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1.发明授权Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith 有权可用作激酶抑制剂的吡咯并嗪化合物及其与激素相关病症的治疗方法公开(公告)号：US07402582B2
公开(公告)日：2008-07-22
申请号：US11475808
申请日：2006-06-27
Applicant: Ashvinikumar V. Gavai , Ping Chen , Derek J. Norris
Inventor： Ashvinikumar V. Gavai , Ping Chen , Derek J. Norris
IPC: C07D487/04 , C07D403/12 , C07D403/14 , A61K31/4155 , A61K31/4162 , A61K31/53 , A61K19/02 , A61K35/00
CPC classification number: C07D487/04
Abstract: The invention relates to at least one pyrrolotriazine derivative, at least one pharmaceutical composition comprising at least one pyrrolotriazine derivative, and at least one method of using at least one pyrrolotriazine derivative to treat at least one kinase associated condition.
Abstract translation: 本发明涉及至少一种吡咯并三嗪衍生物，至少一种包含至少一种吡咯并三嗪衍生物的药物组合物和至少一种使用至少一种吡咯并三嗪衍生物以治疗至少一种激酶相关病症的方法。
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公开(公告)号：US07297695B2
公开(公告)日：2007-11-20
申请号：US11426479
申请日：2006-06-26
Applicant: Brian E. Fink , Ashvinikumar V. Gavai , Gregory D. Vite , Ping Chen , Harold Mastalerz , Derek J. Norris , John S. Tokarski , Yufen Zhao , Wen-Ching Han
Inventor： Brian E. Fink , Ashvinikumar V. Gavai , Gregory D. Vite , Ping Chen , Harold Mastalerz , Derek J. Norris , John S. Tokarski , Yufen Zhao , Wen-Ching Han
IPC: C07D487/04 , C07D401/06 , C07D401/14 , A61K31/53 , A61P35/00
CPC classification number: C07D487/04
Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
Abstract translation: 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制生长因子受体如HER1，HER2和HER4的酪氨酸激酶活性，从而使其成为抗增殖剂。 式I化合物还可用于治疗与通过生长因子受体操作的信号转导途径相关的其它疾病。
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3.发明申请FUSED HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION 有权熔化的杂环化合物作为核细胞受体功能的调节剂有用公开(公告)号：US20100331324A1
公开(公告)日：2010-12-30
申请号：US12666423
申请日：2008-06-26
Applicant: Derek J. Norris , Ashvinikumar V. Gavai , James Aaron Balog , Joel F. Austin , Weifang Shan , Yufen Zhao , Andrew James Nation , Wen-Ching Han
Inventor： Derek J. Norris , Ashvinikumar V. Gavai , James Aaron Balog , Joel F. Austin , Weifang Shan , Yufen Zhao , Andrew James Nation , Wen-Ching Han
IPC: A61K31/5377 , C07D491/18 , A61K31/4035 , C07D401/14 , A61K31/4709 , C07D403/14 , A61K31/506 , C07D413/14 , A61K31/4178 , C07D401/04 , A61K31/4439 , A61P35/00 , A61P17/10
CPC classification number: C07D491/22
Abstract: Disclosed are fused heterocyclic compounds of Formula (I) or pharmaceutically-acceptable salts or stereoisomers thereof. Also disclosed are methods of using such compounds in the treatment of at least one androgen receptor-associated condition, such as, for example, cancer, and pharmaceutical compositions comprising such compounds.
Abstract translation: 公开了式（I）的稠合杂环化合物或其药学上可接受的盐或立体异构体。 还公开了使用这些化合物治疗至少一种雄激素受体相关病症（例如癌症）的方法和包含这些化合物的药物组合物。
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公开(公告)号：US07064203B2
公开(公告)日：2006-06-20
申请号：US11019899
申请日：2004-12-22
Applicant: Ashvinikumar V. Gavai , Wen-Ching Han , Ping Chen , Edward H. Ruediger , Harold Mastalerz , Brian E. Fink , Derek J. Norris
Inventor： Ashvinikumar V. Gavai , Wen-Ching Han , Ping Chen , Edward H. Ruediger , Harold Mastalerz , Brian E. Fink , Derek J. Norris
IPC: C07D487/04 , A61K31/53 , A61P19/02
CPC classification number: C07D487/04
Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The compounds of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.
Abstract translation: 本发明提供式I化合物及其药学上可接受的盐。 本发明的化合物抑制生长因子受体如HER1，HER2和HER4的酪氨酸激酶活性，从而使其可用作治疗癌症和其它疾病的抗增殖剂。
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5.发明授权
公开(公告)号：US5990109A
公开(公告)日：1999-11-23
申请号：US262525
申请日：1999-03-04
Applicant: Ping Chen , Derek J. Norris , Joel C. Barrish , Edwin J. Iwanowicz
Inventor： Ping Chen , Derek J. Norris , Joel C. Barrish , Edwin J. Iwanowicz
IPC: A61K31/4985 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/551 , A61P1/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P19/02 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D471/14 , C07D487/14 , A61K31/50
CPC classification number: C07D471/14 , C07D487/14
Abstract: Novel heterocyclo-substituted imidazopyrazines and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic disorders.
Abstract translation: 新型杂环取代的咪唑并吡嗪及其盐，含有这些化合物的药物组合物，以及使用这些化合物治疗蛋白质酪氨酸激酶相关疾病如免疫疾病的方法。
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Patent Agency Ranking
公开(公告)号：US5508423A
公开(公告)日：1996-04-16
申请号：US459226
申请日：1995-06-02
Applicant: Keshava Murthy , Gamini Weeratunga , Derek J. Norris , Bruno K. Radatus
Inventor： Keshava Murthy , Gamini Weeratunga , Derek J. Norris , Bruno K. Radatus
IPC: C07C17/14 , C07C17/25 , C07C17/26 , C07C25/13 , C07C25/24 , C07C69/63 , C07D249/08 , C07D521/00 , C07D403/06
CPC classification number: C07D231/12 , C07C17/14 , C07C17/25 , C07C17/2637 , C07C25/13 , C07C25/24 , C07C69/63 , C07D233/56 , C07D249/08
Abstract: A process for making Fluconazole comprising the steps of: ##STR1##
Abstract translation: 制备氟康唑的方法包括以下步骤：
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公开(公告)号：US07141571B2
公开(公告)日：2006-11-28
申请号：US11019901
申请日：2004-12-22
Applicant: Brian E. Fink , Ashvinikumar V. Gavai , Gregory D. Vite , Ping Chen , Harold Mastalerz , Derek J. Norris , John S. Tokarski , Yufen Zhao , Wen-Ching Han
Inventor： Brian E. Fink , Ashvinikumar V. Gavai , Gregory D. Vite , Ping Chen , Harold Mastalerz , Derek J. Norris , John S. Tokarski , Yufen Zhao , Wen-Ching Han
IPC: C07D487/04 , A61K31/53
CPC classification number: C07D487/04
Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
Abstract translation: 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制生长因子受体如HER1，HER2和HER4的酪氨酸激酶活性，从而使其成为抗增殖剂。 式I化合物还可用于治疗与通过生长因子受体操作的信号转导途径相关的其它疾病。
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公开(公告)号：US06979694B2
公开(公告)日：2005-12-27
申请号：US10378372
申请日：2003-03-03
Applicant: Jagabandhu Das , Ramesh Padmanabha , Ping Chen , Derek J. Norris , Arthur M. P. Doweyko , Joel C. Barrish , John Wityak
Inventor： Jagabandhu Das , Ramesh Padmanabha , Ping Chen , Derek J. Norris , Arthur M. P. Doweyko , Joel C. Barrish , John Wityak
IPC: C07D277/20 , A61K31/426 , A61K31/427 , A61K31/437 , A61K31/438 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/00 , A61P1/00 , A61P5/14 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07C237/40 , C07D213/81 , C07D213/82 , C07D231/38 , C07D233/90 , C07D239/42 , C07D263/48 , C07D277/30 , C07D277/40 , C07D277/42 , C07D277/44 , C07D277/46 , C07D277/56 , C07D277/62 , C07D409/12 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/20 , A61K31/44
CPC classification number: C07D277/56 , C07C233/65 , C07C237/40 , C07D213/81 , C07D213/82 , C07D231/38 , C07D233/90 , C07D239/42 , C07D263/48 , C07D409/12 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/113
Abstract: Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
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公开(公告)号：US06235740B1
公开(公告)日：2001-05-22
申请号：US09097338
申请日：1998-06-15
Applicant: Joel C. Barrish , Ping Chen , Jagabandhu Das , Edwin J. Iwanowicz , Derek J. Norris , Ramesh Padmanabha , Jacques Y. Roberge , Gary L. Schieven
Inventor： Joel C. Barrish , Ping Chen , Jagabandhu Das , Edwin J. Iwanowicz , Derek J. Norris , Ramesh Padmanabha , Jacques Y. Roberge , Gary L. Schieven
IPC: C07D48704
CPC classification number: C07D487/04 , A61K31/4985 , C07D491/14
Abstract: Novel imidazoquinoxalines and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic disorders.
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公开(公告)号：US07846931B2
公开(公告)日：2010-12-07
申请号：US11869910
申请日：2008-09-24
Applicant: Brian E. Fink , Ashvinikumar V. Gavai , Gregory D. Vite , Ping Chen , Harold Mastalerz , Derek J. Norris , John S. Tokarski , Yufen Zhao , Wen-Ching Han
Inventor： Brian E. Fink , Ashvinikumar V. Gavai , Gregory D. Vite , Ping Chen , Harold Mastalerz , Derek J. Norris , John S. Tokarski , Yufen Zhao , Wen-Ching Han
IPC: A61K31/53 , A61P35/00 , C07D401/06 , C07D401/14
CPC classification number: C07D487/04
Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
Abstract translation: 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制生长因子受体如HER1，HER2和HER4的酪氨酸激酶活性，从而使其成为抗增殖剂。 式I化合物还可用于治疗与通过生长因子受体操作的信号转导途径相关的其它疾病。
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