公开(公告)号：US08999706B2

公开(公告)日：2015-04-07

申请号：US11911400

申请日：2006-04-12

申请人： Xiaowei Xu ,  Hong Yu ,  Douglas Dong Fang ,  Meenhard Herlyn

发明人： Xiaowei Xu ,  Hong Yu ,  Douglas Dong Fang ,  Meenhard Herlyn

IPC分类号： C12N5/00 ,  C12N15/00 ,  C12N5/074 ,  C12N5/071

CPC分类号： C12N5/0607 ,  C12N5/0628 ,  C12N2500/44 ,  C12N2501/11 ,  C12N2501/115

摘要： Isolated human multipotent adult stem cell and isolated populations of cells that include human multipotent adult stem cells are disclosed. Human hair-follicle derived multipotent adult stem cells and methods of preparing isolated populations of cells that include human multipotent adult stem cells are disclosed. Isolated human hair-follicle derived multipotent adult stem cell that can differentiate in culture into a neuronal cell, a glial cell, a melanocyte cell, a muscle cell, an osteocyte, a chondrocyte, and a lymphocyte. Isolated human hair-follicle derived multipotent adult stem cell that can grow in cell culture in spheres are disclosed. Human pancreas derived multipotent adult stem cells, human liver derived multipotent adult stem cells, human kidney derived multipotent adult stem cells, human heart derived multipotent adult stem cells, human neural derived multipotent adult stem cells and methods of preparing isolated populations of cells that include such human multipotent adult stem cells are disclosed. Method of treating an individual who has diabetes, cardiac muscle damage, muscle damage and disease, neurodegenerative disease or nerve damage or injury, bone loss, damage and/or disease, cartilage loss, damage and/or disease, hair loss and immune disorders, are disclosed.

摘要翻译： 公开了分离的人多能成体干细胞和包括人多潜能成体干细胞的分离的细胞群。 公开了人毛囊衍生的多能成体干细胞和制备包括人多潜能成体干细胞的分离的细胞群的方法。 分离的人毛囊衍生的多能成体干细胞，其可以在培养物中分化成神经元细胞，胶质细胞，黑素细胞，肌细胞，骨细胞，软骨细胞和淋巴细胞。 公开了可以在球体的细胞培养物中生长的分离的人毛囊衍生的多潜能成体干细胞。 人胰腺来源的多能成体干细胞，人肝来源的多潜能成体干细胞，人肾来源的多潜能成体干细胞，人心源性多潜能成体干细胞，人神经衍生多潜能成体干细胞以及制备分离的细胞群的方法， 公开了人多能成体干细胞。 治疗患有糖尿病，心肌损伤，肌肉损伤和疾病，神经变性疾病或神经损伤或损伤，骨丢失，损伤和/或疾病，软骨损失，损伤和/或疾病，脱发和免疫疾病的个体的方法， 被披露。

公开(公告)号：US20090130065A1

公开(公告)日：2009-05-21

申请号：US11911400

申请日：2006-04-12

申请人： Xiaowei Xu ,  Hong Yu ,  Douglas Dong Fang ,  Meenhard Herlyn

发明人： Xiaowei Xu ,  Hong Yu ,  Douglas Dong Fang ,  Meenhard Herlyn

IPC分类号： A61K35/12 ,  C12N5/08

CPC分类号： C12N5/0607 ,  C12N5/0628 ,  C12N2500/44 ,  C12N2501/11 ,  C12N2501/115

摘要： Isolated human multipotent adult stem cell and isolated populations of cells that include human multipotent adult stem cells are disclosed. Human hair-follicle derived multipotent adult stem cells and methods of preparing isolated populations of cells that include human multipotent adult stem cells are disclosed. Isolated human hair-follicle derived multipotent adult stem cell that can differentiate in culture into a neuronal cell, a glial cell, a melanocyte cell, a muscle cell, an osteocyte, a chondrocyte, and a lymphocyte. Isolated human hair-follicle derived multipotent adult stem cell that can grow in cell culture in spheres are disclosed. Human pancreas derived multipotent adult stem cells, human liver derived multipotent adult stem cells, human kidney derived multipotent adult stem cells, human heart derived multipotent adult stem cells, human neural derived multipotent adult stem cells and methods of preparing isolated populations of cells that include such human multipotent adult stem cells are disclosed. Method of treating an individual who has diabetes, cardiac muscle damage, muscle damage and disease, neurodegenerative disease or nerve damage or injury, bone loss, damage and/or disease, cartilage loss, damage and/or disease, hair loss and immune disorders, are disclosed.

摘要翻译： 公开了分离的人多能成体干细胞和包括人多潜能成体干细胞的分离的细胞群。 公开了人毛囊衍生的多能成体干细胞和制备包括人多潜能成体干细胞的分离的细胞群的方法。 分离的人毛囊衍生的多能成体干细胞，其可以在培养物中分化成神经元细胞，胶质细胞，黑素细胞，肌细胞，骨细胞，软骨细胞和淋巴细胞。 公开了可以在球体的细胞培养物中生长的分离的人毛囊衍生的多潜能成体干细胞。 人胰腺来源的多能成体干细胞，人肝来源的多潜能成体干细胞，人肾来源的多潜能成体干细胞，人心源性多潜能成体干细胞，人神经衍生多潜能成体干细胞以及制备分离的细胞群的方法， 公开了人多能成体干细胞。 治疗患有糖尿病，心肌损伤，肌肉损伤和疾病，神经变性疾病或神经损伤或损伤，骨丢失，损伤和/或疾病，软骨损失，损伤和/或疾病，脱发和免疫疾病的个体的方法， 被披露。