公开(公告)号：US20170226192A1

公开(公告)日：2017-08-10

申请号：US15120246

申请日：2015-02-19

Applicant: Jody BERRY ,  Erica SAPHIRE

Inventor： Jody BERRY ,  Erica SAPHIRE

IPC: C07K16/10 ,  G01N33/569

CPC classification number: C07K16/10 ,  A61K39/08 ,  A61K39/12 ,  A61K39/42 ,  A61K2039/505 ,  A61K2039/575 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/76 ,  C12N7/00 ,  C12N2760/14122 ,  C12N2760/14134 ,  C12N2760/14222 ,  C12N2760/14234 ,  G01N33/56983 ,  G01N2333/08 ,  G01N2469/10

Abstract: The present invention relates to monoclonal antibodies and antigen-binding portions thereof that specifically bind to a filovirus (e.g., Marburg virus (MARV)), including antibodies that cross-react with at least two filoviruses. Such antibodies are useful for the prevention and treatment of filovirus infection. The invention also provides pharmaceutical compositions comprising the MARV-binding antibodies, nucleic acid molecules encoding these polypeptides and methods of making these molecules.