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67 条记录 (耗时 0.029 秒)

    Pyrrolotriazine kinase inhibitors
    2.
    发明授权
    Pyrrolotriazine kinase inhibitors 有权
    吡咯并三嗪激酶抑制剂

    公开(公告)号：US08268998B2

    公开(公告)日：2012-09-18

    申请号：US13159739

    申请日：2011-06-14

    申请人： Brian E. Fink ,  Ping Chen

    发明人： Brian E. Fink ,  Ping Chen

    IPC分类号： C07D487/04 ,  A61K31/53 ,  A61P35/00

    CPC分类号： C07D487/04 ,  A61K31/53

    摘要： The invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of Trk receptors such as TrkA, TrkB, TrkC or Flt-3 thereby making them useful as anticancer agents.

    摘要翻译： 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制Trk受体如TrkA，TrkB，TrkC或Flt-3的酪氨酸激酶活性，从而使其成为抗癌剂。

    Pyrrolotriazine kinase inhibitors
    3.
    发明授权
    Pyrrolotriazine kinase inhibitors 有权
    吡咯并三嗪激酶抑制剂

    公开(公告)号：US07982033B2

    公开(公告)日：2011-07-19

    申请号：US12447751

    申请日：2007-11-02

    申请人： Brian E. Fink ,  Ping Chen

    发明人： Brian E. Fink ,  Ping Chen

    IPC分类号： C07D487/04 ,  A61K31/53 ,  A61P35/00

    CPC分类号： C07D487/04

    摘要： The invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of Trk receptors such as TrkA, TrkB, TrkC or Flt-3 thereby making them useful as anticancer agents.

    摘要翻译： 本发明提供式I化合物及其药学上可接受的盐。 式I化合物抑制Trk受体如TrkA，TrkB，TrkC或Flt-3的酪氨酸激酶活性，从而使其成为抗癌剂。

    Hexahydroimidazopyrazin-3-one compounds useful as modulators of androgen receptor function
    4.
    发明授权
    Hexahydroimidazopyrazin-3-one compounds useful as modulators of androgen receptor function 有权
    六氢咪唑并吡嗪-3-酮化合物可用作雄激素受体功能的调节剂

    公开(公告)号：US07776859B2

    公开(公告)日：2010-08-17

    申请号：US11546965

    申请日：2006-10-12

    申请人： James Aaron Balog ,  Mark E. Salvati ,  Brian E. Fink

    发明人： James Aaron Balog ,  Mark E. Salvati ,  Brian E. Fink

    IPC分类号： A61K31/4985

    CPC分类号： C07D487/04

    摘要： The present invention is directed to compounds having the formula (I), and/or pharmaceutically-acceptable salts thereof, useful in the treatment of androgen-receptor associated conditions, wherein Ar is aryl, substituted aryl, heteroaryl, or substituted heteroaryl; L is a linker as defined in the specification; R1 may be hydrogen, cyano, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heterocyclo, substituted heterocyclo, heteroaryl, or substituted heteroaryl, as defined in the specification; R2 is hydrogen, lower alkyl, or substituted lower alkyl; and R3, R4 and R5 are optionally non-interfering substituents as defined in the specification.

    摘要翻译： 本发明涉及可用于治疗雄激素受体相关病症的式（I）化合物和/或其药学上可接受的盐，其中Ar为芳基，取代的芳基，杂芳基或取代的杂芳基; L是说明书中定义的接头; R 1可以是如本说明书中定义的氢，氰基，烷基，取代的烷基，芳基，取代的芳基，环烷基，取代的环烷基，杂环，取代的杂环，杂芳基或取代的杂芳基; R2是氢，低级烷基或取代的低级烷基; 并且R 3，R 4和R 5是本说明书中定义的任选的非干扰取代基。

    INTERMEDIATES USEFUL IN PREPARING CERTAIN PYRROLOTRIAZINE COMPOUNDS AND A PROCESS FOR MAKING THE INTERMEDIATES
    6.
    发明申请
    INTERMEDIATES USEFUL IN PREPARING CERTAIN PYRROLOTRIAZINE COMPOUNDS AND A PROCESS FOR MAKING THE INTERMEDIATES 有权
    中间体有用于制备某些吡咯烷酮化合物和制备中间体的方法

    公开(公告)号：US20100056781A1

    公开(公告)日：2010-03-04

    申请号：US12522315

    申请日：2008-01-07

    申请人： Brian E. Fink

    发明人： Brian E. Fink

    IPC分类号： C07D253/10

    CPC分类号： C07D487/04

    摘要： The invention relates to 2,4-dibromoropyrrolo[1,2-f][1,2,4]triazine, which is an intermediate useful in preparing 2,4-disubstituted pyrrolotriazine compounds, and a process for preparing the intermediate.

    摘要翻译： 本发明涉及2,4-二溴基吡咯并[1,2-f] [1,2,4]三嗪，其是可用于制备2,4-二取代吡咯并三嗪化合物的中间体及其制备方法。

    Arm-mountable liquid dispensing apparatus
    8.
    发明授权
    Arm-mountable liquid dispensing apparatus 失效
    可臂式液体分配装置

    公开(公告)号：US06415960B1

    公开(公告)日：2002-07-09

    申请号：US09952863

    申请日：2001-09-14

    申请人： Karen E. Fink ,  Diana L. Kubajak

    发明人： Karen E. Fink ,  Diana L. Kubajak

    IPC分类号： B67D564

    CPC分类号： B67D3/0083 ,  B67D3/00 ,  B67D2210/00131

    摘要： A liquid dispensing apparatus for removably coupling to an arm of a user. The liquid dispensing apparatus includes a container for holding a liquid. The container includes a first wall, a second wall and a peripheral wall extending between the first and second walls to define an interior for receiving the liquid. A port having a hole extending through it is provided for expelling the liquid. A conduit is provided for transporting the liquid from the container to the port. A first end of the conduit is fluidly connected to a second wall of the container. A second end of the conduit is fluidly connected to the port. A valve assembly is provided for controlling the flow of liquid through the conduit and is operationally coupled to a portion of the conduit. A plurality of fastening members is provided for fastening the apparatus to the arm of the user.

    摘要翻译： 一种用于可拆卸地联接到使用者的手臂的液体分配装置。 液体分配装置包括用于保持液体的容器。 容器包括在第一和第二壁之间延伸的第一壁，第二壁和周壁，以限定用于接收液体的内部。 具有延伸通过其的孔的端口被设置用于排出液体。 提供用于将液体从容器运输到端口的导管。 导管的第一端与容器的第二壁流体连接。 导管的第二端与端口流体连接。 提供了一种阀组件，用于控制液体通过导管的流动并且可操作地联接到导管的一部分。 提供多个紧固构件用于将装置固定到使用者的手臂上。

    Pile carpet
    9.
    发明授权
    Pile carpet 失效
    堆地毯

    公开(公告)号：US5876827A

    公开(公告)日：1999-03-02

    申请号：US871500

    申请日：1997-06-09

    申请人： Wilbert E. Fink ,  Jean-Claude Auguste

    发明人： Wilbert E. Fink ,  Jean-Claude Auguste

    IPC分类号： B29B17/00 ,  B32B37/15 ,  D05C17/02 ,  D06N7/00 ,  B32B3/02

    CPC分类号： B32B38/004 ,  B29B17/00 ,  D05C17/02 ,  D06N7/0068 ,  D06N7/0076 ,  B32B2309/02 ,  B32B2309/06 ,  B32B2309/12 ,  B32B37/153 ,  D06N2201/0254 ,  D06N2203/042 ,  Y02W30/62 ,  Y10T428/23979 ,  Y10T428/23993

    摘要： The disclosure relates to a carpet product, a process for manufacturing carpet, and an apparatus used in a carpet manufacturing process. The carpet product is made from tufted polymer filament yarn and includes a sheet of extruded polypropylene, integrally fused to the individual yarn filaments of the yarn back loops. The yarn fibers are substantially all secured to the integrally fused sheet so that the carpet resists fuzzing. The process includes providing a carpet base having a primary backing penetrated by yarn, applying heat to the underside of the base, extruding a heated sheet of polymer and continuously contacting the heated extruded sheet of polymer with the base thereby integrally fusing the base to the extruded sheet. The apparatus includes a source of carpet precursor, a heated cylinder for heating the underside of the carpet, an extruder and a casting roll against which the extruded sheet and heated carpet are pressed.

    摘要翻译： 本公开涉及地毯产品，用于制造地毯的方法以及用于地毯制造过程中的装置。 地毯产品由簇状聚合物长丝纱线制成，并且包括与回丝线的各个纱线整体熔合的挤出聚丙烯片。 纱线纤维基本上都固定在整体熔合的片材上，使得地毯可以抵抗绒毛。 该方法包括提供具有由纱线渗透的主要背衬的地毯基底，向基底的下侧施加热量，挤出加热的聚合物片材并将加热的挤出的聚合物片材与基底连续接触，从而将基底整体地熔合到挤出的 片。 该设备包括地毯前体源，用于加热地毯下侧的加热缸，挤压机和流延辊，挤压的片材和加热的地毯被挤压在该辊上。