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33 条记录 (耗时 0.021 秒)

    Modified Beta Thymosin Peptides
    1.
    发明申请
    Modified Beta Thymosin Peptides 审中-公开
    改性β-胸腺素肽

    公开(公告)号：US20080248993A1

    公开(公告)日：2008-10-09

    申请号：US11722979

    申请日：2006-01-17

    申请人： Ewald Hannappel ,  Thomas Huff ,  Allan L. Goldstein ,  David Crockford

    发明人： Ewald Hannappel ,  Thomas Huff ,  Allan L. Goldstein ,  David Crockford

    IPC分类号： A61K38/02

    CPC分类号： C07K14/57581 ,  A61K38/00

    摘要： A composition including an oxidized or superoxidized methionine-containing beta thymosin peptide, isoform thereof, fragment thereof, isolated R-enantiomer thereof or isolated S-enantiomer thereof, other than racemic thymosin beta 4 sulfoxide, or a modified beta thymosin peptide, isoform or fragment thereof with an amino acid substituent substituted for at least one methionine of an amino acid sequence of a normally methionine-containing beta thymosin peptide, isoform or fragment thereof, and method for forming same.

    摘要翻译： 包含氧化或超氧化的含甲硫氨酸的β胸腺素肽，其同种型，其片段，其分离的R-对映异构体或其分离的S-对映异构体，除外消旋胸腺素β4亚砜，或经修饰的β胸腺素肽，同种型或片段 的氨基酸取代基取代至少一种含有正常甲硫氨酸的β-胸腺素肽，同种型或其片段的氨基酸序列的甲硫氨酸及其形成方法。

    Lkktet and/or Lkktnt Peptide Compositions and Methods
    7.
    发明申请
    Lkktet and/or Lkktnt Peptide Compositions and Methods 审中-公开
    Lkktet和/或Lkktnt肽组合物和方法

    公开(公告)号：US20080214456A1

    公开(公告)日：2008-09-04

    申请号：US11917883

    申请日：2006-06-19

    申请人： Gabriel Sosne ,  Ewald Hannppel ,  David Crockford ,  Allan L. Goldstein

    发明人： Gabriel Sosne ,  Ewald Hannppel ,  David Crockford ,  Allan L. Goldstein

    IPC分类号： A61K38/08 ,  A61K38/00 ,  A61K38/22

    CPC分类号： A61K38/2292 ,  A61K9/0048 ,  A61K9/08 ,  A61K9/10 ,  A61K9/14 ,  A61K38/08 ,  A61K47/186

    摘要： A composition including a peptide agent including amino acid sequence LKKTET or LKKTNT, a conservative variant thereof, or a stimulating agent that stimulates production of an LKKTET or LKKTNT peptide, or a conservative variant thereof, and an ophthalmically acceptable carrier, an antimicrobially effective preservative, a tonicity agent for providing the composition with an ophthalmically acceptable tonicity, a comfort enhancing agent, at least one of an acidic or basic pH adjusting agent capable of adjusting pH of the composition to a desired ophthalmically acceptable pH level, and a buffer to substantially maintain the desired pH level.

    摘要翻译： 包含包含氨基酸序列LKKTET或LKKTNT的肽试剂，其保守变体或刺激LKKTET或LKKTNT肽生产的刺激剂或其保守变体的组合物和眼科可接受的载体，抗微生物有效的防腐剂， 用于向组合物提供眼睛可接受的张力的张度剂，舒适增强剂，能够将组合物的pH调节至所需眼睛可接受的pH水平的酸性或碱性pH调节剂中的至少一种，以及基本保持 所需的pH值。

    Method of treating or preventing tissue deterioration, injury or damage due to periodontal disease or disease of oral mucosa, and/or downregulating NF-kappabeta or supressing NF-kappabeta-mediated actions
    10.
    发明授权
    Method of treating or preventing tissue deterioration, injury or damage due to periodontal disease or disease of oral mucosa, and/or downregulating NF-kappabeta or supressing NF-kappabeta-mediated actions 有权
    治疗或预防由牙周病或口腔粘膜疾病引起的组织退化，损伤或损伤和/或下调NF-κB或抑制NF-κB介导的作用的方法

    公开(公告)号：US08399412B2

    公开(公告)日：2013-03-19

    申请号：US12444331

    申请日：2007-10-05

    申请人： Gabriel Sosne ,  Michelle Wheater ,  Allan L. Goldstein

    发明人： Gabriel Sosne ,  Michelle Wheater ,  Allan L. Goldstein

    IPC分类号： A61K38/17

    CPC分类号： A61K38/08 ,  A61K8/64 ,  A61K38/2292 ,  A61Q11/00

    摘要： A method of treatment for treating, at least partly preventing, inhibiting or reducing tissue deterioration, injury or damage due to a periodontal disease or disease of oral mucosa, or for restoring tissue adversely affected by the disease, in a subject, and/or for downregulating NF-kappaB or suppressing NF-kappaB mediated action in a body, organ, tissue or cell, includes administering to a subject, body, organ, tissue or cell an effective amount of a composition including a peptide agent including at least one of Thymosin beta 4 (Tβ4), an isoform of Tβ4, an N-terminal fragment of Tβ4, a C-terminal fragment of Tβ4, Tβ4 sulfoxide, an LKKTET peptide or conservative variant thereof, an LKKTNT peptide or conservative variant thereof, a KLKKTET peptide or conservative variant thereof, an LKKTETQ peptide or conservative variant thereof, Tβ4ala, Tβ9, Tβ10, Tβ11, Tβ12, Tβ13, Tβ14, Tβ15, gelsolin, vitamin D binding protein (DBP), profilin, cofilin, depactin, DnaseI, vilin, fragmin, severin, capping protein, β-actinin, acumentin, an actin-sequestering peptide, an actin binding peptide, an actin-mobilizing peptide, an actin polymerization-modulating peptide, or a stimulating agent that stimulates production of an effective amount of the peptide agent in the subject, body, organ, tissue or cell.

    摘要翻译： 一种治疗方法，用于治疗，至少部分地预防，抑制或减少由于牙周疾病或口腔粘膜疾病引起的组织退化，损伤或损伤，或用于恢复患者受到不良影响的组织，和/或用于 在身体，器官，组织或细胞中下调NF-κB或抑制NF-κB介导的作用，包括向受试者，身体，器官，组织或细胞施用有效量的组合物，所述组合物包括包含至少一种胸腺素的肽试剂 β4（T＆bgr; 4），T＆bgr的同种型; 4，T＆bgr的N末端片段; 4，T＆bgr; 4，T＆bgr; 4亚砜的C末端片段，LKKTET肽或其保守变体，LKKTNT 肽或其保守变体，KLKKTET肽或其保守变体，LKKTETQ肽或其保守变体，T＆bgr; 4ala，T＆bgr; 9，T＆bgr; 10，T＆bgr; 11，T＆bgr; 12，T＆bgr; 13，T＆bgr; T＆Bgr; 15，凝溶胶蛋白，维生素D结合蛋白（DBP），profilin，cof 肌动蛋白结合肽，肌动蛋白动员肽，肌动蛋白聚合调节肽或刺激剂，肌动蛋白结合肽，肌动蛋白动员肽，肌动蛋白聚合调节肽， 其刺激受试者，身体，器官，组织或细胞中有效量的肽试剂的产生。