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公开(公告)号：US20240279236A1
公开(公告)日：2024-08-22
申请号：US18559471
申请日：2022-05-09
Inventor： James Janetka , Laurel Mydock-McGrane , Keith Haynes , Marvin J. Meyers
IPC: C07D495/04 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/695 , A61K45/06 , A61P31/06 , C07D513/04 , C07D519/00 , C07F7/08
CPC classification number: C07D495/04 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/695 , A61K45/06 , A61P31/06 , C07D513/04 , C07D519/00 , C07F7/0812
Abstract: The present disclosure relates to various compounds and compositions which are useful for the treatment of tuberculosis and other diseases such as infections caused by Mycobacterium tuberculosis. The present disclosure also relates to various methods of using these compounds and compositions to treat tuberculosis and other diseases such as infections caused by Mycobacterium tuberculosis. Further, the present disclosure relates to processes of preparing these compounds and compositions.
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公开(公告)号：US11697665B2
公开(公告)日：2023-07-11
申请号：US17371419
申请日：2021-07-09
Inventor： Michael Joseph Bishop , Eugene L. Stewart , Katherine Louisa Widdowson , James Walter Janetka , Laurel Kathryn McGrane
CPC classification number: C07H7/04 , A61K9/0014 , A61K9/0053 , A61K9/20 , A61K9/48 , A61K45/06
Abstract: Disclosed herein are C-mannoside compounds, compositions thereof and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in a human subject are also provided for the treatment of diseases such as bacterial infection, Crohn's disease (CD) and Inflammatory Bowel Disease (IBD).
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公开(公告)号：US12297223B2
公开(公告)日：2025-05-13
申请号：US17606134
申请日：2020-05-06
Inventor： Michael Joseph Bishop , James Walter Janetka , Laurel Kathryn McGrane , Eugene Lee Stewart , Katherine Louisa Widdowson
IPC: C07H15/26 , C07H15/207
Abstract: Disclosed herein are new C-mannoside compounds and compositions and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in human subjects are also provided for the treatment diseases such as urinary tract infection.
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公开(公告)号：US20210017212A1
公开(公告)日：2021-01-21
申请号：US17063947
申请日：2020-10-06
Inventor： Michael Joseph BISHOP , Vincent J. Colandrea , Yuehu Li , Eugene L. Stewart , Iulia Strambeanu , Katherine Louisa Widdowson , James Walter Janetka , Laurel Kathryn Mcgrane
IPC: C07H7/04
Abstract: Disclosed herein are new C-mannoside compounds and compositions and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in a human subject are also provided for the treatment diseases such as urinary tract infection.
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公开(公告)号：US20250009723A1
公开(公告)日：2025-01-09
申请号：US18887190
申请日：2024-09-17
Applicant: FIMBRION THERAPEUTICS, INC.
Inventor： James W. Janetka , Laurel Mydock-McGrane
IPC: A61K31/439 , A61K9/00 , A61K31/138 , A61K31/7052 , A61K45/06 , A61P31/04 , B65D75/36 , C07H15/203 , C07H15/26
Abstract: The present invention relates to mannoside derivative compounds useful as inhibitors of FimH and methods for the treatment or prevention of urinary tract infection.
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Patent Agency Ranking
公开(公告)号：US20230287028A1
公开(公告)日：2023-09-14
申请号：US18308842
申请日：2023-04-28
Inventor： Michael Joseph BISHOP , Eugene L. Stewart , Katherine Louisa Widdowson , James Walter Janetka , Laurel Kathryn McGrane
IPC: C07H7/04
CPC classification number: C07H7/04 , A61K9/0014
Abstract: Disclosed herein are C-mannoside compounds, compositions thereof and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in a human subject are also provided for the treatment of diseases such as bacterial infection, Crohn's disease (CD) and Inflammatory Bowel Disease (IBD).
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公开(公告)号：US20210395287A1
公开(公告)日：2021-12-23
申请号：US17371419
申请日：2021-07-09
Inventor： Michael Joseph BISHOP , Eugene L. STEWART , Katherine Louisa WIDDOWSON , James Walter JANETKA , Laurel Kathryn MCGRANE
IPC: C07H7/04
Abstract: Disclosed herein are C-mannoside compounds, compositions thereof and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in a human subject are also provided for the treatment of diseases such as bacterial infection, Crohn's disease (CD) and Inflammatory Bowel Disease (IBD).
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公开(公告)号：US11111262B2
公开(公告)日：2021-09-07
申请号：US17063947
申请日：2020-10-06
Inventor： Michael Joseph Bishop , Eugene L. Stewart , Katherine Louisa Widdowson , James Walter Janetka , Laurel Kathryn McGrane
Abstract: Disclosed herein are new C-mannoside compounds and compositions and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in a human subject are also provided for the treatment diseases such as urinary tract infection.
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公开(公告)号：US20200002303A1
公开(公告)日：2020-01-02
申请号：US16084177
申请日：2017-03-11
Applicant: Fimbrion Therapeutics, Inc.
Inventor： James W. JANETKA , Laurel MYDOCK-MCGRANE
IPC: C07D309/10 , C07D413/10 , C07D471/04
Abstract: The present invention relates to mannoside derivative compounds useful as inhibitors of FimH and methods for the treatment or prevention of urinary tract infection.
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公开(公告)号：US20220298197A1
公开(公告)日：2022-09-22
申请号：US17606134
申请日：2020-05-06
Inventor： Michael Joseph BISHOP , James Walter JANETKA , Laurel Kathryn MCGRANE , Eugene Lee STEWART , Katherine Louisa WIDDOWSON
IPC: C07H15/26 , C07H15/207
Abstract: Disclosed herein are new C-mannoside compounds and compositions and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in human subjects are also provided for the treatment diseases such as urinary tract infection.
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