公开(公告)号：US20100204208A1

公开(公告)日：2010-08-12

申请号：US12691607

申请日：2010-01-21

申请人： Rajinder Singh ,  Hui Li ,  Haoran Zhao ,  Rao Kolluri ,  Kin Tso ,  John Ramphal ,  Shihai Gu ,  Carlos Valdez ,  Jing Zhang ,  Emily Stauffer ,  Matthew Duncton ,  Salvador Alvarez

发明人： Rajinder Singh ,  Hui Li ,  Haoran Zhao ,  Rao Kolluri ,  Kin Tso ,  John Ramphal ,  Shihai Gu ,  Carlos Valdez ,  Jing Zhang ,  Emily Stauffer ,  Matthew Duncton ,  Salvador Alvarez

IPC分类号： A61K31/55 ,  C07D401/14 ,  A61K31/496 ,  A61K31/506 ,  C07D413/14 ,  A61K31/5377 ,  C07D403/14 ,  A61P1/00 ,  A61P27/02 ,  A61P37/00 ,  A61P29/00 ,  A61P17/06 ,  A61P25/28 ,  C12Q1/48

CPC分类号： A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/55 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12

摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

公开(公告)号：US08377924B2

公开(公告)日：2013-02-19

申请号：US12691607

申请日：2010-01-21

申请人： Rajinder Singh ,  Huí Li ,  Haoran Zhao ,  Rao Kolluri ,  Kin Tso ,  John Ramphal ,  Shihai Gu ,  Carlos Valdez ,  Jing Zhang ,  Emily Stauffer ,  Matthew Duncton ,  Salvador Alvarez

发明人： Rajinder Singh ,  Huí Li ,  Haoran Zhao ,  Rao Kolluri ,  Kin Tso ,  John Ramphal ,  Shihai Gu ,  Carlos Valdez ,  Jing Zhang ,  Emily Stauffer ,  Matthew Duncton ,  Salvador Alvarez

IPC分类号： A61K31/55 ,  A61K31/497 ,  A61K31/535 ,  A61K31/505 ,  C07D403/10 ,  C07D413/12 ,  C07D401/12

CPC分类号： A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/55 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12

摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

公开(公告)号：US20100130486A1

公开(公告)日：2010-05-27

申请号：US12175441

申请日：2008-07-17

申请人： Rajinder Singh ,  Hui Li ,  Haoran Zhao ,  Donald Payan ,  Rao Kolluri ,  Kin Tso ,  John Ramphal ,  Shihai Gu

发明人： Rajinder Singh ,  Hui Li ,  Haoran Zhao ,  Donald Payan ,  Rao Kolluri ,  Kin Tso ,  John Ramphal ,  Shihai Gu

IPC分类号： A61K31/5383 ,  C07D401/14 ,  C07D403/14 ,  C07D265/38 ,  C07D413/14 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61P35/00

CPC分类号： C07D401/12 ,  C07D239/48 ,  C07D401/14 ,  C07D407/14 ,  C07D413/14 ,  C07D417/14 ,  C07D498/04

摘要： The invention encompasses compounds having formula I or II and the compositions and methods using these compounds in the treatment of conditions in which inhibition of PKC and PKD is therapeutically useful.

摘要翻译： 本发明包括具有式I或II的化合物以及使用这些化合物治疗PKC和PKD的抑制在治疗上有用的条件的组合物和方法。

公开(公告)号：US08993585B2

公开(公告)日：2015-03-31

申请号：US12175441

申请日：2008-07-17

申请人： Rajinder Singh ,  Hui Li ,  Haoran Zhao ,  Donald Payan ,  Rao Kolluri ,  Kin Tso ,  John Ramphal ,  Shihai Gu

发明人： Rajinder Singh ,  Hui Li ,  Haoran Zhao ,  Donald Payan ,  Rao Kolluri ,  Kin Tso ,  John Ramphal ,  Shihai Gu

IPC分类号： C07D401/12 ,  C07D239/48 ,  C07D401/14 ,  C07D407/14 ,  C07D413/14 ,  C07D417/14 ,  C07D498/04

CPC分类号： C07D401/12 ,  C07D239/48 ,  C07D401/14 ,  C07D407/14 ,  C07D413/14 ,  C07D417/14 ,  C07D498/04

摘要： The invention encompasses compounds having formula I or II and the compositions and methods using these compounds in the treatment of conditions in which inhibition of PKC and PKD is therapeutically useful.

摘要翻译： 本发明包括具有式I或II的化合物以及使用这些化合物治疗PKC和PKD的抑制在治疗上有用的条件的组合物和方法。