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公开(公告)号：US08138152B2
公开(公告)日：2012-03-20
申请号：US12537888
申请日：2009-08-07
申请人： Luc Desnoyers , Ellen H. Filvaroff , Diane Pennica
发明人： Luc Desnoyers , Ellen H. Filvaroff , Diane Pennica
CPC分类号： C07K14/475 , A61K38/00 , C07K14/47
摘要： The present invention relates to methods for the treatment and repair of cartilage, including cartilage damaged by injury or degenerative cartilagenous disorders, including arthritis, comprising the administration of WISP polypeptide. Optionally, the administration may be in combination with one or more cartilage agents (e.g., peptide growth factor, catabolism antagonist, osteo-, synovial, anti-inflammatory factor). Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or degenerative cartilagenous disorders comprising the administration of WISP polypeptide in combination with standard surgical techniques. Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or degenerative cartilagenous disorders comprising the administration of chondrocytes previously treated with an effective amount of WISP polypeptide.
摘要翻译： 本发明涉及软骨的治疗和修复方法，包括损伤的软骨或包括关节炎在内的退行性软骨疾病，包括施用WISP多肽。 任选地，给药可以与一种或多种软骨剂（例如肽生长因子，分解代谢拮抗剂，骨，滑膜，抗炎因子）组合。 或者，该方法提供了由损伤或退行性软骨障碍损伤的软骨的治疗和修复，包括与标准手术技术组合施用WISP多肽。 或者，该方法提供对由损伤或退行性软骨障碍损伤的软骨的治疗和修复，包括施用有效量的WISP多肽以前治疗的软骨细胞。
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公开(公告)号：US20100093628A1
公开(公告)日：2010-04-15
申请号：US12537888
申请日：2009-08-07
申请人： Luc DESNOYER , Ellen H. FILVAROFF , Diane PENNICA
发明人： Luc DESNOYER , Ellen H. FILVAROFF , Diane PENNICA
CPC分类号： C07K14/475 , A61K38/00 , C07K14/47
摘要： The present invention relates to methods for the treatment and repair of cartilage, including cartilage damaged by injury or degenerative cartilagenous disorders, including arthritis, comprising the administration of WISP polypeptide. Optionally, the administration may be in combination with one or more cartilage agents (e.g., peptide growth factor, catabolism antagonist, osteo-, synovial, anti-inflammatory factor). Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or degenerative cartilagenous disorders comprising the administration of WISP polypeptide in combination with standard surgical techniques. Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or degenerative cartilagenous disorders comprising the administration of chondrocytes previously treated with an effective amount of WISP polypeptide.
摘要翻译： 本发明涉及软骨的治疗和修复方法，包括损伤的软骨或包括关节炎在内的退行性软骨疾病，包括施用WISP多肽。 任选地，给药可以与一种或多种软骨剂（例如肽生长因子，分解代谢拮抗剂，骨，滑膜，抗炎因子）组合。 或者，该方法提供了由损伤或退行性软骨障碍损伤的软骨的治疗和修复，包括与标准手术技术组合施用WISP多肽。 或者，该方法提供对由损伤或退行性软骨障碍损伤的软骨的治疗和修复，包括施用有效量的WISP多肽以前治疗的软骨细胞。
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公开(公告)号：US07687460B2
公开(公告)日：2010-03-30
申请号：US10399093
申请日：2001-10-12
申请人： Luc Desnoyer , Ellen H. Filvaroff , Diane Pennica
发明人： Luc Desnoyer , Ellen H. Filvaroff , Diane Pennica
IPC分类号： A61K38/00
CPC分类号： C07K14/475 , A61K38/00 , C07K14/47
摘要： The present invention relates to methods for the treatment and repair of cartilage, including cartilage damaged by injury or degenerative cartilagenous disorders, including arthritis, comprising the administration of WISP polypeptide. Optionally, the administration may be in combination with one or more cartilage agents (e.g., peptide growth factor, catabolism antagonist, osteo-, synovial, anti-inflammatory factor). Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or degenerative cartilagenous disorders comprising the administration of WISP polypeptide in combination with standard surgical techniques. Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or degenerative cartilagenous disorders comprising the administration of chondrocytes previously treated with an effective amount of WISP polypeptide.
摘要翻译： 本发明涉及软骨的治疗和修复方法，包括损伤的软骨或包括关节炎在内的退行性软骨疾病，包括施用WISP多肽。 任选地，给药可以与一种或多种软骨剂（例如肽生长因子，分解代谢拮抗剂，骨，滑膜，抗炎因子）组合。 或者，该方法提供了由损伤或退行性软骨障碍损伤的软骨的治疗和修复，包括与标准手术技术组合施用WISP多肽。 或者，该方法提供对由损伤或退行性软骨障碍损伤的软骨的治疗和修复，包括施用有效量的WISP多肽以前治疗的软骨细胞。
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公开(公告)号：US20090285810A1
公开(公告)日：2009-11-19
申请号：US12423664
申请日：2009-04-14
申请人： Camellia W. Adams , Napoleone Ferrara , Ellen H. Filvaroff , Weiguang Mao , Leonard G. Presta , Max L. Tejada
发明人： Camellia W. Adams , Napoleone Ferrara , Ellen H. Filvaroff , Weiguang Mao , Leonard G. Presta , Max L. Tejada
IPC分类号： A61K39/395 , C07K16/22 , A61P35/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/73 , C07K2317/76 , Y10S435/81
摘要： Humanized anti-TGF-beta antibodies are provided, as well as methods for their preparation and use, including methods for treating TGF-beta disorders, for example, cancer. Also provided are articles of manufacture designed for various uses that contain the humanized antibodies.
摘要翻译： 提供人源化抗TGF-β抗体，以及其制备和使用方法，包括治疗TGF-β病症例如癌症的方法。 还提供了针对包含人源化抗体的各种用途设计的制品。
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公开(公告)号：US07268112B2
公开(公告)日：2007-09-11
申请号：US10740098
申请日：2003-12-17
IPC分类号： A61K38/28
CPC分类号： A61K38/30 , A61K9/5031 , A61K38/28 , A61K38/55 , A61K39/3955 , A61K2300/00
摘要： The present invention relates to methods for the treatment and repair of cartilage, including cartilage damaged by injury or cartilaginous disorders, including arthritis, comprising the administration of insulin and/or insulin variants. Optionally, the administration may be in combination with a cartilage agent (e.g., peptide growth factor, catabolism antagonist, osteo-, synovial, anti-inflammatory factor), in an extended- or sustained-release form. Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or cartilaginous disorders comprising the administration of insulin and/or insulin in combination with standard surgical techniques. Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or cartilaginous disorders comprising the administration of chondrocytes previously treated with an effective amount of insulin and/or insulin variant.
摘要翻译： 本发明涉及用于治疗和修复软骨的方法，所述软骨包括损伤的软骨或包括关节炎的软骨疾病，包括施用胰岛素和/或胰岛素变体。 任选地，给药可以与延长或持续释放形式的软骨剂（例如肽生长因子，分解代谢拮抗剂，骨，滑膜，抗炎因子）组合。 或者，该方法提供了由损伤或软骨疾病损伤的软骨的治疗和修复，包括与标准手术技术组合施用胰岛素和/或胰岛素。 或者，该方法提供了由损伤或软骨疾病损伤的软骨的治疗和修复，包括施用以前用有效量的胰岛素和/或胰岛素变体治疗的软骨细胞。
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公开(公告)号：US20100266698A1
公开(公告)日：2010-10-21
申请号：US12825208
申请日：2010-06-28
CPC分类号： A61K38/30 , A61K9/5031 , A61K38/28 , A61K38/55 , A61K39/3955 , A61K2300/00
摘要： The present invention relates to methods for the treatment and repair of cartilage, including cartilage damaged by injury or cartilaginous disorders, including arthritis, comprising the administration of insulin and/or insulin variants. Optionally, the administration may be in combination with a cartilage agent (e.g., peptide growth factor, catabolism antagonist, osteo-, synovial, anti-inflammatory factor), in an extended- or sustained-release form. Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or cartilaginous disorders comprising the administration of insulin and/or insulin in combination with standard surgical techniques. Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or cartilaginous disorders comprising the administration of chondrocytes previously treated with an effective amount of insulin and/or insulin variant.
摘要翻译： 本发明涉及用于治疗和修复软骨的方法，所述软骨包括损伤的软骨或包括关节炎的软骨疾病，包括施用胰岛素和/或胰岛素变体。 任选地，给药可以与延长或持续释放形式的软骨剂（例如肽生长因子，分解代谢拮抗剂，骨，滑膜，抗炎因子）组合。 或者，该方法提供了由损伤或软骨疾病损伤的软骨的治疗和修复，包括与标准手术技术组合施用胰岛素和/或胰岛素。 或者，该方法提供了由损伤或软骨疾病损伤的软骨的治疗和修复，包括施用以前用有效量的胰岛素和/或胰岛素变体治疗的软骨细胞。
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7.发明授权Pharmaceutical compositions, kits, and therapeutic uses of antagonist antibodies to IL-17E 有权IL-17E拮抗剂抗体的药物组合物，试剂盒和治疗用途公开(公告)号：US07771719B1
公开(公告)日：2010-08-10
申请号：US10617573
申请日：2003-07-11
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K38/00 , C07H21/04 , C07K14/54 , C07K14/7155 , C07K2317/21 , C07K2317/24 , C07K2317/35 , C07K2317/54 , C07K2317/55 , C07K2317/62 , G01N33/505 , G01N33/564 , G01N33/574 , G01N33/57407 , G01N33/57423 , G01N33/57438 , G01N33/57492 , G01N2333/54 , G01N2333/7155
摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
摘要翻译： 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。
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公开(公告)号：US07527791B2
公开(公告)日：2009-05-05
申请号：US11096046
申请日：2005-03-31
申请人： Camellia W. Adams , Napoleone Ferrara , Ellen H. Filvaroff , Weiguang Mao , Leonard G. Presta , Max L. Tejada
发明人： Camellia W. Adams , Napoleone Ferrara , Ellen H. Filvaroff , Weiguang Mao , Leonard G. Presta , Max L. Tejada
IPC分类号： A61K39/395 , C12P21/08
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/73 , C07K2317/76 , Y10S435/81
摘要： Humanized anti-TGF-beta antibodies are provided, as well as methods for their preparation and use, including methods for treating TGF-beta disorders, for example, cancer. Also provided are articles of manufacture designed for various uses that contain the humanized antibodies.
摘要翻译： 提供人源化抗TGF-β抗体，以及其制备和使用方法，包括治疗TGF-β病症例如癌症的方法。 还提供了针对包含人源化抗体的各种用途设计的制品。
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公开(公告)号：US06689747B2
公开(公告)日：2004-02-10
申请号：US09815229
申请日：2001-03-22
IPC分类号： A61K3828
CPC分类号： A61K38/30 , A61K9/5031 , A61K38/28 , A61K38/55 , A61K39/3955 , A61K2300/00
摘要： The present invention relates to methods for the treatment and repair of cartilage, including cartilage damaged by injury or cartilagenous disorders, including arthritis, comprising the administration of insulin and/or insulin variants. Optionally, the administration may be in combination with a cartilage agent (e.g., peptide growth factor, catabolism antagonist, osteo-, synovial, anti-inflammatory factor), in an extended- or sustained-release form. Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or cartilagenous disorders comprising the administration of insulin and/or insulin in combination with standard surgical techniques. Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or cartilagenous disorders comprising the administration of chondrocytes previously treated with an effective amount of insulin and/or insulin variant.
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