公开(公告)号：US20080119419A1

公开(公告)日：2008-05-22

申请号：US12004957

申请日：2007-12-21

Applicant: Deping Wang ,  Joyce Sutcliffe ,  Adegboyega Oyelere ,  Timothy McConnell ,  Joseph Ippolito ,  John Abelson ,  Dane Springer ,  Joseph Salvino ,  Joel Goldberg ,  Rongliang Lou ,  Jay Farmer ,  Erin Duffy ,  Ashoke Bhattacharjee

Inventor： Deping Wang ,  Joyce Sutcliffe ,  Adegboyega Oyelere ,  Timothy McConnell ,  Joseph Ippolito ,  John Abelson ,  Dane Springer ,  Joseph Salvino ,  Joel Goldberg ,  Rongliang Lou ,  Jay Farmer ,  Erin Duffy ,  Ashoke Bhattacharjee

IPC: A61K31/7048 ,  A61K31/42 ,  A61K31/44 ,  A61P29/00 ,  A61P31/00 ,  A61K31/497 ,  A61K31/5375

CPC classification number: A61K31/42 ,  A61K31/44 ,  A61K31/497 ,  A61K31/5375 ,  A61K31/7048 ,  C07H17/00

Abstract: The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using such compounds as anti-infective, anti-proliferative agents, anti-inflammatory, and/or prokinetic agents.

公开(公告)号：US20050234090A1

公开(公告)日：2005-10-20

申请号：US10989764

申请日：2004-11-15

Applicant: Roberto Colon-Cruz ,  Mary Didiuk ,  Erin Duffy ,  Ravi Garigipati ,  Wan Lau ,  Wayne McDonald

Inventor： Roberto Colon-Cruz ,  Mary Didiuk ,  Erin Duffy ,  Ravi Garigipati ,  Wan Lau ,  Wayne McDonald

IPC: A61K31/407 ,  A61K31/4155 ,  A61K31/4192 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/455 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/502 ,  A61K31/519 ,  A61P1/02 ,  A61P9/00 ,  A61P9/10 ,  A61P11/02 ,  A61P13/12 ,  A61P17/00 ,  A61P17/02 ,  A61P17/04 ,  A61P17/06 ,  A61P19/02 ,  A61P25/00 ,  A61P29/00 ,  A61P37/02 ,  A61P43/00 ,  C07D487/04 ,  C07D519/00 ,  C07D471/02 ,  A61K31/4745

CPC classification number: C07D487/04

Abstract: Chemokine receptor antagonists, in particular, bicyclic diamine compounds of Formula (I) that act as antagonists of chemokine CCR2 and CCR3 receptors including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leucocyte accumulation are described herein.

Abstract translation: 本文描述了趋化因子受体拮抗剂，特别是作为趋化因子CCR2和CCR3受体的拮抗剂的式（I）的双环二胺化合物，包括药物组合物及其用于治疗或预防与单核细胞积聚，淋巴细胞积聚或白细胞积聚相关的疾病的用途。

公开(公告)号：US20060264385A1

公开(公告)日：2006-11-23

申请号：US11359820

申请日：2006-02-21

Applicant: Deping Wang ,  Joyce Sutcliffe ,  Adegboyega Oyelere ,  Timothy McConnell ,  Joseph Ippolito ,  John Abelson ,  Dane Springer ,  Joseph Salvino ,  Rongliang Lou ,  Joel Goldberg ,  Jay Farmer ,  Erin Duffy ,  Ashoke Bhattacharjee

Inventor： Deping Wang ,  Joyce Sutcliffe ,  Adegboyega Oyelere ,  Timothy McConnell ,  Joseph Ippolito ,  John Abelson ,  Dane Springer ,  Joseph Salvino ,  Rongliang Lou ,  Joel Goldberg ,  Jay Farmer ,  Erin Duffy ,  Ashoke Bhattacharjee

IPC: A61K31/7052 ,  A61K31/7048 ,  C07H17/08

CPC classification number: A61K31/42 ,  A61K31/44 ,  A61K31/497 ,  A61K31/5375 ,  A61K31/7048 ,  C07H17/00

Abstract: The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using such compounds as anti-infective, anti-proliferative agents, anti-inflammatory, and/or prokinetic agents.

Abstract translation: 本发明提供了一种可用作抗感染，抗增殖，抗炎和促动力的双功能杂环化合物。 本发明还提供了制备双官能杂环化合物的方法，以及使用这些化合物作为抗感染剂，抗增殖剂，抗炎剂和/或促动力剂的方法。