公开(公告)号：US06242225B1

公开(公告)日：2001-06-05

申请号：US09313772

申请日：1999-05-18

申请人： Steven J. Catani ,  Stephen A. Roth ,  Edward J. McGuire ,  Juan L. Navia

发明人： Steven J. Catani ,  Stephen A. Roth ,  Edward J. McGuire ,  Juan L. Navia

IPC分类号： C12N910

CPC分类号： C12N9/1051 ,  C12P19/24

摘要： The present invention relates to a process of preparing commercial quantities of glucose and/or fructose from sucrose, a process of preparing commercial quantities of glucose and a polyfructan from sucrose, a reactor for practicing same, a process of preparing commercial quantities of fructose and a polyglucan from sucrose and a reactor for practicing same.

公开(公告)号：US6096725A

公开(公告)日：2000-08-01

申请号：US887270

申请日：1997-07-02

申请人： Paul M. Simon ,  Edward J. McGuire

发明人： Paul M. Simon ,  Edward J. McGuire

IPC分类号： C07H3/04 ,  A61K31/70

CPC分类号： C07H3/06 ,  C07H3/04

摘要： The invention relates to methods for attenuating xenograft rejection in humans and old world monkeys, using oligosaccharides containing a Gal.alpha.1-3Gal motif, to neutralize or remove anti-.alpha.Gal antibodies. The invention additionally relates to methods for site directed activation of the complement cascade or host leukocytes using oligosaccharides containing a Gal.alpha.1-3Gal motif to target anti-.alpha.Gal antibodies. The invention further relates to pharmaceutical compositions that may be used in the practice of the invention. Such compositions contain, as the active ingredient, an oligosaccharide containing a Gal.alpha.1-3Gal motif effective in binding anti-.alpha.Gal antibodies in vivo or ex vivo.

摘要翻译： 本发明涉及使用含有Galα1-3Gal基序的寡糖来中和或去除抗αGal抗体来减弱人类和老世界猴中异种移植物排斥的方法。 本发明还涉及使用含有Galα1-3Gal基序的寡糖靶向抗αGal抗体的位点定向活化补体级联或宿主白细胞的方法。 本发明还涉及可用于实施本发明的药物组合物。 作为活性成分，这样的组合物含有在体内或体外有效结合抗αGal抗体的Galα1-3Gal基序的寡糖。

公开(公告)号：US5883079A

公开(公告)日：1999-03-16

申请号：US75862

申请日：1998-05-12

申请人： David A Zopf ,  Paul M. Simon ,  Stephen Roth ,  Edward J. McGuire ,  Dennis H. Langer

发明人： David A Zopf ,  Paul M. Simon ,  Stephen Roth ,  Edward J. McGuire ,  Dennis H. Langer

IPC分类号： A61K31/70 ,  A61K31/715 ,  A61K38/16 ,  A61K45/06 ,  A61K31/73

CPC分类号： A61K31/7016 ,  A61K31/70 ,  A61K31/702 ,  A61K31/715 ,  A61K38/16 ,  A61K45/06 ,  Y10S514/925 ,  Y10S514/926 ,  Y10S514/927

摘要： A method for treating and/or inhibiting gastric and duodenal ulcers, comprising administering a pharmaceutical composition comprising an oligosaccharide of Formula I(NeuAc-.alpha.(2-3)-pGal-.beta.(1)-(--X--).sub.m --(--Y--).sub.n -).sub.p -ZwhereinX=a chemical bond or a group capable of linking the p galactose to either the linking group Y or the multivalent support Z;wherein the C.sub.1 glycosidic oxygen of galactose may be replaced by N, S or C;Y=a linking group;Z=a multivalent support;m=0 or 1;n=0 or 1; andp=an integer of 2-1,000 is described. Also described is a method for treating and/or inhibiting gastric and duodenal ulcers, comprising administering a pharmaceutical composition comprising an oligosaccharide of Formula IINeuAc-.alpha.(2-3)-pGal-.beta.(1)-AwhereinA=a group capable of bonding to the p galactose;wherein the C.sub.1 glycosidic oxygen of galactose may be replaced by N, S or C.

摘要翻译： 一种治疗和/或抑制胃十二指肠溃疡的方法，包括给予包含式I的寡糖的药物组合物（NeuAc-α（2-3）-pGal-β（1） - （ - X-）m - （ - Y-）n-）pZ其中X =化学键或能够将p半乳糖与连接基团Y或多价载体Z连接的基团; 其中半乳糖的C1糖苷氧可以被N，S或C代替; Y =连接基团; Z =多价支持; m = 0或1; n = 0或1; 并且描述p = 2-1,000的整数。 还描述了治疗和/或抑制胃十二指肠溃疡的方法，包括给予包含式II的寡糖NeuAc-α（2-3）-pGal-β（1）-A的药物组合物，其中A =能够 与p半乳糖结合; 其中半乳糖的C1糖苷氧可以被N，S或C替代。

公开(公告)号：US5409745A

公开(公告)日：1995-04-25

申请号：US167172

申请日：1993-12-16

申请人： Edward J. McGuire

发明人： Edward J. McGuire

IPC分类号： A47G33/06

CPC分类号： A47G33/06

摘要： An artificial Christmas tree has a trunk. The trunk has a branch retaining rod and a plurality of branch retaining ports in the branch retaining rod. There is a branch retaining rod horizontal support member releasably attached to one end of the branch retaining rod. A branch retaining rod vertical support member is attached to another end of the branch retaining rod. There are a plurality of flexible branches. Each flexible branch has a flexible member and a plurality of artificial needles retained in the flexible member. The flexible member has an insertion end for insertion into a branch retaining port. There is an ornament retaining member releasably attached to the flexible branches. The ornament retaining member has a hinged retaining clip and a spring. The spring is attached to and biases the hinged retaining clip from an open position to an closed position. The branch retaining rod also has at least two interconnectable sections releasably and threadingly connected together or alternatively foldingly connected.

摘要翻译： 一个人造圣诞树有一个树干。 躯干具有分支保持杆和分支保持杆中的多个分支保持口。 分支保持杆水平支撑构件可释放地附接到分支保持杆的一端。 分支保持杆垂直支撑构件附接到分支保持杆的另一端。 有多个灵活的分支。 每个柔性分支具有柔性构件和保留在柔性构件中的多个人造针。 柔性构件具有用于插入分支保持口的插入端。 有一个可释放地附接到柔性分支上的装饰物保持构件。 装饰物保持构件具有铰链固定夹和弹簧。 弹簧被连接到铰链固定夹上并将其从打开位置偏压到关闭位置。 分支保持杆还具有至少两个互连部分，可释放地并且螺纹连接在一起或者折叠连接。

公开(公告)号：US06660502B2

公开(公告)日：2003-12-09

申请号：US09873253

申请日：2001-06-05

申请人： Steven J. Catani ,  Stephen A. Roth ,  Edward J. McGuire ,  Juan L. Navia

发明人： Steven J. Catani ,  Stephen A. Roth ,  Edward J. McGuire ,  Juan L. Navia

IPC分类号： C12N1910

CPC分类号： C12N9/1051 ,  C12P19/24

摘要： The present invention relates to a process of preparing commercial quantities of glucose and/or fructose from sucrose, a process of preparing commercial quantities of glucose and a polyfructan from sucrose, a reactor for practicing same, a process of preparing commercial quantities of fructose and a polyglucan from sucrose and a reactor for practicing same.

摘要翻译： 本发明涉及从蔗糖制备商业量的葡萄糖和/或果糖的方法，从蔗糖制备商业量的葡萄糖和多聚果糖的方法，用于实施其的反应器，制备商业量的果糖和 来自蔗糖的聚葡聚糖和用于实施它的反应器。

公开(公告)号：US5753630A

公开(公告)日：1998-05-19

申请号：US598431

申请日：1996-02-08

申请人： David A. Zopf ,  Paul M. Simon ,  Stephen Roth ,  Edward J. McGuire ,  Dennis H. Langer

发明人： David A. Zopf ,  Paul M. Simon ,  Stephen Roth ,  Edward J. McGuire ,  Dennis H. Langer

IPC分类号： A61K31/70 ,  A61K31/715 ,  A61K38/16 ,  A61K45/06 ,  C07H15/00

CPC分类号： A61K31/7016 ,  A61K31/70 ,  A61K31/702 ,  A61K31/715 ,  A61K38/16 ,  A61K45/06 ,  Y10S514/925 ,  Y10S514/926 ,  Y10S514/927

摘要： A method for treating and/or inhibiting gastric and duodenal ulcers, comprising administering a pharmaceutical composition comprising an oligosaccharide of Formula I (NeuAc-.alpha.(2-3)-pGal-.beta.(1)--(--X--).sub.m --(--Y--).sub.n --).sub.p --Z wherein X=a chemical bond or a group capable of linking the p galactose to either the linking group Y or the multivalent support Z; wherein the C.sub.1 glycosidic oxygen of galactose may be replaced by N, S or C; Y=a linking group; Z=a multivalent support; m=0 or 1; n=0 or 1; and p=an integer of 2-1,000 is described. Also described is a method for treating and/or inhibiting gastric and duodenal ulcers, comprising administering a pharmaceutical composition comprising an oligosaccharide of Formula II NeuAc-.alpha.(214 3)-pGal-.beta.(1)-A wherein A=a group capable of bonding to the p galactose; wherein the C.sub.1 glycosidic oxygen of galactose may be replaced by N, S or C.

摘要翻译： 一种治疗和/或抑制胃十二指肠溃疡的方法，包括给予包含式I的寡糖的药物组合物（NeuAc-α（2-3）-pGal-β（1） - （ - X-）m - （ - Y-）n-）pZ其中X =化学键或能够将p半乳糖与连接基团Y或多价载体Z连接的基团; 其中半乳糖的C1糖苷氧可以被N，S或C代替; Y =连接基团; Z =多价支撑; m = 0或1; n = 0或1; 并且描述p = 2-1,000的整数。 还描述了治疗和/或抑制胃和十二指肠溃疡的方法，包括给予包含式II NeuAc-α（214 3）-pGal-β（1）-A的寡糖的药物组合物，其中A =能够 与p半乳糖结合; 其中半乳糖的C1糖苷氧可以被N，S或C替代。

公开(公告)号：US5514660A

公开(公告)日：1996-05-07

申请号：US474199

申请日：1995-06-07

申请人： David A. Zopf ,  Paul M. Simon ,  Stephen Roth ,  Edward J. McGuire ,  Dennis H. Langer

发明人： David A. Zopf ,  Paul M. Simon ,  Stephen Roth ,  Edward J. McGuire ,  Dennis H. Langer

IPC分类号： A61K31/70 ,  A61K31/715 ,  A61K38/16 ,  A61K45/06 ,  A61K31/73

CPC分类号： A61K31/7016 ,  A61K31/70 ,  A61K31/702 ,  A61K31/715 ,  A61K38/16 ,  A61K45/06 ,  Y10S514/925 ,  Y10S514/926 ,  Y10S514/927

摘要： A method for treating and/or inhibiting gastric and duodenal ulcers, comprising administering a pharmaceutical composition comprising an oligosaccharide of Formula I(NeuAc-.alpha.(2-3)-Gal-.beta.(1)-(--X--).sub.m -(--Y--).sub.n -).sub.p -ZwhereinX=a chemical bond or a group capable of linking the galactose to either the linking group Y or the multivalent support Z;wherein the C.sub.1 glycosidic oxygen of galactose may be replaced by N, S or C;Y=a linking group;Z=a multivalent support;m=0 or 1;n=0 or 1; andp=an integer of 2-1,000 is described. Also described is a method for treating and/or inhibiting gastric and duodenal ulcers, comprising administering a pharmaceutical composition comprising an oligosaccharide of Formula IINeuAc-.alpha.(2-3)-Gal-.beta.(1)-AwhereinA=a group capable of bonding to the galactose;wherein the C.sub.1 glycosidic oxygen of galactose may be replaced by N, S or C.

摘要翻译： 一种用于治疗和/或抑制胃和十二指肠溃疡的方法，包括给予包含式I的寡糖的药物组合物（NeuAc-α（2-3）-Gal-β（1） - （ - X-）m - （ - Y-）n-）pZ其中X =化学键或能够将半乳糖连接至连接基团Y或多价载体Z的基团; 其中半乳糖的C1糖苷氧可以被N，S或C代替; Y =连接基团; Z =多价支撑; m = 0或1; n = 0或1; 并且描述p = 2-1,000的整数。 还描述了治疗和/或抑制胃和十二指肠溃疡的方法，包括给予包含式II NeuAc-α（2-3）-Gal-β（1）-A的寡糖的药物组合物，其中A =能够 与半乳糖结合; 其中半乳糖的C1糖苷氧可以被N，S或C替代。

公开(公告)号：US5998177A

公开(公告)日：1999-12-07

申请号：US195680

申请日：1998-11-19

申请人： Steven J. Catani ,  Stephen A. Roth ,  Edward J. McGuire ,  Juan L. Navia

发明人： Steven J. Catani ,  Stephen A. Roth ,  Edward J. McGuire ,  Juan L. Navia

IPC分类号： C12N15/09 ,  C12M1/00 ,  C12P19/02 ,  C12P19/04 ,  C12P19/14 ,  C12N9/10

CPC分类号： C12P19/02 ,  C12P19/04

摘要： The present invention relates to a process of preparing commercial quantities of glucose from sucrose, a process of preparing commercial quantities of glucose and a branched fructan from sucrose, a reactor for practicing same.

摘要翻译： 本发明涉及从蔗糖制备商业量的葡萄糖的方法，从蔗糖制备商业量的葡萄糖和支链果聚糖的方法，用于实施它的反应器。

公开(公告)号：US5952205A

公开(公告)日：1999-09-14

申请号：US19709

申请日：1998-02-06

申请人： Steven J. Catani ,  Stephen A. Roth ,  Edward J. McGuire ,  Juan L. Navia

发明人： Steven J. Catani ,  Stephen A. Roth ,  Edward J. McGuire ,  Juan L. Navia

IPC分类号： C12N15/09 ,  C12M1/00 ,  C12N9/10 ,  C12P19/02 ,  C12P19/04 ,  C12P19/18 ,  C12P19/24

CPC分类号： C12N9/1051 ,  C12P19/24

摘要： The present invention relates to a process of preparing commercial quantities of glucose and/or fructose from sucrose, a process of preparing commercial quantities of glucose and a polyfructan from sucrose, a reactor for practicing same, a process of preparing commercial quantities of fructose and a polyglucan from sucrose and a reactor for practicing same.

公开(公告)号：US5620964A

公开(公告)日：1997-04-15

申请号：US461000

申请日：1995-06-05

申请人： Stephen Roth ,  Edward J. McGuire ,  Dennis H. Langer

发明人： Stephen Roth ,  Edward J. McGuire ,  Dennis H. Langer

IPC分类号： A61K31/70 ,  A61K31/715 ,  A61K38/16 ,  A61K45/06

CPC分类号： A61K31/7016 ,  A61K31/70 ,  A61K31/702 ,  A61K31/715 ,  A61K38/16 ,  A61K45/06 ,  Y10S514/925 ,  Y10S514/926 ,  Y10S514/927

摘要： A composition for treating and/or inhibiting gastric and duodenal ulcers, comprising an oligosaccharide selected from the group consisting of Formula I ##STR1## or a mixture thereof; wherein:X is independently OH or NHAc;Y is independently H, or an amino acid or a peptide of 2-100, preferably 2-20, amino acids; andW, W', and W" are each independently H or ##STR2## where Z is independently H or a pharmaceutically acceptable cation; and P is independently H or ##STR3## where Z is defined as above; wherein at least one of W, W' or W" is an .alpha.-N-acetylneuraminic acid moiety, andwherein W' and W" are not simultaneously .alpha.-N-acetylneuraminic acid moietywith the proviso that the compound of Formula II is not NAN .alpha.(2.fwdarw.3)Gal .beta.1-4 Glu or NAN .alpha.(2.fwdarw.6)Gal .beta.1-4 Glu; and a kit for detecting the presence of Helicobacter pylori comprising at least one compound of the Formula I or II, are described.

摘要翻译： 一种用于治疗和/或抑制胃和十二指肠溃疡的组合物，其包含选自式I的寡糖或其混合物; 其中：X独立地是OH或NHAc; Y独立地为H，或氨基酸或2-100个，优选2-20个氨基酸的肽; W，W'和W“各自独立地为H或者”IMA“，其中Z独立地为H或药学上可接受的阳离子; 并且P独立地为H或，其中Z如上定义; 其中W，W'或W“中的至少一个是α-N-乙酰神经氨酸部分，并且其中W'和W”不同时为α-N-乙酰神经氨酸部分，条件是式II化合物 不是NANα（2-> 3）Galβ1-4 Glu或NANα（2-> 6）Galβ1-4 Glu; 和用于检测幽门螺杆菌存在的试剂盒，其包含至少一种式I或II的化合物。