公开(公告)号：US5939260A

公开(公告)日：1999-08-17

申请号：US845175

申请日：1997-04-21

Applicant: Timothy David Spector ,  Richard William Keen

Inventor： Timothy David Spector ,  Richard William Keen

IPC: C12N15/09 ,  A61K31/00 ,  A61K31/122 ,  A61K31/55 ,  A61K31/5575 ,  C12Q1/68 ,  C12P19/34

CPC classification number: A61K31/5575 ,  A61K31/00 ,  A61K31/122 ,  A61K31/55 ,  C12Q1/6883 ,  C12Q2535/125 ,  C12Q2600/156

Abstract: A method of diagnosing a disease associated with a genetic polymorphism in a vitamin D receptor gene comprises determining the genotype of said vitamin D receptor gene in an animal. The method can be used to diagnose predisposition or susceptibility to osteoarthritis. Compositions for said diagnosis are provided. Methods of treatment of osteoarthritis are provided, comprising identifying an individual having a predisposition or susceptibility to the disease and subsequently treating that individual.

Abstract translation: 诊断与维生素D受体基因中的遗传多态性相关的疾病的方法包括确定动物中所述维生素D受体基因的基因型。 该方法可用于诊断骨关节炎的倾向或易感性。 提供了用于所述诊断的组合物。 提供治疗骨关节炎的方法，包括鉴定具有对该疾病的倾向或易感性并随后治疗该个体的个体。

公开(公告)号：US07588904B2

公开(公告)日：2009-09-15

申请号：US11651733

申请日：2007-01-10

Applicant: Sui Huang ,  Rajesh V. Kamath ,  David Spector ,  Ann Thor ,  Chen Wang

Inventor： Sui Huang ,  Rajesh V. Kamath ,  David Spector ,  Ann Thor ,  Chen Wang

IPC: G01N33/574

CPC classification number: G01N33/5011 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  G01N33/574

Abstract: The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers.

Abstract translation: 本发明涉及癌症诊断，预后和预测的组合物和方法，包括但不限于癌症标志物。 特别地，本发明提供了作为癌症标记物的周围核隔室及其驻留分子。

公开(公告)号：US07347070B1

公开(公告)日：2008-03-25

申请号：US11560214

申请日：2006-11-15

Applicant: David Spector

Inventor： David Spector

IPC: B65D55/14

CPC classification number: B65D55/14 ,  E02D29/1427 ,  Y10T70/5584 ,  Y10T70/5589

Abstract: A locking access box cover includes an access box cover having a key aperture and a locking mechanism coupled to the access box cover. The locking mechanism includes a base plate, a guide plate coupled to the base plate and a rotating mechanism operatively coupled between the base plate and the guide plate. The rotating mechanism may be rotatable between a locked and an unlocked position and include a key hole corresponding to the key aperture of the cover. The locking mechanism may also include a lock rod operatively coupled to the rotating mechanism. The locking mechanism includes a lock bracket having an aperture for receiving the lock rod therethrough, wherein the rotation of the rotating mechanism produces translational movement of the at least one lock rod with respect to the base plate. The locking access box cover may also comprise a cap removably securable over the key aperture.

Abstract translation: 锁定进入箱盖包括具有钥匙孔的接近箱盖和连接到接近箱盖的锁定机构。 锁定机构包括基板，联接到基板的引导板和可操作地联接在基板和引导板之间的旋转机构。 旋转机构可以在锁定位置和解锁位置之间旋转，并且包括对应于盖的键孔的键孔。 锁定机构还可以包括可操作地联接到旋转机构的锁定杆。 锁定机构包括具有用于接收锁定杆的孔的锁定支架，其中旋转机构的旋转产生至少一个锁定杆相对于基板的平移运动。 锁定进入箱盖还可以包括可拆卸地固定在钥匙孔上的盖。

公开(公告)号：US20070117168A1

公开(公告)日：2007-05-24

申请号：US11651733

申请日：2007-01-10

Applicant: Sui Huang ,  Rajesh Kamath ,  David Spector ,  Ann Thor ,  Chen Wang

Inventor： Sui Huang ,  Rajesh Kamath ,  David Spector ,  Ann Thor ,  Chen Wang

IPC: G01N33/574

CPC classification number: G01N33/5011 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  G01N33/574

Abstract: The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers.

Abstract translation: 本发明涉及癌症诊断，预后和预测的组合物和方法，包括但不限于癌症标志物。 特别地，本发明提供了作为癌症标记物的周围核隔室及其驻留分子。

公开(公告)号：US20080162692A1

公开(公告)日：2008-07-03

申请号：US11968986

申请日：2008-01-03

Applicant: Martin Schultz ,  David Spector

Inventor： Martin Schultz ,  David Spector

IPC: G06F15/173

CPC classification number: H04L63/0245 ,  G06F21/552 ,  G06F2221/2149 ,  H04L67/02 ,  H04L67/025

Abstract: A method for preventing undesired communication with a target computer across a distributed network. At least one rule regarding electronic communication is stored. Electronic communications are monitored at a server. The server applies at least one rule to the electronic communication. The server controls the electronic communications with the target computer and the source of the electronic communications as a function of the rule.

Abstract translation: 一种防止在分布式网络上与目标计算机的不期望的通信的方法。 存储关于电子通信的至少一个规则。 在服务器上监控电子通信。 服务器至少应用一个规则给电子通信。 服务器根据规则控制与目标计算机的电子通信和电子通信的来源。

公开(公告)号：US20050084852A1

公开(公告)日：2005-04-21

申请号：US10403422

申请日：2003-03-31

Applicant: Sui Huang ,  Rajesh Kamath ,  David Spector ,  Ann Thor ,  Chen Wang

Inventor： Sui Huang ,  Rajesh Kamath ,  David Spector ,  Ann Thor ,  Chen Wang

IPC: C12Q1/68 ,  G01N33/50 ,  G01N33/574

CPC classification number: G01N33/5011 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  G01N33/574

Abstract: The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers.

Abstract translation: 本发明涉及癌症诊断，预后和预测的组合物和方法，包括但不限于癌症标志物。 特别地，本发明提供了作为癌症标记物的周围核隔室及其驻留分子。