公开(公告)号：US20090122313A1

公开(公告)日：2009-05-14

申请号：US12228871

申请日：2008-08-15

Applicant: Lewis Jones ,  Nigel Lightfoot ,  David Spriggs ,  David Stringfellow

Inventor： Lewis Jones ,  Nigel Lightfoot ,  David Spriggs ,  David Stringfellow

IPC: G01J3/28

CPC classification number: G01N15/0205 ,  G01N21/51 ,  G01N2021/4707 ,  G01N2021/4709 ,  G01N2021/4711 ,  G02B27/0966

Abstract: In one general aspect, a particle characterization instrument is disclosed that includes a first spatially coherent light source with a beam output aligned with an optical axis. A focusing optic is positioned along the optical axis after the coherent light source, and a sample cell is positioned along the optical axis after the focusing optic. The instrument also includes a diverging optic positioned along the optical axis after the sample cell, and a detector positioned outside of the optical axis to receive scattered light within a first range of scattering angles from the diverging optic. In another general aspect, an instrument can direct at least a portion of a first beam and at least a portion of a second beam along a same optical axis and a can receive scattered light from the sample cell resulting from interaction between the sample and either the first beam or the second beam.

Abstract translation: 在一个一般方面，公开了一种粒子表征仪器，其包括具有与光轴对准的光束输出的第一空间相干光源。 在相干光源之后，聚焦光学器件沿着光轴定位，并且在聚焦光学器件之后沿着光轴定位样品池。 该仪器还包括在样品池之后沿着光轴定位的发散光学器件，以及位于光轴外侧的检测器，以在来自发散光学器件的散射角度的第一范围内接收散射光。 在另一个总体方面，仪器可以引导第一光束的至少一部分和沿着相同光轴的第二光束的至少一部分，并且可以从样品与第二光束之间的相互作用接收来自样品池的散射光 第一光束或第二光束。

公开(公告)号：US20070269831A1

公开(公告)日：2007-11-22

申请号：US10595135

申请日：2004-09-10

Applicant: David Spriggs ,  Jakob Dupont

Inventor： David Spriggs ,  Jakob Dupont

IPC: G01N33/574

CPC classification number: G01N33/57449

Abstract: YKL-40 levels in serum and plasma samples provide as an indicator of both the presence of early stage ovarian cancer and of its aggressiveness. Thus testing for YKL-40 levels in patients at risk but not yet displaying symptoms associated with ovarian cancer, or in patients newly diagnosed with early stage ovarian cancer (Stage I or II) enhance both the detection of early stage ovarian cancer and selection of treatment protocols used for early stage ovarian cancer patients.

Abstract translation: 血清和血浆样品中的YKL-40水平提供了早期卵巢癌的存在及其侵袭性的指标。 因此，在有风险但尚未显示与卵巢癌相关症状的患者中或在新诊断患有早期卵巢癌的患者（I期或II期）中检测YKL-40水平可增强早期卵巢癌的检测和治疗选择 用于早期卵巢癌患者的方案。

公开(公告)号：US20130171152A1

公开(公告)日：2013-07-04

申请号：US13635090

申请日：2011-03-25

Applicant: David Spriggs ,  Dharmarao Thapi

Inventor： David Spriggs ,  Dharmarao Thapi

IPC: C07K16/30

CPC classification number: C07K16/3092 ,  A61K2039/505 ,  A61K2039/5156 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/02 ,  C07K2319/03 ,  G01N33/57488 ,  G01N2333/705

Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to a polypeptide, or antigenic portion thereof, wherein the polypeptide is selected from a) MUC16 ectodomain polypeptide, b) MUC16 cytoplasmic domain polypeptide, and c) MUC16 extracellular domain polypeptide that contains a cysteine loop polypeptide. The invention's antibodies and compositions containing them are useful in diagnostic and therapeutic applications for diseases in which MUC16 is overexpressed, such as cancer.

Abstract translation: 本发明提供特异性结合多肽或其抗原部分的抗体及其抗原结合片段，其中所述多肽选自a）MUC16胞外域多肽，b）MUC16胞质域多肽，和c）MUC16细胞外结构域多肽 其含有半胱氨酸环多肽。 本发明的抗体和含有它们的组合物可用于MUC16过表达的疾病如癌症的诊断和治疗应用。

公开(公告)号：US09169328B2

公开(公告)日：2015-10-27

申请号：US13635090

申请日：2011-03-25

Applicant: David Spriggs ,  Dharmarao Thapi

Inventor： David Spriggs ,  Dharmarao Thapi

IPC: A61K39/395 ,  C07K16/30 ,  A61K39/00

CPC classification number: C07K16/3092 ,  A61K2039/505 ,  A61K2039/5156 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/02 ,  C07K2319/03 ,  G01N33/57488 ,  G01N2333/705

Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to a polypeptide, or antigenic portion thereof, wherein the polypeptide is selected from a) MUC16 ectodomain polypeptide, b) MUC16 cytoplasmic domain polypeptide, and c) MUC16 extracellular domain polypeptide that contains a cysteine loop polypeptide. The invention's antibodies and compositions containing them are useful in diagnostic and therapeutic applications for diseases in which MUC16 is overexpressed, such as cancer.

Abstract translation: 本发明提供特异性结合多肽或其抗原部分的抗体及其抗原结合片段，其中所述多肽选自a）MUC16胞外域多肽，b）MUC16胞质域多肽，和c）MUC16细胞外结构域多肽 其含有半胱氨酸环多肽。 本发明的抗体和含有它们的组合物可用于MUC16过表达的疾病如癌症的诊断和治疗应用。

公开(公告)号：US20150116708A1

公开(公告)日：2015-04-30

申请号：US14345089

申请日：2012-09-11

Applicant: David Spriggs

Inventor： David Spriggs

IPC: G01N15/02 ,  G01N21/49

CPC classification number: G01N15/0211 ,  G01N21/49 ,  G01N2015/03 ,  G01N2201/06113

Abstract: Apparatus for determining particle-size distribution of a sample by light-scattering includes a helium neon laser (102), a sample cell having cell windows (120, 122) and a focal plane detector (124). Detectors are also provided for detecting light scattered by a sample within or flowing through the sample cell. The apparatus includes a first (114) and second (116) folding mirrors arranged to fold the optical path from the laser to the sample cell so that the laser is vertically below the sample cell. The folding mirrors are mounted within a dust-proof housing (104), the entrance (106) and exit (108) components thereof being other optical components generally used within light- scattering apparatus. The entrance component is mounted such that its outward normal points downwards and the exit component is mounted substantially vertically so that these components do not accumulate dust. The invention allows the laser of a light-scattering apparatus to be positioned vertically below a sample cell of the apparatus without the accumulation of dust on optical components, which tends to degrade performance.

Abstract translation: 用于通过光散射确定样品的粒度分布的装置包括氦氖激光器（102），具有单元窗口（120,122）和焦平面检测器（124）的样品池。 还提供检测器，用于检测由样品在样品池内或流过样品池的散射光。 该装置包括第一（114）和第二（116）折叠反射镜，其布置成将来自激光器的光路折叠到样品池，使得激光垂直地位于样品池下方。 折叠镜安装在防尘壳体（104）内，入口（106）和出口（108）的部件是通常在光散射装置中使用的其它光学部件。 入口部件被安装成使得其向外的法向点向下并且出口部件基本垂直地安装，使得这些部件不积聚灰尘。 本发明允许光散射装置的激光器垂直地定位在装置的样品池下方，而不会在光学部件上积聚灰尘，这倾向于降低性能。

公开(公告)号：US07869038B2

公开(公告)日：2011-01-11

申请号：US12228871

申请日：2008-08-15

Applicant: Lewis Jones ,  Nigel Lightfoot ,  David Spriggs ,  David Stringfellow

Inventor： Lewis Jones ,  Nigel Lightfoot ,  David Spriggs ,  David Stringfellow

IPC: G01N15/02 ,  G01N21/00

CPC classification number: G01N15/0205 ,  G01N21/51 ,  G01N2021/4707 ,  G01N2021/4709 ,  G01N2021/4711 ,  G02B27/0966

Abstract: In one general aspect, a particle characterization instrument is disclosed that includes a first spatially coherent light source with a beam output aligned with an optical axis. A focusing optic is positioned along the optical axis after the coherent light source, and a sample cell is positioned along the optical axis after the focusing optic. The instrument also includes a diverging optic positioned along the optical axis after the sample cell, and a detector positioned outside of the optical axis to receive scattered light within a first range of scattering angles from the diverging optic. In another general aspect, an instrument can direct at least a portion of a first beam and at least a portion of a second beam along a same optical axis and a can receive scattered light from the sample cell resulting from interaction between the sample and either the first beam or the second beam.

Abstract translation: 在一个一般方面，公开了一种粒子表征仪器，其包括具有与光轴对准的光束输出的第一空间相干光源。 在相干光源之后，聚焦光学器件沿着光轴定位，并且在聚焦光学器件之后沿着光轴定位样品池。 该仪器还包括在样品池之后沿着光轴定位的发散光学器件，以及位于光轴外侧的检测器，以在来自发散光学器件的散射角度的第一范围内接收散射光。 在另一个总体方面，仪器可以引导第一光束的至少一部分和沿着相同光轴的第二光束的至少一部分，并且可以从样品与第二光束之间的相互作用接收来自样品池的散射光 第一光束或第二光束。