公开(公告)号：US11944099B2

公开(公告)日：2024-04-02

申请号：US17173229

申请日：2021-02-11

Applicant: CORTEVA AGRISCIENCE LLC

Inventor： Ronald J. Heemstra ,  Ronald Ross, Jr. ,  Timothy P. Martin ,  Nicolaas Vermeulen ,  John F. Daeuble, Sr. ,  Joseph D. Eckelbarger ,  Alex Nolan ,  Kaitlyn Gray ,  David A. Demeter ,  Ricky Hunter ,  Tony K. Trullinger

IPC: A01N53/00 ,  C07C237/42 ,  C07C237/52 ,  C07C243/38 ,  C07C255/19 ,  C07C255/46 ,  C07C255/58 ,  C07C255/60 ,  C07C271/18 ,  C07C271/22 ,  C07C271/28 ,  C07C271/66 ,  C07C281/02 ,  C07C281/06 ,  C07C311/09 ,  C07C311/10 ,  C07C311/21 ,  C07C311/48 ,  C07C317/24 ,  C07C337/06 ,  C07C381/00 ,  C07D213/77 ,  C07D213/81 ,  C07D237/20 ,  C07D239/42 ,  C07D307/68 ,  C07D333/38

CPC classification number: A01N53/00 ,  C07C237/42 ,  C07C237/52 ,  C07C243/38 ,  C07C255/19 ,  C07C255/46 ,  C07C255/58 ,  C07C255/60 ,  C07C271/18 ,  C07C271/22 ,  C07C271/28 ,  C07C271/66 ,  C07C281/02 ,  C07C281/06 ,  C07C311/09 ,  C07C311/10 ,  C07C311/21 ,  C07C311/48 ,  C07C317/24 ,  C07C337/06 ,  C07C381/00 ,  C07D213/77 ,  C07D213/81 ,  C07D237/20 ,  C07D239/42 ,  C07D307/68 ,  C07D333/38 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/16

Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

公开(公告)号：US11091448B2

公开(公告)日：2021-08-17

申请号：US16312164

申请日：2017-06-26

Applicant: TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH CO., LTD.

Inventor： Guilong Zhao ,  Changying Liu ,  Yuqiang Liu ,  Huihui Chen ,  Yuquan Li ,  Haizhi Zhang ,  Yafei Xie ,  Jingwei Wu ,  Wei Liu ,  Weiren Xu ,  Meixiang Zou ,  Lida Tang

IPC: C07D249/12 ,  C07D249/08 ,  C07C331/04 ,  C07C337/06 ,  C07C25/22

Abstract: Provided is a method for preparing a URAT1 inhibitor, 2-((5-bromo-4-((4-bromonaphthalen-1-yl)methyl)-4H-1,2,4-triazol-3-yl)thio) acetic acid represented by the following formula ZXS-BR, the reaction equation of which being shown as follows. Compared with the prior art, the preparation method provided by the present application is of low cost, ease of handling, ease of quality control, and applicable to industrialization.

公开(公告)号：US09283254B2

公开(公告)日：2016-03-15

申请号：US14569416

申请日：2014-12-12

Applicant: Ottawa Hospital Research Institute

Inventor： John Bell ,  Jean-Simon Diallo ,  Fabrice Le Boeuf

IPC: A61K35/766 ,  A61K31/341 ,  A61K45/06 ,  C07C49/675 ,  C07C49/747 ,  C07C205/37 ,  C07C217/84 ,  C07C233/32 ,  C07C233/38 ,  C07C243/38 ,  C07C255/37 ,  C07C311/44 ,  C07C323/42 ,  C07C323/60 ,  C07C335/16 ,  C07C337/06 ,  C07C337/08 ,  C07D213/75 ,  C07D233/90 ,  C07D257/04 ,  C07D307/58 ,  C07D319/20 ,  C07D333/04 ,  C07D403/12 ,  C07D409/12 ,  C12N7/00 ,  A61K31/275 ,  A61K31/365 ,  A61K38/00

CPC classification number: A61K35/766 ,  A61K31/275 ,  A61K31/341 ,  A61K31/365 ,  A61K38/00 ,  A61K45/06 ,  C07C49/675 ,  C07C49/747 ,  C07C205/37 ,  C07C217/84 ,  C07C233/32 ,  C07C233/38 ,  C07C243/38 ,  C07C255/37 ,  C07C311/44 ,  C07C323/42 ,  C07C323/60 ,  C07C335/16 ,  C07C337/06 ,  C07C337/08 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2603/26 ,  C07C2603/34 ,  C07D213/75 ,  C07D233/90 ,  C07D257/04 ,  C07D307/58 ,  C07D319/20 ,  C07D333/04 ,  C07D403/12 ,  C07D409/12 ,  C12N7/00 ,  C12N2760/20232 ,  C12N2760/20251 ,  A61K2300/00

Abstract: Provided are viral sensitizing compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the cytotoxicity of virus to cells. Other uses, compositions and methods of using same are also provided.

公开(公告)号：US20140371291A1

公开(公告)日：2014-12-18

申请号：US14375006

申请日：2013-01-24

Applicant: National University Corporation University of Toyama

Inventor： Hisashi Mori ,  Naoki Toyooka ,  Mineyuki Mizuguchi ,  Takayuki Obita ,  Syuichi Hirono ,  Hiroaki Goda

IPC: C07C337/06 ,  C07D333/24

CPC classification number: C07C337/06 ,  C07C237/22 ,  C07C311/13 ,  C07C311/19 ,  C07C311/21 ,  C07C311/29 ,  C07C311/58 ,  C07C327/42 ,  C07C335/08 ,  C07C335/16 ,  C07C335/18 ,  C07C2601/14 ,  C07D333/24 ,  C07D333/38

Abstract: A novel serine racemase inhibitor exhibits sufficient activity and specificity. The serine racemase inhibitor includes one or more compounds selected from compounds respectively represented by the following general formulas [MM_1], [DR_1], [DR′_1], [LW_1], and [ED_1] as an active ingredient.

Abstract translation: 新型丝氨酸消旋酶抑制剂具有足够的活性和特异性。 丝氨酸消旋酶抑制剂包括选自分别由以下通式[MM_1]，[DR_1]，[DR'_1]，[LW_1]和[ED_1]表示的化合物作为活性成分的一种或多种化合物。

公开(公告)号：US07838559B2

公开(公告)日：2010-11-23

申请号：US11930730

申请日：2007-10-31

Applicant: Michael Frank Treacy ,  Raymond Frank Borysewicz ,  Kurt Allen Schwinghammer ,  Paul E. Rensner ,  Hassan Oloumi-Sadeghi

Inventor： Michael Frank Treacy ,  Raymond Frank Borysewicz ,  Kurt Allen Schwinghammer ,  Paul E. Rensner ,  Hassan Oloumi-Sadeghi

IPC: A61K31/175 ,  C07C337/06 ,  C07C337/08 ,  C07C281/06 ,  C07C281/08 ,  C07C281/14

CPC classification number: A01N47/34 ,  A01N37/50 ,  A01N43/56 ,  A01N47/38 ,  A01N63/00 ,  A01N53/00 ,  A01N47/40 ,  A01N47/24 ,  A01N47/02 ,  A01N43/54 ,  A01N43/22 ,  A01N37/52 ,  A01N2300/00

Abstract: The present invention provides a synergistic insecticidal composition comprising as essential active ingredients a neuronal sodium channel antagonist in combination with one or more compounds selected from the group consisting of pyrethroids, pyrethroid-type compounds, recombinant nucleopolyhedroviruses capable of expressing an insect toxin, organophosphates, carbamates, formamidines, macrocyclic lactones, amidinohydrazones, GABA antagonists and acetylcholine receptor ligands. Also provided are methods for synergistic insect control and crop protection.

公开(公告)号：US20090076076A1

公开(公告)日：2009-03-19

申请号：US12138806

申请日：2008-06-13

Applicant: Rogelio Siles ,  Ming Zhou ,  J. Freeland Ackley ,  Kevin G. Pinney ,  Shen-En Chen ,  Wara Milenka Arispe-Angulo ,  Mary Lynn Trawick

Inventor： Rogelio Siles ,  Ming Zhou ,  J. Freeland Ackley ,  Kevin G. Pinney ,  Shen-En Chen ,  Wara Milenka Arispe-Angulo ,  Mary Lynn Trawick

IPC: A61K31/47 ,  C07C337/06 ,  A61K31/18 ,  C07D335/06 ,  A61K31/382 ,  C07D215/00

CPC classification number: C07D335/06 ,  C07C337/08 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/10 ,  C07D209/40 ,  C07D215/42 ,  C07D311/04 ,  C07D311/68

Abstract: The present invention relates to semicarbazone or thiosemicarbazone inhibitors of cysteine proteases and methods of using such compounds to prevent and treat protozoan infections such as trypanosomiasis, malaria and leishmaniasis. The compounds also find use in inhibiting cysteine proteases associated with carcinogenesis, including cathepsins B and L.

Abstract translation: 本发明涉及半胱氨酸蛋白酶的缩氨基脲或缩氨基硫脲抑制剂以及使用这些化合物预防和治疗原生动物感染如锥虫病，疟疾和利什曼病的方法。 该化合物还可用于抑制与癌发生相关的半胱氨酸蛋白酶，包括组织蛋白酶B和L.

公开(公告)号：US5858327A

公开(公告)日：1999-01-12

申请号：US613121

申请日：1996-03-08

Applicant: Alfred Pollak ,  Robert Kirby ,  Robert Dunn-Dufault

Inventor： Alfred Pollak ,  Robert Kirby ,  Robert Dunn-Dufault

IPC: A61K51/08 ,  C07C337/06 ,  G01N33/534 ,  A61K51/04

CPC classification number: C07C337/06 ,  A61K51/0478 ,  G01N33/534

Abstract: Radionuclide chelating compounds are provided for conjugation to targetting molecules such as proteins, peptides or antibodies. The resulting labelled targetting molecules may be used in diagnosis and therapy.

Abstract translation: 提供放射性核素螯合化合物用于与靶向分子例如蛋白质，肽或抗体结合。 所得标记的靶向分子可用于诊断和治疗。

公开(公告)号：US5705651A

公开(公告)日：1998-01-06

申请号：US517676

申请日：1995-08-22

Applicant: Chikako Ota ,  Bunji Natsume

Inventor： Chikako Ota ,  Bunji Natsume

IPC: C07D285/14 ,  A01N43/824 ,  C07C337/06 ,  C07D285/12 ,  C07D285/135 ,  C07D513/04 ,  C07D401/00

CPC classification number: C07D285/135 ,  C07C337/06 ,  C07D513/04

Abstract: According to the process of the present invention, a 3,4-alkylene-1,3,4-thiadiazolidin-2-one, which is useful as a herbicide, can be easily produced in a high yield by reacting a 1,3,4-thiadiazolidin-2-one with a dihaloalkane in the presence of a base.

Abstract translation: 根据本发明的方法，作为除草剂有用的3,4-亚烷基-1,3,4-噻二唑烷-2-酮可以容易地通过使1,3， 4-二噻唑烷-2-酮与二卤烷在碱的存在下反应。

公开(公告)号：US4911745A

公开(公告)日：1990-03-27

申请号：US215281

申请日：1988-07-08

Applicant: Raymond A. Felix

Inventor： Raymond A. Felix

IPC: A01N43/82 ,  A01N43/824 ,  A01N47/18 ,  A01N47/36 ,  A01N47/40 ,  A01N53/00 ,  C07C67/00 ,  C07C325/00 ,  C07C327/56 ,  C07C337/02 ,  C07C337/06 ,  C07D285/12 ,  C07D285/135 ,  C07D417/06 ,  C07D417/12

CPC classification number: C07D285/135 ,  A01N43/82 ,  A01N47/18 ,  A01N47/36 ,  A01N47/40 ,  A01N53/00 ,  C07D417/12

Abstract: Novel herbicides are 3-(substituted) phenyl-2-(substituted imino)-1,3,4-dihydrothiadiazoles. Also disclosed are intermediates for such compounds, and processes for producing the herbicidal compounds and their intermediates.

公开(公告)号：US4294919A

公开(公告)日：1981-10-13

申请号：US156949

申请日：1980-06-06

Applicant: Nobuyuki Tsujino ,  Shigeo Hirano

Inventor： Nobuyuki Tsujino ,  Shigeo Hirano

IPC: C07C67/00 ,  C07C325/00 ,  C07C335/10 ,  C07C335/40 ,  C07C335/42 ,  C07C335/44 ,  C07C337/06 ,  C07C337/08 ,  C07C381/10 ,  G03C1/485 ,  G03C1/36

CPC classification number: G03C1/48561

Abstract: A direct positive silver halide photographic light-sensitive material is described, comprising a support having coated thereon a light-sensitive silver halide photographic emulsion layer and a hydrophilic colloid layer, at least one of said layers containing a compound represented by the formula (I): ##STR1## wherein R.sup.1 represents R.sup.6 or R.sup.6 CO--; and R.sup.6 represents an aliphatic group, an aromatic group, a heterocyclic aromatic group or hydrogen; R.sup.2 and R.sup.4, which may be the same or different, each represents an aliphatic group, an aromatic group, a heterocyclic aromatic group or a hydrogen atom; or R.sup.1 and R.sup.2 together can form a ring; R.sup.3 represents hydrogen or an aliphatic group; R.sup.5 represents Y or X--A--Y wherein X and Y, which may be the same or different, each represents a divalent aromatic group; and A represents a divalent group selected from --CONH--, --NHCONH--, --SO.sub.2 NH--, --B--CONH-- and --B--SO.sub.2 NH-- wherein B represents --E--, --O--E-- or --S--E-- wherein O and S is bonded to X; and E represents a divalent aliphatic group; the compound represented by formula (I) is a fogging agent which imparts a desired fogging activity without detracting from spectral sensitization.

Abstract translation: 描述了直接正性卤化银照相感光材料，其包括其上涂覆有感光卤化银照相乳剂层和亲水胶体层的载体，所述层中的至少一层含有由式（I）表示的化合物， （I） 其中R1表示R6或R6CO-; R 6表示脂肪族基团，芳香族基团，杂环芳香族基团或氢原子; R 2和R 4可以相同或不同，表示脂族基团，芳族基团，杂环芳族基团或氢原子; 或者R 1和R 2一起形成环; R3表示氢或脂族基; R5表示Y或X-A-Y，其中X和Y可以相同或不同，表示二价芳族基团; 并且A表示选自-CONH - ， - NHCONH-， - SO 2 NH - ， - CON-CONH和-B-SO 2 NH-的二价基团，其中B表示-E-，-OE-或-SE-，其中O和S为 与X键合; E表示二价脂族基; 由式（I）表示的化合物是赋予所需起雾活性而不降低光谱增感作用的起雾剂。