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1.发明申请METHOD AND SYSTEM FOR NETWORK MODELING TO ENLARGE THE SEARCH SPACE OF CANDIDATE GENES FOR DISEASES 审中-公开用于网络建模的方法和系统，用于扩大病毒基因的搜索空间公开(公告)号：US20130090908A1
公开(公告)日：2013-04-11
申请号：US13526317
申请日：2012-06-18
申请人： Frederick E. Dewey , Euan A. Ashley
发明人： Frederick E. Dewey , Euan A. Ashley
IPC分类号： G06F19/12
CPC分类号： G16B5/00
摘要： With the advent of low cost, high-throughput whole genome sequencing (“next generation sequencing”), tools are available to assay human genetic variation contributing to inherited disease syndromes. A method is disclosed for prioritization of genetic variants, and identification of disease genes, using network modeling of gene associations.
摘要翻译： 随着低成本，高通量全基因组测序（下一代测序）的出现，工具可用于测定对遗传性疾病综合征有贡献的人类遗传变异。 公开了一种利用遗传变异的优先次序和使用基因关联的网络建模鉴定疾病基因的方法。
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公开(公告)号：US20080221225A1
公开(公告)日：2008-09-11
申请号：US12074964
申请日：2008-03-07
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158
摘要： The present invention identifies genes whose gene products are differentially expressed during restenosis, including de novo restenosis and in stent restenosis (ISR). Also provided are therapeutic methods for treating a patient or methods for prophylactically treating an individual susceptible to restenosis. Additionally, the invention describes screening methods for identifying agents that can be administered to treat individuals that have or at risk of developing restenosis.
摘要翻译： 本发明鉴定基因产物在再狭窄期间差异表达的基因，包括从头再狭窄和支架再狭窄（ISR）。 还提供了治疗患者的治疗方法或用于预防性治疗对再狭窄敏感的个体的方法。 另外，本发明描述了用于鉴定可以施用以治疗具有或有发展为再狭窄风险的个体的药剂的筛选方法。
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3.发明授权公开(公告)号：US10347359B2
公开(公告)日：2019-07-09
申请号：US13526317
申请日：2012-06-18
申请人： Frederick E. Dewey , Euan A. Ashley
发明人： Frederick E. Dewey , Euan A. Ashley
摘要： With the advent of low cost, high-throughput whole genome sequencing (“next generation sequencing”), tools are available to assay human genetic variation contributing to inherited disease syndromes. A method is disclosed for prioritization of genetic variants, and identification of disease genes, using network modeling of gene associations.
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公开(公告)号：US20080182779A1
公开(公告)日：2008-07-31
申请号：US11985460
申请日：2007-11-14
申请人： Euan A. Ashley , Mary M. Chen , Thomas Quertermous
发明人： Euan A. Ashley , Mary M. Chen , Thomas Quertermous
CPC分类号： G01N33/6893 , A61K38/00 , A61K38/1709 , G01N2333/4703 , G01N2333/726 , G01N2800/325 , Y10T436/143333
摘要： The invention provides a method of treating or preventing heart failure or a disease or condition associated with heart failure comprising administering an effective dose of an apelin peptide or APJ receptor ligand to the subject. According to certain embodiments of the invention the apelin peptide is administered chronically. In certain embodiments of the invention the apelin peptide is administered in an amount effective to improve at least one hemodynamic parameter or prognostic variable for heart failure. Clinical conditions associated with heart failure include, but are not limited to, atherosclerosis, restenosis, ischemic cardiovascular diseases, idiopathic or viral cardiomyopathy, and the like.
摘要翻译： 本发明提供了治疗或预防心力衰竭或与心力衰竭相关的疾病或病症的方法，其包括向受试者施用有效剂量的apelin肽或APJ受体配体。 根据本发明的某些实施方案，长链地施用apelin肽。 在本发明的某些实施方案中，以有效改善心脏衰竭的至少一种血液动力学参数或预后变量的量施用apelin肽。 与心力衰竭相关的临床病症包括但不限于动脉粥样硬化，再狭窄，缺血性心血管疾病，特发性或病毒性心肌病等。
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公开(公告)号：US10127346B2
公开(公告)日：2018-11-13
申请号：US13445923
申请日：2012-04-13
摘要： In an embodiment of the present invention, three novel human reference genome sequences were developed based on the most common population-specific DNA sequence (“major allele”). Methods were developed for their integration into interpretation pipelines for highthroughput whole genome sequencing.
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公开(公告)号：US09443056B2
公开(公告)日：2016-09-13
申请号：US13445925
申请日：2012-04-13
申请人： Frederick Dewey , Euan A. Ashley , Jake Byrnes , Carlos Daniel Bustamante , Atul J. Butte , Rong Chen
发明人： Frederick Dewey , Euan A. Ashley , Jake Byrnes , Carlos Daniel Bustamante , Atul J. Butte , Rong Chen
摘要： An embodiment of the present invention is a methodology for prioritizing variants relevant to inherited Mendelian (“single gene”) disease syndromes according to disease phenotype, gene, and variant level information.
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公开(公告)号：US20130080365A1
公开(公告)日：2013-03-28
申请号：US13445926
申请日：2012-04-13
申请人： Frederick Dewey , Euan A. Ashley , Matthew Wheeler , Sergio Cordero , Colleen Caleshu , Kelly Ormond
发明人： Frederick Dewey , Euan A. Ashley , Matthew Wheeler , Sergio Cordero , Colleen Caleshu , Kelly Ormond
IPC分类号： G06N5/02
摘要： An embodiment of the present invention is a method for resolving long-range haplotype phase based on family pedigree data, inheritance state determination, and population linkage disequilibrium data. A method according to an embodiment of the present invention provides for the evaluation of genome wide risk using phased haplotype data.
摘要翻译： 本发明的一个实施方案是一种基于家族血统数据，遗传状态确定和群体连锁不平衡数据来解决长程单倍型相位的方法。 根据本发明的实施方案的方法提供使用分期单倍体数据评价基因组全面风险。
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公开(公告)号：US07947280B2
公开(公告)日：2011-05-24
申请号：US11985460
申请日：2007-11-14
申请人： Euan A. Ashley , Mary M. Chen , Thomas Quertermous
发明人： Euan A. Ashley , Mary M. Chen , Thomas Quertermous
CPC分类号： G01N33/6893 , A61K38/00 , A61K38/1709 , G01N2333/4703 , G01N2333/726 , G01N2800/325 , Y10T436/143333
摘要： The invention provides a method of treating or preventing heart failure or a disease or condition associated with heart failure comprising administering an effective dose of an apelin peptide or APJ receptor ligand to the subject. According to certain embodiments of the invention the apelin peptide is administered chronically. In certain embodiments of the invention the apelin peptide is administered in an amount effective to improve at least one hemodynamic parameter or prognostic variable for heart failure. Clinical conditions associated with heart failure include, but are not limited to, atherosclerosis, restenosis, ischemic cardiovascular diseases, idiopathic or viral cardiomyopathy, and the like.
摘要翻译： 本发明提供了治疗或预防心力衰竭或与心力衰竭相关的疾病或病症的方法，其包括向受试者施用有效剂量的apelin肽或APJ受体配体。 根据本发明的某些实施方案，长链地施用apelin肽。 在本发明的某些实施方案中，以有效改善心脏衰竭的至少一种血液动力学参数或预后变量的量施用apelin肽。 与心力衰竭相关的临床病症包括但不限于动脉粥样硬化，再狭窄，缺血性心血管疾病，特发性或病毒性心肌病等。
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