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    Antibodies to human CK&bgr;-10/MCP-4
    1.
    发明授权
    Antibodies to human CK&bgr;-10/MCP-4 失效
    人类CKbeta-10 / MCP-4的抗体

    公开(公告)号：US06673344B1

    公开(公告)日：2004-01-06

    申请号：US09717209

    申请日：2000-11-22

    申请人： Haodong Li ,  Mark Adams ,  Solange Hanschke Lima ,  Ralph Alderson ,  Yuling Li ,  David Parmelee ,  John White ,  Edward Appelbaum

    发明人： Haodong Li ,  Mark Adams ,  Solange Hanschke Lima ,  Ralph Alderson ,  Yuling Li ,  David Parmelee ,  John White ,  Edward Appelbaum

    IPC分类号： A61K39395

    CPC分类号： C07K14/52 ,  C07K14/523 ,  Y10S930/14

    摘要： Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.

    摘要翻译： 公开了人趋化因子多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。

    Human chemokines, CK&bgr;4 and CK&bgr;10/MCP-4
    2.
    发明授权
    Human chemokines, CK&bgr;4 and CK&bgr;10/MCP-4 失效
    人类趋化因子，CKbeta4和CKbeta10 / MCP-4

    公开(公告)号：US06174995B1

    公开(公告)日：2001-01-16

    申请号：US08613822

    申请日：1996-02-23

    申请人： Haodong Li ,  Mark Adams ,  Solange Hanschke Lima ,  Ralph Alderson ,  Yuling Li ,  David Parmelee ,  John White ,  Edward Applebaum

    发明人： Haodong Li ,  Mark Adams ,  Solange Hanschke Lima ,  Ralph Alderson ,  Yuling Li ,  David Parmelee ,  John White ,  Edward Applebaum

    IPC分类号： C07K1452

    CPC分类号： C07K14/52 ,  C07K14/523 ,  Y10S930/14

    摘要： Human chemokine polypeptides and DNA/(RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.

    摘要翻译： 公开了人类趋化因子多肽和编码这种趋化因子多肽的DNA /（RNA）和通过重组技术产生此类多肽的方法。 还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。

    Antibodies to MCP-4
    4.
    发明授权
    Antibodies to MCP-4 有权
    MCP-4的抗体

    公开(公告)号：US07138498B2

    公开(公告)日：2006-11-21

    申请号：US10646770

    申请日：2003-08-25

    申请人： Haodong Li ,  Mark D. Adams ,  Solange H. Gentz ,  Ralph Alderson ,  Yuling Li ,  David Parmelee ,  John R. White ,  Edward R. Appelbaum

    发明人： Haodong Li ,  Mark D. Adams ,  Solange H. Gentz ,  Ralph Alderson ,  Yuling Li ,  David Parmelee ,  John R. White ,  Edward R. Appelbaum

    IPC分类号： C07K16/24

    CPC分类号： C07K14/52 ,  C07K14/523 ,  Y10S930/14

    摘要： Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.

    摘要翻译： 公开了人趋化因子多肽和编码这种趋化因子多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还公开了利用这种趋化因子多肽治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化因子多肽的拮抗剂及其作为治疗类风湿性关节炎，自身免疫性和慢性炎性和感染性疾病，过敏反应，前列腺素依赖性发烧和骨髓衰竭的治疗剂的用途。

    Neutrokine-alpha conjugate, neutrokine-alpha complex, and uses thereof
    7.
    发明申请
    Neutrokine-alpha conjugate, neutrokine-alpha complex, and uses thereof 审中-公开
    中性粒细胞α偶联物，中性粒细胞α复合物及其应用

    公开(公告)号：US20050249671A9

    公开(公告)日：2005-11-10

    申请号：US10742634

    申请日：2003-12-22

    申请人： David Parmelee ,  Ren-Hwa Yeh ,  Olga Galperina ,  David Hilbert ,  Craig Rosen

    发明人： David Parmelee ,  Ren-Hwa Yeh ,  Olga Galperina ,  David Hilbert ,  Craig Rosen

    IPC分类号： A61K47/48 ,  C07K14/52 ,  A61K49/00 ,  C07K14/525

    CPC分类号： C07K14/52 ,  A61K47/66 ,  A61K47/6903 ,  B82Y5/00

    摘要： The present invention is directed to a Neutrokine-alpha conjugate, wherein said Neutrokine-alpha conjugate comprises a Neutrokine-alpha protein and a chelator. The present invention is also directed to a Neutrokine-alpha complex, wherein said Neutrokine-alpha complex comprises a Neutrokine-alpha conjugate and a metal ion wherein said metal ion is noncovalently associated with the chelator of said conjugate. The present invention is further directed to compositions, specifically pharmaceutical and diagnostic compositions, comprising a Neutrokine-alpha conjugate or complex as described herein. Therapeutic and diagnostic uses of said conjugate, complex, and compositions are described.

    摘要翻译： 本发明涉及一种Neutrokine-α缀合物，其中所述Neutrokine-α缀合物包含Neutrokine-α蛋白和螯合剂。 本发明还涉及一种中枢神经素α复合物，其中所述中枢神经素α复合物包含中枢神经素α偶联物和金属离子，其中所述金属离子与所述缀合物的螯合剂非共价结合。 本发明进一步涉及包含如本文所述的中和型α结合物或复合物的组合物，特别是药物和诊断组合物。 描述了所述缀合物，复合物和组合物的治疗和诊断用途。