公开(公告)号：US20100222863A1

公开(公告)日：2010-09-02

申请号：US12750947

申请日：2010-03-31

申请人： David M. Gravett ,  Pierre E. Signore ,  Kaiyue Wang ,  Philip M. Toleikis ,  Dechi Guan ,  Zengxuan Hu ,  Arpita Maiti

发明人： David M. Gravett ,  Pierre E. Signore ,  Kaiyue Wang ,  Philip M. Toleikis ,  Dechi Guan ,  Zengxuan Hu ,  Arpita Maiti

IPC分类号： A61F2/82

CPC分类号： A61F2/07 ,  A61F2/89 ,  A61F2002/065 ,  A61F2002/075 ,  A61L31/005 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/258 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2300/432 ,  A61L2300/434 ,  A61L2300/602

摘要： Silk-containing stent grafts are provided comprising an endoluminal stent and a graft, wherein the silk induces the in vivo adhesion of the stent graft to vessel walls, or, otherwise induces or accelerates an in vivo fibrotic reaction causing said stent graft to adhere to vessel wall. Also provided are methods for making and using such stent grafts.

摘要翻译： 提供的含有丝素的支架移植物包括腔内支架和移植物，其中所述丝诱导所述支架移植物体内粘附于血管壁，或以其它方式诱导或加速体内纤维化反应，导致所述支架移植物附着于血管 壁。 还提供了制造和使用这种支架移植物的方法。

公开(公告)号：US20050175661A1

公开(公告)日：2005-08-11

申请号：US10999205

申请日：2004-11-29

申请人： William Hunter ,  David Gravett ,  Philip Toleikis ,  Arpita Maiti ,  Pierre Signore ,  Richard Liggins ,  Dechi Guan

发明人： William Hunter ,  David Gravett ,  Philip Toleikis ,  Arpita Maiti ,  Pierre Signore ,  Richard Liggins ,  Dechi Guan

IPC分类号： A61B17/00 ,  A61B17/11 ,  A61B17/12 ,  A61F2/00 ,  A61F2/86 ,  A61F13/00 ,  A61K38/48 ,  A61L27/00 ,  A61L27/54 ,  A61L31/00 ,  A61L31/16 ,  A61M29/00 ,  A61M31/00

CPC分类号： A61B17/12172 ,  A61B17/00491 ,  A61B17/11 ,  A61B17/12022 ,  A61B17/12045 ,  A61B17/12136 ,  A61B17/1215 ,  A61B17/12177 ,  A61B17/12186 ,  A61B17/1219 ,  A61B2017/00004 ,  A61F2/86 ,  A61F2250/0067 ,  A61L31/16 ,  A61L2300/412

摘要： Intravascular devices (e.g., stents, stent grafts, covered stents, aneurysm coils, embolic agents and drug delivery catheters and balloons) are used in combination with fibrosing agents in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or to promote fibrosis betweent the devices and the host tissues. Compositions and methods are described for use in the treatment of aneurysms and unstable arterial (vulnerable) plaque.

公开(公告)号：US20050149175A1

公开(公告)日：2005-07-07

申请号：US11007719

申请日：2004-12-07

申请人： William Hunter ,  David Gravett ,  Philip Toleikis ,  Arpita Maiti ,  Pierre Signore ,  Richard Liggins ,  Dechi Guan

发明人： William Hunter ,  David Gravett ,  Philip Toleikis ,  Arpita Maiti ,  Pierre Signore ,  Richard Liggins ,  Dechi Guan

IPC分类号： A61B17/00 ,  A61B17/11 ,  A61B17/12 ,  A61F2/00 ,  A61F2/86 ,  A61F13/00 ,  A61K38/48 ,  A61L27/00 ,  A61L27/54 ,  A61L31/00 ,  A61L31/16 ,  A61M29/00 ,  A61M31/00 ,  A61F2/06

CPC分类号： A61B17/12172 ,  A61B17/00491 ,  A61B17/11 ,  A61B17/12022 ,  A61B17/12045 ,  A61B17/12136 ,  A61B17/1215 ,  A61B17/12177 ,  A61B17/12186 ,  A61B17/1219 ,  A61B2017/00004 ,  A61F2/86 ,  A61F2250/0067 ,  A61L31/16 ,  A61L2300/412

摘要： Intravascular devices (e.g., stents, stent grafts, covered stents, aneurysm coils, embolic agents and drug delivery catheters and balloons) are used in combination with fibrosing agents in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or to promote fibrosis betweent the devices and the host tissues. Compositions and methods are described for use in the treatment of aneurysms and unstable arterial (vulnerable) plaque.

公开(公告)号：US07241736B2

公开(公告)日：2007-07-10

申请号：US11129763

申请日：2005-05-12

申请人： William L Hunter ,  Philip M Toleikis ,  David M Gravett ,  Rui Avelar ,  Dechi Guan

发明人： William L Hunter ,  Philip M Toleikis ,  David M Gravett ,  Rui Avelar ,  Dechi Guan

IPC分类号： A61K38/00 ,  A61K38/17 ,  C12P21/02

CPC分类号： A61L27/54 ,  A61B17/11 ,  A61B17/12022 ,  A61B17/12099 ,  A61B17/12109 ,  A61B17/1214 ,  A61B17/12168 ,  A61B17/12186 ,  A61B17/1219 ,  A61B17/68 ,  A61F2250/0067 ,  A61K38/363 ,  A61K38/38 ,  A61K38/39 ,  A61K38/4833 ,  A61K45/06 ,  A61L31/16 ,  A61L2300/00 ,  A61L2300/412 ,  A61L2430/38 ,  A61K2300/00

摘要： Agents, compositions, and implants are provided herein for treating diverticular disease (e.g., diverticulosis and diverticulitis). In particular, fibrosis-inducing agents, hemostatic agents, and/or anti-infective agents, or compositions containing one or more of these agents are provided for use in methods for treating diverticular disease.

摘要翻译： 本文提供了用于治疗憩室疾病（例如憩室病和憩室炎）的药剂，组合物和植入物。 特别地，提供了用于治疗憩室疾病的方法中的纤维化诱导剂，止血剂和/或抗感染剂或含有这些药物中的一种或多种的组合物。

公开(公告)号：US20050186242A1

公开(公告)日：2005-08-25

申请号：US10999204

申请日：2004-11-29

申请人： William Hunter ,  David Gravett ,  Philip Toleikis ,  Arpita Maiti ,  Pierre Signore ,  Richard Liggins ,  Dechi Guan

发明人： William Hunter ,  David Gravett ,  Philip Toleikis ,  Arpita Maiti ,  Pierre Signore ,  Richard Liggins ,  Dechi Guan

IPC分类号： A61B17/00 ,  A61B17/11 ,  A61B17/12 ,  A61F2/00 ,  A61F2/86 ,  A61F13/00 ,  A61K38/48 ,  A61L27/00 ,  A61L27/54 ,  A61L31/00 ,  A61L31/16 ,  A61M29/00 ,  A61M31/00

CPC分类号： A61B17/12172 ,  A61B17/00491 ,  A61B17/11 ,  A61B17/12022 ,  A61B17/12045 ,  A61B17/12136 ,  A61B17/1215 ,  A61B17/12177 ,  A61B17/12186 ,  A61B17/1219 ,  A61B2017/00004 ,  A61F2/86 ,  A61F2250/0067 ,  A61L31/16 ,  A61L2300/412

摘要： Intravascular devices (e.g., stents, stent grafts, covered stents, aneurysm coils, embolic agents and drug delivery catheters and balloons) are used in combination with fibrosing agents in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or to promote fibrosis betweent the devices and the host tissues. Compositions and methods are described for use in the treatment of aneurysms and unstable arterial (vulnerable) plaque.

公开(公告)号：US20050154454A1

公开(公告)日：2005-07-14

申请号：US11006290

申请日：2004-12-07

申请人： William Hunter ,  David Gravett ,  Philip Toleikis ,  Arpita Maiti ,  Pierre Signore ,  Richard Liggins ,  Dechi Guan

发明人： William Hunter ,  David Gravett ,  Philip Toleikis ,  Arpita Maiti ,  Pierre Signore ,  Richard Liggins ,  Dechi Guan

IPC分类号： A61B17/00 ,  A61B17/11 ,  A61B17/12 ,  A61F2/00 ,  A61F2/86 ,  A61F13/00 ,  A61K38/48 ,  A61L27/00 ,  A61L27/54 ,  A61L31/00 ,  A61L31/16 ,  A61M29/00 ,  A61M31/00 ,  A61F2/06

CPC分类号： A61B17/12172 ,  A61B17/00491 ,  A61B17/11 ,  A61B17/12022 ,  A61B17/12045 ,  A61B17/12136 ,  A61B17/1215 ,  A61B17/12177 ,  A61B17/12186 ,  A61B17/1219 ,  A61B2017/00004 ,  A61F2/86 ,  A61F2250/0067 ,  A61L31/16 ,  A61L2300/412

摘要： Intravascular devices (e.g., stents, stent grafts, covered stents, aneurysm coils, embolic agents and drug delivery catheters and balloons) are used in combination with fibrosing agents in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or to promote fibrosis betweent the devices and the host tissues. Compositions and methods are described for use in the treatment of aneurysms and unstable arterial (vulnerable) plaque.

公开(公告)号：US20050154445A1

公开(公告)日：2005-07-14

申请号：US11006266

申请日：2004-12-07

申请人： William Hunter ,  David Gravett ,  Philip Toleikis ,  Arpita Maiti ,  Pierre Signore ,  Richard Liggins ,  Dechi Guan

发明人： William Hunter ,  David Gravett ,  Philip Toleikis ,  Arpita Maiti ,  Pierre Signore ,  Richard Liggins ,  Dechi Guan

IPC分类号： A61B17/00 ,  A61B17/11 ,  A61B17/12 ,  A61F2/00 ,  A61F2/86 ,  A61F13/00 ,  A61K38/48 ,  A61L27/00 ,  A61L27/54 ,  A61L31/00 ,  A61L31/16 ,  A61M29/00 ,  A61M31/00 ,  A61F2/06

CPC分类号： A61B17/12172 ,  A61B17/00491 ,  A61B17/11 ,  A61B17/12022 ,  A61B17/12045 ,  A61B17/12136 ,  A61B17/1215 ,  A61B17/12177 ,  A61B17/12186 ,  A61B17/1219 ,  A61B2017/00004 ,  A61F2/86 ,  A61F2250/0067 ,  A61L31/16 ,  A61L2300/412

摘要： Intravascular devices (e.g., stents, stent grafts, covered stents, aneurysm coils, embolic agents and drug delivery catheters and balloons) are used in combination with fibrosing agents in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or to promote fibrosis betweent the devices and the host tissues. Compositions and methods are described for use in the treatment of aneurysms and unstable arterial (vulnerable) plaque.

公开(公告)号：US20080146652A1

公开(公告)日：2008-06-19

申请号：US11834498

申请日：2007-08-06

申请人： Richard Liggins ,  Larry Murphy ,  Dechi Guan

发明人： Richard Liggins ,  Larry Murphy ,  Dechi Guan

IPC分类号： A61K31/337 ,  A61K47/32 ,  A61P35/00

CPC分类号： A61K31/337 ,  A61K9/0019 ,  A61K9/107 ,  A61K9/19

摘要： Anhydrous formulations are formed of a diblock copolymer (X-Y) having a hydrophilic block X comprising residues of monomer x, and a hydrophobic block Y comprising residues of monomer y; an additive selected from a polymer and an organic solvent, where the solvent is water-miscible and biocompatible, and the polymer is hydrophobic or hydrophilic and comprises residues of monomers x and/or y, the polymer optionally having a molecular weight that is less than the molecular weight of the diblock copolymer; and a drug. Upon admixture with water, the anhydrous formulations form drug delivery vehicles, preferably in micellar form. The inclusion of polymer and/or organic solvent provides for the formation of micelles at an enhanced rate, and/or provides the formation of micelles having an enhanced ability to incorporate drug(s), and/or provides the formation of micelles having advantageous physical characteristics, e.g., advantageous viscosity and/or melting point.

公开(公告)号：US20050186243A1

公开(公告)日：2005-08-25

申请号：US11000097

申请日：2004-11-29

申请人： William Hunter ,  David Gravett ,  Philip Toleikis ,  Arpita Maiti ,  Pierre Signore ,  Richard Liggins ,  Dechi Guan

发明人： William Hunter ,  David Gravett ,  Philip Toleikis ,  Arpita Maiti ,  Pierre Signore ,  Richard Liggins ,  Dechi Guan

IPC分类号： A61B17/00 ,  A61B17/11 ,  A61B17/12 ,  A61F2/00 ,  A61F2/86 ,  A61F13/00 ,  A61K38/48 ,  A61L27/00 ,  A61L27/54 ,  A61L31/00 ,  A61L31/16 ,  A61M29/00 ,  A61M31/00

CPC分类号： A61B17/12172 ,  A61B17/00491 ,  A61B17/11 ,  A61B17/12022 ,  A61B17/12045 ,  A61B17/12136 ,  A61B17/1215 ,  A61B17/12177 ,  A61B17/12186 ,  A61B17/1219 ,  A61B2017/00004 ,  A61F2/86 ,  A61F2250/0067 ,  A61L31/16 ,  A61L2300/412

摘要： Intravascular devices (e.g., stents, stent grafts, covered stents, aneurysm coils, embolic agents and drug delivery catheters and balloons) are used in combination with fibrosing agents in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or to promote fibrosis betweent the devices and the host tissues. Compositions and methods are described for use in the treatment of aneurysms and unstable arterial (vulnerable) plaque.

公开(公告)号：US20050181004A1

公开(公告)日：2005-08-18

申请号：US11006289

申请日：2004-12-07

申请人： William Hunter ,  David Gravett ,  Philip Toleikis ,  Arpita Maiti ,  Pierre Signore ,  Richard Liggins ,  Dechi Guan

发明人： William Hunter ,  David Gravett ,  Philip Toleikis ,  Arpita Maiti ,  Pierre Signore ,  Richard Liggins ,  Dechi Guan

IPC分类号： A61B17/00 ,  A61B17/11 ,  A61B17/12 ,  A61F2/00 ,  A61F2/86 ,  A61F13/00 ,  A61K38/48 ,  A61L27/00 ,  A61L27/54 ,  A61L31/00 ,  A61L31/16 ,  A61M29/00 ,  A61M31/00

CPC分类号： A61B17/12172 ,  A61B17/00491 ,  A61B17/11 ,  A61B17/12022 ,  A61B17/12045 ,  A61B17/12136 ,  A61B17/1215 ,  A61B17/12177 ,  A61B17/12186 ,  A61B17/1219 ,  A61B2017/00004 ,  A61F2/86 ,  A61F2250/0067 ,  A61L31/16 ,  A61L2300/412

摘要： Intravascular devices (e.g., stents, stent grafts, covered stents, aneurysm coils, embolic agents and drug delivery catheters and balloons) are used in combination with fibrosing agents in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or to promote fibrosis betweent the devices and the host tissues. Compositions and methods are described for use in the treatment of aneurysms and unstable arterial (vulnerable) plaque.