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5 条记录 (耗时 0.023 秒)

    Use of substituted 3,4-dihydro-2H-benzopyrans as remedies for obstructive functional disorders of the lungs
    1.
    发明授权
    Use of substituted 3,4-dihydro-2H-benzopyrans as remedies for obstructive functional disorders of the lungs 失效
    使用取代的3,4-二氢-2H-苯并吡喃作为肺部阻塞性功能障碍的补救措施

    公开(公告)号：US5364878A

    公开(公告)日：1994-11-15

    申请号：US4648

    申请日：1993-01-14

    申请人： Heinrich C. Englert ,  Erik Klaus ,  Dieter Mania ,  Bernward Scholkens

    发明人： Heinrich C. Englert ,  Erik Klaus ,  Dieter Mania ,  Bernward Scholkens

    IPC分类号： A61K31/40 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/445 ,  A61K31/495 ,  A61K31/505 ,  A61K31/535 ,  A61K31/55

    CPC分类号： A61K31/42 ,  A61K31/40 ,  A61K31/425 ,  A61K31/44 ,  A61K31/445 ,  A61K31/495 ,  A61K31/505 ,  A61K31/535 ,  Y10S514/826

    摘要： The use of substituted 3,4-dihydro-2H-benzopyrans as remedies for obstructive functional disorders of the lungs and/or disorders of the efferent urinary passagesThe use of 3,4-dihydro-2H-benzo[b]pyrans of the formula I ##STR1## in which R.sup.1 represents H, OH, (C.sub.1 -C.sub.2)-alkoxy, (C.sub.1 -C.sub.2)-alkyl or NR.sup.4 R.sup.5, where R.sup.4 and R.sup.5 are identical or different and represent H, (C.sub.1 -C.sub.2)-alkyl or (C.sub.1 -C.sub.3)-alkyl-carbonyl,R.sup.2 and R.sup.3 are identical or different and represent alkyl having 1-4 carbon atoms,Ar represents an aromatic or heteroaromatic system which is unsubstituted or substituted by 1 to 3 identical or different radicals (C.sub.1 -C.sub.2)-alkyl, (C.sub.1 -C.sub.2)-alkoxy, halogen, trifluoromethyl, CN, NO.sub.2, CO--(C.sub.1 -C.sub.2)-alkyl or SO.sub.m --(C.sub.1 -C.sub.2)-alkyl with m=1 or 2,n represents 1 or 2,X represents a chain (CH.sub.2).sub.r which can be interrupted by a heteroatom O, S or NR.sup.6, where R.sup.6 denotes H or (C.sub.1 -C.sub.4)-alkyl, and r represents the numbers 2, 3, 4 or 5,for the preparation of a remedy for obstructive functional disorders of the lungs and/or disorders of the efferent urinary passages, is described.

    摘要翻译： 使用取代的3,4-二氢-2H-苯并吡喃作为肺部阻塞性功能障碍的补救措施和/或传出的尿道的障碍使用式（I）的3,4-二氢-2H-苯并[b]吡喃 其中R 1表示H，OH，（C 1 -C 2） - 烷氧基，（C 1 -C 2） - 烷基或NR 4 R 5，其中R 4和R 5相同或不同并且表示H，（C 1 -C 2） - 烷基 或（C 1 -C 3） - 烷基 - 羰基，R 2和R 3相同或不同并且表示具有1-4个碳原子的烷基，Ar表示未被取代或被1至3个相同或不同基团取代的芳族或杂芳族体系 （C 1 -C 2） - 烷基，（C 1 -C 2） - 烷氧基，卤素，三氟甲基，CN，NO 2，CO-（C 1 -C 2） - 烷基或SO m-（C 1 -C 2） - 烷基，m = 1或2，X表示可以被杂原子O，S或NR6中断的链（CH 2）r，其中R 6表示H或（C 1 -C 4） - 烷基，r表示数2，3，4或5 ，用于制备肺部阻塞性功能障碍的补救措施 描述了传出尿道的d /或紊乱。

    Arylcarbonylaminoalkyl-dihydro-oxo-pyridines, their production and their use
    2.
    发明授权
    Arylcarbonylaminoalkyl-dihydro-oxo-pyridines, their production and their use 失效
    芳基羰基氨基烷基 - 二氢 - 氧代 - 吡啶，其生产及其用途

    公开(公告)号：US5360808A

    公开(公告)日：1994-11-01

    申请号：US19296

    申请日：1993-02-18

    申请人： Heinrich Englert ,  Dieter Mania ,  David Wettlaufer ,  Erik Klaus

    发明人： Heinrich Englert ,  Dieter Mania ,  David Wettlaufer ,  Erik Klaus

    IPC分类号： A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4425 ,  A61P9/00 ,  A61P21/00 ,  C07D213/64 ,  C07D213/79 ,  C07D213/80 ,  C07D213/81 ,  C07D213/89 ,  C07D401/12

    CPC分类号： C07D213/80 ,  C07D213/81 ,  C07D401/12

    摘要： Arylcarbonylaminoalkyl-dihydro-oxo-pyridines of Formula I ##STR1## are disclosed wherein aryl is an aromatic or heteroaromatic system, n is zero through 5; R and R(1), are hydrogen, or loweralkyl; W is hydrogen, (hetero)-(aryl)-loweralkyl; Z is hydrogen, CH.sub.2 OR(2.sub.), CHO, (CO)OR(2), (CO)NR(2).sub.2.Processes for the preparation of compound I are also disclosed.Compounds I are suitable for the treatment of disorders of the cardiovascular system, for example of hypertension, of cardiac insufficiency or of disturbances of blood flow in the coronary systems such as, for example, angina. Disturbances of cerebral and peripheral blood flow are likewise influenced beneficially. Furthermore, compounds I are able to influence smooth-muscle organs such as uterus, bronchi, intestines and biliary system, the urinary tract (ureter, bladder and urethra) in the sense of spasmolysis. They are therefore also suitable for the treatment of diseases associated with spasms of these organs, for example for the treatment of premature labor in pregnancy, of ureteral or biliary colic, of obstructive airway diseases such as asthma, of disturbances of intestinal motility such as, for example, of irritable colon or of bladder incontinence. Additionally, compounds of formula 1 can serve as anticonvulsants in the treatment of epilepsy.

    摘要翻译： 公开了式I的芳基羰基氨基烷基 - 二氢 - 氧代 - 吡啶，其中芳基是芳族或杂芳族体系，n为0至5; R和R（1）是氢或低级烷基; W是氢，（杂） - （芳基） - 低级烷基; Z是氢，CH2OR（2），CHO，（CO）OR（2），（CO）NR（2）2。 还公开了制备化合物I的方法。 化合物I适用于治疗冠状动脉系统（例如心绞痛）的心脏功能不全或血液流动紊乱的心血管系统疾病，例如高血压。 脑和周围血流紊乱同样受到有利影响。 此外，化合物I能够影响平滑肌器官如子宫，支气管，肠和胆汁系统，尿道（输尿管，膀胱和尿道）在解剖意义上。 因此，它们也适用于治疗与这些器官的痉挛有关的疾病，例如用于治疗怀孕期间的输尿管或胆道绞痛，阻塞性气道疾病如哮喘，肠蠕动紊乱， 例如，肠易激综合症或膀胱失禁。 此外，式1的化合物可用作治疗癫痫的抗惊厥药。

    2,3,4,5-tetrahydro-1-benzoxepins, the use thereof and pharmaceutical products based on these compounds
    3.
    发明授权
    2,3,4,5-tetrahydro-1-benzoxepins, the use thereof and pharmaceutical products based on these compounds 失效
    2,3,4,5-四氢-1-苯并氧杂基，其用途和基于这些化合物的药物产品

    公开(公告)号：US5194442A

    公开(公告)日：1993-03-16

    申请号：US606132

    申请日：1990-10-31

    申请人： Roland Utz ,  Heinrich C. Englert ,  Bernward Scholkens ,  Erik Klaus

    发明人： Roland Utz ,  Heinrich C. Englert ,  Bernward Scholkens ,  Erik Klaus

    IPC分类号： C07D405/04

    CPC分类号： C07D405/04

    摘要： 2,3,4,5-Tetrahydro-1-benzoxepins of the formula I ##STR1## with R.sup.1 equaling, inter alia, H, alkyl, alkoxy, Hal, alkylsulfonyl, arylsulfonyl, R.sup.2 equaling H, alkyl, alkoxy, OH, R.sup.3 to R.sup.6 H or alkyl and X equaling ##STR2## have excellent efficacy as antihypertensives, as coronary therapeutics, as agents for the treatment of cardiac insufficiency, of disturbances of cerebral and peripheral blood flow or of disturbances of intestinal motility, premature labor, obstructions of the airways or of the urinary tract or of the biliary tract or as spasmolytics.

    摘要翻译： 其中R 1等于H，烷基，烷氧基，卤素，烷基磺酰基，芳基磺酰基，R 2等于H，烷基，烷氧基，C 1 -C 6烷基， OH，R3至R6 H或烷基和X等于“IMAGE”作为抗高血压药物，作为冠状动脉治疗剂，作为治疗心功能不全的药物，脑和周围血流紊乱或肠蠕动紊乱，早产 ，气道或尿道或胆道阻塞或作为解痉药。