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公开(公告)号：US08889130B2
公开(公告)日：2014-11-18
申请号：US13369177
申请日：2012-02-08
Applicant: Rajesh V. Kamath
Inventor： Rajesh V. Kamath
IPC: A61K39/395 , A61K39/40 , C07K16/24 , C07K16/00 , A61K39/00
CPC classification number: C07K16/245 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/244 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/515 , C07K2317/76 , C07K2317/92 , C07K2317/94 , Y02A50/386 , Y02A50/41 , Y02A50/412
Abstract: The present invention relates to the treatment of osteoarthritis and pain using IL-1α and IL-1β binding proteins, including anti-IL-1α and anti-IL-1β antibodies and engineered multivalent and multispecific IL-1α and IL-1β binding proteins.
Abstract translation: 本发明涉及使用IL-1α和IL-1和bgr治疗骨关节炎和疼痛。 结合蛋白，包括抗IL-1α和抗IL-1和bgr; 抗体和工程化多价和多特异性IL-1α和IL-1＆bgr; 结合蛋白。
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公开(公告)号：US20110091463A1
公开(公告)日：2011-04-21
申请号：US12905474
申请日：2010-10-15
Applicant: Tariq Ghayur , Rajesh V. Kamath , Junian Liu , Marie P. Honore
Inventor： Tariq Ghayur , Rajesh V. Kamath , Junian Liu , Marie P. Honore
IPC: C07K16/24 , C07K16/46 , C12N15/13 , C12N15/63 , C12N15/70 , C12N15/80 , C12N15/81 , C12N15/82 , C12N15/85 , C12N5/10 , C12N1/15 , C12N1/19 , C12N1/21 , C12P21/08 , A61K39/395 , A61K51/10 , A61P19/02 , A61P37/00 , A61P3/10 , A61P9/10 , A61P9/00 , A61P13/12 , A61P25/16 , A61P7/06 , A61P11/00 , A61P17/06 , A61P19/08 , A61P15/00 , A61P5/00 , A61P35/00 , A61P35/02 , A61P31/12 , A61P1/04 , A61P31/18 , A61P31/00
CPC classification number: C07K16/00 , C07K16/22 , C07K16/241 , C07K16/245 , C07K16/2866 , C07K16/44 , C07K16/46 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/73 , C07K2317/76
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号：US20120309017A1
公开(公告)日：2012-12-06
申请号：US13584921
申请日：2012-08-14
Applicant: Sui Huang , Rajesh V. Kamath , David L. Spector , Ann D. Thor , Chen Wang
Inventor： Sui Huang , Rajesh V. Kamath , David L. Spector , Ann D. Thor , Chen Wang
IPC: G01N33/574 , G01N33/577
CPC classification number: G01N33/57496 , A61K49/0004 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , G01N33/57419 , G01N2500/10 , G01N2800/56
Abstract: The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers.
Abstract translation: 本发明涉及癌症诊断，预后和预测的组合物和方法，包括但不限于癌症标志物。 特别地，本发明提供了作为癌症标记物的周围核隔室及其驻留分子。
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公开(公告)号：US20090311253A1
公开(公告)日：2009-12-17
申请号：US12477711
申请日：2009-06-03
Applicant: Tariq Ghayur , Peter C. Isakson , Lisa M. Olson , Chengbin Wu , Margaret Hugunin , Rajesh V. Kamath , Carolyn A. Cuff , Hamish J. Allen
Inventor： Tariq Ghayur , Peter C. Isakson , Lisa M. Olson , Chengbin Wu , Margaret Hugunin , Rajesh V. Kamath , Carolyn A. Cuff , Hamish J. Allen
IPC: A61K39/395 , C07K16/00 , C07H21/04 , C12N15/63 , C12N1/21 , C12N1/10 , C12N5/10 , C12N1/15 , C12P21/06
CPC classification number: C07K16/2887 , A61K39/3955 , A61K45/06 , A61K47/6845 , A61K2039/505 , A61K2039/70 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/247 , C07K16/248 , C07K16/2866 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/64 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , G01N33/6869 , G01N2333/545 , Y02A50/386 , Y02A50/41 , Y02A50/412
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
Abstract translation: 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。
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公开(公告)号：US09035027B2
公开(公告)日：2015-05-19
申请号：US12477711
申请日：2009-06-03
Applicant: Tariq Ghayur , Peter C. Isakson , Lisa M. Olson , Chengbin Wu , Margaret Hugunin , Rajesh V. Kamath , Carolyn A. Cuff , Hamish J. Allen
Inventor： Tariq Ghayur , Peter C. Isakson , Lisa M. Olson , Chengbin Wu , Margaret Hugunin , Rajesh V. Kamath , Carolyn A. Cuff , Hamish J. Allen
CPC classification number: C07K16/2887 , A61K39/3955 , A61K45/06 , A61K47/6845 , A61K2039/505 , A61K2039/70 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/247 , C07K16/248 , C07K16/2866 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/64 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , G01N33/6869 , G01N2333/545 , Y02A50/386 , Y02A50/41 , Y02A50/412
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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Patent Agency Ranking
公开(公告)号：US08241862B2
公开(公告)日：2012-08-14
申请号：US12559634
申请日：2009-09-15
Applicant: Sui Huang , Rajesh V. Kamath , David L. Spector , Ann D. Thor , Chen Wang
Inventor： Sui Huang , Rajesh V. Kamath , David L. Spector , Ann D. Thor , Chen Wang
IPC: G01N33/574
CPC classification number: G01N33/57496 , A61K49/0004 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , G01N33/57419 , G01N2500/10 , G01N2800/56
Abstract: The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers.
Abstract translation: 本发明涉及癌症诊断，预后和预测的组合物和方法，包括但不限于癌症标志物。 特别地，本发明提供了作为癌症标记物的周围核隔室及其驻留分子。
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公开(公告)号：US20120201781A1
公开(公告)日：2012-08-09
申请号：US13369177
申请日：2012-02-08
Applicant: Rajesh V. KAMATH
Inventor： Rajesh V. KAMATH
IPC: A61K39/395 , A61P19/02 , A61P25/00 , A61K38/20
CPC classification number: C07K16/245 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/244 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/515 , C07K2317/76 , C07K2317/92 , C07K2317/94 , Y02A50/386 , Y02A50/41 , Y02A50/412
Abstract: The present invention relates to the treatment of osteoarthritis and pain using IL-1α and IL-1β binding proteins, including anti-IL-1α and anti-IL-1β antibodies and engineered multivalent and multispecific IL-1α and IL-1β binding proteins.
Abstract translation: 本发明涉及使用IL-1α和IL-1和bgr治疗骨关节炎和疼痛。 结合蛋白，包括抗IL-1α和抗IL-1和bgr; 抗体和工程化多价和多特异性IL-1α和IL-1＆bgr; 结合蛋白。
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公开(公告)号：US07588904B2
公开(公告)日：2009-09-15
申请号：US11651733
申请日：2007-01-10
Applicant: Sui Huang , Rajesh V. Kamath , David Spector , Ann Thor , Chen Wang
Inventor： Sui Huang , Rajesh V. Kamath , David Spector , Ann Thor , Chen Wang
IPC: G01N33/574
CPC classification number: G01N33/5011 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , G01N33/574
Abstract: The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers.
Abstract translation: 本发明涉及癌症诊断，预后和预测的组合物和方法，包括但不限于癌症标志物。 特别地，本发明提供了作为癌症标记物的周围核隔室及其驻留分子。
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公开(公告)号：US08716450B2
公开(公告)日：2014-05-06
申请号：US12905474
申请日：2010-10-15
Applicant: Tariq Ghayur , Rajesh V. Kamath , Junian Liu , Marie P. Honore
Inventor： Tariq Ghayur , Rajesh V. Kamath , Junian Liu , Marie P. Honore
CPC classification number: C07K16/00 , C07K16/22 , C07K16/241 , C07K16/245 , C07K16/2866 , C07K16/44 , C07K16/46 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/73 , C07K2317/76
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
Abstract translation: 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。
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公开(公告)号：US20100075365A1
公开(公告)日：2010-03-25
申请号：US12559634
申请日：2009-09-15
Applicant: Sui Huang , Rajesh V. Kamath , David L. Spector , Ann D. Thor , Chen Wang
Inventor： Sui Huang , Rajesh V. Kamath , David L. Spector , Ann D. Thor , Chen Wang
IPC: C12Q1/02
CPC classification number: G01N33/57496 , A61K49/0004 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , G01N33/57419 , G01N2500/10 , G01N2800/56
Abstract: The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers.
Abstract translation: 本发明涉及癌症诊断，预后和预测的组合物和方法，包括但不限于癌症标志物。 特别地，本发明提供了作为癌症标记物的周围核隔室及其驻留分子。
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