公开(公告)号：US20200268871A1

公开(公告)日：2020-08-27

申请号：US16644123

申请日：2018-09-21

Applicant: Emergex Vaccines Holding Limited

Inventor： Ramila Philip

IPC: A61K39/12 ,  C07K14/18 ,  A61K9/51 ,  A61P31/12 ,  A61K39/00 ,  C12N15/113

Abstract: The invention provides a vaccine composition comprising a flavivirus peptide comprising one or more CD8+ T cell C1 epitopes, wherein the peptide is attached to a nanoparticle.

公开(公告)号：US20190321460A1

公开(公告)日：2019-10-24

申请号：US16475602

申请日：2018-01-03

Applicant: Emergex Vaccines Holding Limited

Inventor： Ramila Philip

IPC: A61K39/145 ,  A61P31/16

Abstract: The invention provides a vaccine composition comprising an influenza virus peptide comprising a CD8+ T cell epitope and an influenza virus peptide comprising a B cell epitope, wherein each peptide is attached to a nanoparticle.

公开(公告)号：US12156909B2

公开(公告)日：2024-12-03

申请号：US17054104

申请日：2019-05-20

Applicant: Emergex Vaccines Holding Limited

Inventor： Ramila Philip ,  Richard David Perrins ,  Xiaofang Huang ,  Thomas Rademacher ,  Christopher Upton

IPC: A61K39/145 ,  A61K39/12 ,  A61P31/16 ,  C07K14/005 ,  C12Q1/70

Abstract: The invention relates to vaccine compositions comprising peptides encoded by an open reading frame (ORF) encoded by at least part of the genome of a ssRNA virus in the opposite sense to positive sense RNA capable of translation, and the use of such compositions for the treatment and prevention of viral infection.

公开(公告)号：US20230129352A1

公开(公告)日：2023-04-27

申请号：US17898069

申请日：2022-08-29

Applicant: Emergex Vaccines Holding Limited

Inventor： Ramila Philip

IPC: A61K39/12 ,  A61P31/12 ,  A61K39/00 ,  A61K9/51 ,  C07K14/18 ,  C12N15/113

Abstract: The invention provides a vaccine composition comprising a flavivirus peptide comprising one or more CD8+ T cell epitopes, wherein the peptide is attached to a nanoparticle.

公开(公告)号：US11273216B2

公开(公告)日：2022-03-15

申请号：US16475602

申请日：2018-01-03

Applicant: Emergex Vaccines Holding Limited

Inventor： Ramila Philip

IPC: A61K39/145 ,  A61P31/16 ,  A61K39/00

Abstract: The invention provides a vaccine composition comprising an influenza virus peptide comprising a CD8+ T cell epitope and an influenza virus peptide comprising a B cell epitope, wherein each peptide is attached to a nanoparticle.

公开(公告)号：US20210283237A1

公开(公告)日：2021-09-16

申请号：US16982036

申请日：2019-03-29

Applicant: Emergex Vaccines Holding Limited

Inventor： Laurens Rademacher ,  Thomas Rademacher ,  Ramila Philip

IPC: A61K39/12 ,  A61K47/69 ,  A61P31/14 ,  A61K9/16 ,  C12N7/00

Abstract: The invention provides a vaccine composition comprising a filovirus peptide comprising one or more CD8+ T cell epitopes, wherein the peptide is attached to a nanoparticle

公开(公告)号：US20240269264A1

公开(公告)日：2024-08-15

申请号：US18564886

申请日：2022-06-01

Applicant: EMERGEX VACCINES HOLDING LIMITED

Inventor： Thomas Rademacher ,  Xiaofang Huang

IPC: A61K39/215 ,  A61K39/00 ,  C07K14/005 ,  C12N7/00

CPC classification number: A61K39/215 ,  C07K14/005 ,  C12N7/00 ,  A61K2039/53 ,  A61K2039/55555 ,  C12N2770/20022 ,  C12N2770/20034

Abstract: The invention relates to common cold coronavirus peptides derived from HcoV-229E, and related polynucleotides, complexes pharmaceutical compositions, methods of treatment, and medical uses.

公开(公告)号：US11931407B2

公开(公告)日：2024-03-19

申请号：US17898069

申请日：2022-08-29

Applicant: Emergex Vaccines Holding Limited

Inventor： Ramila Philip

IPC: A61K39/12 ,  A61K9/51 ,  A61K39/00 ,  A61P31/12 ,  C07K14/18 ,  C12N15/113

CPC classification number: A61K39/12 ,  A61K9/5115 ,  A61K39/001129 ,  A61P31/12 ,  C07K14/1825 ,  C12N15/1131 ,  A61K2039/57 ,  A61K2039/605

Abstract: The invention provides a vaccine composition comprising a flavivirus peptide comprising one or more CD8+ T cell epitopes, wherein the peptide is attached to a nanoparticle.

公开(公告)号：US20210361760A1

公开(公告)日：2021-11-25

申请号：US16957931

申请日：2019-01-04

Applicant: Emergex Vaccines Holding Limited

Inventor： Ramila Philip

IPC: A61K39/12 ,  A61K47/69

Abstract: The invention provides a vaccine composition comprising a flavi peptide comprising one or more CD8+ T cell epitopes.

公开(公告)号：US20210299241A1

公开(公告)日：2021-09-30

申请号：US17054104

申请日：2019-05-20

Applicant: Emergex Vaccines Holding Limited

Inventor： Ramila Philip ,  Richard David Perrins ,  Xiaofang Huang ,  Thomas Rademacher ,  Christopher Upton

IPC: A61K39/145 ,  A61K39/12 ,  C07K14/005 ,  C12Q1/70 ,  A61P31/16

Abstract: The invention relates to vaccine compositions comprising peptides encoded by an open reading frame (ORF) encoded by at least part of the genome of a ssRNA virus in the opposite sense to positive sense RNA capable of translation, and the use of such compositions for the treatment and prevention of viral infection.