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    Methods for Compounding and Delivering a Therapeutic Agent to the Adventitia of a Vessel
    1.
    发明申请
    Methods for Compounding and Delivering a Therapeutic Agent to the Adventitia of a Vessel 审中-公开
    将治疗剂复合并递送至血管外膜的方法

    公开(公告)号：US20090204104A1

    公开(公告)日：2009-08-13

    申请号：US11568779

    申请日：2005-05-04

    申请人： Patrice Tremble ,  Dianne Judd ,  Kishore Udipi ,  Peiwen Cheng ,  Rangarajan Sundar ,  Kaushik A. Patel ,  Eugene Tedeschi

    发明人： Patrice Tremble ,  Dianne Judd ,  Kishore Udipi ,  Peiwen Cheng ,  Rangarajan Sundar ,  Kaushik A. Patel ,  Eugene Tedeschi

    IPC分类号： A61M25/10 ,  A61M25/06 ,  A61K9/14 ,  A61P9/02

    CPC分类号： A61M25/0084 ,  A61K9/16

    摘要： The invention provides a method of delivering a therapeutic agent to the adventitia of a vessel using a catheter-based microsyringe. A therapeutic agent is formed into microparticles, which are dispersed throughout an appropriate liquid carrier to form a therapeutic mixture. A catheter is provided that includes a microsyringe operably attached to an actuator. The microsyringe includes a hollow needle in fluid communication with a therapeutic agent delivery conduit. The catheter is introduced into a target area of a vessel. The actuator is operated to thrust the needle into a wall of the vessel. The therapeutic mixture is supplied to the therapeutic agent delivery conduit and delivered through the conduit to the needle and thereby into the adventitia of the vessel. The actuator is again operated to withdraw the needle from the wall of the vessel and to enclose it within the actuator. The catheter is then removed from the vessel.

    摘要翻译： 本发明提供了使用基于导管的微量注射器将治疗剂递送至血管外膜的方法。 将治疗剂形成为微粒，其分散在适当的液体载体中以形成治疗性混合物。 提供了一种导管，其包括可操作地附接到致动器的微量注射器。 微量注射器包括与治疗剂输送管道流体连通的中空针头。 将导管引入血管的靶区域。 致动器被操作以将针推入容器的壁中。 将治疗性混合物供应到治疗剂递送导管并通过导管输送到针，从而被输送到血管的外膜。 致动器再次被操作以将针从容器的壁中抽出并将其封闭在致动器内。 然后从血管中取出导管。

    Stent with phenoxy primer coating
    2.
    发明授权
    Stent with phenoxy primer coating 有权
    支架用苯氧基底漆涂层

    公开(公告)号：US07001421B2

    公开(公告)日：2006-02-21

    申请号：US10376860

    申请日：2003-02-28

    申请人： Peiwen Cheng ,  Rangarajan Sundar ,  Kaushik A. Patel ,  Kishore Udipi

    发明人： Peiwen Cheng ,  Rangarajan Sundar ,  Kaushik A. Patel ,  Kishore Udipi

    IPC分类号： A61F2/06

    CPC分类号： A61L31/10 ,  A61F2250/0067

    摘要： The present invention provides a system for treating a vascular condition, which includes a catheter; a stent coupled to the catheter, the stent including a stent framework; a phenoxy primer coating operably disposed on the stent framework; and a drug-polymer coating disposed on the phenoxy primer coating. The present invention also provides a drug-coated stent and a method of manufacturing a drug-coated stent.

    摘要翻译： 本发明提供一种治疗血管状态的系统，其包括导管; 支架，其联接到所述导管，所述支架包括支架框架; 可操作地设置在支架框架上的苯氧基底漆; 以及设置在苯氧基底漆涂层上的药物 - 聚合物涂层。 本发明还提供了药物包衣的支架和药物包衣支架的制造方法。

    Gradient coated stent and method of fabrication
    3.
    发明授权
    Gradient coated stent and method of fabrication 有权
    梯度涂层支架及其制造方法

    公开(公告)号：US08801692B2

    公开(公告)日：2014-08-12

    申请号：US10921735

    申请日：2004-08-18

    申请人： Peiwen Cheng ,  Patrice Tremble ,  Wenda Carlyle ,  Diane Judd ,  Kishore Udipi

    发明人： Peiwen Cheng ,  Patrice Tremble ,  Wenda Carlyle ,  Diane Judd ,  Kishore Udipi

    IPC分类号： A61M31/00 ,  A61F2/06 ,  A61L33/00

    CPC分类号： A61F2/86 ,  A61F2/0077 ,  A61F2/91 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/072 ,  A61F2002/91541 ,  A61F2210/0004 ,  A61F2230/0054 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2300/606

    摘要： The gradient coated stent 150 of the present invention provides a coated stent having a continuous coating 130 disposed on the stent elements. The continuous coating 130 includes a first coating component and a second coating component. The concentration of the first coating component varies continuously over at least part of the thickness of the continuous coating 130. The concentration of the second coating component can also vary over at least part of the thickness of the continuous coating 130. In one embodiment, the concentration of the first coating component decreases in the direction from the stent element towards the outer edge of the continuous coating 130 and the concentration of the second coating component increases in the direction from the stent element towards the outer edge of the continuous coating 130.

    摘要翻译： 本发明的梯度涂层支架150提供了涂层支架，其具有设置在支架元件上的连续涂层130。 连续涂层130包括第一涂层组分和第二涂层组分。 第一涂层组分的浓度在连续涂层130的厚度的至少一部分上连续变化。第二涂层组分的浓度也可以在连续涂层130的至少一部分厚度上变化。在一个实施方案中， 第一涂层组分的浓度在从支架元件朝向连续涂层130的外边缘的方向上减小，并且第二涂层组分的浓度在从支架元件朝向连续涂层130的外边缘的方向上增加。

    Gradient coated stent and method of fabrication
    4.
    发明申请
    Gradient coated stent and method of fabrication 有权
    梯度涂层支架及其制造方法

    公开(公告)号：US20050075714A1

    公开(公告)日：2005-04-07

    申请号：US10921735

    申请日：2004-08-18

    申请人： Peiwen Cheng ,  Patrice Tremble ,  Wenda Carlyle ,  Diane Judd ,  Kishore Udipi

    发明人： Peiwen Cheng ,  Patrice Tremble ,  Wenda Carlyle ,  Diane Judd ,  Kishore Udipi

    IPC分类号： A61F2/00 ,  A61F2/02 ,  A61F2/90 ,  A61F2/06

    CPC分类号： A61F2/86 ,  A61F2/0077 ,  A61F2/91 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/072 ,  A61F2002/91541 ,  A61F2210/0004 ,  A61F2230/0054 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2300/606

    摘要： The gradient coated stent 150 of the present invention provides a coated stent having a continuous coating 130 disposed on the stent elements. The continuous coating 130 includes a first coating component and a second coating component. The concentration of the first coating component varies continuously over at least part of the thickness of the continuous coating 130. The concentration of the second coating component can also vary over at least part of the thickness of the continuous coating 130. In one embodiment, the concentration of the first coating component decreases in the direction from the stent element towards the outer edge of the continuous coating 130 and the concentration of the second coating component increases in the direction from the stent element towards the outer edge of the continuous coating 130.

    摘要翻译： 本发明的梯度涂层支架150提供了涂层支架，其具有设置在支架元件上的连续涂层130。 连续涂层130包括第一涂层组分和第二涂层组分。 第一涂层组分的浓度在连续涂层130的厚度的至少一部分上连续变化。第二涂层组分的浓度也可以在连续涂层130的至少一部分厚度上变化。在一个实施方案中， 第一涂层组分的浓度在从支架元件朝向连续涂层130的外边缘的方向上减小，并且第二涂层组分的浓度在从支架元件朝向连续涂层130的外边缘的方向上增加。

    Biocompatible controlled release coatings for medical devices and related methods
    10.
    发明授权
    Biocompatible controlled release coatings for medical devices and related methods 有权
    用于医疗器械和相关方法的生物相容性控释涂层

    公开(公告)号：US08088404B2

    公开(公告)日：2012-01-03

    申请号：US11005463

    申请日：2004-12-06

    申请人： Kishore Udipi ,  Peiwen Cheng ,  Mingfei Chen ,  Su-Ping Lyu

    发明人： Kishore Udipi ,  Peiwen Cheng ,  Mingfei Chen ,  Su-Ping Lyu

    IPC分类号： A61F2/04 ,  A61F2/00

    CPC分类号： A61L31/10 ,  A61L31/16 ,  A61L2300/406 ,  A61L2300/416 ,  A61L2300/602

    摘要： Biocompatible coatings for medical devices are disclosed. Specifically, polymer coatings designed to control the release of bioactive agents from medical devices in vivo are disclosed wherein the solubility parameters of polymers and drugs are closely matched to control elute rate profiles. The present application also discloses providing vascular stents with controlled release coatings and related methods for making these coatings.

    摘要翻译： 公开了用于医​​疗装置的生物相容性涂层。 具体地，公开了设计用于在体内控制生物活性剂从医疗装置释放的聚合物涂层，其中聚合物和药物的溶解度参数与控制洗脱速率曲线紧密匹配。 本申请还公开了提供具有控制释放涂层的血管支架和用于制备这些涂层的相关方法。