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公开(公告)号:US20190237315A1
公开(公告)日:2019-08-01
申请号:US16280319
申请日:2019-02-20
IPC分类号: H01J49/04
CPC分类号: H01J49/0436 , H01J49/0013
摘要: The invention generally relates to zero volt mass spectrometry probes and systems. In certain embodiments, the invention provides a system including a mass spectrometry probe including a porous material, and a mass spectrometer (bench-top or miniature mass spectrometer). The system operates without an application of voltage to the probe. In certain embodiments, the probe is oriented such that a distal end faces an inlet of the mass spectrometer. In other embodiments, the distal end of the probe is 5 mm or less from an inlet of the mass spectrometer.
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公开(公告)号:US20180061620A1
公开(公告)日:2018-03-01
申请号:US15697560
申请日:2017-09-07
CPC分类号: H01J49/0436 , H01J49/0013
摘要: The invention generally relates to zero volt mass spectrometry probes and systems. In certain embodiments, the invention provides a system including a mass spectrometry probe including a porous material, and a mass spectrometer (bench-top or miniature mass spectrometer). The system operates without an application of voltage to the probe. In certain embodiments, the probe is oriented such that a distal end faces an inlet of the mass spectrometer. In other embodiments, the distal end of the probe is 5 mm or less from an inlet of the mass spectrometer.
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公开(公告)号:US08920339B2
公开(公告)日:2014-12-30
申请号:US14007496
申请日:2012-04-18
申请人: Guoqiang Mao , James P. Wingo
发明人: Guoqiang Mao , James P. Wingo
IPC分类号: A61B5/00
CPC分类号: G01N1/10 , A61B5/150343 , A61B5/150358 , A61B5/151 , A61B5/15101 , A61B10/0045 , A61B10/0096 , B01L3/50 , B01L3/5023 , B01L3/5029 , B01L3/508 , B01L3/5085 , B01L3/5088 , B01L2200/12 , B01L2300/042 , B01L2300/069 , B01L2300/0832 , B01L2300/0861 , B01L2400/0406 , G01N1/02 , G01N33/521 , G01N2001/028 , H01J49/0031 , H01J49/0436 , Y10T29/49826 , Y10T436/25
摘要: The present invention provides a liquid sampling, storage, transfer and delivery device comprising housing containing a porous nib. The porous nib in the device contacts the sample, collects the sample, stores the sample, transports the sample inside its porous matrix and releases the sample from the porous matrix upon demand.
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公开(公告)号:US08852122B2
公开(公告)日:2014-10-07
申请号:US14254325
申请日:2014-04-16
申请人: Porex Corporation
发明人: Guoqiang Mao , James P. Wingo
IPC分类号: A61B5/00
CPC分类号: G01N1/10 , A61B5/150343 , A61B5/150358 , A61B5/151 , A61B5/15101 , A61B10/0045 , A61B10/0096 , B01L3/50 , B01L3/5023 , B01L3/5029 , B01L3/508 , B01L3/5085 , B01L3/5088 , B01L2200/12 , B01L2300/042 , B01L2300/069 , B01L2300/0832 , B01L2300/0861 , B01L2400/0406 , G01N1/02 , G01N33/521 , G01N2001/028 , H01J49/0031 , H01J49/0436 , Y10T29/49826 , Y10T436/25
摘要: The present invention provides a liquid sampling, storage, transfer and delivery device comprising housing containing a porous nib. The porous nib in the device contacts the sample, collects the sample, stores the sample, transports the sample inside its porous matrix and releases the sample from the porous matrix upon demand.
摘要翻译: 本发明提供了一种液体采样,存储,传送和传送装置,其包括容纳多孔笔尖的壳体。 设备中的多孔笔尖接触样品,收集样品,储存样品,将样品运送到其多孔基质内,并根据需要从多孔基质中释放样品。
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公开(公告)号:US07705299B2
公开(公告)日:2010-04-27
申请号:US12132730
申请日:2008-06-04
申请人: Andrei G. Fedorov
发明人: Andrei G. Fedorov
IPC分类号: H05H3/02
CPC分类号: H01J49/165 , G01Q30/02 , G01Q30/14 , H01J49/0004 , H01J49/0436
摘要: Briefly described, embodiments of this disclosure, among others, include scanning ion probe systems, methods of use thereof, scanning ion source systems, methods of use thereof, scanning ion probe mass spectrometry systems, methods of use thereof, methods of simultaneous ion analysis and imaging, and methods of simultaneous mass spectrometry and imaging.
摘要翻译: 简而言之,本公开的实施例包括扫描离子探针系统,其使用方法,扫描离子源系统,其使用方法,扫描离子探针质谱系统,其使用方法,同时离子分析方法和 成像和同时质谱法和成像方法。
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公开(公告)号:US07087436B2
公开(公告)日:2006-08-08
申请号:US10465637
申请日:2003-06-20
申请人: James Baumgardner , Gordon Neufeld
发明人: James Baumgardner , Gordon Neufeld
CPC分类号: H01J49/0436 , G01N1/22 , G01N1/24 , G01N2001/4066 , Y10T436/117497 , Y10T436/204998 , Y10T436/207497 , Y10T436/209163 , Y10T436/21 , Y10T436/24 , Y10T436/25 , Y10T436/255 , Y10T436/25875
摘要: A method and apparatus for the analysis of blood or other liquids by mass spectrometry to determine the partial pressures of gases and other volatile substances dissolved in the blood or other liquid in a manner independent of the solubility of the gases in the blood or other liquid. A countercurrent membrane exchanger (CCME) is provided for equilibrating a carrier fluid with the sample of blood or other liquid, the output of which is coupled to a tubular direct insertion membrane probe (t-DIMP) type of membrane inlet mass spectrometer. The CCME preferably has complementary spiral grooves on opposing metal plates for the water carrier and sample liquids so as to induce secondary flows which greatly reduce the resistance to equilibration between the liquid sample and water carrier phases. The t-DIMP is characterized by the use of Teflon™ sleeves specifically to reduce noise introduced at the connection between the silicone membrane in the t-DIMP and the steel tubing for the water carrier, by the use of radiation shields to prevent heating of the silicone membrane and water carrier to allow lower carrier flow rates, and by the heating of the section between the ion source and the vacuum pumps specifically to improve linearity of the t-DIMP.
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公开(公告)号:US06297499B1
公开(公告)日:2001-10-02
申请号:US09109887
申请日:1998-07-03
申请人: John B Fenn
发明人: John B Fenn
IPC分类号: H01J4900
CPC分类号: H01J49/167 , H01J49/0436
摘要: Sample liquid is supplied to the ion source of an Electrospray Ionization Mass Spectrometer (ESIMS) by capillarity induced flow through a wick element comprising a permeable porous aggregate of fibers or particles of material that is wetted by the sample liquid. This method of liquid introduction eliminates the need for pumps of pressurized gas to drive the flow. It also makes possible the convenient extraction of a representative sample from a stream of liquid flowing at any rate, no matter how large.
摘要翻译: 将样品液体通过毛细管引入的流过芯体元件的电喷雾离子化质谱仪(ESIMS)的离子源提供,所述芯芯元件包括由样品液体润湿的纤维或材料颗粒的渗透性多孔聚集体。 这种液体引入方法不需要加压气体泵来驱动流体。 它也可以方便地从任何速率流动的液体流中提取代表性样品,无论多大。
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公开(公告)号:US11988652B2
公开(公告)日:2024-05-21
申请号:US16951909
申请日:2020-11-18
申请人: Thermo Finnigan LLC
发明人: Joshua A. Silveira , Dale Lindseth , Gary A. Schultz , Eloy R. Wouters , Michael L. Poltash , Brandon Howard Robson
IPC分类号: G01N30/72 , G01N30/14 , G01N30/60 , G01N33/68 , H01J49/00 , H01J49/04 , H01J49/16 , G01N30/02 , G01N30/04
CPC分类号: G01N30/7233 , G01N30/14 , G01N30/60 , G01N33/6848 , H01J49/0031 , H01J49/004 , H01J49/0436 , H01J49/165 , G01N2030/027
摘要: Packed-tip electrospray ionization (ESI) emitters for mass spectrometry are described. In one aspect an ESI emitter stores a first type of particle. A liquid chromatography (LC) column is coupled with the emitter via a junction. The LC column stores a different type of particle than the ESI emitter to facilitate better chromatographic and ESI performance.
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公开(公告)号:US09786478B2
公开(公告)日:2017-10-10
申请号:US14957661
申请日:2015-12-03
CPC分类号: H01J49/0436 , H01J49/0013
摘要: The invention generally relates to zero volt mass spectrometry probes and systems. In certain embodiments, the invention provides a system including a mass spectrometry probe including a porous material, and a mass spectrometer (bench-top or miniature mass spectrometer). The system operates without an application of voltage to the probe. In certain embodiments, the probe is oriented such that a distal end faces an inlet of the mass spectrometer. In other embodiments, the distal end of the probe is 5 mm or less from an inlet of the mass spectrometer.
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公开(公告)号:US09696241B2
公开(公告)日:2017-07-04
申请号:US15234519
申请日:2016-08-11
申请人: Porex Corporation
发明人: Guoqiang Mao , James P. Wingo
IPC分类号: A61B5/00 , G01N1/10 , G01N33/52 , B01L3/00 , A61B10/00 , G01N1/02 , A61B5/151 , A61B5/15 , H01J49/00 , H01J49/04
CPC分类号: G01N1/10 , A61B5/150343 , A61B5/150358 , A61B5/151 , A61B5/15101 , A61B10/0045 , A61B10/0096 , B01L3/50 , B01L3/5023 , B01L3/5029 , B01L3/508 , B01L3/5085 , B01L3/5088 , B01L2200/12 , B01L2300/042 , B01L2300/069 , B01L2300/0832 , B01L2300/0861 , B01L2400/0406 , G01N1/02 , G01N33/521 , G01N2001/028 , H01J49/0031 , H01J49/0436 , Y10T29/49826 , Y10T436/25
摘要: The present invention provides a liquid sampling, storage, transfer and delivery device comprising housing containing a porous nib. The porous nib in the device contacts the sample, collects the sample, stores the sample, transports the sample inside its porous matrix and releases the sample from the porous matrix upon demand.
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