公开(公告)号：US20070053954A1

公开(公告)日：2007-03-08

申请号：US11410269

申请日：2006-04-24

Applicant: Stephen Rowe ,  Durga Annavajjula

Inventor： Stephen Rowe ,  Durga Annavajjula

IPC: A61F2/02

CPC classification number: A61K9/1647 ,  A61K9/0024 ,  A61K9/0043 ,  A61K9/0073 ,  A61K9/1635 ,  A61K9/1641

Abstract: The invention provides methods and articles for the administration of a biologically active substance (BAS). These methods and articles provide for the controlled and sustained delivery of relatively large quantities of these substances with a low burst effect. The articles made using the method of the invention have increased percentages (w/w) of macromer, increased crosslinking density, and reduced pore size in comparison to articles made using solution methods.

Abstract translation: 本发明提供了用于施用生物活性物质（BAS）的方法和制品。 这些方法和物品提供了具有低爆发作用的相对大量这些物质的受控和持续的输送。 使用本发明的方法制备的制品与使用溶液方法制备的制品相比，具有增加的大分子单体的百分比（w / w），增加的交联密度和减小的孔径。

公开(公告)号：US5980998A

公开(公告)日：1999-11-09

申请号：US42182

申请日：1998-03-12

Applicant: Sunity Sharma ,  Durga Annavajjula ,  Kuldip Bhasin ,  Subhash Narang ,  Asutosh Nigam

Inventor： Sunity Sharma ,  Durga Annavajjula ,  Kuldip Bhasin ,  Subhash Narang ,  Asutosh Nigam

IPC: G03F7/105 ,  B05D3/06 ,  B05D5/12 ,  C23C18/14 ,  C23C18/16 ,  G03F7/16 ,  H05K3/10 ,  H05K3/12 ,  H05K3/18 ,  B32B3/00 ,  B32B7/00 ,  B32B15/00

CPC classification number: H05K3/105 ,  G03F7/16 ,  H05K3/1241

Abstract: Methods and apparatus are provided in which a coating is deposited onto a substrate by a process which includes the following steps: depositing a precursor onto the substrate in a desired pattern; depositing an appropriate ligand onto the substrate; and applying sufficient energy to transfer electrons from the ligand to the precursor, thereby decomposing the precursor to form a precipitate. In one aspect of preferred embodiments, the precursor comprises a metallic salt, and the precipitate comprises a metal. Especially preferred salts are carboxylates, halides, nitrates, and pseudo halides. In another aspect of preferred embodiments, the ligand comprises an amine, an amide, a phosphine, a sulfide, or any other ligand containing nitrogen, phosphorous, sulphur or other donor atoms. In another aspect of preferred embodiments, the energy is supplied at least partially as radiant heat. In another aspect of the preferred embodiments, the deposited material has a high purity of at least 80% by weight, a desired pattern is produced without removing from the substrate a substantial quantity of either the precursor or the deposited coating.

Abstract translation: 提供了一种方法和装置，其中通过包括以下步骤的方法将涂层沉积到基底上：将前体以期望的图案沉积到基底上; 在基底上沉积合适的配体; 并施加足够的能量以将电子从配体转移到前体，从而分解前体以形成沉淀物。 在优选实施方案的一个方面，前体包含金属盐，沉淀物包含金属。 特别优选的盐是羧酸盐，卤化物，硝酸盐和假卤化物。 在优选实施方案的另一方面，配体包含胺，酰胺，膦，硫化物或含有氮，磷，硫或其它供体原子的任何其它配体。 在优选实施例的另一方面，能量至少部分地作为辐射热供应。 在优选实施方案的另一方面，所沉积的材料具有至少80重量％的高纯度，产生期望的图案，而不从基底中去除大量的前体或沉积涂层。