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    COMPOSITIONS CONTAINING O-SULFATE AND O-PHOSPHATE CONTAINING ARYL SULFONAMIDE DERIVATIVES USEFUL AS beta-AMYLOID INHIBITORS
    7.
    发明申请
    COMPOSITIONS CONTAINING O-SULFATE AND O-PHOSPHATE CONTAINING ARYL SULFONAMIDE DERIVATIVES USEFUL AS beta-AMYLOID INHIBITORS 审中-公开
    含有硫酸钠和含有磺酰亚胺衍生物的O-磷酸酯的组合物作为β-AMYLOID抑制剂有用

    公开(公告)号：US20090181932A1

    公开(公告)日：2009-07-16

    申请号：US12349850

    申请日：2009-01-07

    申请人： David Zenan LI ,  Dane Springer ,  Sayed Elmarakby ,  Appavu Chandrasekaran ,  Anthony F. Kreft, III

    发明人： David Zenan LI ,  Dane Springer ,  Sayed Elmarakby ,  Appavu Chandrasekaran ,  Anthony F. Kreft, III

    IPC分类号： A61K31/18 ,  C07D333/34 ,  C07C305/02 ,  A61K31/66 ,  A61P35/00 ,  A61P25/28 ,  C07F9/09 ,  A61K31/381

    CPC分类号： C07C305/04 ,  A61K31/18 ,  A61K31/381 ,  A61K31/661 ,  C07D333/34

    摘要： A synthetic compound characterized by having the structure of formula I or II or a pharmaceutically acceptable salt and/or hydrate thereof is provided. Formula I and formula II are defined as follows. wherein R1 is substituted aryl or substituted heteroaryl; R2 and R3 are independently selected from the group consisting of CF3, substituted phenyl, C1-C4 alkyl, substituted C1-C4 alkyl, (CF3)nC1-C4alkyl, (CF3)n(substituted C1-C4 alkyl), provided that when R2 or R3 is CF3, the other is not an unsubstituted alkyl; R4 and R4′ are independently selected from the group consisting of M, C1-C4 alkyl, phenyl, and benzyl, wherein M is a metal ion is selected from the group consisting of sodium, lithium, calcium, magnesium and potassium, or R4 and R4′ are taken together to form a cyclic structure. Methods of making such compounds and uses thereof are also provided.

    摘要翻译： 提供了具有式I或II结构或其药学上可接受的盐和/或水合物的合成化合物。 式I和式II定义如下。 其中R1是取代的芳基或取代的杂芳基; R 2和R 3独立地选自CF 3，取代的苯基，C 1 -C 4烷基，取代的C 1 -C 4烷基，（CF 3）n C 1 -C 4烷基，（CF 3）n（取代的C 1 -C 4烷基），条件是当R 2 或R3是CF3，另一个不是未取代的烷基; R4和R4'独立地选自M，C1-C4烷基，苯基和苄基，其中M是金属离子选自钠，锂，钙，镁和钾，或R4和 R4'一起形成环状结构。 还提供了制备这些化合物的方法及其用途。

    Yoga mat
    9.
    外观设计
    Yoga mat 有权

    公开(公告)号：USD807077S1

    公开(公告)日：2018-01-09

    申请号：US29583081

    申请日：2016-11-02

    申请人： Dane Springer

    设计人： Dane Springer

    摘要： The Industrial Design consists of the features of shape, pattern, ornament and configuration of the yoga mat shown in the drawings.Drawing(s)/photograph(s) of the design is (are) included.Fig. 1 is a top, front, right side perspective view of a yoga mat illustrating the present design;Fig. 2 is a top plan view of the yoga mat as shown in Fig. 1;Fig. 3 is a front elevation view of the yoga mat shown in Fig. 1, the rear elevation view being a mirror image;Fig. 4 is a left side elevation view of the yoga mat shown in Fig. 1, the right side elevation view being a mirror image; andFig. 5 is a bottom plan view of the yoga mat as shown in Fig. 1.