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公开(公告)号：US08546104B2
公开(公告)日：2013-10-01
申请号：US12700073
申请日：2010-02-04
申请人： David Rutenberg
发明人： David Rutenberg
IPC分类号： C12P1/00
CPC分类号： C12P7/6481 , C12P9/00 , C12P13/06
摘要： The present invention discloses processes a process for the preparation of phosphatide-salt complexes, the process including the steps of: using at least one raw material lecithin as a substrate; and enzymatically processing at least one raw material lecithin with phospholipase-D, racemic or enantiomerically-pure serine, and/or amine in an aqueous carboxylate-salt-complex solution, wherein the step of processing is performed in a single-phase reaction environment, to produce phosphatide-salt complexes having a structural fatty-acid chain derived from at least one raw material lecithin. Preferably, the step of processing is performed at a pH in the range of about 4.5-8.0 at a temperature in the range of about 25-60° C. Preferably, the aqueous carboxylate-salt-complex solution is formed from an aqueous solution of a carboxylic acid with a chain length of C2-C8 and a salt in an approximately 1:2 (weight per weight) acid-to-salt ratio.
摘要翻译： 本发明公开了制备磷脂 - 盐络合物的方法的方法，该方法包括以下步骤：使用至少一种原料卵磷脂作为底物; 并在羧酸盐 - 盐 - 络合物溶液中用磷脂酶-D，外消旋或对映体纯的丝氨酸和/或胺酶处理至少一种原料卵磷脂，其中处理步骤在单相反应环境中进行， 以产生具有衍生自至少一种原料卵磷脂的结构脂肪酸链的磷脂 - 盐配合物。 优选地，加工步骤在约4.5-8.0的范围内，在约25-60℃的温度范围内进行。优选地，羧酸盐 - 盐络合物溶液由水溶液 具有C2-C8链长和约1：2（重量/重量）酸 - 盐比的盐的羧酸。
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2.发明申请COMPOSITIONS AND METHODS OF TREATMENT FOR ALLEVIATING PREMENSTRUAL SYNDROME SYMPTOMS 有权治疗原发性综合征症状的组合物和治疗方法公开(公告)号：US20110098249A1
公开(公告)日：2011-04-28
申请号：US12606975
申请日：2009-10-27
IPC分类号： A61K31/685
CPC分类号： A61K31/685
摘要： The present invention discloses pharmaceutical/nutritional compositions for alleviating symptoms associated with premenstrual syndrome (PMS) and methods of treatment for PMS using such pharmaceutical/nutritional composition including: at least 2% (w/w) phosphatidyl-L-serine, or salts thereof, out of a total composition, as an effective ingredient, wherein: the phosphatidyl-L-serine has a structural fatty-acid chain derived from at least one raw material lecithin. Preferably, the phosphatidyl-L-serine is produced by enzymatic reaction of at least one raw material lecithin with phospholipase-D; at least one raw material lecithin is selected from the group consisting of: a vegetal lecithin and a non-vegetal lecithin; and the phospholipase-D is selected from the group consisting of: vegetal phospholipase-D, bacterial-originated enzyme phospholipase-D, and a combination of vegetal phospholipase-D and bacterial-originated enzyme phospholipase-D. Preferably, the structural fatty-acid chain is a saturated, hydrogenated fatty-acid chain. Preferably, the phosphatidyl-L-serine is derived from a dairy lecithin.
摘要翻译： 本发明公开了用于减轻与经前综合征（PMS）相关的症状的药物/营养组合物，以及使用这种药物/营养组合物治疗PMS的方法，包括：至少2％（w / w）磷脂酰-L-丝氨酸或其盐 作为有效成分，其中：磷脂酰-L-丝氨酸具有衍生自至少一种原料卵磷脂的结构脂肪酸链。 优选地，磷脂酰-L-丝氨酸通过至少一种原料卵磷脂与磷脂酶-D的酶反应产生; 至少一种原料卵磷脂选自：植物卵磷脂和非植物卵磷脂; 磷脂酶-D选自：植物性磷脂酶-D，细菌来源的酶磷脂酶D，以及植物磷脂酶-D和细菌来源的酶磷脂酶-D的组合。 优选地，结构脂肪酸链是饱和的，氢化的脂肪酸链。 优选地，磷脂酰-L-丝氨酸衍生自乳品卵磷脂。
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公开(公告)号：US20100036141A1
公开(公告)日：2010-02-11
申请号：US12502258
申请日：2009-07-14
申请人： David RUTENBERG
发明人： David RUTENBERG
CPC分类号： C12P7/6481 , C12P9/00 , C12P13/06
摘要： The present invention discloses processes for the preparation of phosphatides and salts thereof, the processes including the steps of using at least one raw material lecithin as a substrate and a water-insoluble surfactant-matrix material having a particulate size greater than about 0.01 mm; and enzymatically processing at least one raw material lecithin with the water-insoluble surfactant-matrix material, phospholipase-D, racemic or enantiomerically-pure amino acid, and/or amine and salts in a pH-buffered aqueous solution, wherein the step of processing is performed in a single-phase reaction environment, to produce phosphatides, or the salts thereof, having a structural fatty-acid chain derived from at least one raw material lecithin. Preferably, the step of processing is performed in the presence of a buffer having a pH in the range of about 4.5-8.0. Preferably, the step of processing is performed in the presence of a calcium salt.
摘要翻译： 本发明公开了制备磷脂及其盐的方法，包括使用至少一种原料卵磷脂作为底物的步骤和具有大于约0.01mm的颗粒尺寸的水不溶性表面活性剂基质材料的方法; 并在pH缓冲水溶液中用至少一种原料卵磷脂与水不溶性表面活性剂基质材料，磷脂酶-D，外消旋或对映异构纯氨基酸和/或胺和盐进行酶处理，其中处理步骤 在单相反应环境中进行，以产生具有衍生自至少一种原料卵磷脂的结构脂肪酸链的磷脂或其盐。 优选地，在pH为约4.5-8.0的缓冲剂存在下进行处理步骤。 优选地，在钙盐的存在下进行处理步骤。
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公开(公告)号：US20050129738A1
公开(公告)日：2005-06-16
申请号：US11048763
申请日：2005-02-03
申请人： David Rutenberg
发明人： David Rutenberg
CPC分类号： A23J7/00 , A23L33/40 , A23V2002/00 , A23V2250/1852 , A23V2250/1844 , A23V2250/1846 , A23V2250/185 , A23V2250/1848
摘要： An infant formula supplemented with phospholipids. A composition for feeding infants is claimed. The composition includes an infant formula base and a phospholipid supplement. The supplement includes a product of an enzymatic reaction between a crude phospholipid source and phospholipase-D and includes phosphatidylserine or salts thereof as an effective ingredient. Phosphatidylserine from the phospholipid supplement represents between 0.1% and 19.99% (w/w) of a total phospholipid content of the composition. Preferably the phosphatidylserine has a structural fatty acid chain derived from the raw material lecithin. The composition is more similar to human milk with regard to phospholipid composition. Methods of production and articles of manufacture are also disclosed.
摘要翻译： 补充磷脂的婴儿配方奶粉。 声称饲喂婴儿的组合物。 该组合物包括婴儿配方基料和磷脂补充剂。 补充剂包括粗磷脂源和磷脂酶-D之间的酶反应的产物，并且包括磷脂酰丝氨酸或其盐作为有效成分。 来自磷脂补充剂的磷脂酰丝氨酸占组合物总磷脂含量的0.1％至19.99％（w / w）。 优选地，磷脂酰丝氨酸具有衍生自原料卵磷脂的结构脂肪酸链。 关于磷脂组合物，组合物更类似于人乳。 还公开了生产方法和制品。
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公开(公告)号：US08846338B2
公开(公告)日：2014-09-30
申请号：US12502258
申请日：2009-07-14
申请人： David Rutenberg
发明人： David Rutenberg
CPC分类号： C12P7/6481 , C12P9/00 , C12P13/06
摘要： The present invention discloses processes for the preparation of phosphatides and salts thereof, the processes including the steps of: using at least one raw material lecithin as a substrate and a water-insoluble surfactant-matrix material having a particulate size greater than about 0.01 mm; and enzymatically processing at least one raw material lecithin with the water-insoluble surfactant-matrix material, phospholipase-D, racemic or enantiomerically-pure serine, amino acid, and/or amine and salts in a pH-buffered aqueous solution, wherein the step of processing is performed in a single-phase reaction environment, to produce phosphatides, or the salts thereof, having a structural fatty-acid chain derived from at least one raw material lecithin. Preferably, the step of processing is performed in the presence of a buffer having a pH in the range of about 4.5-8.0. Preferably, the step of processing is performed in the presence of a calcium salt.
摘要翻译： 本发明公开了制备磷脂及其盐的方法，所述方法包括以下步骤：使用至少一种原料卵磷脂作为底物和具有大于约0.01mm的颗粒尺寸的水不溶性表面活性剂基质材料; 并且在pH缓冲的水溶液中用至少一种原料卵磷脂与水不溶性表面活性剂基质材料，磷脂酶-D，外消旋或对映体纯的丝氨酸，氨基酸和/或胺和盐进行酶处理，其中步骤 的处理在单相反应环境中进行，以产生具有衍生自至少一种原料卵磷脂的结构脂肪酸链的磷脂或其盐。 优选地，在pH为约4.5-8.0的缓冲剂存在下进行处理步骤。 优选地，在钙盐的存在下进行处理步骤。
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6.发明授权Compositions and methods of treatment for alleviating premenstrual syndrome symptoms 有权缓解经前综合征症状的组合物和治疗方法公开(公告)号：US08399432B2
公开(公告)日：2013-03-19
申请号：US12606975
申请日：2009-10-27
CPC分类号： A61K31/685
摘要： The present invention discloses pharmaceutical/nutritional compositions for alleviating symptoms associated with premenstrual syndrome (PMS) and methods of treatment for PMS using such pharmaceutical/nutritional composition including: at least 2% (w/w) phosphatidyl-L-serine, or salts thereof, out of a total composition, as an effective ingredient, wherein: the phosphatidyl-L-serine has a structural fatty-acid chain derived from at least one raw material lecithin. Preferably, the phosphatidyl-L-serine is produced by enzymatic reaction of at least one raw material lecithin with phospholipase-D; at least one raw material lecithin is selected from the group consisting of: a vegetal lecithin and a non-vegetal lecithin; and the phospholipase-D is selected from the group consisting of: vegetal phospholipase-D, bacterial-originated enzyme phospholipase-D, and a combination of vegetal phospholipase-D and bacterial-originated enzyme phospholipase-D. Preferably, the structural fatty-acid chain is a saturated, hydrogenated fatty-acid chain. Preferably, the phosphatidyl-L-serine is derived from a dairy lecithin.
摘要翻译： 本发明公开了用于减轻与经前综合征（PMS）相关的症状的药物/营养组合物，以及使用这种药物/营养组合物治疗PMS的方法，包括：至少2％（w / w）磷脂酰-L-丝氨酸或其盐 作为有效成分，其中：磷脂酰-L-丝氨酸具有衍生自至少一种原料卵磷脂的结构脂肪酸链。 优选地，磷脂酰-L-丝氨酸通过至少一种原料卵磷脂与磷脂酶-D的酶反应产生; 至少一种原料卵磷脂选自：植物卵磷脂和非植物卵磷脂; 磷脂酶-D选自：植物性磷脂酶-D，细菌来源的酶磷脂酶D，以及植物磷脂酶-D和细菌来源的酶磷脂酶-D的组合。 优选地，结构脂肪酸链是饱和的，氢化的脂肪酸链。 优选地，磷脂酰-L-丝氨酸衍生自乳品卵磷脂。
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公开(公告)号：US20110212922A1
公开(公告)日：2011-09-01
申请号：US12700073
申请日：2010-02-04
申请人： David Rutenberg
发明人： David Rutenberg
IPC分类号： A61K31/685 , C12P7/64 , C07F9/02 , A23J7/00
CPC分类号： C12P7/6481 , C12P9/00 , C12P13/06
摘要： The present invention discloses processes a process for the preparation of phosphatide-salt complexes, the process including the steps of: using at least one raw material lecithin as a substrate; and enzymatically processing at least one raw material lecithin with phospholipase-D, racemic or enantiomerically-pure serine, and/or amine in an aqueous carboxylate-salt-complex solution, wherein the step of processing is performed in a single-phase reaction environment, to produce phosphatide-salt complexes having a structural fatty-acid chain derived from at least one raw material lecithin. Preferably, the step of processing is performed at a pH in the range of about 4.5-8.0 at a temperature in the range of about 25-60° C. Preferably, the aqueous carboxylate-salt-complex solution is formed from an aqueous solution of a carboxylic acid with a chain length of C2-C8 and a salt in an approximately 1:2 (weight per weight) acid-to-salt ratio.
摘要翻译： 本发明公开了制备磷脂 - 盐络合物的方法的方法，该方法包括以下步骤：使用至少一种原料卵磷脂作为底物; 并在羧酸盐 - 盐 - 络合物溶液中用磷脂酶-D，外消旋或对映体纯的丝氨酸和/或胺酶处理至少一种原料卵磷脂，其中处理步骤在单相反应环境中进行， 以产生具有衍生自至少一种原料卵磷脂的结构脂肪酸链的磷脂 - 盐配合物。 优选地，加工步骤在约4.5-8.0的范围内，在约25-60℃的温度范围内进行。优选地，羧酸盐 - 盐络合物溶液由水溶液 具有C2-C8链长和约1：2（重量/重量）酸 - 盐比的盐的羧酸。
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