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公开(公告)号：US09388384B2
公开(公告)日：2016-07-12
申请号：US13504881
申请日：2009-10-28
Applicant: Hyo Soo Kim , Hyun Jae Kang , Eun Ju Lee , Young Bae Park
Inventor： Hyo Soo Kim , Hyun Jae Kang , Eun Ju Lee , Young Bae Park
IPC: C12N5/00 , C12N5/0775 , A61K35/48
CPC classification number: C12N5/0662 , A61K35/48 , C12N2500/38 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/155 , C12N2501/165 , C12N2501/39 , C12N2506/02
Abstract: Provided is a method for producing mesenchymal stem cells from human pluripotent stem cells, the method including: a) forming embryonic bodies from human pluripotent stem cells; b) attaching the embryonic bodies to a culture dish to induce natural differentiation of the embryonic bodies into mesenchymal stem cells; and c) performing continuous proliferative culturing of the mesenchymal stem cells while still maintaining the identity of the mesenchymal stem cells. Also, provided is a standardized method for inducing differentiation of mesenchymal stem cells, which can be broadly applied to all human pluripotent stem cells regardless of a difference in the genetic background thereof. Ultimately, the present invention can continuously mass-produces the mesenchymal stem cells necessary for regenerative medicine and cell therapy by using human pluripotent stem cells, thereby realizing practical uses of cell therapy products, and further the present invention is expected to highly contribute to treatments of incurable diseases, such as cardiovascular diseases and neurological disorders.
Abstract translation: 提供一种从人多能干细胞产生间充质干细胞的方法，所述方法包括：a）从人多能干细胞形成胚体; b）将胚胎体附着到培养皿中以诱导胚胎体自然分化成间充质干细胞; 和c）对间充质干细胞进行连续增殖培养，同时仍保持间充质干细胞的特性。 此外，提供了诱导间充质干细胞分化的标准化方法，其可以广泛地应用于所有人多能干细胞，而与其遗传背景的差异无关。 最终，本发明可以通过使用人多能干细胞连续批量生产再生医学和细胞治疗所需的间充质干细胞，从而实现细胞治疗产品的实际应用，并且进一步预期本发明对 不治之症，如心血管疾病和神经系统疾病。
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2.发明授权Anode material of excellent conductivity and high power secondary battery employed with the same 有权具有优良导电性和高功率二次电池的阳极材料采用公开(公告)号：US09034521B2
公开(公告)日：2015-05-19
申请号：US12665653
申请日：2008-06-20
Applicant: Eun Ju Lee , Ji Heon Ryu , Inchul Kim , HanHo Lee
Inventor： Eun Ju Lee , Ji Heon Ryu , Inchul Kim , HanHo Lee
IPC: H01M4/13 , H01M10/0525 , H01M4/131 , H01M4/133 , H01M4/1391 , H01M4/1393 , H01M4/36 , H01M4/02 , H01M4/485 , H01M4/587
CPC classification number: H01M10/0525 , H01M4/02 , H01M4/131 , H01M4/133 , H01M4/1391 , H01M4/1393 , H01M4/36 , H01M4/364 , H01M4/366 , H01M4/485 , H01M4/587 , H01M2004/021 , H01M2004/027 , Y02E60/122
Abstract: Provided is an anode material for an electrode mix comprising a carbon material and a lithium titanium oxide (LTO), wherein a ratio of an average particle size of LTO relative to that of the carbon material is in a range of 0.1 to 20%, and LTO is distributed mainly on a surface of the carbon material. The anode material of the present invention can prevent excessive formation of a SEI film, and is of a high capacity due to a high energy density and exhibits excellent output characteristics and rate characteristics. Further, it has superior electrolyte wettability which consequently results in improved battery performance and life characteristics.
Abstract translation: 本发明提供一种用于电极混合物的负极材料，其包含碳材料和锂钛氧化物（LTO），其中LTO的平均粒度与碳材料的平均粒径的比例在0.1至20％的范围内，以及 LTO主要分布在碳材料的表面上。 本发明的负极材料可以防止SEI膜的过度形成，并且由于高能量密度而具有高容量并且表现出优异的输出特性和速率特性。 此外，其具有优异的电解质润湿性，因此导致电池性能和寿命特性的改善。
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3.发明授权公开(公告)号：US08895187B2
公开(公告)日：2014-11-25
申请号：US12713936
申请日：2010-02-26
Applicant: Ji Heon Ryu , Min Su Kim , Jung Eun Hyun , Jaepil Lee , Eun Ju Lee , Youngjoon Shin
Inventor： Ji Heon Ryu , Min Su Kim , Jung Eun Hyun , Jaepil Lee , Eun Ju Lee , Youngjoon Shin
CPC classification number: H01M4/364 , H01M4/0404 , H01M4/131 , H01M4/505 , H01M4/525 , H01M10/0525 , H01M2004/021 , H01M2004/028 , Y02E60/122
Abstract: Provided is a non-aqueous electrolyte-based, high-power lithium secondary battery having a long service life and superior safety at both room temperature and high temperature, even after repeated high-current charging and discharging. The battery comprises a cathode active material composed of a mixture of lithium/manganese spinel oxide and lithium/nickel/cobalt/manganese composite oxide wherein the cathode active material exhibits the life characteristics that the capacity at 300 cycles is more than 70% relative to the initial capacity, in the provision of satisfying the condition (i) regarding the particle size and the condition (ii) regarding the mixing ratio.
Abstract translation: 本发明提供一种即使在反复进行大电流充放电之后，在室温和高温下也具有使用寿命长，安全性高的非水电解质型大功率锂二次电池。 电池包括由锂/锰尖晶石氧化物和锂/镍/钴/锰复合氧化物的混合物组成的正极活性材料，其中正极活性材料表现出寿命特性，即300次循环下的容量相对于 在提供满足条件（i）关于颗粒大小和关于混合比的条件（ii）的情况下）的初始容量。
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公开(公告)号：US20140011275A1
公开(公告)日：2014-01-09
申请号：US13981508
申请日：2011-12-27
Applicant: Eun Ju Lee , Hyo Soo Kim
Inventor： Eun Ju Lee , Hyo Soo Kim
IPC: C12N5/00
CPC classification number: C12N5/0018 , A61K31/4409 , C12N5/0663 , C12N2501/727
Abstract: The present invention relates to a composition for suppressing the death of stem cells during suspension culturing, a composition for mass culturing of stem cells, and a method for suppressing cell death of stem cells during suspension culturing. The composition of the present invention can be usefully used for effective single suspension culturing of stem cells, particularly, mesenchymal stem cells, or used for mass suspension culturing under the circumstances in which cell aggregation does not occur.
Abstract translation: 本发明涉及一种用于抑制悬浮培养期间干细胞死亡的组合物，用于干细胞的大规模培养的组合物，以及用于在悬浮培养期间抑制干细胞的细胞死亡的方法。 本发明的组合物可有效地用于干细胞，特别是间充质干细胞的有效单悬液培养，或用于在不发生细胞聚集的情况下进行大规模悬浮培养。
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5.发明授权Anode coated with lithium fluoride compounds, method for preparing the same, and lithium secondary battery having the same 有权用氟化锂化合物涂覆的阳极及其制备方法，以及具有该阳极的锂二次电池公开(公告)号：US08609273B2
公开(公告)日：2013-12-17
申请号：US12919148
申请日：2009-02-24
Applicant: Yoon-Jung Bae , Han-Ho Lee , Jin-Hyuk Min , Eun-Ju Lee , Jong-Seok Jeong
Inventor： Yoon-Jung Bae , Han-Ho Lee , Jin-Hyuk Min , Eun-Ju Lee , Jong-Seok Jeong
CPC classification number: H01M4/0438 , H01M4/133 , H01M4/1393 , H01M4/366 , H01M4/587 , H01M10/052 , H01M10/058
Abstract: An anode for a lithium ion secondary battery includes an anode, and a LiF-based coating layer formed with LiF-based particles on a surface of the anode. The LiF-based coating layer has a thickness of 0.05 to 1 μm. The anode allows the LiF-based coating layer created by side reaction of LiPF6 during a battery charging/discharging process to be relatively uniformly formed on the anode surface, thereby elongating the life cycle of a lithium ion secondary battery.
Abstract translation: 用于锂离子二次电池的阳极包括阳极和在阳极表面上形成有LiF基颗粒的LiF基涂层。 LiF基涂层的厚度为0.05〜1μm。 阳极允许在电池充电/放电过程中由LiPF 6的副反应产生的LiF基涂层在阳极表面上相对均匀地形成，从而延长锂离子二次电池的寿命周期。
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Patent Agency Ranking
6.发明申请Method of Inducing High Activity of Human Adipose Stem Cell and Medium Therefor 有权诱导人类脂肪干细胞及其介质的高活性的方法公开(公告)号：US20130023048A1
公开(公告)日：2013-01-24
申请号：US13510528
申请日：2010-10-08
Applicant: Hyo Soo Kim , Hyun Jae Kang , Eun Ju Lee
Inventor： Hyo Soo Kim , Hyun Jae Kang , Eun Ju Lee
IPC: C12N5/0775
CPC classification number: C12N5/0667 , C12N2500/36 , C12N2502/1305
Abstract: The present invention relates to a method of inducing high activity of human adipose stem cells, highly active stem cells induced by the method, cell therapeutic agents including the highly active stem cells, and a medium for inducing high activity of human adipose stem cells.The method of the present invention enables a long-term culture of human adipose stem cells while maintaining high activity, production yield and differentiation potency of the stem cells through in vitro culture, even in case culture conditions are not appropriate for mature human adipocytes, security of adipocytes is not guaranteed, or adipocytes are diseased.
Abstract translation: 本发明涉及一种诱导人类脂肪干细胞高活性的方法，由该方法诱导的高活性干细胞，包括高活性干细胞的细胞治疗剂和诱导人类脂肪干细胞高活性的培养基。 本发明的方法能够通过体外培养保持人体脂肪干细胞的长期培养，同时通过体外培养保持干细胞的高活性，产量和分化效能，即使培养条件不适合成熟的人类脂肪细胞，安全性 的脂肪细胞不能保证，或脂肪细胞患病。
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7.发明授权公开(公告)号：US08334070B2
公开(公告)日：2012-12-18
申请号：US11853302
申请日：2007-09-11
Applicant: Ji Heon Ryu , Songhun Yoon , HanHo Lee , Eun Ju Lee
Inventor： Ji Heon Ryu , Songhun Yoon , HanHo Lee , Eun Ju Lee
CPC classification number: H01M4/133 , H01G11/24 , H01G11/30 , H01M4/134 , H01M4/62 , H01M2004/027 , H01M2004/028 , Y02E60/13 , Y02T10/7022
Abstract: Provided is an electrode material, which contains an electrode active material, comprising a clay mineral in an amount of the range of 5% by weight or less based on the total weight of the electrode material for increasing the mechanical strength of the electrode material and improving the impregnation ability of an electrolyte.
Abstract translation: 本发明提供一种电极材料，其含有电极活性物质，其包含相对于电极材料的总重量为5重量％以下的量的粘土矿物，用于提高电极材料的机械强度并提高 电解液的浸渍能力。
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8.发明申请METHOD FOR PRODUCING MESENCHYMAL STEM CELLS FROM HUMAN PLURIPOTENT STEM CELLS, AND MESENCHYMAL STEM CELLS PRODUCED BY SAME 有权用于从人源性干细胞生产间充质干细胞的方法和由其生产的骨髓干细胞公开(公告)号：US20120276625A1
公开(公告)日：2012-11-01
申请号：US13504881
申请日：2009-10-28
Applicant: Hyo Soo Kim , Hyun Jae Kang , Eun Ju Lee , Young Bae Park
Inventor： Hyo Soo Kim , Hyun Jae Kang , Eun Ju Lee , Young Bae Park
IPC: C12N5/0775
CPC classification number: C12N5/0662 , A61K35/48 , C12N2500/38 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/155 , C12N2501/165 , C12N2501/39 , C12N2506/02
Abstract: Provided is a method for producing mesenchymal stem cells from human pluripotent stem cells, the method including: a) forming embryonic bodies from human pluripotent stem cells; b) attaching the embryonic bodies to a culture dish to induce natural differentiation of the embryonic bodies into mesenchymal stem cells; and c) performing continuous proliferative culturing of the mesenchymal stem cells while still maintaining the identity of the mesenchymal stem cells. Also, provided is a standardized method for inducing differentiation of mesenchymal stem cells, which can be broadly applied to all human pluripotent stem cells regardless of a difference in the genetic background thereof. Ultimately, the present invention can continuously mass-produces the mesenchymal stem cells necessary for regenerative medicine and cell therapy by using human pluripotent stem cells, thereby realizing practical uses of cell therapy products, and further the present invention is expected to highly contribute to treatments of incurable diseases, such as cardiovascular diseases and neurological disorders.
Abstract translation: 提供一种从人多能干细胞产生间充质干细胞的方法，所述方法包括：a）从人多能干细胞形成胚体; b）将胚胎体附着到培养皿中以诱导胚胎体自然分化成间充质干细胞; 和c）对间充质干细胞进行连续增殖培养，同时仍保持间充质干细胞的特性。 此外，提供了诱导间充质干细胞分化的标准化方法，其可以广泛地应用于所有人多能干细胞，而与其遗传背景的差异无关。 最终，本发明可以通过使用人多能干细胞连续批量生产再生医学和细胞治疗所需的间充质干细胞，从而实现细胞治疗产品的实际应用，并且进一步预期本发明对 不治之症，如心血管疾病和神经系统疾病。
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9.发明授权Benzopyran derivatives having inhibitory activities against liver fibrosis and cirrhosis and their pharmaceutical uses 有权具有对肝纤维化和肝硬化的抑制活性的苯并吡喃衍生物及其药物用途公开(公告)号：US08048912B2
公开(公告)日：2011-11-01
申请号：US11794564
申请日：2005-06-15
Applicant: Young-Dae Gong , Jin-Soo Seo , Moon-Kook Jeon , Wie-Jong Kwak , Yong-Baik Cho , Nam Kyu Lee , Eun Ju Lee , Jung Bum Lee , Jun Won Lee , Sukho Lee , Mi-Sook Dong , Jeong-Ran Kim
Inventor： Young-Dae Gong , Jin-Soo Seo , Moon-Kook Jeon , Wie-Jong Kwak , Yong-Baik Cho , Nam Kyu Lee , Eun Ju Lee , Jung Bum Lee , Jun Won Lee , Sukho Lee , Mi-Sook Dong , Jeong-Ran Kim
IPC: A61K31/352 , C07D311/60 , C07D311/70
CPC classification number: C07D311/70
Abstract: The present invention relates to a novel benzopyran derivative having goodantagonistic activity on TGF-β receptor which can be effectively used as a prophylactic and therapeutic agent for liver disease as well as several fibroplasiadiseases such as hepatic fibrosis, liver cirrhosis, pulmonary fibrosis, dermatosclerosis, glomerular fibrosis and the like; and a pharmaceutical use thereof.
Abstract translation: 本发明涉及一种对TGF-βb具有优异活性的新型苯并吡喃衍生物。 受体，其可以有效地用作肝脏疾病的预防和治疗剂以及若干纤维平滑酶如肝纤维化，肝硬化，肺纤维化，皮肤硬化，肾小球纤维化等; 及其药物用途。
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10.发明申请ANODE MATERIAL OF EXCELLENT CONDUCTIVITY AND HIGH POWER SECONDARY BATTERY EMPLOYED WITH THE SAME 有权优异电导率的阳极材料和与其同时使用的高功率二次电池公开(公告)号：US20110027646A1
公开(公告)日：2011-02-03
申请号：US12665653
申请日：2008-06-20
Applicant: Eun Ju Lee , Ji Heon Ryu , Inchul Kim , HanHo Lee
Inventor： Eun Ju Lee , Ji Heon Ryu , Inchul Kim , HanHo Lee
CPC classification number: H01M10/0525 , H01M4/02 , H01M4/131 , H01M4/133 , H01M4/1391 , H01M4/1393 , H01M4/36 , H01M4/364 , H01M4/366 , H01M4/485 , H01M4/587 , H01M2004/021 , H01M2004/027 , Y02E60/122
Abstract: Provided is an anode material for an electrode mix comprising a carbon material and a lithium titanium oxide (LTO), wherein a ratio of an average particle size of LTO relative to that of the carbon material is in a range of 0.1 to 20%, and LTO is distributed mainly on a surface of the carbon material. The anode material of the present invention can prevent excessive formation of a SEI film, and is of a high capacity due to a high energy density and exhibits excellent output characteristics and rate characteristics. Further, it has superior electrolyte wettability which consequently results in improved battery performance and life characteristics.
Abstract translation: 本发明提供一种用于电极混合物的负极材料，其包含碳材料和锂钛氧化物（LTO），其中LTO的平均粒度与碳材料的平均粒径的比例在0.1至20％的范围内，以及 LTO主要分布在碳材料的表面上。 本发明的负极材料可以防止SEI膜的过度形成，并且由于高能量密度而具有高容量并且表现出优异的输出特性和速率特性。 此外，其具有优异的电解质润湿性，因此导致电池性能和寿命特性的改善。
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