公开(公告)号：US20070059771A1

公开(公告)日：2007-03-15

申请号：US11595319

申请日：2006-11-09

Applicant: Alma Burlingame ,  Katalin Medzihradszky ,  Zsuzsanna Darula ,  Eran Perlson ,  Michael Fainzilber ,  Robert Chalkley ,  Darren Tyson ,  Ralph Bradshaw

Inventor： Alma Burlingame ,  Katalin Medzihradszky ,  Zsuzsanna Darula ,  Eran Perlson ,  Michael Fainzilber ,  Robert Chalkley ,  Darren Tyson ,  Ralph Bradshaw

IPC: G01N33/53 ,  C07K16/18

CPC classification number: G01N33/6842 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/622 ,  G01N33/6803

Abstract: Post-translational O-sulfonation of a serine or threonine residue of proteins is detected, optionally comparatively, wherein the detected O-sulfonation is detected under a first physiological condition, and is compared with a control O-sulfonation detected under a second physiological condition, and a difference between the detected and control O-sulfonations indicates a difference between the first and second physiological conditions. Predetermined changes in physiological conditions are used to infer specific changes in O-sulfonation. Proteins are modified by introducing a predetermined change in O-sulfonation at a serine or threonine residue of the protein, and optionally, detecting a resultant change in O-sulfonation. These methods include introducing or increasing O-sulfonation, eliminating or reducing O-sulfonation; and derivatizing or substituting O-sulfonation.

Abstract translation: 检测蛋白质丝氨酸或苏氨酸残基的翻译后O-磺化，任选比较，其中在第一生理条件下检测到检测到的O-磺化，并与在第二生理条件下检测到的对照O-磺化进行比较， 并且检测到和控制的O-磺化物之间的差异表示第一和第二生理条件之间的差异。 使用生理条件的预定变化来推测O-磺化的具体变化。 通过在蛋白质的丝氨酸或苏氨酸残基处引入O-磺化的预定变化，并任选地检测所得到的O-磺化变化来修饰蛋白质。 这些方法包括引入或增加O-磺化，消除或减少O-磺化; 并衍生化或取代O-磺化。

公开(公告)号：US07741021B2

公开(公告)日：2010-06-22

申请号：US11595319

申请日：2006-11-09

Applicant: Alma L. Burlingame ,  Katalin F. Medzihradszky ,  Zsuzsanna Darula ,  Eran Perlson ,  Michael Fainzilber ,  Robert J. Chalkley ,  Darren Tyson ,  Ralph A. Bradshaw

Inventor： Alma L. Burlingame ,  Katalin F. Medzihradszky ,  Zsuzsanna Darula ,  Eran Perlson ,  Michael Fainzilber ,  Robert J. Chalkley ,  Darren Tyson ,  Ralph A. Bradshaw

IPC: C12Q1/00 ,  C12Q1/48 ,  C12Q1/37

CPC classification number: G01N33/6842 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/622 ,  G01N33/6803

Abstract: Post-translational O-sulfonation of a serine or threonine residue of proteins is detected, optionally comparatively, wherein the detected O-sulfonation is detected under a first physiological condition, and is compared with a control O-sulfonation detected under a second physiological condition, and a difference between the detected and control O-sulfonations indicates a difference between the first and second physiological conditions.Predetermined changes in physiological conditions are used to infer specific changes in O-sulfonation. Proteins are modified by introducing a predetermined change in O-sulfonation at a serine or threonine residue of the protein, and optionally, detecting a resultant change in O-sulfonation. These methods include introducing or increasing O-sulfonation, eliminating or reducing O-sulfonation; and derivatizing or substituting O-sulfonation.

Abstract translation: 检测蛋白质丝氨酸或苏氨酸残基的翻译后O-磺化，任选比较，其中在第一生理条件下检测到检测到的O-磺化，并与在第二生理条件下检测到的对照O-磺化进行比较， 并且检测到和控制的O-磺化物之间的差异表示第一和第二生理条件之间的差异。 使用生理条件的预定变化来推测O-磺化的具体变化。 通过在蛋白质的丝氨酸或苏氨酸残基处引入O-磺化的预定变化，并任选地检测所得到的O-磺化变化来修饰蛋白质。 这些方法包括引入或增加O-磺化，消除或减少O-磺化; 并衍生化或取代O-磺化。

公开(公告)号：US20060239988A1

公开(公告)日：2006-10-26

申请号：US10559871

申请日：2004-06-09

Applicant: Michael Fainzilber ,  Shlomit Hanz ,  Eran Perlson

Inventor： Michael Fainzilber ,  Shlomit Hanz ,  Eran Perlson

IPC: A61K38/48 ,  C07H21/04 ,  C12P21/06 ,  C12N5/08 ,  C07K14/705

CPC classification number: A61K38/45 ,  A61K38/1709 ,  C12N5/0619 ,  C12N2501/998 ,  C12N2510/00

Abstract: A method of modulating growth of an axon is disclosed. The method comprises regulating importin mediated retrograde transport in the axon.

Abstract translation: 公开了调节轴突生长的方法。 该方法包括调节导管素介导的轴突逆行转运。

公开(公告)号：US20050054020A1

公开(公告)日：2005-03-10

申请号：US10657027

申请日：2003-09-05

Applicant: Alma Burlingame ,  Katalin Medzihradszky ,  Zsuzsanna Darula ,  Eran Perlson ,  Michael Fainzilber ,  Robert Chalkley ,  Darren Tyson ,  Ralph Bradshaw

Inventor： Alma Burlingame ,  Katalin Medzihradszky ,  Zsuzsanna Darula ,  Eran Perlson ,  Michael Fainzilber ,  Robert Chalkley ,  Darren Tyson ,  Ralph Bradshaw

IPC: C07K16/44 ,  C12N20060101 ,  G01N33/53 ,  G01N33/537 ,  G01N33/543 ,  G01N33/68

CPC classification number: G01N33/6842 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/622 ,  G01N33/6803

Abstract: Post-translational O-sulfonation of a serine or threonine residue of proteins is detected, optionally comparatively, wherein the detected O-sulfonation is detected under a first physiological condition, and is compared with a control O-sulfonation detected under a second physiological condition, and a difference between the detected and control O-sulfonations indicates a difference between the first and second physiological conditions. Predetermined changes in physiological conditions are used to infer specific changes in O-sulfonation. Proteins are modified by introducing a predetermined change in O-sulfonation at a serine or threonine residue of the protein, and optionally, detecting a resultant change in O-sulfonation. These methods include introducing or increasing O-sulfonation, eliminating or reducing O-sulfonation; and derivatizing or substituting O-sulfonation.

Abstract translation: 检测蛋白质丝氨酸或苏氨酸残基的翻译后O-磺化，任选比较，其中在第一生理条件下检测到检测到的O-磺化，并与在第二生理条件下检测到的对照O-磺化进行比较， 并且检测到和控制的O-磺化物之间的差异表示第一和第二生理条件之间的差异。 使用生理条件的预定变化来推测O-磺化的具体变化。 通过在蛋白质的丝氨酸或苏氨酸残基处引入O-磺化的预定变化，并任选地检测所得到的O-磺化变化来修饰蛋白质。 这些方法包括引入或增加O-磺化，消除或减少O-磺化; 并衍生化或取代O-磺化。

公开(公告)号：US07138228B2

公开(公告)日：2006-11-21

申请号：US10657027

申请日：2003-09-05

Applicant: Alma L. Burlingame ,  Katalin F. Medzihradszky ,  Zsuzsanna Darula ,  Eran Perlson ,  Michael Fainzilber ,  Robert J. Chalkley ,  Darren Tyson ,  Ralph A. Bradshaw

Inventor： Alma L. Burlingame ,  Katalin F. Medzihradszky ,  Zsuzsanna Darula ,  Eran Perlson ,  Michael Fainzilber ,  Robert J. Chalkley ,  Darren Tyson ,  Ralph A. Bradshaw

IPC: C12Q1/00 ,  C12Q1/48 ,  C12Q1/44 ,  C12P21/04 ,  G01N33/53

CPC classification number: G01N33/6842 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/622 ,  G01N33/6803

Abstract: Post-translational O-sulfonation of a serine or threonine residue of proteins is detected, optionally comparatively, wherein the detected O-sulfonation is detected under a first physiological condition, and is compared with a control O-sulfonation detected under a second physiological condition, and a difference between the detected and control O-sulfonations indicates a difference between the first and second physiological conditions. Predetermined changes in physiological conditions are used to infer specific changes in O-sulfonation. Proteins are modified by introducing a predetermined change in O-sulfonation at a serine or threonine residue of the protein, and optionally, detecting a resultant change in O-sulfonation. These methods include introducing or increasing O-sulfonation, eliminating or reducing O-sulfonation; and derivatizing or substituting O-sulfonation.

Abstract translation: 检测蛋白质丝氨酸或苏氨酸残基的翻译后O-磺化，任选比较，其中在第一生理条件下检测到检测到的O-磺化，并与在第二生理条件下检测到的对照O-磺化进行比较， 并且检测到和控制的O-磺化物之间的差异表示第一和第二生理条件之间的差异。 使用生理条件的预定变化来推测O-磺化的具体变化。 通过在蛋白质的丝氨酸或苏氨酸残基处引入O-磺化的预定变化，并任选地检测所得到的O-磺化变化来修饰蛋白质。 这些方法包括引入或增加O-磺化，消除或降低O-磺化; 并衍生化或取代O-磺化。