公开(公告)号：US20240293483A1

公开(公告)日：2024-09-05

申请号：US18578507

申请日：2022-07-13

申请人： AB-BIOTICS, S.A.

发明人： Marta PÉREZ GARCIA ,  Jordi ESPADALER MAZO

IPC分类号： A61K35/745 ,  A61K31/702 ,  A61P1/00 ,  C12N1/20 ,  C12P9/00

CPC分类号： A61K35/745 ,  A61K31/702 ,  A61P1/00 ,  C12N1/20 ,  C12P9/00

摘要： A probiotic composition comprising Bifidobacterium longum subsp. longum CECT 7894 is provided. The probiotic composition is useful in treating, preventing, or ameliorating an intestinal barrier dysfunction (e.g., increased intestinal permeability) or associated condition, or symptoms, complications and/or sequela thereof in a subject in need thereof, by producing polyphosphate. A combination of the probiotic composition with at at least one human milk oligosaccharide is also provided.

公开(公告)号：US11999757B2

公开(公告)日：2024-06-04

申请号：US16760369

申请日：2018-10-30

申请人： MELINTA SUBSIDIARY CORP.

发明人： Serge Henri Boyer ,  Scott J. Hecker ,  Gerardus K. M. Verzijl ,  Petrus J. Hermsen

IPC分类号： C07F5/02 ,  B01J23/46 ,  C07C67/31 ,  C07C69/675 ,  C07F5/04 ,  C12P9/00

CPC分类号： C07F5/025 ,  B01J23/462 ,  C07C67/31 ,  C07C69/675 ,  C07F5/04 ,  C12P9/00 ,  C07C67/31 ,  C07C69/675

摘要： Disclosed herein are methods for the preparation of boronate derivatives in the synthesis of antimicrobial compounds and uses thereof. Disclosed herein includes method of making a compound of Formula (B) by reducing the ketone group of the keto-ester compound of Formula (A), and the reduction can be performed using a Ruthenium based catalyst system or using an alcohol dehydrogenase bioreduction system.

公开(公告)号：US11913049B2

公开(公告)日：2024-02-27

申请号：US16878032

申请日：2020-05-19

申请人： Ramon Gonzalez ,  James Clomburg ,  Alexander Chou

发明人： Ramon Gonzalez ,  James Clomburg ,  Alexander Chou

IPC分类号： C12N9/00 ,  C12P19/32 ,  C12P7/02 ,  C12P7/24 ,  C12P7/40 ,  C12P7/46 ,  C12N9/04 ,  C12N9/02 ,  C12P7/625 ,  C12N9/10 ,  C12N9/88 ,  C12N9/90 ,  C12P5/02 ,  C12P7/42 ,  C12P9/00 ,  C12P13/00 ,  C12P13/04

CPC分类号： C12P19/32 ,  C12N9/00 ,  C12N9/001 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/0077 ,  C12N9/13 ,  C12N9/88 ,  C12N9/90 ,  C12N9/93 ,  C12P5/02 ,  C12P5/026 ,  C12P7/02 ,  C12P7/24 ,  C12P7/40 ,  C12P7/42 ,  C12P7/46 ,  C12P7/625 ,  C12P9/00 ,  C12P13/001 ,  C12P13/04 ,  C12Y101/01 ,  C12Y101/03039 ,  C12Y102/01 ,  C12Y102/04001 ,  C12Y103/05001 ,  C12Y103/99 ,  C12Y108/01004 ,  C12Y114/15003 ,  C12Y203/01012 ,  C12Y203/01054 ,  C12Y207/01031 ,  C12Y208/03 ,  C12Y401/00 ,  C12Y401/01 ,  C12Y401/01047 ,  C12Y401/03024 ,  C12Y402/01 ,  C12Y402/01002 ,  C12Y402/01011 ,  C12Y501/99001 ,  C12Y501/99002 ,  C12Y504/02 ,  C12Y504/99 ,  C12Y504/99001 ,  C12Y504/99002 ,  C12Y602/01 ,  C12Y602/01005 ,  C12Y604/01003 ,  Y02E50/30

摘要： An engineered microorganism(s) with novel pathways for the conversion of short-chain hydrocarbons to fuels and chemicals (e.g. carboxylic acids, alcohols, hydrocarbons, and their alpha-, beta-, and omega-functionalized derivatives) is described. Key to this approach is the use of hydrocarbon activation enzymes able to overcome the high stability and low reactivity of hydrocarbon compounds through the cleavage of an inert C—H bond. Oxygen-dependent or oxygen-independent activation enzymes can be exploited for this purpose, which when combined with appropriate pathways for the conversion of activated hydrocarbons to key metabolic intermediates, enables the generation of product precursors that can subsequently be converted to desired compounds through established pathways. These novel engineered microorganism(s) provide a route for the production of fuels and chemicals from short chain hydrocarbons such as methane, ethane, propane, butane, and pentane.

公开(公告)号：US11905538B2

公开(公告)日：2024-02-20

申请号：US17530018

申请日：2021-11-18

申请人： BASF SE

发明人： Brian Michael Green ,  Michelle Lorraine Gradley

IPC分类号： C12P13/02 ,  C12P41/00 ,  C12P9/00 ,  C12P13/04 ,  A01N25/30 ,  A01N57/20 ,  C12N1/20 ,  C12N9/10

CPC分类号： C12P13/02 ,  A01N25/30 ,  A01N57/20 ,  C12N1/20 ,  C12N9/10 ,  C12P9/00 ,  C12P13/04 ,  C12P41/00 ,  C12Y104/03003 ,  C12Y206/01019 ,  A01N57/20 ,  A01N25/30 ,  A01N57/18

摘要： Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.

公开(公告)号：US20230364157A1

公开(公告)日：2023-11-16

申请号：US18226395

申请日：2023-07-26

申请人： Aker BioMarine Antarctic AS ,  The Board of Trustees of the University of Illinois

发明人： Finn Myhren ,  Petter-Arnt Hals ,  Nils Hoem ,  Andreas Berg Storsve ,  Papasani V. Subbaiah ,  Poorna Yalagala ,  Sugasini Dhavamani ,  Leon Tai

IPC分类号： A61K35/612 ,  A61K9/00 ,  A61K31/685 ,  A61P27/02 ,  C12P9/00 ,  A61K31/122 ,  A61K31/047

CPC分类号： A61K35/612 ,  A61K9/0019 ,  A61K31/685 ,  A61P27/02 ,  C12P9/00 ,  A61K31/122 ,  A61K9/0053 ,  A61K31/047

摘要： The present invention provides compositions comprising phosphatidylcholine derived compounds carrying an omega-3 fatty acid for use in prophylaxis or therapy, particularly when administered systemically. This invention further relates to a modified krill oil composition enriched in LPC-DHA and LPC-EPA, methods of making and methods of using to treat neurological and ocular disorders.

公开(公告)号：US11802280B2

公开(公告)日：2023-10-31

申请号：US16483716

申请日：2018-02-12

申请人： Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences

发明人： Huifeng Jiang ,  Xiaoyun Lu ,  Yuwan Liu ,  Yiqun Yang ,  Lina Lu ,  Sheng Yang ,  Junran Gou

IPC分类号： C12N9/88 ,  C12P7/24 ,  C12P7/28 ,  C12P9/00 ,  C12P19/32

CPC分类号： C12N9/88 ,  C12P7/24 ,  C12P7/28 ,  C12P9/00 ,  C12P19/32 ,  C12Y401/01007

摘要： An enzyme synthesizes hydroxyl acetaldehyde and/or 1,3-dihydroxyacetone by catalyzing formaldehyde. Site-directed mutation of benzoylformate decarboxylase (BFD) creates a mutant of the enzyme, which can polymerize the formaldehyde, A phosphoketalose (F/XPK) generates acetyl phosphoric acid from the hydroxyl acetaldehyde or 1,3-dihydroxyacetone (DHA). Combination with phosphotransacetylase (Pta) provides a route from the formaldehyde to acetyl coenzyme A in three steps.

公开(公告)号：US11732281B2

公开(公告)日：2023-08-22

申请号：US17464887

申请日：2021-09-02

申请人： BASF SE

发明人： Brian Michael Green ,  Michelle Lorraine Gradley

IPC分类号： C12P13/02 ,  C12P41/00 ,  C12P9/00 ,  C12P13/04 ,  A01N25/30 ,  A01N57/20 ,  C12N1/20 ,  C12N9/10

CPC分类号： C12P13/02 ,  A01N25/30 ,  A01N57/20 ,  C12N1/20 ,  C12N9/10 ,  C12P9/00 ,  C12P13/04 ,  C12P41/00 ,  C12Y104/03003 ,  C12Y206/01019 ,  A01N57/20 ,  A01N25/30 ,  A01N57/18

摘要： Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.

公开(公告)号：US20180223266A1

公开(公告)日：2018-08-09

申请号：US15748034

申请日：2016-07-27

申请人： Global Bioenergies ,  Scientist of Fortune, S.A.

发明人： Sabine Mazaleyrat ,  Jean-Baptiste Barbaroux ,  Marc Delcourt ,  Francois Stricher ,  Philippe Marlière

IPC分类号： C12N9/12 ,  C12N9/88 ,  C12P5/02 ,  C07C11/09

CPC分类号： C12N9/12 ,  C07C11/09 ,  C12N9/88 ,  C12P5/026 ,  C12P9/00 ,  C12Y401/01033

摘要： Described are HIV kinase variants showing an improved activity in converting 3-hydroxyisovalerate (HIV) into 3-phosphonoxyisovalerate (PIV), methods for the production of PIV using such enzyme variants as well as methods for the production isobutene in a subsequent reaction.

公开(公告)号：US10030256B2

公开(公告)日：2018-07-24

申请号：US15852864

申请日：2017-12-22

申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

发明人： Beung Tae Ryu ,  Young Pyo Lee ,  Ji Hye Jung ,  Sung Hee Jung

IPC分类号： C12P7/64 ,  C12P13/00 ,  C07F9/10

CPC分类号： C12P13/001 ,  C07F9/10 ,  C07F9/103 ,  C12P9/00 ,  C12Y301/01004

摘要： A method for producing lysophosphatidylethanolamine 18:1 includes extracting phospholipids including mainly phosphatidylethanolamine from a microorganism of Pseudomonas sp. and treating the extracted phospholipids with phospholipase A2. An alternative method for producing lysophosphatidylethanolamine 18:1 includes treating a microorganism of Pseudomonas sp. directly with phospholipase A2. The lysophosphatidylethanolamine 18:1 can be used as a plant vaccine material for preventing the plants from injuries caused by pathogen infections and/or environmental stresses and accelerating the recovery of plants injured by pathogen infections and/or environmental stresses, and can also be used as a composition for enhancing fruit ripening (color and sweetness) and storage properties, and as it can be used for an application in plant tissues, food products, pharmaceuticals, cosmetics, and agricultural use, it would be very advantageously used in related industries. This invention also provides a method of producing a phosphatidylethanolamine itself from a microorganism of Pseudomonas sp.

公开(公告)号：US20180105849A1

公开(公告)日：2018-04-19

申请号：US15852864

申请日：2017-12-22

申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

发明人： Beung Tae Ryu ,  Young Pyo Lee ,  Ji Hye Jung ,  Sung Hee Jung

IPC分类号： C12P13/00 ,  C07F9/10

CPC分类号： C12P13/001 ,  C07F9/10 ,  C07F9/103 ,  C12P9/00 ,  C12Y301/01004

摘要： A method for producing lysophosphatidylethanolamine 18:1 includes treating phospholipids extracted from a microorganisms of Pseudomonas sp. with phospholipase A2. The lysophosphatidylethanolamine 18:1 can be used as a plant vaccine material for preventing the plants from injuries caused by pathogen infections and/or environmental stresses and accelerating the recovery of plants injured by pathogen infections and/or environmental stresses, and can also be used as a composition for enhancing fruit ripening (color and sweetness) and storage properties, and as it can be used for an application in plant tissues, food products, pharmaceuticals, cosmetics, and agricultural use, it would be very advantageously used in related industries.