公开(公告)号：US20070231361A1

公开(公告)日：2007-10-04

申请号：US11277637

申请日：2006-03-28

Applicant: David Brin ,  Jack Chu ,  Prema Ganesan ,  Dianne Judd ,  Michel Letort ,  Patrice Tremble ,  Eugene Tedeschi

Inventor： David Brin ,  Jack Chu ,  Prema Ganesan ,  Dianne Judd ,  Michel Letort ,  Patrice Tremble ,  Eugene Tedeschi

IPC: A61K31/202

CPC classification number: A61K31/202

Abstract: Methods of treating an aneurysm in a patient in need thereof are provided. The methods comprise delivering to a treatment site an effective amount of a fatty acid inhibitor of a matrix metalloproteinase (MMP) such that the fatty acid inhibitor of the MMP causes the regression of a pre-existing aneurysm. Additionally, an implantable medical device is provided for implanting in a vessel wall of a patient comprising a structural support and a fatty acid inhibitor of an MMP.

Abstract translation: 提供了在有需要的患者中治疗动脉瘤的方法。 所述方法包括向治疗部位递送有效量的基质金属蛋白酶（MMP）的脂肪酸抑制剂，使得MMP的脂肪酸抑制剂导致预先存在的动脉瘤的消退。 另外，可植入医疗装置用于植入患者的血管壁，包括结构支持物和MMP的脂肪酸抑制剂。

公开(公告)号：US20150038418A1

公开(公告)日：2015-02-05

申请号：US14235364

申请日：2012-07-19

Applicant: William Van Antwerp ,  Dianne Judd ,  Andrew Walsh ,  Lian Luo

Inventor： William Van Antwerp ,  Dianne Judd ,  Andrew Walsh ,  Lian Luo

IPC: C07K14/58

CPC classification number: C07K14/58 ,  A61K9/0019 ,  A61K38/00 ,  A61K38/2242 ,  A61K47/02 ,  A61K47/10

Abstract: Therapeutic compositions containing natriuretic peptides for treating chronic kidney disease alone, heart failure alone, or chronic kidney disease with concomitant heart failure are described. The therapeutic compositions have enhanced stability characteristics to facilitate storage and delivery by provisioning apparatuses under conditions of elevated temperature and mechanical stress. Methods for increasing the stability of therapeutic compositions containing natriuretic peptides are further described.

Abstract translation: 描述了含有用于单独治疗慢性肾脏疾病，单独心力衰竭或伴有心力衰竭的慢性肾脏疾病的利尿钠肽的治疗组合物。 治疗组合物具有增强的稳定性特征，以便在高温和机械应力的条件下通过供应装置的储存和递送。 进一步描述了增加含利钠肽的治疗组合物的稳定性的方法。

公开(公告)号：US20090204104A1

公开(公告)日：2009-08-13

申请号：US11568779

申请日：2005-05-04

Applicant: Patrice Tremble ,  Dianne Judd ,  Kishore Udipi ,  Peiwen Cheng ,  Rangarajan Sundar ,  Kaushik A. Patel ,  Eugene Tedeschi

Inventor： Patrice Tremble ,  Dianne Judd ,  Kishore Udipi ,  Peiwen Cheng ,  Rangarajan Sundar ,  Kaushik A. Patel ,  Eugene Tedeschi

IPC: A61M25/10 ,  A61M25/06 ,  A61K9/14 ,  A61P9/02

CPC classification number: A61M25/0084 ,  A61K9/16

Abstract: The invention provides a method of delivering a therapeutic agent to the adventitia of a vessel using a catheter-based microsyringe. A therapeutic agent is formed into microparticles, which are dispersed throughout an appropriate liquid carrier to form a therapeutic mixture. A catheter is provided that includes a microsyringe operably attached to an actuator. The microsyringe includes a hollow needle in fluid communication with a therapeutic agent delivery conduit. The catheter is introduced into a target area of a vessel. The actuator is operated to thrust the needle into a wall of the vessel. The therapeutic mixture is supplied to the therapeutic agent delivery conduit and delivered through the conduit to the needle and thereby into the adventitia of the vessel. The actuator is again operated to withdraw the needle from the wall of the vessel and to enclose it within the actuator. The catheter is then removed from the vessel.

Abstract translation: 本发明提供了使用基于导管的微量注射器将治疗剂递送至血管外膜的方法。 将治疗剂形成为微粒，其分散在适当的液体载体中以形成治疗性混合物。 提供了一种导管，其包括可操作地附接到致动器的微量注射器。 微量注射器包括与治疗剂输送管道流体连通的中空针头。 将导管引入血管的靶区域。 致动器被操作以将针推入容器的壁中。 将治疗性混合物供应到治疗剂递送导管并通过导管输送到针，从而被输送到血管的外膜。 致动器再次被操作以将针从容器的壁中抽出并将其封闭在致动器内。 然后从血管中取出导管。

公开(公告)号：US20080075628A1

公开(公告)日：2008-03-27

申请号：US11535762

申请日：2006-09-27

Applicant: Dianne Judd ,  Jennifer Raeder-Devens ,  William Ferris

Inventor： Dianne Judd ,  Jennifer Raeder-Devens ,  William Ferris

IPC: A61L2/00

CPC classification number: A61L29/16 ,  A61L2/0011 ,  A61L2/087 ,  A61L31/16 ,  A61L2202/24 ,  A61L2300/406

Abstract: A sterilized medical device comprising minocycline and rifampin is described. The device is setrerilized by e-beam raditation such that degradation of minocycline and rifampin is minimized. Methods for sterilizing minocycline and rifampin-containing devices by e-beam radiation and methods of manufacturing devices, which methods include e-beam sterilization, are also described.

Abstract translation: 描述了包含二甲胺四环素和利福平的灭菌医疗器械。 该装置通过电子束辐射被固定，使得二甲胺四环素和利福平的降解最小化。 还描述了通过电子束辐射灭菌米诺环素和含利福平装置的方法以及制造装置的方法，该方法包括电子束灭菌。