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1.
公开(公告)号:US20120040903A1
公开(公告)日:2012-02-16
申请号:US12992356
申请日:2009-05-15
CPC分类号: A61K38/2221 , C07K14/64 , A61K2300/00
摘要: The disclosure pertains to methods of reducing decompensation through acute intervention including in subjects afflicted with acute decompensated heart failure. Particularly, the disclosure provides methods for treating acute cardiac decompensation by administering a pharmaceutically effective amount of relaxin.
摘要翻译: 本公开涉及通过急性干预减少代偿失调的方法,包括患有急性失代偿性心力衰竭的受试者。 特别地,本公开提供了通过施用药学有效量的松弛素治疗急性心脏代偿失调的方法。
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公开(公告)号:US20110144019A1
公开(公告)日:2011-06-16
申请号:US12992667
申请日:2009-05-15
申请人: Elaine Unemori , Sam L. Teichman , Thomas Dschietzig , Dennis R. Stewart , Martha J. Whitehouse
发明人: Elaine Unemori , Sam L. Teichman , Thomas Dschietzig , Dennis R. Stewart , Martha J. Whitehouse
CPC分类号: A61K38/2221 , A61K9/0019 , C07K14/64 , A61K2300/00
摘要: The present disclosure relates to methods for treating human subjects afflicted with chronic heart failure. The methods described herein employ administration of relaxin.
摘要翻译: 本公开涉及治疗患有慢性心力衰竭的人类受试者的方法。 本文描述的方法使用松弛素的施用。
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公开(公告)号:US06984128B2
公开(公告)日:2006-01-10
申请号:US10695299
申请日:2003-10-27
IPC分类号: A61C7/00
CPC分类号: A61K45/06 , A61C7/00 , A61C7/08 , A61C7/12 , A61C19/063 , A61K31/19 , A61K31/485 , A61K31/56 , A61K38/1825 , A61K38/1866 , A61K38/2221 , A61K38/4886 , A61K2300/00
摘要: Orthodontic methods comprise applying force to reposition teeth and administering a tissue remodeling and/or an angiogenic substance(s) to the periodontal tissue surrounding the teeth to be moved. The substance(s) may be delivered before, during, or after the teeth are moved, and the substance(s) may be selectively applied only to those teeth undergoing movement at any particular time. The substance(s) may be applied from the dental repositioning appliance or may be applied separately, either topically or by injection.
摘要翻译: 正畸方法包括施加力以重新定位牙齿并且向围绕要移动的牙齿的牙周组织施用组织重塑和/或血管生成物质。 物质可以在齿移动之前,期间或之后递送,并且物质可以选择性地仅施加到在任何特定时间经历运动的那些牙齿。 物质可以从牙齿重新定位装置施用,或者可以局部施用或通过注射单独施用。
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公开(公告)号:US06660531B2
公开(公告)日:2003-12-09
申请号:US09102981
申请日:1998-06-22
IPC分类号: G01N3353
CPC分类号: G01N33/689 , G01N33/74 , G01N2800/368
摘要: A method of determining the probability of an in vitro fertilization (IVF) or embryo transfer (ET) method being successful is disclosed. Relaxin can be measured directly in the serum or indirectly by culturing granulosa lutein cells extracted from the patient as part of an IVF/ET procedure. A method of enhancing the rate of a successful pregnancy resulting from an IVF/ET procedure is also disclosed whereby relaxin is administered and/or endogenous relaxin levels are enhanced by varying convention IVF/ET procedures.
摘要翻译: 公开了一种确定体外受精(IVF)或胚胎移植(ET)方法成功概率的方法。 可以直接在血清中测量松弛素,或通过培养作为IVF / ET程序的一部分从患者中提取的颗粒细胞叶黄素细胞间接测量。 还公开了提高IVF / ET程序产生的成功妊娠率的方法,其中通过改变常规IVF / ET程序来施用松弛素和/或内源性松弛素水平。
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5.
公开(公告)号:US5994148A
公开(公告)日:1999-11-30
申请号:US879662
申请日:1997-06-23
CPC分类号: G01N33/689 , G01N33/74 , G01N2800/368
摘要: A method of determining the probability of an in vitro fertilization (IVF) or embryo transfer (ET) method being successful is disclosed. Relaxin can be measured directly in the serum or indirectly by culturing granulosa lutein cells extracted from the patient as part of an IVF/ET procedure. A method of enhancing the rate of a successful pregnancy resulting from an IVF/ET procedure is also disclosed whereby relaxin is administered.
摘要翻译: 公开了一种确定体外受精(IVF)或胚胎移植(ET)方法成功概率的方法。 可以直接在血清中测量松弛素,或通过培养作为IVF / ET程序的一部分从患者中提取的颗粒细胞叶黄素细胞间接测量。 还公开了提高IVF / ET程序引起的成功妊娠率的方法,由此施用松弛素。
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6.
公开(公告)号:US20160287672A1
公开(公告)日:2016-10-06
申请号:US15137054
申请日:2016-04-25
CPC分类号: A61K38/2221 , A61K9/0019 , C07K14/64 , A61K2300/00
摘要: The present disclosure relates to methods for treating human subjects afflicted with chronic heart failure. The methods described herein employ administration of relaxin.
摘要翻译: 本公开涉及治疗患有慢性心力衰竭的人类受试者的方法。 本文描述的方法使用松弛素的施用。
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公开(公告)号:US08372809B2
公开(公告)日:2013-02-12
申请号:US13242012
申请日:2011-09-23
CPC分类号: A61K38/2221 , C07K14/64 , A61K2300/00
摘要: The disclosure pertains to methods of reducing decompensation through acute intervention including in subjects afflicted with acute decompensated heart failure. Particularly, the disclosure provides methods for treating acute cardiac decompensation by administering a pharmaceutically effective amount of relaxin.
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公开(公告)号:US08053411B2
公开(公告)日:2011-11-08
申请号:US12467214
申请日:2009-05-15
CPC分类号: A61K38/2221 , C07K14/64 , A61K2300/00
摘要: The disclosure pertains to methods of reducing decompensation through acute intervention including in subjects afflicted with acute decompensated heart failure. Particularly, the disclosure provides methods for treating acute cardiac decompensation by administering a pharmaceutically effective amount of relaxin.
摘要翻译: 本公开涉及通过急性干预减少代偿失调的方法,包括患有急性失代偿性心力衰竭的受试者。 特别地,本公开提供了通过施用药学有效量的松弛素治疗急性心脏代偿失调的方法。
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公开(公告)号:US20110166070A1
公开(公告)日:2011-07-07
申请号:US12992384
申请日:2009-05-15
申请人: Dennis R. Stewart
发明人: Dennis R. Stewart
CPC分类号: A61K38/2221
摘要: The disclosure pertains to methods of decreasing the risk of premature birth and miscarriage in human females. Particularly, the disclosure provides methods of reducing cervical dialation and preterm delivery by administration of relaxin.
摘要翻译: 本公开涉及降低人类女性早产和流产风险的方法。 特别地,本公开提供了通过施用松弛素来减少子宫颈拨压和早产的方法。
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10.
公开(公告)号:US20140005112A1
公开(公告)日:2014-01-02
申请号:US13939648
申请日:2013-07-11
IPC分类号: A61K38/22
CPC分类号: A61K38/2221 , A61K9/0019 , C07K14/64 , A61K2300/00
摘要: The present disclosure relates to methods for treating human subjects afflicted with chronic heart failure. The methods described herein employ administration of relaxin.
摘要翻译: 本公开涉及治疗患有慢性心力衰竭的人类受试者的方法。 本文描述的方法使用松弛素的施用。
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