允许活性剂组合物在操作期间从剂型中排出。 双层膜系统和渗透芯被配制和形成以提供包含在活性剂组合物中的活性剂的受控释放，同时促进活性剂在给定维度的剂型中的负载增加，并且提高 这种活性剂相对于包括推层的先前的渗透剂型。

    Osmotic device with wall comprising cellulose ether and permeability enhancer
    10.
    发明授权
    Osmotic device with wall comprising cellulose ether and permeability enhancer 失效
    具有包含纤维素醚和渗透性增强剂的壁的渗透装置

    公开(公告)号：US4519801A

    公开(公告)日：1985-05-28

    申请号：US397517

    申请日：1982-07-12

    申请人： David Edgren

    发明人： David Edgren

    IPC分类号： A61K9/00 ,  A61K9/22

    CPC分类号： A61K9/0004

    摘要： An osmotic delivery system is disclosed for dispensing a useful agent. The system comprises a semipermeable wall surrounding a compartment housing the agent. The wall comprises a cellulose ether, an organic solvent soluble polymer, and optionally an aqueous soluble polymer. A passageway in the wall connects the interior of the system with the exterior for dispensing an agent from the system.

    摘要翻译： 公开了用于分配有用试剂的渗透递送系统。 该系统包括围绕容纳该试剂的隔室的半透壁。 该壁包括纤维素醚，有机溶剂可溶性聚合物和任选的水溶性聚合物。 墙壁上的通道将系统的内部与外部连接，用于从系统分配代理。