公开(公告)号：US20060029594A1

公开(公告)日：2006-02-09

申请号：US11076395

申请日：2005-10-20

Applicant: Robert Ames ,  Edward Appelbaum ,  Irwin Chaiken ,  Richard Cook ,  Mitchell Gross ,  Stephen Holmes ,  Lynette McMillan ,  Timothy Theisen

Inventor： Robert Ames ,  Edward Appelbaum ,  Irwin Chaiken ,  Richard Cook ,  Mitchell Gross ,  Stephen Holmes ,  Lynette McMillan ,  Timothy Theisen

IPC: A61K39/395 ,  C12N5/06 ,  C07K16/44

CPC classification number: C07K16/244 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2319/00

Abstract: Chimeric, humanized and other IL-5 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.

公开(公告)号：US20100028904A1

公开(公告)日：2010-02-04

申请号：US12530546

申请日：2008-03-28

Applicant: Edward Appelbaum ,  Susanne Corisdeo ,  Subiney Ganguly ,  Dennis M. Kraichely ,  Sunil Mehta ,  Gordon Moore ,  Richard Siegel

Inventor： Edward Appelbaum ,  Susanne Corisdeo ,  Subiney Ganguly ,  Dennis M. Kraichely ,  Sunil Mehta ,  Gordon Moore ,  Richard Siegel

IPC: G01N33/53 ,  C12Q1/02 ,  C12N5/12 ,  C12N1/19 ,  C12N5/073 ,  C12N1/21 ,  C12N1/12

CPC classification number: C07K16/00 ,  G01N33/6854

Abstract: The invention provides a genetic screening method for identifying a transfected cell expressing the polypeptide of interest. The methods allows for high throughput screening of recombinant cells for elevated levels of expression of the polypeptide of interest using methylcellulose comprising fluorescent protein A or G to improve detection and cloning. The invention also provides capture media, formulations and methods of making and using thereof.

Abstract translation: 本发明提供了用于鉴定表达感兴趣多肽的转染细胞的遗传筛选方法。 所述方法允许使用包含荧光蛋白A或G的甲基纤维素来重组细胞的高通量筛选以提高感兴趣的多肽的表达水平，以改善检测和克隆。 本发明还提供捕获介质，制剂及其制备和使用方法。

公开(公告)号：US20070238644A1

公开(公告)日：2007-10-11

申请号：US11561963

申请日：2006-11-21

Applicant: Haodong Li ,  Mark Adams ,  Solange Lima ,  Ralph Alderson ,  Yuling Li ,  David Parmelee ,  John White ,  Edward Appelbaum

Inventor： Haodong Li ,  Mark Adams ,  Solange Lima ,  Ralph Alderson ,  Yuling Li ,  David Parmelee ,  John White ,  Edward Appelbaum

IPC: A61K48/00 ,  A61K31/7052 ,  C07H21/04 ,  C07K14/00 ,  C07K16/18 ,  C12N15/00 ,  C12N5/06 ,  C12P1/04

CPC classification number: C07K14/52 ,  C07K14/523 ,  Y10S930/14

Abstract: Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.

Abstract translation: 公开了人趋化因子多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。

公开(公告)号：US06673344B1

公开(公告)日：2004-01-06

申请号：US09717209

申请日：2000-11-22

Applicant: Haodong Li ,  Mark Adams ,  Solange Hanschke Lima ,  Ralph Alderson ,  Yuling Li ,  David Parmelee ,  John White ,  Edward Appelbaum

Inventor： Haodong Li ,  Mark Adams ,  Solange Hanschke Lima ,  Ralph Alderson ,  Yuling Li ,  David Parmelee ,  John White ,  Edward Appelbaum

IPC: A61K39395

CPC classification number: C07K14/52 ,  C07K14/523 ,  Y10S930/14

Abstract: Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.

Abstract translation: 公开了人趋化因子多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。