公开(公告)号：US20240279236A1

公开(公告)日：2024-08-22

申请号：US18559471

申请日：2022-05-09

申请人： Fimbrion Therapeutics, Inc. ,  Washington University ,  Saint Louis University

发明人： James Janetka ,  Laurel Mydock-McGrane ,  Keith Haynes ,  Marvin J. Meyers

IPC分类号： C07D495/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/695 ,  A61K45/06 ,  A61P31/06 ,  C07D513/04 ,  C07D519/00 ,  C07F7/08

CPC分类号： C07D495/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/695 ,  A61K45/06 ,  A61P31/06 ,  C07D513/04 ,  C07D519/00 ,  C07F7/0812

摘要： The present disclosure relates to various compounds and compositions which are useful for the treatment of tuberculosis and other diseases such as infections caused by Mycobacterium tuberculosis. The present disclosure also relates to various methods of using these compounds and compositions to treat tuberculosis and other diseases such as infections caused by Mycobacterium tuberculosis. Further, the present disclosure relates to processes of preparing these compounds and compositions.

公开(公告)号：US09353089B2

公开(公告)日：2016-05-31

申请号：US14226295

申请日：2014-03-26

申请人： Saint Louis University ,  Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences

发明人： Xiaoping Chen ,  Ke Ding ,  Marvin J. Meyers ,  Micky D. Tortorella ,  Jing Xu

IPC分类号： C07D405/14 ,  C07D233/02 ,  C07D401/10 ,  C07D403/04

CPC分类号： C07D405/14 ,  C07D233/02 ,  C07D401/10 ,  C07D403/04

摘要： The present invention provides aminohydantoin anti-malarial agents. In some embodiments, these agents have the property of functions of targeting malarial aspartic proteases while at the same time having low activity against human BACE. Methods of employing such agents are also provided.

摘要翻译： 本发明提供氨基乙内酰脲抗疟剂。 在一些实施方案中，这些试剂具有靶向疟疾天冬氨酸蛋白酶的功能的性质，同时对人BACE具有低活性。 还提供了使用这种试剂的方法。

公开(公告)号：US20140296532A1

公开(公告)日：2014-10-02

申请号：US14226295

申请日：2014-03-26

申请人： Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences ,  Saint Louis University

发明人： Xiaoping Chen ,  Ke Ding ,  Marvin J. Meyers ,  Micy D. Tortorella ,  Jing Xu

IPC分类号： C07D405/14 ,  C07D401/10 ,  C07D403/04 ,  C07D233/02

CPC分类号： C07D405/14 ,  C07D233/02 ,  C07D401/10 ,  C07D403/04

摘要： The present invention provides aminohydantoin anti-malarial agents. In some embodiments, these agents have the property of functions of targeting malarial aspartic proteases while at the same time having low activity against human BACE. Methods of employing such agents are also provided.

摘要翻译： 本发明提供氨基乙内酰脲抗疟剂。 在一些实施方案中，这些试剂具有靶向疟疾天冬氨酸蛋白酶的功能的性质，同时对人BACE具有低活性。 还提供了使用这种试剂的方法。

公开(公告)号：US10463664B2

公开(公告)日：2019-11-05

申请号：US15038515

申请日：2014-11-25

申请人： Saint Louis University

发明人： John Edwin Tavis ,  Lynda Anne Morrison ,  Marvin J. Meyers

IPC分类号： A61K31/122 ,  A61K31/506 ,  A61K45/06 ,  A61K31/4418 ,  A61K31/352 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/4375 ,  A61K31/4433 ,  A61K31/4704 ,  C07D413/12 ,  C07D471/04 ,  A61K31/047 ,  A61K31/045

摘要： The present invention involves identification of inhibitors of herpesvirus nucleic acid metabolism. Also provided are methods of treatment using agents identified.

公开(公告)号：US20230212172A1

公开(公告)日：2023-07-06

申请号：US18001148

申请日：2021-06-08

申请人： University of Vermont and State Agricultural College ,  Saint Louis University

发明人： Christopher D. Huston ,  Erin E. Stebbins ,  Marvin J. Meyers ,  Edmund Oboh ,  Tanner Schubert

IPC分类号： C07D487/04 ,  A61P33/14

CPC分类号： C07D487/04 ,  A61P33/14

摘要： Provided are compounds with the following structure: Formula (I), and methods of making and using same. The methods of using the compounds may be methods for treating or prophylaxis of a cryptosporidium infection.

公开(公告)号：US11358994B2

公开(公告)日：2022-06-14

申请号：US16633467

申请日：2018-07-25

申请人： Saint Louis University

发明人： Marvin J. Meyers ,  David C. Wood ,  Stacy D. Arnett ,  Matthew P. Yates ,  Peter G. Ruminski

IPC分类号： C07K14/485 ,  A61K38/00 ,  A61P1/12 ,  A61K9/00

摘要： The disclosure provides for new epidermal growth factor (EGF)-based reagents that have been modified by fatty acid conjugation. Method of using such agents to treatment Short Bowel Syndrome (SBS) are also described.

公开(公告)号：US10980754B2

公开(公告)日：2021-04-20

申请号：US16094682

申请日：2017-04-19

申请人： SAINT LOUIS UNIVERSITY ,  Research Foundation of the City University of New York

发明人： Maureen J. Donlin ,  John Edwin Tavis ,  Ryan Murelli ,  Marvin J. Meyers

IPC分类号： A61K31/122 ,  A61K31/4375 ,  C07C63/38 ,  A61K31/341 ,  A61K31/365 ,  A61K31/381 ,  A61K31/4418 ,  A61K31/506 ,  A61P31/10 ,  A61K31/7048 ,  A61K31/513 ,  A61K31/4196 ,  A61K31/496 ,  C07C49/835 ,  C07C69/757 ,  C07C49/84 ,  C07C49/743 ,  C07C49/717 ,  C07C62/38 ,  C07C49/747 ,  A61K31/4409 ,  C07C49/723 ,  C07C327/22 ,  C07C69/76 ,  C07C69/92 ,  C07C49/687 ,  C07C49/753 ,  C07C323/22 ,  C07C69/78 ,  A61K31/343 ,  A61K31/4412 ,  C07C327/26 ,  C07D213/89 ,  C07D471/04

摘要： The present disclosure provides compounds of the formula (I), (II), (III), wherein the variables are as defined herein for use in the treatment of fungal infections. In some embodiments, the fungal infection is an infection of Cryptococcus neojormans fungus. Also provided herein are compositions comprising a compound of formula I, II, or III and a second anti-fungal agent.