公开(公告)号：US08394417B2

公开(公告)日：2013-03-12

申请号：US12903615

申请日：2010-10-13

申请人： Yoichi Ishii ,  Kazuyuki Ishii ,  Hiroyuki Sumi ,  Etsuo Yoshida ,  Sayaka Ishii

发明人： Yoichi Ishii ,  Kazuyuki Ishii ,  Hiroyuki Sumi ,  Etsuo Yoshida ,  Sayaka Ishii

IPC分类号： A61K35/56

CPC分类号： A61K35/62

摘要： Provided is a simple and easy method of producing an innoxious dry earthworm powder, while suppressing inactivation of the enzymes contained in earthworms. In the method, a homogenate obtained by grinding living earthworms is freeze-dried and the dried product is heat-treated at a temperature of 110° C. or higher but lower than 130° C. Preferably, the method according to the present invention comprises further a process for preparation of the living earthworms, which precedes the grinding step, comprising the steps of: standing the living earthworms under light for 10 to 50 hours; removing the dirt formed on the skin thereof, bringing the earthworms into contact with an organic acid for 30 seconds or less; diluting the acid with addition of water to adjust the pH of the aqueous acidic solution to a pH in the range of 2 to 5; standing the earthworm mixture under the pH condition for 3 to 180 minutes; and then washing the earthworms with water.

摘要翻译： 提供了一种简单易行的生产无嗅干蚯蚓粉的方法，同时抑制蚯蚓中含有的酶的失活。 在该方法中，通过研磨活蚯蚓获得的匀浆物被冷冻干燥，干燥产物在110℃以上且低于130℃的温度下进行热处理。优选地，根据本发明的方法包括 进一步的在研磨步骤之前制备活蚯蚓的方法，包括以下步骤：将活蚯蚓放在灯下10-50小时; 除去形成在其皮肤上的污垢，使蚯蚓与有机酸接触30秒以下; 通过添加水稀释酸，以将酸性水溶液的pH调节至2至5范围内的pH; 在pH条件下静置蚯蚓混合物3〜180分钟; 然后用水洗蚯蚓。

公开(公告)号：US08137701B2

公开(公告)日：2012-03-20

申请号：US12076738

申请日：2008-03-21

申请人： Yoichi Ishii ,  Hiroyuki Sumi ,  Etsuo Yoshida

发明人： Yoichi Ishii ,  Hiroyuki Sumi ,  Etsuo Yoshida

IPC分类号： A61K35/56

CPC分类号： A61K35/62

摘要： Provided is a method of producing a dry earthworm powder without deterioration in useful pharmacological action, by removing dirt on the skin of earthworms while allowing the earthworms to excrete the digest remaining in the digestive tracts efficiently without weakening the earthworms, which comprises the steps of: standing living earthworms under light for 10 to 50 hours, removing the dirt formed on the skin thereof, adding an organic acid to the living earthworms, diluting the acid rapidly with addition of water, adjusting the pH of the aqueous acidic solution to 2 to 5, standing the earthworm mixture for 3 to 180 minutes under the pH condition, washing the earthworms with water, grinding the earthworms into a homogenate, freezing the homogenate at −18° C. to −35° C., keeping the frozen homogenate for 20 to 240 hours, and freeze-drying and degassing the frozen homogenate under vacuum simultaneously.

摘要翻译： 本发明提供一种干燥蚯蚓粉的制造方法，其不会劣化有用的药理作用，通过去除蚯蚓皮肤上的污物，同时允许蚯蚓有效排出消化道中残留的消化物而不削弱蚯蚓，这包括以下步骤： 静置蚯蚓在灯下10〜50小时，除去皮肤上形成的污垢，向活蚯蚓加入有机酸，加入水快速稀释酸，将酸性水溶液的pH调节至2〜5 ，在pH条件下将蚯蚓混合物静置3〜180分钟，用水洗涤蚯蚓，将蚯蚓粉碎成匀浆，将匀浆在-18℃冷冻至-35℃，保持冷冻匀浆20 至240小时，同时在真空下对冷冻匀浆进行冷冻干燥脱气。

公开(公告)号：US20090238891A1

公开(公告)日：2009-09-24

申请号：US12076738

申请日：2008-03-21

申请人： Yoichi ISHII ,  Hiroyuki SUMI ,  Etsuo YOSHIDA

发明人： Yoichi ISHII ,  Hiroyuki SUMI ,  Etsuo YOSHIDA

IPC分类号： A61K35/56

CPC分类号： A61K35/62

摘要： Provided is a method of producing a dry earthworm powder without deterioration in useful pharmacological action, by removing dirt on the skin of earthworms while allowing the earthworms to excrete the digest remaining in the digestive tracts efficiently without weakening the earthworms, which comprises the steps of: standing living earthworms under light for 10 to 50 hours, removing the dirt formed on the skin thereof, adding an organic acid to the living earthworms, diluting the acid rapidly with addition of water, adjusting the pH of the aqueous acidic solution to 2 to 5, standing the earthworm mixture for 3 to 180 minutes under the pH condition, washing the earthworms with water, grinding the earthworms into a homogenate, freezing the homogenate at −18° C to −35°0 C, keeping the frozen homogenate for 20 to 240 hours, and freeze-drying and degassing the frozen homogenate under vacuum simultaneously.

摘要翻译： 本发明提供一种干燥蚯蚓粉的制造方法，其不会劣化有用的药理作用，通过去除蚯蚓皮肤上的污物，同时允许蚯蚓有效排出消化道中残留的消化物而不削弱蚯蚓，这包括以下步骤： 静置蚯蚓在灯下10〜50小时，除去皮肤上形成的污垢，向活蚯蚓加入有机酸，加入水快速稀释酸，将酸性水溶液的pH调节至2〜5 ，在pH条件下将蚯蚓混合物放置3〜180分钟，用水洗涤蚯蚓，将蚯蚓粉碎成匀浆，将匀浆物在-18℃冷冻至-35℃，保持冷冻匀浆20℃ 240小时，同时在真空下对冷冻匀浆进行冷冻干燥和脱气。

公开(公告)号：US20110086106A1

公开(公告)日：2011-04-14

申请号：US12903615

申请日：2010-10-13

申请人： Yoichi ISHII ,  Kazuyuki Ishii ,  Hiroyuki Sumi ,  Etsuo Yoshida ,  Sayaka Ishii

发明人： Yoichi ISHII ,  Kazuyuki Ishii ,  Hiroyuki Sumi ,  Etsuo Yoshida ,  Sayaka Ishii

IPC分类号： A61K35/56

CPC分类号： A61K35/62

摘要： Provided is a simple and easy method of producing an innoxious dry earthworm powder, while suppressing inactivation of the enzymes contained in earthworms. In the method, a homogenate obtained by grinding living earthworms is freeze-dried and the dried product is heat-treated at a temperature of 110° C. or higher but lower than 130° C. Preferably, the method according to the present invention comprises further a process for preparation of the living earthworms, which precedes the grinding step, comprising the steps of: standing the living earthworms under light for 10 to 50 hours; removing the dirt formed on the skin thereof, bringing the earthworms into contact with an organic acid for 30 seconds or less; diluting the acid with addition of water to adjust the pH of the aqueous acidic solution to a pH in the range of 2 to 5; standing the earthworm mixture under the pH condition for 3 to 180 minutes; and then washing the earthworms with water.

摘要翻译： 提供了一种简单易行的生产无嗅干蚯蚓粉的方法，同时抑制蚯蚓中含有的酶的失活。 在该方法中，通过研磨活蚯蚓获得的匀浆物被冷冻干燥，干燥产物在110℃以上且低于130℃的温度下进行热处理。优选地，根据本发明的方法包括 进一步的在研磨步骤之前制备活蚯蚓的方法，包括以下步骤：将活蚯蚓放在灯下10-50小时; 除去形成在其皮肤上的污垢，使蚯蚓与有机酸接触30秒以下; 通过添加水稀释酸，以将酸性水溶液的pH调节至2至5范围内的pH; 在pH条件下静置蚯蚓混合物3〜180分钟; 然后用水洗蚯蚓。

公开(公告)号：US5373035A

公开(公告)日：1994-12-13

申请号：US704

申请日：1993-01-05

申请人： Hiroshi Uemura ,  Etsuo Yoshida

发明人： Hiroshi Uemura ,  Etsuo Yoshida

IPC分类号： C09J4/00 ,  C09J4/02 ,  C09J4/04 ,  C09J4/06 ,  C08K9/06

CPC分类号： C09J4/00

摘要： An adhesive composition comprising an alpha-cyanoacrylate and a hydrophobic silica surface-treated with dimethyldichlorosilane, the composition being characterized in that the composition has incorporated therein at least one of a polyether-modified silicone or alcohol-modified silicone in an amount of 0.05 to 5.0% based on the weight of the composition.

摘要翻译： 一种包含α-氰基丙烯酸酯和用二甲基二氯硅烷表面处理的疏水性二氧化硅的粘合剂组合物，其特征在于该组合物中掺入至少一种量为0.05-5.0的聚醚改性的有机硅或醇改性的硅氧烷 基于组合物的重量％。