公开(公告)号：US20100204208A1

公开(公告)日：2010-08-12

申请号：US12691607

申请日：2010-01-21

申请人： Rajinder Singh ,  Hui Li ,  Haoran Zhao ,  Rao Kolluri ,  Kin Tso ,  John Ramphal ,  Shihai Gu ,  Carlos Valdez ,  Jing Zhang ,  Emily Stauffer ,  Matthew Duncton ,  Salvador Alvarez

发明人： Rajinder Singh ,  Hui Li ,  Haoran Zhao ,  Rao Kolluri ,  Kin Tso ,  John Ramphal ,  Shihai Gu ,  Carlos Valdez ,  Jing Zhang ,  Emily Stauffer ,  Matthew Duncton ,  Salvador Alvarez

IPC分类号： A61K31/55 ,  C07D401/14 ,  A61K31/496 ,  A61K31/506 ,  C07D413/14 ,  A61K31/5377 ,  C07D403/14 ,  A61P1/00 ,  A61P27/02 ,  A61P37/00 ,  A61P29/00 ,  A61P17/06 ,  A61P25/28 ,  C12Q1/48

CPC分类号： A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/55 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12

摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

公开(公告)号：US20060229294A1

公开(公告)日：2006-10-12

申请号：US11362553

申请日：2006-02-24

申请人： Hui Hong ,  Eileen Goldstein ,  Emily Stauffer ,  Dane Goff ,  Rao Kolluri ,  Ihab Darwish ,  Rajinder Singh ,  Henry Lu

发明人： Hui Hong ,  Eileen Goldstein ,  Emily Stauffer ,  Dane Goff ,  Rao Kolluri ,  Ihab Darwish ,  Rajinder Singh ,  Henry Lu

IPC分类号： C07D417/02 ,  C07D471/02 ,  C07D473/02 ,  A61K31/52 ,  A61K31/506 ,  A61K31/4745 ,  A61K31/4709 ,  A61K31/454 ,  A61K31/4439 ,  A61K31/42

CPC分类号： C07D275/04 ,  C07D417/12 ,  C07D513/04

摘要： The present invention relates to benzisothiazoles and pharmaceutical compositions thereof that inhibit replication and/or proliferation of HCV virus. The present invention also relates to the use of the benzisothiazoles and pharmaceutical compositions comprising the compounds to treat or prevent HCV infections.

摘要翻译： 本发明涉及抑制HCV病毒复制和/或增殖的苯并异噻唑及其药物组合物。 本发明还涉及包含该化合物的苯并异噻唑和药物组合物用于治疗或预防HCV感染的用途。

公开(公告)号：US08377924B2

公开(公告)日：2013-02-19

申请号：US12691607

申请日：2010-01-21

申请人： Rajinder Singh ,  Huí Li ,  Haoran Zhao ,  Rao Kolluri ,  Kin Tso ,  John Ramphal ,  Shihai Gu ,  Carlos Valdez ,  Jing Zhang ,  Emily Stauffer ,  Matthew Duncton ,  Salvador Alvarez

发明人： Rajinder Singh ,  Huí Li ,  Haoran Zhao ,  Rao Kolluri ,  Kin Tso ,  John Ramphal ,  Shihai Gu ,  Carlos Valdez ,  Jing Zhang ,  Emily Stauffer ,  Matthew Duncton ,  Salvador Alvarez

IPC分类号： A61K31/55 ,  A61K31/497 ,  A61K31/535 ,  A61K31/505 ,  C07D403/10 ,  C07D413/12 ,  C07D401/12

CPC分类号： A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/55 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12

摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

公开(公告)号：US07776847B2

公开(公告)日：2010-08-17

申请号：US11362553

申请日：2006-02-24

申请人： Hui Hong ,  Eileen Goldstein ,  Emily Stauffer ,  Dane Goff ,  Rao Kolluri ,  Ihab Darwish ,  Rajinder Singh ,  Henry Lu

发明人： Hui Hong ,  Eileen Goldstein ,  Emily Stauffer ,  Dane Goff ,  Rao Kolluri ,  Ihab Darwish ,  Rajinder Singh ,  Henry Lu

IPC分类号： A61K31/33

CPC分类号： C07D275/04 ,  C07D417/12 ,  C07D513/04

摘要： The present invention relates to benzisothiazoles and pharmaceutical compositions thereof that inhibit replication and/or proliferation of HCV virus. The present invention also relates to the use of the benzisothiazoles and pharmaceutical compositions comprising the compounds to treat or prevent HCV infections.

摘要翻译： 本发明涉及抑制HCV病毒复制和/或增殖的苯并异噻唑及其药物组合物。 本发明还涉及包含该化合物的苯并异噻唑和药物组合物用于治疗或预防HCV感染的用途。