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1.发明授权
公开(公告)号：US5436137A
公开(公告)日：1995-07-25
申请号：US39778
申请日：1993-03-23
IPC分类号： A61K38/00 , A61P13/02 , A61P15/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/575 , C12N15/09 , C12P21/06 , A61K7/46 , C07H19/00 , C12N9/48
CPC分类号： C07K14/57572 , C07K7/086 , A61K38/00
摘要： A pure DNA encoding a peptide which is capable of promoting acrosome reaction and the encoded peptide. Also disclosed are a vector and a cell containing such a DNA, a pharmaceutical composition which includes such a peptide, a method of promoting fertilization using such a peptide, and a method of preparing such a peptide by recombinant technology.
摘要翻译： 编码能够促进顶体反应的肽的纯DNA和编码的肽。 还公开了含有这种DNA的载体和细胞，包含这种肽的药物组合物，使用这种肽促进受精的方法，以及通过重组技术制备这种肽的方法。
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公开(公告)号：US5439884A
公开(公告)日：1995-08-08
申请号：US919731
申请日：1992-07-27
IPC分类号： A61K38/00 , C07K7/08 , C07K14/575 , A61K38/10 , A61K38/17
CPC分类号： C07K14/57572 , C07K7/086 , A61K38/00
摘要： A method of promoting or blocking fertilization, which method includes the step of contacting sperm either at the time of sperm capacitation or at the time of egg fertilization with an effective amount of bombesin or its analog capable of stimulating or inhibiting the acrosome reaction.
摘要翻译： 一种促进或阻断受精的方法，该方法包括在精子获能时或在卵子受精时将精子与有效量的铃蟾肽或其能够刺激或抑制顶体反应的类似物接触的步骤。
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3.发明申请METHODS FOR DETECTING PRE-DIABETES AND DIABETES USING DIFFERENTIAL PROTEIN GLYCOSYLATION 有权使用差异蛋白质糖蛋白检测预先糖尿病和糖尿病的方法公开(公告)号：US20120208218A1
公开(公告)日：2012-08-16
申请号：US13457243
申请日：2012-04-26
IPC分类号： G01N33/566
CPC分类号： G01N33/6893 , G01N2333/42 , G01N2400/00 , G01N2440/38 , G01N2500/02 , G01N2800/042 , G01N2800/50 , G01N2800/52
摘要： Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.
摘要翻译： 本文公开了用于鉴定还没有糖尿病（糖尿病前），但具有发展为糖尿病的重大风险的个体的方法，例如2型糖尿病。 还提供了用于鉴定糖尿病受试者的方法。 还公开了用于鉴定患有糖尿病并发症的个体的方法。 所述方法包括鉴定生物液体如唾液，尿液或血清中蛋白质的总体糖基化谱。 在一些实例中，所述方法包括测定生物流体中的一种或多种蛋白质的量或确定生物流体中一种或多种蛋白质的糖基化模式。
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4.发明授权Methods for detecting pre-diabetes and diabetes using differential protein glycosylation 有权使用差异蛋白糖基化检测糖尿病前期和糖尿病的方法公开(公告)号：US08168396B2
公开(公告)日：2012-05-01
申请号：US12777955
申请日：2010-05-11
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2333/42 , G01N2400/00 , G01N2440/38 , G01N2500/02 , G01N2800/042 , G01N2800/50 , G01N2800/52
摘要： Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.
摘要翻译： 本文公开了用于鉴定还没有糖尿病（糖尿病前），但具有发展为糖尿病的重大风险的个体的方法，例如2型糖尿病。 还提供了用于鉴定糖尿病受试者的方法。 还公开了用于鉴定患有糖尿病并发症的个体的方法。 所述方法包括鉴定生物液体如唾液，尿液或血清中蛋白质的总体糖基化谱。 在一些实例中，所述方法包括测定生物流体中的一种或多种蛋白质的量或确定生物流体中一种或多种蛋白质的糖基化模式。
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公开(公告)号：US08497077B2
公开(公告)日：2013-07-30
申请号：US13457243
申请日：2012-04-26
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2333/42 , G01N2400/00 , G01N2440/38 , G01N2500/02 , G01N2800/042 , G01N2800/50 , G01N2800/52
摘要： Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.
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公开(公告)号：US20120214179A1
公开(公告)日：2012-08-23
申请号：US13457225
申请日：2012-04-26
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2333/42 , G01N2400/00 , G01N2440/38 , G01N2500/02 , G01N2800/042 , G01N2800/50 , G01N2800/52
摘要： Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.
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公开(公告)号：US20110124022A1
公开(公告)日：2011-05-26
申请号：US13055605
申请日：2009-07-23
IPC分类号： C12Q1/48
CPC分类号： G01N33/6893 , G01N2800/042 , G01N2800/50 , G01N2800/52
摘要： Non-invasive methods are provided herein for the diagnosis of pre-diabetes and diabetes using biomarkers identified in a biological fluid, such as saliva. These biomarkers can be identified using proteomic methods, including but not limited to antibody based methods, such as an enzyme-linked immunosorbant assay (ELISA), a radioimmunoassay (RIA), or a lateral flow immunoassay.
摘要翻译： 本文提供了非侵入性方法，用于使用生物流体（例如唾液）中鉴定的生物标志物来诊断糖尿病前和糖尿病。 可以使用蛋白质组学方法鉴定这些生物标志物，包括但不限于基于抗体的方法，例如酶联免疫吸附测定（ELISA），放射免疫测定（RIA）或侧流免疫测定。
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8.发明申请METHODS FOR DETECTING PRE-DIABETES AND DIABETES USING DIFFERENTIAL PROTEIN GLYCOSYLATION 有权使用差异蛋白质糖蛋白检测预先糖尿病和糖尿病的方法公开(公告)号：US20100285498A1
公开(公告)日：2010-11-11
申请号：US12777955
申请日：2010-05-11
IPC分类号： G01N33/68 , G01N33/53 , G01N33/566
CPC分类号： G01N33/6893 , G01N2333/42 , G01N2400/00 , G01N2440/38 , G01N2500/02 , G01N2800/042 , G01N2800/50 , G01N2800/52
摘要： Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.
摘要翻译： 本文公开了用于鉴定还没有糖尿病（糖尿病前），但具有发展为糖尿病的重大风险的个体的方法，例如2型糖尿病。 还提供了用于鉴定糖尿病受试者的方法。 还公开了用于鉴定患有糖尿病并发症的个体的方法。 所述方法包括鉴定生物液体如唾液，尿液或血清中蛋白质的总体糖基化谱。 在一些实例中，所述方法包括测定生物流体中的一种或多种蛋白质的量或确定生物流体中一种或多种蛋白质的糖基化模式。
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公开(公告)号：US08530175B2
公开(公告)日：2013-09-10
申请号：US13457225
申请日：2012-04-26
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2333/42 , G01N2400/00 , G01N2440/38 , G01N2500/02 , G01N2800/042 , G01N2800/50 , G01N2800/52
摘要： Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.
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10.发明授权Methods for detecting pre-diabetes and diabetes using differential protein glycosylation 有权使用差异蛋白糖基化检测糖尿病前期和糖尿病的方法公开(公告)号：US08497076B2
公开(公告)日：2013-07-30
申请号：US13457200
申请日：2012-04-26
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2333/42 , G01N2400/00 , G01N2440/38 , G01N2500/02 , G01N2800/042 , G01N2800/50 , G01N2800/52
摘要： Methods for identifying individuals who are not yet diabetic (pre-diabetic), but who are at significant risk of developing diabetes, such as type 2 diabetes, are disclosed herein. Methods are also provided for the identification of diabetic subjects. Also disclosed are methods for identifying individuals with diabetic complications. The methods include the identification of an overall glycosylation profile of proteins in a biological fluid, such as saliva, urine, or serum. In some examples, the methods include determining the amount of one or more protein in a biological fluid or determining the glycosylation pattern of one or more proteins in a biological fluid.
摘要翻译： 本文公开了用于鉴定还没有糖尿病（糖尿病前），但具有发展为糖尿病的重大风险的个体的方法，例如2型糖尿病。 还提供了用于鉴定糖尿病受试者的方法。 还公开了用于鉴定患有糖尿病并发症的个体的方法。 所述方法包括鉴定生物液体如唾液，尿液或血清中蛋白质的总体糖基化谱。 在一些实例中，所述方法包括测定生物流体中的一种或多种蛋白质的量或确定生物流体中一种或多种蛋白质的糖基化模式。
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