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公开(公告)号：US20080090783A1
公开(公告)日：2008-04-17
申请号：US11748331
申请日：2007-05-14
申请人： Duane Miller , Gabor Tigyi , Gangadhar Durgam , Tamas Virag , Michelle Walker , Ryoko Tsukahara
发明人： Duane Miller , Gabor Tigyi , Gangadhar Durgam , Tamas Virag , Michelle Walker , Ryoko Tsukahara
IPC分类号： A61K31/661 , A61K31/675 , A61P43/00
CPC分类号： C07F9/11 , A61K31/661 , A61K31/675 , C07F9/113 , C07F9/1651 , C07F9/1653 , C07F9/17 , C07F9/173 , C07F9/3808 , C07F9/4006
摘要： Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermatological condition.
摘要翻译： 公开了根据式（I）的化合物以及包括这些化合物的药物组合物。 还公开了使用这些化合物的方法，其具有活性作为LPA受体的激动剂或拮抗剂; 这样的方法包括抑制LPA受体的LPA活性，调节LPA受体活性，治疗癌症，增强细胞增殖，治疗伤口，治疗细胞，组织或器官中的凋亡或维持或恢复功能，培养细胞，保存器官或组织 功能，治疗皮肤病。
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公开(公告)号：US20060009507A1
公开(公告)日：2006-01-12
申请号：US10963085
申请日：2004-10-12
申请人： Duane Miller , Gabor Tigyi , Gangadhar Durgam , Tamas Virag , Michelle Walker , Ryoko Tsukahara
发明人： Duane Miller , Gabor Tigyi , Gangadhar Durgam , Tamas Virag , Michelle Walker , Ryoko Tsukahara
IPC分类号： A61K31/40 , C07D207/02
CPC分类号： C07F9/11 , A61K31/661 , A61K31/675 , C07F9/113 , C07F9/1651 , C07F9/1653 , C07F9/17 , C07F9/173 , C07F9/3808 , C07F9/4006
摘要： The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermatological condition.
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公开(公告)号：US20120135967A1
公开(公告)日：2012-05-31
申请号：US13114010
申请日：2011-05-23
申请人： Duane D. Miller , Gabor Tigyi , Gangadhar G. Durgam , Tamas Virag , Michelle D. Walker , Ryoko Tsukahara
发明人： Duane D. Miller , Gabor Tigyi , Gangadhar G. Durgam , Tamas Virag , Michelle D. Walker , Ryoko Tsukahara
IPC分类号： A61K31/661 , A61P1/12
CPC分类号： C07F9/11 , A61K31/661 , A61K31/675 , C07F9/113 , C07F9/1651 , C07F9/1653 , C07F9/17 , C07F9/173 , C07F9/3808 , C07F9/4006
摘要： Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermatological condition.
摘要翻译： 公开了根据式（I）的化合物以及包括这些化合物的药物组合物。 还公开了使用这些化合物的方法，其具有活性作为LPA受体的激动剂或拮抗剂; 这样的方法包括抑制LPA受体的LPA活性，调节LPA受体活性，治疗癌症，增强细胞增殖，治疗伤口，治疗细胞，组织或器官中的凋亡或维持或恢复功能，培养细胞，保存器官或组织 功能，治疗皮肤病。
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公开(公告)号：US07217704B2
公开(公告)日：2007-05-15
申请号：US10963085
申请日：2004-10-12
申请人： Duane D. Miller , Gabor Tigyi , Gangadhar G. Durgam , Tamas Virag , Michelle D. Walker , Ryoko Tsukahara
发明人： Duane D. Miller , Gabor Tigyi , Gangadhar G. Durgam , Tamas Virag , Michelle D. Walker , Ryoko Tsukahara
IPC分类号： A61K31/6615 , C07F9/165 , C07D233/56 , C07D233/20 , A61K31/675
CPC分类号： C07F9/11 , A61K31/661 , A61K31/675 , C07F9/113 , C07F9/1651 , C07F9/1653 , C07F9/17 , C07F9/173 , C07F9/3808 , C07F9/4006
摘要： The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermatological condition.
摘要翻译： 本发明涉及本文公开的式（I）化合物以及包括那些化合物的药物组合物。 还公开了使用这些化合物的方法，其具有活性作为LPA受体的激动剂或拮抗剂; 这样的方法包括抑制LPA受体的LPA活性，调节LPA受体活性，治疗癌症，增强细胞增殖，治疗伤口，治疗细胞，组织或器官中的凋亡或维持或恢复功能，培养细胞，保存器官或组织 功能，治疗皮肤病。
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公开(公告)号：US07947665B2
公开(公告)日：2011-05-24
申请号：US11748331
申请日：2007-05-14
申请人： Duane D. Miller , Gabor Tigyi , Gangadhar G. Durgam , Tamas Virag , Michelle D. Walker , Ryoko Tsukahara
发明人： Duane D. Miller , Gabor Tigyi , Gangadhar G. Durgam , Tamas Virag , Michelle D. Walker , Ryoko Tsukahara
IPC分类号： A61K31/675
CPC分类号： C07F9/11 , A61K31/661 , A61K31/675 , C07F9/113 , C07F9/1651 , C07F9/1653 , C07F9/17 , C07F9/173 , C07F9/3808 , C07F9/4006
摘要： Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermatological condition.
摘要翻译： 公开了根据式（I）的化合物以及包括这些化合物的药物组合物。 还公开了使用这些化合物的方法，其具有活性作为LPA受体的激动剂或拮抗剂; 这样的方法包括抑制LPA受体的LPA活性，调节LPA受体活性，治疗癌症，增强细胞增殖，治疗伤口，治疗细胞，组织或器官中的凋亡或维持或恢复功能，培养细胞，保存器官或组织 功能，治疗皮肤病。
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公开(公告)号：US20050261252A1
公开(公告)日：2005-11-24
申请号：US11067884
申请日：2005-02-28
申请人： Duane Miller , Gabor Tigyi , James Dalton , Vineet Sardar , Don Elrod , Huiping Xu , Daniel Baker , Dean Wang , Karoly Liliom , David Fischer , Tamas Virag , Nora Nusser
发明人： Duane Miller , Gabor Tigyi , James Dalton , Vineet Sardar , Don Elrod , Huiping Xu , Daniel Baker , Dean Wang , Karoly Liliom , David Fischer , Tamas Virag , Nora Nusser
IPC分类号： C12N15/09 , A61K31/27 , A61K31/66 , A61K31/685 , A61P17/02 , A61P35/00 , A61P43/00 , C07F9/09 , C07F9/10 , C07F9/11 , C07F9/17 , C07F9/22 , C07F9/38 , C07F9/40 , A61K31/675 , A61K31/663 , C07F9/28
摘要： The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, and treating a wound.
摘要翻译： 本发明涉及本文公开的式（I）化合物以及包括那些化合物的药物组合物。 还公开了使用这些化合物的方法，其具有活性作为LPA受体的激动剂或拮抗剂; 这些方法包括抑制LPA受体的LPA活性，调节LPA受体活性，治疗癌症，增强细胞增殖和治疗伤口。
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公开(公告)号：US06875757B2
公开(公告)日：2005-04-05
申请号：US09811838
申请日：2001-03-19
申请人： Duane D. Miller , Gabor Tigyi , James T. Dalton , Vineet M. Sardar , Don B. Elrod , Huiping Xu , Daniel L. Baker , Dean Wang , Karoly Liliom , David J. Fischer , Tamas Virag , Nora Nusser
发明人： Duane D. Miller , Gabor Tigyi , James T. Dalton , Vineet M. Sardar , Don B. Elrod , Huiping Xu , Daniel L. Baker , Dean Wang , Karoly Liliom , David J. Fischer , Tamas Virag , Nora Nusser
IPC分类号： C12N15/09 , A61K31/27 , A61K31/66 , A61K31/685 , A61P17/02 , A61P35/00 , A61P43/00 , C07F9/09 , C07F9/10 , C07F9/11 , C07F9/17 , C07F9/22 , C07F9/38 , C07F9/40 , A61K31/661 , C07F9/06
CPC分类号： C07F9/4028 , A61K31/27 , A61K31/66 , C07F9/091 , C07F9/093 , C07F9/094 , C07F9/098 , C07F9/11 , C07F9/17 , C07F9/222 , C07F9/3808
摘要： The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, and treating a wound.
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公开(公告)号：US08945919B2
公开(公告)日：2015-02-03
申请号：US12733108
申请日：2008-08-14
申请人： Keita Mori , Martha C. Bohn , Ciara Tate , Irina Aizman , Aleksandra Glavaski , Tamas Virag
发明人： Keita Mori , Martha C. Bohn , Ciara Tate , Irina Aizman , Aleksandra Glavaski , Tamas Virag
CPC分类号： A61K35/28 , A61K2035/124 , C12N5/0618 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N2501/42 , C12N2502/1394 , C12N2506/1353 , C12N2510/00
摘要： Disclosed herein are methods and compositions for the use of marrow adherent stem cells and their descendents; e.g., bone marrow-derived neural regenerating cells; in the treatment of various neurodegenerative disorders. In certain embodiments, bone marrow-derived neural regenerating cells transplanted to sites of neural degeneration stimulate growth and/or survival of host neurons.
摘要翻译： 本文公开了使用骨髓粘附干细胞及其后代的方法和组合物; 例如骨髓来源的神经再生细胞; 在治疗各种神经退行性疾病。 在某些实施方案中，移植到神经变性位点的骨髓来源的神经再生细胞刺激宿主神经元的生长和/或存活。
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公开(公告)号：US20100266554A1
公开(公告)日：2010-10-21
申请号：US12733108
申请日：2008-08-14
申请人： Keita Mori , Martha C. Bohn , Ciara Tate , Irina Aizman , Aleksandra Glavaski , Tamas Virag
发明人： Keita Mori , Martha C. Bohn , Ciara Tate , Irina Aizman , Aleksandra Glavaski , Tamas Virag
CPC分类号： A61K35/28 , A61K2035/124 , C12N5/0618 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N2501/42 , C12N2502/1394 , C12N2506/1353 , C12N2510/00
摘要： Disclosed herein are methods and compositions for the use of marrow adherent stem cells and their descendents; e.g., bone marrow-derived neural regenerating cells; in the treatment of various neurodegenerative disorders. In certain embodiments, bone marrow-derived neural regenerating cells transplanted to sites of neural degeneration stimulate growth and/or survival of host neurons.
摘要翻译： 本文公开了使用骨髓粘附干细胞及其后代的方法和组合物; 例如骨髓来源的神经再生细胞; 在治疗各种神经退行性疾病。 在某些实施方案中，移植到神经变性位点的骨髓来源的神经再生细胞刺激宿主神经元的生长和/或存活。
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