公开(公告)号：US20030207307A1

公开(公告)日：2003-11-06

申请号：US10410996

申请日：2003-04-10

申请人： ESA, Inc.

发明人： Wayne R. Matson

IPC分类号： C12Q001/68 ,  C07H021/04

CPC分类号： C12Q1/6809 ,  C12Q1/6883 ,  C12Q2600/154 ,  G01N2570/00 ,  G01N2800/2871 ,  C12Q2525/117

摘要： Methods for determining the inventory of small process and control molecules (The Metabolome) and the interaction of the Metabolome with the Genome and Proteome (Metabolomic databases). Methods for evaluating Metabolomic databases for biochemical markers that correlate with outcome of a disease, allow monitoring of therapy and direct therapy. Methods for evaluating Metabolomic databases for lead therapeutic molecules and target systems for therapeutic manipulation. Methods of evaluating all relationships in a Metabolomic database for outcome of disease or therapy. The methods of Metabolomic database evaluation have application to stroke. Outcome predicting and therapy directing or monitoring markers of Methylation and oxidative processes in stroke have been determined. Methylation processes have been identified as targets for therapeutic development. A novel class of potential therapeutic agents that bind to DNA have been identified in stroke.

摘要翻译： 确定小过程和对照分子（代谢组）库存的方法和代谢组学与基因组和蛋白质组学（代谢组学数据库）的相互作用。 用于评估与疾病结果相关的生化标志物的代谢组学数据库的方法，允许监测治疗和直接治疗。 评估用于治疗性治疗的铅治疗分子和靶系统的代谢组学数据库的方法。 评估代谢组学数据库中疾病或治疗结果的所有关系的方法。 代谢组学数据库评估方法应用于中风。 已经确定了指导或监测中风甲基化和氧化过程标志物的结果预测和治疗。 甲基化过程已被确定为治疗发展的目标。 已经在中风中鉴定了一类新的与DNA结合的潜在治疗剂。

公开(公告)号：US20030062475A1

公开(公告)日：2003-04-03

申请号：US10245176

申请日：2002-09-17

申请人： ESA, INC.

发明人： Uwe Karst ,  Georg Diehl ,  Heiko Hayen

IPC分类号： G01N001/00

CPC分类号： G01N30/64 ,  G01N30/7266 ,  G01N30/74 ,  G01N30/78 ,  Y10T436/24

摘要： A hyphenated technique based on the combination of high performance liquid chromatography (HPLC), electrochemical (coulometric) oxidation (EC) and electrospray ionization (ESI)- or atmospheric pressure chemical ionization (APCI)- mass spectrometry (MS), allows access of selected groups of low and medium polarity analytes to ESI- or APCI- mass spectrometry after HPLC by electrochemical treatment of the sample.

摘要翻译： 基于高效液相色谱（HPLC），电化学（库仑）氧化（EC）和电喷雾离子化（ESI））或大气压化学电离（APCI） - 质谱（MS）的组合的连字技术允许选择 通过电化学处理样品在HPLC后通过ESI-或APCI-质谱分析的低和中极性分析物组。

公开(公告)号：US20040245457A1

公开(公告)日：2004-12-09

申请号：US10849098

申请日：2004-05-19

申请人： ESA, Inc.

发明人： Michael C. Granger ,  Gary J. Van Berkel

IPC分类号： H01J049/10

CPC分类号： H01J49/165 ,  H01J49/0436

摘要： Disclosed are systems and methods that include a flow-cell that includes porous conductive material(s) that provides a working electrode(s), an inlet connected to the flow-cell to deliver a solution containing an analyte(s), an outlet connected to the flow-cell to allow the solution to exit the flow-cell, a counter electrode positioned proximate to the outlet, and a voltage source(s) coupled to the working electrode(s) and the counter electrode. The methods can include delivering a solution containing an analyte(s) through an inlet to a flow-cell that includes porous conductive material(s) that provides a working electrode(s), connecting the flow-cell to an outlet for allowing the solution to exit the flow-cell, placing a counter-electrode proximate the outlet, and supplying a voltage from a voltage source(s) to the working electrode(s) and/or the counter-electrode.

摘要翻译： 公开了包括流动池的系统和方法，流动池包括提供工作电极的多孔导电材料，连接到流动池以输送含有分析物的溶液的入口，连接的出口 流动池以允许溶液离开流动池，靠近出口定位的对电极和耦合到工作电极和对电极的电压源。 所述方法可以包括将含有分析物的溶液通过入口输送到流动池，该流动池包括提供工作电极的多孔导电材料，将流动池连接到出口以允许溶液 离开流通池，将反电极放置在靠近出口处，并将电压从电压源提供给工作电极和/或对电极。