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    Method of diagnosis, treatment and useful agents for conditions characterised by modulation in the level of activin ssc
    1.
    发明申请
    Method of diagnosis, treatment and useful agents for conditions characterised by modulation in the level of activin ssc 审中-公开
    用于以激活素水平调节为特征的病症的诊断，治疗和有用药剂的方法

    公开(公告)号：US20060172347A1

    公开(公告)日：2006-08-03

    申请号：US10538431

    申请日：2003-12-12

    申请人： Sally Mellor ,  Gail Risbridger ,  Emma Ball ,  Hong Wang ,  Catriona McClean ,  John Pedersen ,  Anne O'Connor ,  Mark Cranfield ,  Nigel Groome

    发明人： Sally Mellor ,  Gail Risbridger ,  Emma Ball ,  Hong Wang ,  Catriona McClean ,  John Pedersen ,  Anne O'Connor ,  Mark Cranfield ,  Nigel Groome

    IPC分类号： G01N33/574

    CPC分类号： G01N33/74 ,  C07K16/22 ,  G01N33/574

    摘要： The present invention relates generally to a method of diagnosing, predicting or monitoring the development or progress of a condition characterised by modulation in the level of activin expression and, more particularly, a method of diagnosing, predicting or monitoring the development or progress of a condition characterised by modulation in the level of expression of activin bc subunit. The present invention still further provides methods for the therapeutic or prophylactic treatment of conditions characterised by aberrant, unwanted or otherwise inappropriate activin expression, for example, conditions characterised by over-expression or underexpression of activin and most particularly, conditions characterised by overexpression or underexpression of activin bc subunit. A further aspect of the present invention extends to agents for use in the methods of the present invention.

    摘要翻译： 本发明一般涉及诊断，预测或监测以激活素表达水平调节为特征的疾病的发展或进展的方法，更具体地，涉及诊断，预测或监测病症发展或进展的方法 其特征在于激活素bc亚基的表达水平的调节。 本发明还进一步提供了用于治疗或预防性治疗以异常，不想要的或不适当的激活素表达为特征的病症的方法，例如以激活素过度表达或低表达为特征的病症，特别是以过表达或低表达为特征的病症 激活素bc亚基。 本发明的另一方面扩展到用于本发明方法的试剂。

    Method For Monitoring The Progress Of Cancer
    2.
    发明申请
    Method For Monitoring The Progress Of Cancer 审中-公开
    监测癌症进展的方法

    公开(公告)号：US20080038729A1

    公开(公告)日：2008-02-14

    申请号：US11578711

    申请日：2005-04-15

    申请人： Gail Risbridger ,  Sally Mellor ,  Emma Ball ,  Hong Wang ,  John Pedersen ,  Catriona McLean

    发明人： Gail Risbridger ,  Sally Mellor ,  Emma Ball ,  Hong Wang ,  John Pedersen ,  Catriona McLean

    IPC分类号： C12Q1/68 ,  G01N33/574 ,  G01N33/68 ,  G01N33/74

    CPC分类号： G01N33/57434 ,  C12Q1/6886 ,  C12Q2600/112 ,  G01N33/74 ,  G01N2333/475

    摘要： The present invention relates generally to a method of diagnosing, predicting or monitoring the development or progress of a cancer and, in particular, to a method of diagnosing, predicting or monitoring the development of or progress of prostate cancer in a mammal. The present invention more specifically provides a method for delineating early stage and advanced stage cancers, or predispositions thereto, by screening for changes in the level of two or more of inhibin-α, activin-βA, activin-βB, activin-βC, activin-βD, activin-βE or follistatin expression in a mammal. The present invention further provides a method for diagnosing or monitoring conditions associated with or characterized by the onset of a cancer.

    摘要翻译： 本发明一般涉及一种诊断，预测或监测癌症的发展或进展的方法，尤其涉及诊断，预测或监测哺乳动物前列腺癌发展或进展的方法。 本发明更具体地提供了通过筛选两种或更多种抑制素-α，激活素βA激活素水平的变化来描述早期阶段和晚期阶段癌症或其倾向的方法 β-激活素β1，活化素β-β，活化素β-β，活化素-βE，或活化素-β 哺乳动物 本发明还提供了用于诊断或监测与癌症发作相关或特征在于癌症发病的病症的方法。

    Method and apparatus for copper plating using electroless plating and electroplating
    3.
    发明申请
    Method and apparatus for copper plating using electroless plating and electroplating 审中-公开
    使用化学镀和电镀的镀铜方法和设备

    公开(公告)号：US20050189213A1

    公开(公告)日：2005-09-01

    申请号：US11085908

    申请日：2005-03-21

    申请人： Daniel Woodruff ,  Kyle Hanson ,  Thomas Oberlitner ,  LinLin Chen ,  John Pedersen ,  Vladimir Zila

    发明人： Daniel Woodruff ,  Kyle Hanson ,  Thomas Oberlitner ,  LinLin Chen ,  John Pedersen ,  Vladimir Zila

    IPC分类号： C23C18/16 ,  A61K35/12 ,  C23C28/00 ,  C25D5/08 ,  C25D7/12 ,  C25D17/06 ,  H01L21/288 ,  C25D17/04

    CPC分类号： H01L21/2885 ,  A61K35/12 ,  C12N2500/25 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/40 ,  C12N2501/11 ,  C12N2501/39 ,  C12N2501/395 ,  C12N2506/22 ,  C25D5/08 ,  C25D7/123 ,  C25D17/001 ,  C25D17/06

    摘要： A reactor for plating a metal onto a surface of a workpiece is set forth. The reactor comprises a reactor bowl including an electroplating solution disposed therein and an anode disposed in the reactor bowl in contact with the electroplating solution. A contact assembly is spaced from the anode within the reactor bowl. The contact assembly includes a plurality of contacts disposed to contact a peripheral edge of the surface of the workpiece to provide electroplating power to the surface of the workpiece. The contacts execute a wiping action against the surface of the workpiece as the workpiece is brought into engagement therewith The contact assembly also including a barrier disposed interior of the plurality of contacts. The barrier includes a member disposed to engage the surface of the workpiece to assist in isolating the plurality of contacts from the electroplating solution. In one embodiment, the plurality of contacts are in the form of discrete flexures while in another embodiment the plurality of contacts are in the form of a Belleville ring contact. A flow path may be provided in the contact assembly for providing a purging gas to the plurality of contacts and the peripheral edge of the workpiece. The purging gas may be used to assist in the formation of the barrier of the contact assembly. A combined electroplating/electroless plating tool and method are also set forth.

    摘要翻译： 阐述了将金属镀在工件表面上的反应器。 反应器包括反应器碗，其包括设置在其中的电镀溶液和设置在与电镀溶液接触的反应器碗中的阳极。 接触组件与反应器碗内的阳极间隔开。 接触组件包括多个触点，其设置成接触工件表面的周边边缘以向工件的表面提供电镀功率。 当工件与其接合时，触头在工件的表面上执行擦拭动作。触头组件还包括设置在多个触点内部的屏障。 阻挡层包括设置成接合工件的表面以帮助将多个触点与电镀溶液隔离的构件。 在一个实施例中，多个触点是离散弯曲的形式，而在另一个实施例中，多个触点是贝尔维尔环接触的形式。 可以在接触组件中设置流路，以向多个触点和工件的周边边缘提供净化气体。 吹扫气体可用于帮助形成接触组件的屏障。 还提出了组合电镀/无电镀工具和方法。

    Microelectronic workpiece holders and contact assemblies for use therewith
    4.
    发明申请
    Microelectronic workpiece holders and contact assemblies for use therewith 有权
    微电子工件保持器和与其一起使用的接触组件

    公开(公告)号：US20060226000A1

    公开(公告)日：2006-10-12

    申请号：US11248667

    申请日：2005-10-12

    申请人： Kyle Hanson ,  Jurek Koziol ,  John Pedersen ,  Michal Zmaj

    发明人： Kyle Hanson ,  Jurek Koziol ,  John Pedersen ,  Michal Zmaj

    IPC分类号： C25B9/00 ,  C25D17/00

    CPC分类号： C25D17/001 ,  C25D17/005 ,  C25D17/06

    摘要： The invention provides an improved contact ring and an improved workpiece support, each of which is useful alone or jointly with the other in a workpiece holder for electrochemically treating microelectronic workpieces. Several embodiments of the invention provide a composite contact ring having a dielectric base carrying a conductor which delivers electric power to a microelectronic workpiece. The dielectric base may be rigid and define a plurality of rigid fingers, each of which carries a separate electrical contact of the conductor. Such a contact ring is expected to have a long service life and enhance uniformity of electrochemical treatment. Several embodiments of the invention provide a workpiece support which induces a control the flexure of a microelectronic workpiece without damaging the workpiece. This controlled flexure can ensure more uniform contact between the workpiece and a contact assembly despite variations in the workpiece and/or the contact assembly.

    摘要翻译： 本发明提供了一种改进的接触环和改进的工件支撑件，每个支承件在工件保持器中单独使用或与另一个共同使用，用于电化学处理微电子工件。 本发明的几个实施例提供一种复合接触环，其具有承载向微电子工件传递电力的导体的电介质基底。 电介质基底可以是刚性的，并且限定多个刚性指状物，每个刚性指状物携带导体的单独电接触。 预期这种接触环具有长的使用寿命并增强电化学处理的均匀性。 本发明的几个实施例提供了一种工件支撑件，其引导控制微电子工件的弯曲而不损坏工件。 尽管工件和/或接触组件有变化，但这种受控弯曲可以确保工件和接触组件之间更均匀的接触。

    Amino-terminally extended human growth hormone (HGH)
    6.
    发明授权
    Amino-terminally extended human growth hormone (HGH) 失效
    氨基末端延长的人生长激素（HGH）

    公开(公告)号：US5635604A

    公开(公告)日：1997-06-03

    申请号：US450094

    申请日：1995-05-25

    申请人： Henrik Dalb.o slashed.ge ,  John Pedersen ,  Thorkild Christensen ,  J.o slashed.rli W. Ringsted ,  Torben E. Jessen

    发明人： Henrik Dalb.o slashed.ge ,  John Pedersen ,  Thorkild Christensen ,  J.o slashed.rli W. Ringsted ,  Torben E. Jessen

    IPC分类号： C07K14/545 ,  C07K14/61 ,  C12N9/22 ,  C12N9/36 ,  C12N15/62 ,  C12P21/06

    CPC分类号： C12N9/2462 ,  C07K14/545 ,  C07K14/61 ,  C12N15/62 ,  C12N9/22 ,  C12P21/06 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/50 ,  C07K2319/75

    摘要： A desired protein having the formula:A-B-C-P,wherein (a) A is Lys or Arg, and B and C are arbitrary amino acids, or (b) A is an arbitrary amino acid different from Pro, Lys, and Arg, and B and/or C is Pro is produced from a biosynthetically formed amino-terminally extended protein having the formula:X-A-B-C-P,wherein A, B, C are defined above, and X is an amino acid sequence with an even number of amino acids, of which the first amino acid, seen from the N-terminal end, is different from Lys and Arg, all other am/no acids are different from Pro, Lys and Arg, and all even amino acids are different from Pro, by reaction with the enzyme dipeptidyl aminopeptidase (DAP I). The desired protein is obtained in a pure state. Specifically, P is human growth hormone (hGH). Thus, compositions of hGH may be produced without the presence of Met-hGH.

    摘要翻译： 具有下式的所需蛋白质：ABCP，其中（a）A是Lys或Arg，B和C是任意氨基酸，或（b）A是不同于Pro，Lys和Arg的任意氨基酸，B和 /或C是Pro由具有下式的生物合成形成的氨基末端延伸蛋白产生：XABCP，其中A，B，C如上定义，X​​是具有偶数氨基酸的氨基酸序列，其中 从N-末端观察到的第一个氨基酸不同于Lys和Arg，所有其他am / no酸都不同于Pro，Lys和Arg，并且所有甚至氨基酸与Pro不同，通过与酶二肽基 氨基肽酶（DAP I）。 在纯状态下获得所需的蛋白质。 具体来说，P是人生长激素（hGH）。 因此，可以在不存在Met-hGH的情况下生产hGH的组合物。

    Tissue Bath System With Air Heating
    7.
    发明申请
    Tissue Bath System With Air Heating 审中-公开
    组织浴系统与空气加热

    公开(公告)号：US20080145921A1

    公开(公告)日：2008-06-19

    申请号：US10573876

    申请日：2003-09-29

    申请人： John Pedersen

    发明人： John Pedersen

    IPC分类号： C12M1/36 ,  C12M1/38

    CPC分类号： C12M45/22

    摘要： A tissue bath system with containers and sample holders for holding tissue sample inside tissue medium in the containers, where each sample holder is connected to a force transducer for measuring force exerted on the holder by contraction of the tissue sample upon stimulation. The system further comprises a temperature regulation system for regulating the temperature of the tissue medium in the sample container. The system comprises a container station with chambers for placement of at sample containers in the chambers, wherein the temperature regulation system has means for providing a temperature regulated air stream into the chambers for regulation of the temperature in the container.

    摘要翻译： 一种具有容器和样品保持器的组织浴系统，用于将组织样本保持在容器中的组织介质内，其中每个样品保持器连接到力传感器，用于通过刺激时组织样品的收缩来测量施加在保持器上的力。 该系统还包括用于调节样品容器中的组织介质的温度的温度调节系统。 该系统包括具有用于将样品容器放置在室中的室的容器站，其中温度调节系统具有用于向室内提供温度调节的空气流以调节容器中的温度的装置。