公开(公告)号：US08211646B1

公开(公告)日：2012-07-03

申请号：US12619345

申请日：2009-11-16

申请人： Meera Nanjundan ,  Gordon Mills ,  Dawn Smith

发明人： Meera Nanjundan ,  Gordon Mills ,  Dawn Smith

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12N15/1135 ,  C12N2310/14 ,  C12Q2600/158 ,  C12Q2600/178

摘要： Genomic analysis of ovarian cancers demonstrated a regional chromosomal increase in expression and gene duplication. TGF-β stimulation indicated a link between SnoN RNA and TGF-β. In TIOSE, SnoN protein levels were reduced 15 min post TGF-β-stimulation, likely by proteosome-mediated degradation. SnoN inhibition decreased cell growth between 20 and 50% concurrent with increased p21 levels. Stable expression of SnoN led to growth arrest through induction of senescence. Collectively, these results implicate SnoN levels in multiple roles during ovarian carcinogenesis: promoting cellular proliferation in ovarian cancer cells and as a positive mediator of cell cycle arrest and senescence in non-transformed ovarian epithelial cells.

摘要翻译： 卵巢癌的基因组学分析表明，染色体表达和基因重复的区域增加。 TGF- 刺激表明SnoN RNA与TGF-β1的结合。 在TIOSE中，SnoN蛋白水平在TGF-和bgr-刺激后15分钟减少，可能通过蛋白质介导的降解。 SnoN抑制使细胞增殖在20和50％之间同时增加p21水平。 SnoN的稳定表达通过诱导衰老导致生长停滞。 总的来说，这些结果涉及卵巢癌发生过程中多种作用的SnoN水平：促进卵巢癌细胞中的细胞增殖，以及非转化卵巢上皮细胞中细胞周期阻滞和衰老的阳性介质。

公开(公告)号：US07968050B2

公开(公告)日：2011-06-28

申请号：US12229111

申请日：2008-08-20

申请人： Jürgen Vogt ,  Mary Flowers Mowrey-McKee ,  Dawn Smith

发明人： Jürgen Vogt ,  Mary Flowers Mowrey-McKee ,  Dawn Smith

IPC分类号： A61L2/08 ,  C09K3/00 ,  C08F126/02 ,  C08F118/00 ,  C08L53/00 ,  G02C7/04 ,  A45C11/04

CPC分类号： A61L12/04 ,  A61L12/08 ,  A61L12/14 ,  C11D1/722 ,  C11D3/0078 ,  C11D7/10 ,  C11D7/263 ,  C11D7/265 ,  C11D7/3218 ,  C11D7/34 ,  C11D7/36

摘要： The present invention provides an aqueous solution for sterilizing and storing ophthalmic devices, preferably a contact lens, made of a hydrogel material, preferably a poly(oxyalkylene)-containing hydrogel material. The solution comprises one or more organic buffer agents, such as a Good buffer or a bis-aminopolyols; an organic tonicity-adjusting agent with multiple hydroxyl groups in an amount sufficient to provide an osmolarity of from about 200 to about 450 mosm/l, wherein the aqueous solution has a pH of from about 5.5 to about 8.5, provided that the aqueous solution include phosphate buffer at a concentration of about 15 mM or less and about 5000 ppm sodium chloride. The present invention also provides a method for sterilizing and storing an ophthalmic device using an aqueous solution of the invention.

摘要翻译： 本发明提供一种水溶液，用于消毒和储存由水凝胶材料，优选含有（含氧化烯）的水凝胶材料制成的眼科装置，优选隐形眼镜。 溶液包含一种或多种有机缓冲剂，例如Good缓冲液或双 - 氨基多元醇; 具有多个羟基的有机张力调节剂，其量足以提供约200至约450 mosm / l的渗透压，其中所述水溶液的pH为约5.5至约8.5，条件是所述水溶液包括 浓度为约15mM或更低和约5000ppm氯化钠的磷酸盐缓冲液。 本发明还提供使用本发明的水溶液对眼科装置进行消毒和储存的方法。

公开(公告)号：US20080004372A1

公开(公告)日：2008-01-03

申请号：US11427589

申请日：2006-06-29

申请人： Thaddeus PRUSIK ,  Dawn SMITH ,  Ray H. Baughman

发明人： Thaddeus PRUSIK ,  Dawn SMITH ,  Ray H. Baughman

IPC分类号： C09D11/00

CPC分类号： C09D11/50

摘要： Indicator inks, indicators formed by printing or otherwise utilizing the inks and host products utilizing the indicators are disclosed. Reactivity-enhancing adjuvants stimulate enhanced thermal reactivity of diacetylenic or other indicator agents capable of responding to ambient thermal conditions with a visual change signaling an end point. The diacetylenic or other agents may be sensitive or relatively insensitive to ambient temperatures. Use of a reactivity-enhancing adjuvant provides a useful means for adapting the reactivities of indicator agents to the response characteristics of prospective host products, for example perishables such as vaccines or fresh fish and maturables such as fruit, cheese and wine. Some exemplary adjuvants include low-temperature polymerization initiators, for example methyl ethyl ketone peroxide and polymerization accelerators, for example cobalt compounds. Such initiators and accelerators can also be used in combination.

摘要翻译： 公开了指示剂油墨，通过使用指示剂印刷或以其它方式利用油墨和主体产品形成的指示剂。 反应性增强佐剂刺激能够响应于环境热条件的二乙炔或其他指示剂的增强的热反应性，其中以指示终点的视觉改变。 二乙炔或其它试剂可能对环境温度敏感或相对不敏感。 使用反应性增强佐剂提供了一种有用的方法，用于使指示剂的反应性适应于预期宿主产物的反应特性，例如易腐食物例如疫苗或鲜鱼以及可食用如水果，奶酪和葡萄酒。 一些示例性的助剂包括低温聚合引发剂，例如甲基乙基酮过氧化物和聚合促进剂，例如钴化合物。 这样的引发剂和促进剂也可以组合使用。

公开(公告)号：US07019171B1

公开(公告)日：2006-03-28

申请号：US11002818

申请日：2004-12-02

申请人： Thaddeus Prusik ,  Dawn Smith ,  Ingo Leubner

发明人： Thaddeus Prusik ,  Dawn Smith ,  Ingo Leubner

IPC分类号： C07C273/18

CPC分类号： C07C273/189 ,  C07C275/20

摘要： Precipitation of polyacetylenic agents can be effected with control of a particle size parameter such as mean size or spread, by mixing a warm solution of the acetylenic agent with a cold precipitation fluid and appropriate selection of a constituent of the cold precipitation fluid and/or of the temperature conditions and collecting the precipitated acetylenic agent. Precipitation additives such as nitrocellulose or gelatin can usefully be employed. Solvents such as aqueous methanol and ethyl 3-ethoxypropionate can be useful. Polyacetylenic agents, e.g. substituted diacetylenics are useful to provide visual changes in condition-monitoring indicators such as time-temperature indicators, “TTIs”, useful as freshness indicators for radiation exposure monitoring and for other purposes. Controlled, small and/or consistent particle sizes of such polyacetylenic agents are helpful in providing consistent commercial properties, especially in inks in which they may be formulated.

摘要翻译： 通过将炔属试剂的温溶液与冷沉淀流体混合并适当选择冷沉淀液和/或冷沉淀液的组分，可以通过控制诸如平均尺寸或扩展率的粒度参数来进行聚乙炔化沉淀 温度条件并收集沉淀的炔属剂。 可以有效地使用沉淀添加剂如硝酸纤维素或明胶。 溶剂如甲醇水溶液和3-乙氧基丙酸乙酯是有用的。 聚乙炔化剂，例如 取代的二乙酰基可用于提供条件监测指标的视觉变化，例如时间 - 温度指标“TTI”，作为辐射暴露监测的新鲜度指标和用于其他目的。 这种聚乙炔化剂的受控的，小的和/或一致的颗粒大小有助于提供一致的商业性质，特别是在它们可以配制的油墨中。

公开(公告)号：US5166972A

公开(公告)日：1992-11-24

申请号：US426418

申请日：1989-10-26

申请人： Dawn Smith

发明人： Dawn Smith

IPC分类号： H04M11/04 ,  H04Q3/00

CPC分类号： H04Q3/00 ,  H04M11/04

摘要： A group emergency call system for use in a central office exchange or other communication system for alerting a group of people in the event of an emergency. Data in the form of a hunt group assignment table is stored within the communication system, containing a predetermined pilot number for defining a particular emergency hunt group within the communication system, and a plurality of directory numbers corresponding to respective ones of the subscriber sets assigned to the emergency hunt group. Circuitry is provided for receiving dialed digit signals designating an incoming emergency call from a predetermined one of the subscriber sets and comparing the dialed digits with the pilot number, and in the event the dialed digit signals correspond to the predetermined pilot number generating a request device message signal. Circuitry is provided for receiving the request device message signal and in response retrieving the directory numbers from the emergency hunt group assignment table and generating a plurality of ringing signals for simultaneously ringing respective ones of the subscriber sets assigned to the emergency hunt group, such that members of the emergency hunt group are alerted to the incoming emergency call.

摘要翻译： 用于中央局交换机或其他通信系统的集团紧急呼叫系统，用于在发生紧急情况时提醒一群人。 寻线组分配表形式的数据被存储在通信系统内，其中包含用于定义通信系统内的特定紧急寻线组的预定导频号，以及对应于分配给 紧急寻线组。 提供电路用于接收拨号数字信号，用于指定来自预定的一个用户组的进入紧急呼叫，并将拨号数字与导频号进行比较，并且在拨号数字信号对应于产生请求装置消息的预定导频号 信号。 提供电路用于接收请求设备消息信号，并且响应于从紧急寻线组分配表中检索目录号码并产生多个振铃信号，以同时振铃分配给紧急寻线组的各个用户集合，使得成员 的紧急寻线组警告进入的紧急呼叫。

公开(公告)号：US20140331396A1

公开(公告)日：2014-11-13

申请号：US13750702

申请日：2013-05-07

申请人： Kimberly Dawn Smith

发明人： Kimberly Dawn Smith

IPC分类号： A41D31/00

CPC分类号： A41D31/0038 ,  A41D13/0512 ,  A41D31/065

摘要： A neck protector which helps eliminate someone from burning their neck while using curling irons and hair straighteners is disclosed. My invention appears to be the first that will be displayed in stores everywhere. It will sell very well if displayed in the hair section near the curling irons, hair straighteners, hot rollers and other heated styling devices. My invention will sell very well in retail stores including beauty supply houses and salons.

摘要翻译： 公开了一种颈部保护器，其在使用卷发器熨斗和直发器时有助于消除某人烧伤颈部。 我的发明似乎是第一个在各地商店展示的。 如果显示在卷发熨斗，直发器，热辊和其他加热造型装置附近的头发部分，它将会很好地销售。 我的发明会在包括美容供应商和沙龙在内的零售店销售得很好。

公开(公告)号：US20070037897A1

公开(公告)日：2007-02-15

申请号：US11500721

申请日：2006-08-08

申请人： Guigui Wang ,  Dawn Smith ,  Juergen Vogt ,  John Lally ,  Brian Devlin

发明人： Guigui Wang ,  Dawn Smith ,  Juergen Vogt ,  John Lally ,  Brian Devlin

IPC分类号： B29D11/00 ,  G02B1/04

CPC分类号： B29C33/60 ,  B29C33/62 ,  B29D11/00134 ,  B29D11/00192 ,  G02B1/043

摘要： The instant invention pertains to a method and a fluid composition for producing contact lenses with improved lens quality and with increased product yield. The method of the invention involves adding a non-crosslinkable hydrophilic polymer into a fluid composition including a lens-forming material in an amount sufficient to reduce an averaged mold separation force by at least about 40% in comparison with that without the non-crosslinkable hydrophilic polymer and to provide a disparity of about 10 N or less in mold separation force. The non-crosslinkable hydrophilic polymer has a limited miscibility with the lens-forming material low enough to successfully and timely form an intact interfacial film with a sufficient thickness at an interface between the mold and the fluid composition therein, and has a structure that minimizes entanglement of the non-crosslinkable hydrophilic polymer in the interfacial film with the polymer matrix of the formed lens.

摘要翻译： 本发明涉及一种用于制造具有改善的镜片质量和增加的产品产量的隐形眼镜的方法和流体组合物。 本发明的方法包括将不可交联的亲水性聚合物添加到包含透镜形成材料的流体组合物中，该透镜形成材料的量足以将平均的模具分离力减小至少约40％，与没有不可交联的亲水性 并且在模具分离力中提供约10N或更小的差异。 不可交联的亲水性聚合物与透镜形成材料的混溶性有限，足够低以在模具和其中的流体组合物之间的界面处成功地及时地形成具有足够厚度的完整界面膜，并且具有最小化缠结的结构 的界面膜中的不可交联的亲水聚合物与形成的透镜的聚合物基体。

公开(公告)号：US20060241242A1

公开(公告)日：2006-10-26

申请号：US11365546

申请日：2006-03-01

申请人： Brian Devlin ,  Troy Holland ,  Dawn Smith ,  Alexander Azzawi

发明人： Brian Devlin ,  Troy Holland ,  Dawn Smith ,  Alexander Azzawi

IPC分类号： C08F297/08

CPC分类号： B01J19/0093 ,  B01J2219/00006 ,  B01J2219/0004 ,  B01J2219/00835 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00932 ,  B01J2219/00984 ,  C08F2/01 ,  C08F2/04 ,  C08G18/0895 ,  C08G18/5024 ,  C08G18/6685

摘要： The invention provides a continuous-flow process for producing a polymeric material. The process of the invention comprises the steps of: introducing at least two solutions, each comprising one or more reactants, into a microreactor to mix the two solutions to form a reacting solution, wherein the one or more reactants are selected from the group consisting of a monomer, an initiator, a coupling agent, a prepolymer, a macromer, and mixtures thereof; feeding continuously the reacting solution into a flow-through polymerization reactor in a coil form, wherein the flow-through polymerization reactor is capable of providing a residence time sufficient for (co)polymerizing the reactants to form a polymer with a desired polydispersity, wherein the flow-through polymerization reactor is immersed in an ultrasonic bath to minimize or substantially eliminate unwanted high-molecular-weight fractions of the polymer.

摘要翻译： 本发明提供了用于生产聚合物材料的连续流动方法。 本发明的方法包括以下步骤：将至少两种各自包含一种或多种反应物的溶液引入微反应器以混合两种溶液以形成反应溶液，其中所述一种或多种反应物选自 单体，引发剂，偶联剂，预聚物，大分子单体及其混合物; 将反应溶液连续进料到线圈形式的流通聚合反应器中，其中流通聚合反应器能够提供足够的（共）聚合反应物以形成具有所需多分散性的聚合物的停留时间，其中 将流通聚合反应器浸入超声波浴中以最小化或基本上消除聚合物的不需要的高分子量级分。

公开(公告)号：US20060025647A1

公开(公告)日：2006-02-02

申请号：US10900448

申请日：2004-07-28

申请人： Thaddeus Prusik ,  Dawn Smith ,  Ingo Leubner ,  Wesley Olmsted

发明人： Thaddeus Prusik ,  Dawn Smith ,  Ingo Leubner ,  Wesley Olmsted

IPC分类号： C07C7/14

CPC分类号： C07C7/14 ,  Y10T436/13 ,  C07C11/22

摘要： A system for recovering a diacetylenic monomer shelf life monitoring compound of reduced particle size and narrow size distribution range which comprises quenching a solution of the monomer by mixing the solution in a lower temperature quenching fluid having a base temperature which is at least about 30° C. below the nominal temperature at which the monomer compound recrystallizes from solution, the mixing being effected in such a manner as to limit the resulting quenching mixture temperature to one which is not higher than a maximum of about 15° C. above the quenching fluid base temperature.

摘要翻译： 一种用于回收粒径小，分布范围窄的二炔单体保质期监测化合物的系统，其包括通过将溶液混合在基础温度为至少约30℃的较低温淬火流体中来淬灭单体溶液 在单体化合物从溶液中重结晶的标称温度以下的混合下，将所得到的淬火混合物温度限制在不高于骤冷流体基质上方最大约15℃的温度 温度。

公开(公告)号：US08131333B2

公开(公告)日：2012-03-06

申请号：US10566406

申请日：2004-08-06

申请人： L. Lawrence Chapoy ,  Angelika Maria Domschke ,  Dawn Smith

发明人： L. Lawrence Chapoy ,  Angelika Maria Domschke ,  Dawn Smith

IPC分类号： A61B5/1455

CPC分类号： G02C7/04 ,  G01N33/582 ,  G01N33/66

摘要： This invention is generally related to a biocompatible sensor for detecting/measuring sugar, especially glucose, in an ocular fluid in a non-invasive or minimally invasive manner and a method for using the biocompatible sensor. A biocompatible sensor of the invention comprises, consists essentially, or consists of an ophthalmic device comprising a molecular sensing moiety which interacts or, reacts with sugar to provide an optical signal which is indicative of sugar level in an ocular fluid.

摘要翻译： 本发明通常涉及用于以非侵入性或微创方式检测/测量眼液中的糖，特别是葡萄糖的生物相容性传感器，以及使用生物相容性传感器的方法。 本发明的生物相容性传感器包括，基本上由...组成或由包括与糖相互作用或与糖反应的分子感测部分的眼科装置组成，以提供指示眼液中糖水平的光学信号。