公开(公告)号：US20050033044A1

公开(公告)日：2005-02-10

申请号：US10848403

申请日：2004-05-18

申请人： Iain Pickersgill ,  Edward Cheesman

发明人： Iain Pickersgill ,  Edward Cheesman

IPC分类号： C07H19/00 ,  C07H19/16

CPC分类号： C07H19/16

摘要： Disclosed are methods for preparing 2-alkynyladenosine derivatives of formula A: or a stereoisomer, pharmaceutically acceptable salt, hydrate, solvate, acid salt hydrate or isomorphic crystalline form thereof, the method comprising the step of: contacting 2-iodoadenosine-5′-N-ethyluronamide with a compound of formula B: wherein Z is —C(═O)OR or —CH2OC(═O)R, where R is a C1 to C5 alkyl, preferably methyl. The methods are useful for preparing 2-alkynyladenosine derivatives that are, in certain embodiments, adenosine receptor agonists.

摘要翻译： 公开了制备式A的2-链炔基腺苷衍生物的方法：或其立体异构体，药学上可接受的盐，水合物，溶剂化物，酸盐水合物或同构晶体形式的方法，所述方法包括以下步骤：将2-碘腺嘌呤-5'-N - 乙基脲与式B化合物反应：其中Z是-C（= O）OR或-CH 2 OC（= O）R，其中R是C1-C5烷基，优选甲基。 所述方法可用于制备在某些实施方案中为腺苷受体激动剂的2-炔基腺苷衍生物。

公开(公告)号：US20070048574A1

公开(公告)日：2007-03-01

申请号：US11511726

申请日：2006-08-29

申请人： Marc Aiello ,  Edward Cheesman ,  Wayne Jordan

发明人： Marc Aiello ,  Edward Cheesman ,  Wayne Jordan

IPC分类号： H01M8/04 ,  H01M8/02

CPC分类号： H05K7/20927 ,  H02M7/003

摘要： A power delivery system includes a group of removable power cells. Each power cell includes a water cooled heat sink, an air intake, and an air output. The system also includes a heat exchanger. The heat exchanger draws air from the cells, cools it, and recirculates the cooled air to the cells via each cell's air intake. The cell may be designed so that components that are not near the heat sink are cooled by air from the intake before that air reaches the heat sink.

摘要翻译： 电力输送系统包括一组可移动电力单元。 每个电池包括水冷散热器，进气口和空气输出。 该系统还包括热交换器。 热交换器从细胞抽吸空气，冷却它，并通过每个电池的进气口将冷却的空气再循环到电池。 电池可以设计成使得在空气到达散热器之前，不靠近散热器的部件被来自进气口的空气冷却。

公开(公告)号：US20070036716A1

公开(公告)日：2007-02-15

申请号：US11492729

申请日：2006-07-25

申请人： David Casebier ,  Richard Cesati ,  Edward Cheesman

发明人： David Casebier ,  Richard Cesati ,  Edward Cheesman

IPC分类号： A61K51/00 ,  C07D237/02

CPC分类号： C07D237/14 ,  A61K51/0421 ,  A61K51/0459 ,  C07B59/002 ,  C07D237/02 ,  C07D237/16 ,  C07D239/88 ,  C07D311/42

摘要： The present disclosure relates to a solid-phase process for the production of radiolabeled tracers, in particular for the production of 18F-labeled compounds which may be used as Positron Emission Tomography (PET) radiolabeled tracers. The disclosure also relates to radiopharmaceutical kits comprising precursors to the radiolabeled tracers, which can be converted to the radiolabeled tracers using the processes described herein.

摘要翻译： 本公开内容涉及用于生产放射性标记的示踪剂的固相方法，特别是用于生产可用作正电子发射断层扫描（PET）放射性标记的示踪剂的标记为“F”的化合物。 本公开还涉及放射性药物试剂盒，其包含放射性标记的示踪剂的前体，其可以使用本文所述的方法转化为放射性标记的示踪剂。

公开(公告)号：US20070268482A1

公开(公告)日：2007-11-22

申请号：US11750628

申请日：2007-05-18

申请人： Marc Aiello ,  Edward Cheesman ,  Xuan Zhang

发明人： Marc Aiello ,  Edward Cheesman ,  Xuan Zhang

IPC分类号： G01J1/42

CPC分类号： G01J1/04 ,  G01J1/0407 ,  G01R31/027 ,  G01R31/1218

摘要： A method for optically detecting an electrical arc in a power supply. The method includes capturing light with a light pipe, transmitting the captured light along at least a portion of a length of the light pipe, optically detecting the transmitted light with a photodetector which is optically coupled to the light pipe, generating a signal indicative of an intensity of the detected light, and determining whether the detected light is associated with an electrical arc.

摘要翻译： 一种光电检测电源电弧的方法。 该方法包括用光管捕获光，沿着光管的长度的至少一部分传输捕获的光，用光学耦合到光管的光电检测器光学地检测透射光，产生指示 检测光的强度，以及确定检测到的光是否与电弧相关联。

公开(公告)号：US20050154185A1

公开(公告)日：2005-07-14

申请号：US10770380

申请日：2004-02-02

申请人： Milind Rajopadhye ,  Thomas Harris ,  Edward Cheesman

发明人： Milind Rajopadhye ,  Thomas Harris ,  Edward Cheesman

IPC分类号： A61K49/00 ,  C07D401/12 ,  C07D401/14 ,  C07K5/02 ,  C07K5/06 ,  C07K5/078 ,  C07K5/12 ,  C07D471/02 ,  C07D487/02

CPC分类号： C07D401/14 ,  A61K49/0002 ,  C07D401/12 ,  C07K5/0205 ,  C07K5/0215 ,  C07K5/06139 ,  C07K5/06191

摘要： The present invention describes novel compounds of the formula: (Q)d-Ln-Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. The present invention also provides novel compounds useful for monitoring therapeutic angiogenesis treatment and destruction of new angiogenic vasculature. The present invention also provides novel compounds useful for imaging atherosclerosis, restenosis, cardiac ischemia, and myocardial reperfusion injury. The present invention also provides novel compounds useful for the treatment of rheumatoid arthritis. The pharmaceuticals are comprised of a targeting moiety that binds to a receptor that is upregulated during angiogenesis, an optional linking group, and a therapeutically effective radioisotope or diagnostically effective imageable moiety. The imageable moiety is a gamma ray or positron emitting radioisotope, a magnetic resonance imaging contrast agent, an X-ray contrast agent, or an ultrasound contrast agent.

摘要翻译： 本发明描述了新的下式化合物：<？in-line-formula description =“In-line Formulas”end =“lead”？>（Q） 对于癌症的诊断和治疗有用的<？in-line-formula description =“在线公式”end =“tail”？>，肿瘤成像方法 患者，以及在患者中治疗癌症的方法。 本发明还提供了可用于监测治疗性血管生成治疗和破坏新的血管生成脉管系统的新型化合物。 本发明还提供了用于成像动脉粥样硬化，再狭窄，心脏缺血和心肌再灌注损伤的新型化合物。 本发明还提供了可用于治疗类风湿性关节炎的新化合物。 药物由与血管发生期间上调的受体结合的靶向部分，任选的连接基团和治疗有效的放射性同位素或诊断上有效的可成像部分组成。 可成像部分是伽马射线或正电子发射放射性同位素，磁共振成像造影剂，X射线造影剂或超声造影剂。

公开(公告)号：US06301053B1

公开(公告)日：2001-10-09

申请号：US09547470

申请日：2000-06-19

申请人： Edward Cheesman

发明人： Edward Cheesman

IPC分类号： G02B2714

CPC分类号： G02B27/0149

摘要： A combiner assembly 20 has an optical combiner 21 mounted to a housing 22 which is further arranged for mounting to a roof structure of a flight deck of an aircraft. The combiner 21 is mounted within a frame 23 which is mounted to the housing 22. The frame 23 has first pivot point 24 which is attached to a first arm 25 which is also attached to the housing 22 at a second pivot point 26 located at a position remote from the first pivot point 24. First arm 25 is arranged to allow the combiner 21 to rotate around the housing 22 between a deployed position and a stowed position. A second arm 27 is pivotally connected to the frame 22 at a third pivot point 28, at a position spaced from the first pivot point 24, and to the housing 22 at a fourth pivot point 29, located at a position remote from the third pivot point 28 and at a position spaced from the second pivot point 26. The pivot points 24, 26, 28 and 29 are arranged such that the first and second arm 25, 27 are positioned in a non-parallel arrangement and traverse a pathway wherein the mean distance between the combiner 21 and housing 22 varies during rotational movement of the combiner 21 with respect to the housing 22.

摘要翻译： 组合器组件20具有安装到壳体22上的光学组合器21，其进一步布置成用于安装到飞行器的驾驶舱的顶部结构。 组合器21安装在安装到壳体22的框架23内。框架23具有第一枢转点24，第一枢转点24附接到第一臂25，第一臂25还在位于壳体22处的第二枢转点26处附接到壳体22。 位置远离第一枢轴点24.第一臂25布置成允许组合器21围绕壳体22在展开位置和收起位置之间旋转。 第二臂27在第三枢转点28处，在与第一枢转点24间隔开的位置处枢转地连接到框架22，并且在位于远离第三枢轴的位置的第四枢转点29处枢转地连接到框架22 点28和与第二枢转点26间隔开的位置。枢转点24,26,28和29被布置成使得第一和第二臂25,27定位成非平行布置，并横穿通道，其中 组合器21和壳体22之间的平均距离在组合器21相对于壳体22的旋转运动期间变化。

公开(公告)号：US20070048561A1

公开(公告)日：2007-03-01

申请号：US11515294

申请日：2006-08-31

申请人： Marc Aiello ,  Edward Cheesman ,  Wayne Jordan

发明人： Marc Aiello ,  Edward Cheesman ,  Wayne Jordan

IPC分类号： H01M8/04

CPC分类号： H05K7/20927 ,  H02M7/003

摘要： A method of operating a power delivery system that has at least one power cell includes directing air into the power cells to cool them, receiving the air from the cells, directing the air to a cooling system, and recirculating the cooled air to the power cells. Each cell may include an air intake, an air output, a water-cooled heat sink, and optionally a plurality of capacitor connectors and/or a circuit board. The air may be directed through the air intake to the air output so that air passes over the capacitor connectors and/or the circuit board before passing over the heat sink.

摘要翻译： 操作具有至少一个功率单元的功率传递系统的方法包括将空气引导到功率单元中以冷却它们，从单元接收空气，将空气引导到冷却系统，以及将冷却的空气再循环到功率单元 。 每个电池可以包括进气口，空气输出口，水冷散热器，以及可选地多个电容器连接器和/或电路板。 空气可以通过进气口被引导到空气输出端，使得空气在通过散热器之前通过电容器连接器和/或电路板。