公开(公告)号：US20110206640A1

公开(公告)日：2011-08-25

申请号：US13060028

申请日：2009-08-20

申请人： John C. Bell ,  Fabrice Le Boeuf

发明人： John C. Bell ,  Fabrice Le Boeuf

IPC分类号： A61K35/76 ,  A61P35/00

CPC分类号： A61K38/162 ,  A61K35/76 ,  A61K35/766 ,  A61K38/193 ,  C12N2710/24132 ,  C12N2760/20232 ,  A61K2300/00

摘要： In one aspect, the invention provides methods for preferentially killing target proliferating cells in a host, such as cancer cells, by infecting host tissues with two or more strains of virus. The strains of virus may be selected to provide a synergistic and symbiotic effect, involving a contemporaneous lytic infection in the target proliferating cells. In selected embodiments, the viruses are selected so that expression of a first virulence factor in proliferating cells infected with the first virus increases the lytic effect of the second virus; and, expression of the second virulence factor in proliferating cells infected with the second virus increases the lytic effect of the first virus. The genomes of the first and second viruses may be selected so that they are incompatible for recombination between the viral genomes in cells of the host.

摘要翻译： 一方面，本发明提供了通过用两种或多种病毒株感染宿主组织来优先杀死宿主例如癌细胞中的靶增殖细胞的方法。 可以选择病毒株以提供协同和共生作用，其涉及目标增殖细胞中的同时溶解感染。 在选择的实施方案中，选择病毒使得第一毒力因子在被第一病毒感染的增殖细胞中的表达增加了第二病毒的溶解作用; 并且第二种毒力因子在用第二种病毒感染的增殖细胞中的表达增加了第一种病毒的溶解作用。 可以选择第一和第二病毒的基因组，使得它们与宿主细胞中的病毒基因组之间的重组不相容。

公开(公告)号：US10603351B2

公开(公告)日：2020-03-31

申请号：US13060028

申请日：2009-08-20

申请人： John C. Bell ,  Fabrice Le Boeuf

发明人： John C. Bell ,  Fabrice Le Boeuf

IPC分类号： A61K38/16 ,  A61K35/766 ,  A61K35/768 ,  A61K38/19 ,  A61K35/76

摘要： In one aspect, the invention provides methods for preferentially killing target proliferating cells in a host, such as cancer cells, by infecting host tissues with two or more strains of virus. The strains of virus may be selected to provide a synergistic and symbiotic effect, involving a contemporaneous lytic infection in the target proliferating cells. In selected embodiments, the viruses are selected so that expression of a first virulence factor in proliferating cells infected with the first virus increases the lytic effect of the second virus; and, expression of the second virulence factor in proliferating cells infected with the second virus increases the lytic effect of the first virus. The genomes of the first and second viruses may be selected so that they are incompatible for recombination between the viral genomes in cells of the host.

公开(公告)号：US08940291B2

公开(公告)日：2015-01-27

申请号：US13382355

申请日：2010-07-07

申请人： John Bell ,  Jean-Simon Diallo ,  Fabrice Le Boeuf

发明人： John Bell ,  Jean-Simon Diallo ,  Fabrice Le Boeuf

IPC分类号： A01N63/00 ,  C12N7/00 ,  A61K31/341 ,  A61K45/06 ,  C07C49/675 ,  C07C49/747 ,  C07C205/37 ,  C07C217/84 ,  C07C233/32 ,  C07C233/38 ,  C07C243/38 ,  C07C255/37 ,  C07C311/44 ,  C07C323/42 ,  C07C323/60 ,  C07C335/16 ,  C07C337/06 ,  C07C337/08 ,  C07D213/75 ,  C07D233/90 ,  C07D257/04 ,  C07D307/58 ,  C07D319/20 ,  C07D333/04 ,  C07D403/12 ,  C07D409/12 ,  A61K38/00

CPC分类号： A61K35/766 ,  A61K31/275 ,  A61K31/341 ,  A61K31/365 ,  A61K38/00 ,  A61K45/06 ,  C07C49/675 ,  C07C49/747 ,  C07C205/37 ,  C07C217/84 ,  C07C233/32 ,  C07C233/38 ,  C07C243/38 ,  C07C255/37 ,  C07C311/44 ,  C07C323/42 ,  C07C323/60 ,  C07C335/16 ,  C07C337/06 ,  C07C337/08 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2603/26 ,  C07C2603/34 ,  C07D213/75 ,  C07D233/90 ,  C07D257/04 ,  C07D307/58 ,  C07D319/20 ,  C07D333/04 ,  C07D403/12 ,  C07D409/12 ,  C12N7/00 ,  C12N2760/20232 ,  C12N2760/20251 ,  A61K2300/00

摘要： Provided are viral sensitizing compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the cytotoxicity of virus to cells. Other uses, compositions and methods of using same are also provided.

摘要翻译： 提供的病毒敏化化合物通过增加病毒在细胞中的扩散，增加病毒在细胞中的滴度或增加病毒对细胞的细胞毒性而增强病毒的功效。 还提供了其他用途，组合物和使用方法。